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P05937

- CALB1_HUMAN

UniProt

P05937 - CALB1_HUMAN

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Protein
Calbindin
Gene
CALB1, CAB27
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi24 – 35121
Add
BLAST
Calcium bindingi111 – 122122
Add
BLAST
Calcium bindingi155 – 166123
Add
BLAST
Calcium bindingi199 – 210124
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: UniProt
  2. protein binding Source: IntAct
  3. vitamin D binding Source: UniProtKB-KW
  4. zinc ion binding Source: UniProt
Complete GO annotation...

GO - Biological processi

  1. cellular response to organic substance Source: Ensembl
  2. cytosolic calcium ion homeostasis Source: Ensembl
  3. locomotory behavior Source: Ensembl
  4. long-term memory Source: UniProt
  5. metanephric collecting duct development Source: Ensembl
  6. metanephric connecting tubule development Source: Ensembl
  7. metanephric distal convoluted tubule development Source: Ensembl
  8. metanephric part of ureteric bud development Source: Ensembl
  9. regulation of synaptic plasticity Source: Ensembl
  10. retina layer formation Source: Ensembl
  11. short-term memory Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Calbindin
Alternative name(s):
Calbindin D28
D-28K
Vitamin D-dependent calcium-binding protein, avian-type
Gene namesi
Name:CALB1
Synonyms:CAB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:1434. CALB1.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: UniProt
  2. cytosol Source: Ensembl
  3. dendrite Source: UniProt
  4. extracellular vesicular exosome Source: UniProt
  5. neuronal cell body Source: UniProt
  6. nucleus Source: UniProtKB
  7. synapse Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 261260Calbindin
PRO_0000073472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP05937.
PaxDbiP05937.
PeptideAtlasiP05937.
PRIDEiP05937.

PTM databases

PhosphoSiteiP05937.

Expressioni

Gene expression databases

ArrayExpressiP05937.
BgeeiP05937.
CleanExiHS_CALB1.
GenevestigatoriP05937.

Organism-specific databases

HPAiCAB002138.
HPA023099.

Interactioni

Subunit structurei

Interacts with RANBP9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
IKBKGQ9Y6K93EBI-4286943,EBI-81279
TRPV5Q9NQA54EBI-4286943,EBI-1053443

Protein-protein interaction databases

BioGridi107244. 5 interactions.
IntActiP05937. 5 interactions.
MINTiMINT-2834520.
STRINGi9606.ENSP00000265431.

Structurei

3D structure databases

ProteinModelPortaliP05937.
SMRiP05937. Positions 1-261.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 4636EF-hand 1
Add
BLAST
Domaini53 – 8836EF-hand 2
Add
BLAST
Domaini98 – 13336EF-hand 3
Add
BLAST
Domaini142 – 17736EF-hand 4
Add
BLAST
Domaini186 – 22136EF-hand 5
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 76Interaction with RANBP9

Domaini

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

Sequence similaritiesi

Belongs to the calbindin family.
Contains 5 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG299305.
HOGENOMiHOG000231866.
HOVERGENiHBG000855.
InParanoidiP05937.
KOiK14757.
OMAiEENFLLF.
OrthoDBiEOG71G9VB.
PhylomeDBiP05937.
TreeFamiTF325083.

Family and domain databases

Gene3Di1.10.238.10. 3 hits.
InterProiIPR029634. Calbindin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PANTHERiPTHR19972:SF3. PTHR19972:SF3. 1 hit.
PfamiPF13405. EF-hand_6. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P05937-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA    50
GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC 100
EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM 150
LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ 200
DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT 250
DLALILCAGD N 261
Length:261
Mass (Da):30,025
Last modified:January 23, 2007 - v2
Checksum:i8ED7A09BCC5FE5E4
GO
Isoform 2 (identifier: P05937-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: Missing.

Note: No experimental confirmation available.

