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Protein

Calbindin

Gene

CALB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi24 – 351Add BLAST12
Calcium bindingi111 – 1222Add BLAST12
Calcium bindingi155 – 1663Add BLAST12
Calcium bindingi199 – 2104Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • vitamin D binding Source: UniProtKB-KW
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Enzyme and pathway databases

ReactomeiR-HSA-977225 Amyloid fiber formation

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:CALB1
Synonyms:CAB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104327.7
HGNCiHGNC:1434 CALB1
MIMi114050 gene
neXtProtiNX_P05937

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi793
OpenTargetsiENSG00000104327
PharmGKBiPA26026

Polymorphism and mutation databases

BioMutaiCALB1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000734722 – 261CalbindinAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiP05937
MaxQBiP05937
PaxDbiP05937
PeptideAtlasiP05937
PRIDEiP05937

PTM databases

iPTMnetiP05937
PhosphoSitePlusiP05937

Expressioni

Gene expression databases

BgeeiENSG00000104327
CleanExiHS_CALB1
ExpressionAtlasiP05937 baseline and differential
GenevisibleiP05937 HS

Organism-specific databases

HPAiCAB002138
HPA023099
HPA056734

Interactioni

Subunit structurei

Interacts with RANBP9.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107244, 5 interactors
IntActiP05937, 5 interactors
MINTiP05937
STRINGi9606.ENSP00000265431

Structurei

3D structure databases

ProteinModelPortaliP05937
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 46EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini98 – 133EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini142 – 177EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini186 – 221EF-hand 5PROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 7Interaction with RANBP91 Publication6

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000013118
HOGENOMiHOG000231866
HOVERGENiHBG000855
InParanoidiP05937
KOiK14757
OMAiMQTWRKY
OrthoDBiEOG091G0GNH
PhylomeDBiP05937
TreeFamiTF325083

Family and domain databases

InterProiView protein in InterPro
IPR029634 Calbindin
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PANTHERiPTHR19972:SF3 PTHR19972:SF3, 1 hit
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 2 hits
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05937-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA
60 70 80 90 100
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC
110 120 130 140 150
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM
160 170 180 190 200
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ
210 220 230 240 250
DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT
260
DLALILCAGD N
Length:261
Mass (Da):30,025
Last modified:January 23, 2007 - v2
Checksum:i8ED7A09BCC5FE5E4
GO
Isoform 2 (identifier: P05937-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,609
Checksum:i50B8050A3B9210E3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555081 – 57Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06661 mRNA Translation: CAA29860.1
AF068862 Genomic DNA Translation: AAC62230.1
AC004612 Genomic DNA Translation: AAC14672.1
AK054881 mRNA Translation: BAG51438.1
AK312491 mRNA Translation: BAG35393.1
AK315959 mRNA Translation: BAH14330.1
AF049895 Genomic DNA No translation available.
AC123779 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW91665.1
CH471060 Genomic DNA Translation: EAW91666.1
BC006478 mRNA Translation: AAH06478.1
BC020864 mRNA Translation: AAH20864.1
M19878 Genomic DNA Translation: AAA98991.1
M19879 Genomic DNA Translation: AAA98992.1
CCDSiCCDS6251.1 [P05937-1]
PIRiS00234
RefSeqiNP_004920.1, NM_004929.3 [P05937-1]
UniGeneiHs.65425

Genome annotation databases

EnsembliENST00000265431; ENSP00000265431; ENSG00000104327 [P05937-1]
ENST00000518457; ENSP00000429602; ENSG00000104327 [P05937-2]
GeneIDi793
KEGGihsa:793
UCSCiuc003yel.2 human [P05937-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALB1_HUMAN
AccessioniPrimary (citable) accession number: P05937
Secondary accession number(s): B2R696, B7Z9J4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 172 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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