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Protein

Calbindin

Gene

CALB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351Add BLAST12
Calcium bindingi111 – 1222Add BLAST12
Calcium bindingi155 – 1663Add BLAST12
Calcium bindingi199 – 2104Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • vitamin D binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Enzyme and pathway databases

ReactomeiR-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:CALB1
Synonyms:CAB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104327.7.
HGNCiHGNC:1434. CALB1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi793.
OpenTargetsiENSG00000104327.
PharmGKBiPA26026.

Polymorphism and mutation databases

BioMutaiCALB1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000734722 – 261CalbindinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP05937.
MaxQBiP05937.
PaxDbiP05937.
PeptideAtlasiP05937.
PRIDEiP05937.

PTM databases

iPTMnetiP05937.
PhosphoSitePlusiP05937.

Expressioni

Gene expression databases

BgeeiENSG00000104327.
CleanExiHS_CALB1.
ExpressionAtlasiP05937. baseline and differential.
GenevisibleiP05937. HS.

Organism-specific databases

HPAiCAB002138.
HPA023099.
HPA056734.

Interactioni

Subunit structurei

Interacts with RANBP9.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107244. 5 interactors.
IntActiP05937. 5 interactors.
MINTiMINT-2834520.
STRINGi9606.ENSP00000265431.

Structurei

3D structure databases

ProteinModelPortaliP05937.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 177EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini186 – 221EF-hand 5PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 7Interaction with RANBP91 Publication6

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000013118.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP05937.
KOiK14757.
OMAiMQTWRKY.
OrthoDBiEOG091G0GNH.
PhylomeDBiP05937.
TreeFamiTF325083.

Family and domain databases

InterProiView protein in InterPro
IPR029634. Calbindin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PANTHERiPTHR19972:SF3. PTHR19972:SF3. 1 hit.
PfamiView protein in Pfam
PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05937-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA
60 70 80 90 100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT
260
DLALILCAGD N
Length:261
Mass (Da):30,025
Last modified:January 23, 2007 - v2
Checksum:i8ED7A09BCC5FE5E4
GO
Isoform 2 (identifier: P05937-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,609
Checksum:i50B8050A3B9210E3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555081 – 57Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06661 mRNA. Translation: CAA29860.1.
AF068862 Genomic DNA. Translation: AAC62230.1.
AC004612 Genomic DNA. Translation: AAC14672.1.
AK054881 mRNA. Translation: BAG51438.1.
AK312491 mRNA. Translation: BAG35393.1.
AK315959 mRNA. Translation: BAH14330.1.
AF049895 Genomic DNA. No translation available.
AC123779 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91665.1.
CH471060 Genomic DNA. Translation: EAW91666.1.
BC006478 mRNA. Translation: AAH06478.1.
BC020864 mRNA. Translation: AAH20864.1.
M19878 Genomic DNA. Translation: AAA98991.1.
M19879 Genomic DNA. Translation: AAA98992.1.
CCDSiCCDS6251.1. [P05937-1]
PIRiS00234.
RefSeqiNP_004920.1. NM_004929.3. [P05937-1]
UniGeneiHs.65425.

Genome annotation databases

EnsembliENST00000265431; ENSP00000265431; ENSG00000104327. [P05937-1]
ENST00000518457; ENSP00000429602; ENSG00000104327. [P05937-2]
GeneIDi793.
KEGGihsa:793.
UCSCiuc003yel.2. human. [P05937-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALB1_HUMAN
AccessioniPrimary (citable) accession number: P05937
Secondary accession number(s): B2R696, B7Z9J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families