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Reviewed, UniProtKB/Swiss-Prot P05937 (CALB1_HUMAN)

Last modified November 3, 2009. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Calbindin
Alternative name(s):
    Vitamin D-dependent calcium-binding protein, avian-type
    Calbindin D28
    D-28K
Gene names
Name: CALB1
Synonyms: CAB27
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length261 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Subunit structure

Interacts with RANBP9. Ref.5

Domain

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similarities

Belongs to the calbindin family.

Contains 5 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Vitamin D
   PTMAcetylation
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentnucleus

Inferred from direct assay. Source: UniProtKB

   Molecular functioncalcium ion binding Ref.1

Traceable author statement. Source: ProtInc

protein binding Ref.1

Traceable author statement. Source: ProtInc

vitamin D binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 261260Calbindin
PRO_0000073472

Regions

Domain11 – 4636EF-hand 1
Domain53 – 8836EF-hand 2
Domain98 – 13336EF-hand 3
Domain142 – 17736EF-hand 4
Domain186 – 22136EF-hand 5
Calcium binding24 – 35121
Calcium binding111 – 122122
Calcium binding155 – 166123
Calcium binding199 – 210124
Region2 – 76Interaction with RANBP9

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
P05937-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 8ED7A09BCC5FE5E4

FASTA26130,025
        10         20         30         40         50         60 
MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT 

        70         80         90        100        110        120 
FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET 

       130        140        150        160        170        180 
EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK 

       190        200        210        220        230        240 
FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA 

       250        260 
LSDGGKLYRT DLALILCAGD N 

« Hide

References

« Hide 'large scale' references
[1]"Human 27-kDa calbindin complementary DNA sequence. Evolutionary and functional implications."
Parmentier M., Lawson D.E.M., Vassart G.
Eur. J. Biochem. 170:207-215(1987) [PubMed: 3691519] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"DNA sequence and analysis of human chromosome 8."
Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T. expand/collapse author list , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
Nature 439:331-335(2006) [PubMed: 16421571] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Lung.
[4]"The human calbindin 27-kDa gene: structural organization of the 5' and 3' regions, chromosomal assignment, and restriction fragment length polymorphism."
Parmentier M., de Vijlder J.J.M., Muir E., Szpirer C., Islam M.Q., Geurts van Kessel A., Lawson D.E.M., Vassart G.
Genomics 4:309-319(1989) [PubMed: 2565876] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 201-261.
Tissue: Brain.
[5]"Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy."
Lutz W., Frank E.M., Craig T.A., Thompson R., Venters R.A., Kojetin D., Cavanagh J., Kumar R.
Biochem. Biophys. Res. Commun. 303:1186-1192(2003) [PubMed: 12684061] [Abstract]
Cited for: INTERACTION WITH RANBP9.
[6]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Web resources

Wikipedia

Calbindin entry

Cross-references

Sequence databases

X06661 mRNA. Translation: CAA29860.1.
AF068862 Genomic DNA. Translation: AAC62230.1.
AC004612 Genomic DNA. Translation: AAC14672.1.
AF049895 Genomic DNA. No translation available.
BC006478 mRNA. Translation: AAH06478.1.
BC020864 mRNA. Translation: AAH20864.1.
M19878 Genomic DNA. Translation: AAA98991.1.
M19879 Genomic DNA. Translation: AAA98992.1.
IPIIPI00220361.
PIRS00234.
RefSeqNP_004920.1.
UniGeneHs.65425

3D structure databases

HSSPHSSP built from PDB template 1A75 based on UniProtKB P02621.
SMRP05937. Positions 1-261.
ModBaseSearch...

Protein-protein interaction databases

STRINGP05937.

Proteomic databases

PeptideAtlasP05937.
PRIDEP05937.

Genome annotation databases

EnsemblENST00000265431; ENSP00000265431; ENSG00000104327; Homo sapiens. [Genome view]
GeneID793.
KEGGhsa:793.
UCSCuc003yel.1. human.

Organism-specific databases

CTD793.
GeneCardsGC08M091140.
H-InvDBHIX0007639.
HGNCHGNC:1434. CALB1.
HPACAB002138.
HPA023099.
MIM114050. gene.
PharmGKBPA26026.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP05937.
HOVERGENP05937.
OMAEENFLLF.

Gene expression databases

ArrayExpressP05937.
BgeeP05937.
CleanExHS_CALB1.
GenevestigatorP05937.
GermOnlineENSG00000104327. Homo sapiens.

Family and domain databases

InterProIPR011992. EF-Hand_type.
IPR018248. EF_hand.
IPR018247. EF_HAND_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca_bd.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PfamPF00036. efhand. 3 hits.
[Graphical view]
ProDomPD000012. EF-hand. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00054. EFh. 4 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio3218.
SOURCESearch...

Entry information

Entry nameCALB1_HUMAN
AccessionPrimary (citable) accession number: P05937
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 3, 2009
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents