ID   CALB1_HUMAN             Reviewed;         261 AA.
AC   P05937;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-JAN-2012, entry version 115.
DE   RecName: Full=Calbindin;
DE   AltName: Full=Calbindin D28;
DE   AltName: Full=D-28K;
DE   AltName: Full=Vitamin D-dependent calcium-binding protein, avian-type;
GN   Name=CALB1; Synonyms=CAB27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   MEDLINE=88082818; PubMed=3691519;
RX   DOI=10.1111/j.1432-1033.1987.tb13688.x;
RA   Parmentier M., Lawson D.E.M., Vassart G.;
RT   "Human 27-kDa calbindin complementary DNA sequence. Evolutionary and
RT   functional implications.";
RL   Eur. J. Biochem. 170:207-215(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S.,
RA   Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A.,
RA   Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Allen N.R., Anderson S., Asakawa T., Blechschmidt K., Bloom T.,
RA   Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K.,
RA   DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G.,
RA   Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B.,
RA   Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C.,
RA   O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K.,
RA   Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R.,
RA   Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K.,
RA   Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q.,
RA   Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 201-261.
RC   TISSUE=Brain;
RX   MEDLINE=89233120; PubMed=2565876; DOI=10.1016/0888-7543(89)90335-2;
RA   Parmentier M., de Vijlder J.J.M., Muir E., Szpirer C., Islam M.Q.,
RA   Geurts van Kessel A., Lawson D.E.M., Vassart G.;
RT   "The human calbindin 27-kDa gene: structural organization of the 5'
RT   and 3' regions, chromosomal assignment, and restriction fragment
RT   length polymorphism.";
RL   Genomics 4:309-319(1989).
RN   [5]
RP   INTERACTION WITH RANBP9.
RX   MEDLINE=22570652; PubMed=12684061; DOI=10.1016/S0006-291X(03)00499-6;
RA   Lutz W., Frank E.M., Craig T.A., Thompson R., Venters R.A.,
RA   Kojetin D., Cavanagh J., Kumar R.;
RT   "Calbindin D28K interacts with Ran-binding protein M: identification
RT   of interacting domains by NMR spectroscopy.";
RL   Biochem. Biophys. Res. Commun. 303:1186-1192(2003).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Buffers cytosolic calcium. May stimulate a membrane
CC       Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
CC   -!- SUBUNIT: Interacts with RANBP9.
CC   -!- DOMAIN: This protein has four functional calcium-binding sites;
CC       potential sites II and VI have lost affinity for calcium.
CC   -!- SIMILARITY: Belongs to the calbindin family.
CC   -!- SIMILARITY: Contains 5 EF-hand domains.
CC   -!- WEB RESOURCE: Name=Wikipedia; Note=Calbindin entry;
CC       URL="http://en.wikipedia.org/wiki/Calbindin";
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DR   EMBL; X06661; CAA29860.1; -; mRNA.
DR   EMBL; AF068862; AAC62230.1; -; Genomic_DNA.
DR   EMBL; AC004612; AAC14672.1; -; Genomic_DNA.
DR   EMBL; AF049895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC006478; AAH06478.1; -; mRNA.
DR   EMBL; BC020864; AAH20864.1; -; mRNA.
DR   EMBL; M19878; AAA98991.1; -; Genomic_DNA.
DR   EMBL; M19879; AAA98992.1; -; Genomic_DNA.
DR   IPI; IPI00220361; -.
DR   PIR; S00234; S00234.
DR   RefSeq; NP_004920.1; NM_004929.2.
DR   UniGene; Hs.65425; -.
DR   ProteinModelPortal; P05937; -.
DR   SMR; P05937; 1-261.
DR   IntAct; P05937; 1.
DR   MINT; MINT-2834520; -.
DR   STRING; P05937; -.
DR   DMDM; 115394; -.
DR   PeptideAtlas; P05937; -.
DR   PRIDE; P05937; -.
DR   Ensembl; ENST00000265431; ENSP00000265431; ENSG00000104327.
DR   GeneID; 793; -.
DR   KEGG; hsa:793; -.
DR   UCSC; uc003yel.1; human.
DR   CTD; 793; -.
DR   GeneCards; GC08M091070; -.
DR   H-InvDB; HIX0007639; -.
DR   HGNC; HGNC:1434; CALB1.
DR   HPA; CAB002138; -.
DR   HPA; HPA023099; -.
DR   MIM; 114050; gene.
DR   neXtProt; NX_P05937; -.
DR   GeneTree; ENSGT00390000013118; -.
DR   HOGENOM; HBG444505; -.
DR   HOVERGEN; HBG000855; -.
DR   InParanoid; P05937; -.
DR   OMA; EENFLLF; -.
DR   OrthoDB; EOG48SGTQ; -.
DR   PhylomeDB; P05937; -.
DR   NextBio; 3218; -.
DR   ArrayExpress; P05937; -.
DR   Bgee; P05937; -.
DR   CleanEx; HS_CALB1; -.
DR   Genevestigator; P05937; -.
DR   GermOnline; ENSG00000104327; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; TAS:ProtInc.
DR   GO; GO:0005499; F:vitamin D binding; IEA:UniProtKB-KW.
DR   InterPro; IPR018248; EF-hand.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR002048; EF_hand_Ca-bd.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 3.
DR   KO; K14757; -.
DR   Pfam; PF00036; efhand; 2.
DR   SMART; SM00054; EFh; 4.
DR   PROSITE; PS00018; EF_HAND_1; 4.
DR   PROSITE; PS50222; EF_HAND_2; 5.
PE   1: Evidence at protein level;
KW   Acetylation; Calcium; Complete proteome; Reference proteome; Repeat;
KW   Vitamin D.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    261       Calbindin.
FT                                /FTId=PRO_0000073472.
FT   DOMAIN       11     46       EF-hand 1.
FT   DOMAIN       53     88       EF-hand 2.
FT   DOMAIN       98    133       EF-hand 3.
FT   DOMAIN      142    177       EF-hand 4.
FT   DOMAIN      186    221       EF-hand 5.
FT   CA_BIND      24     35       1.
FT   CA_BIND     111    122       2.
FT   CA_BIND     155    166       3.
FT   CA_BIND     199    210       4.
FT   REGION        2      7       Interaction with RANBP9.
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   261 AA;  30025 MW;  8ED7A09BCC5FE5E4 CRC64;
     MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT
     FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET
     EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK
     FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA
     LSDGGKLYRT DLALILCAGD N
//