Show »
Length:204
Mass (Da):23,609
Checksum:i50B8050A3B9210E3
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757Missing in isoform 2.
VSP_055508Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06661 mRNA. Translation: CAA29860.1.
AF068862 Genomic DNA. Translation: AAC62230.1.
AC004612 Genomic DNA. Translation: AAC14672.1.
AK054881 mRNA. Translation: BAG51438.1.
AK312491 mRNA. Translation: BAG35393.1.
AK315959 mRNA. Translation: BAH14330.1.
AF049895 Genomic DNA. No translation available.
AC123779 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91665.1.
CH471060 Genomic DNA. Translation: EAW91666.1.
BC006478 mRNA. Translation: AAH06478.1.
BC020864 mRNA. Translation: AAH20864.1.
M19878 Genomic DNA. Translation: AAA98991.1.
M19879 Genomic DNA. Translation: AAA98992.1.
CCDSiCCDS6251.1.
PIRiS00234.
RefSeqiNP_004920.1. NM_004929.2.
UniGeneiHs.65425.

Genome annotation databases

EnsembliENST00000265431; ENSP00000265431; ENSG00000104327.
ENST00000518457; ENSP00000429602; ENSG00000104327.
GeneIDi793.
KEGGihsa:793.
UCSCiuc003yel.1. human.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Calbindin entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06661 mRNA. Translation: CAA29860.1 .
AF068862 Genomic DNA. Translation: AAC62230.1 .
AC004612 Genomic DNA. Translation: AAC14672.1 .
AK054881 mRNA. Translation: BAG51438.1 .
AK312491 mRNA. Translation: BAG35393.1 .
AK315959 mRNA. Translation: BAH14330.1 .
AF049895 Genomic DNA. No translation available.
AC123779 Genomic DNA. No translation available.
CH471060 Genomic DNA. Translation: EAW91665.1 .
CH471060 Genomic DNA. Translation: EAW91666.1 .
BC006478 mRNA. Translation: AAH06478.1 .
BC020864 mRNA. Translation: AAH20864.1 .
M19878 Genomic DNA. Translation: AAA98991.1 .
M19879 Genomic DNA. Translation: AAA98992.1 .
CCDSi CCDS6251.1.
PIRi S00234.
RefSeqi NP_004920.1. NM_004929.2.
UniGenei Hs.65425.

3D structure databases

ProteinModelPortali P05937.
SMRi P05937. Positions 1-261.
ModBasei Search...

Protein-protein interaction databases

BioGridi 107244. 5 interactions.
IntActi P05937. 5 interactions.
MINTi MINT-2834520.
STRINGi 9606.ENSP00000265431.

PTM databases

PhosphoSitei P05937.

Proteomic databases

MaxQBi P05937.
PaxDbi P05937.
PeptideAtlasi P05937.
PRIDEi P05937.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000265431 ; ENSP00000265431 ; ENSG00000104327 .
ENST00000518457 ; ENSP00000429602 ; ENSG00000104327 .
GeneIDi 793.
KEGGi hsa:793.
UCSCi uc003yel.1. human.

Organism-specific databases

CTDi 793.
GeneCardsi GC08M091070.
HGNCi HGNC:1434. CALB1.
HPAi CAB002138.
HPA023099.
MIMi 114050. gene.
neXtProti NX_P05937.
PharmGKBi PA26026.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG299305.
HOGENOMi HOG000231866.
HOVERGENi HBG000855.
InParanoidi P05937.
KOi K14757.
OMAi EENFLLF.
OrthoDBi EOG71G9VB.
PhylomeDBi P05937.
TreeFami TF325083.

Miscellaneous databases

GenomeRNAii 793.
NextBioi 3218.
PROi P05937.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05937.
Bgeei P05937.
CleanExi HS_CALB1.
Genevestigatori P05937.

Family and domain databases

Gene3Di 1.10.238.10. 3 hits.
InterProi IPR029634. Calbindin.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
PANTHERi PTHR19972:SF3. PTHR19972:SF3. 1 hit.
Pfami PF13405. EF-hand_6. 2 hits.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 4 hits.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human 27-kDa calbindin complementary DNA sequence. Evolutionary and functional implications."
    Parmentier M., Lawson D.E.M., Vassart G.
    Eur. J. Biochem. 170:207-215(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Amygdala, Cerebellum and Substantia nigra.
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Lung.
  6. "The human calbindin 27-kDa gene: structural organization of the 5' and 3' regions, chromosomal assignment, and restriction fragment length polymorphism."
    Parmentier M., de Vijlder J.J.M., Muir E., Szpirer C., Islam M.Q., Geurts van Kessel A., Lawson D.E.M., Vassart G.
    Genomics 4:309-319(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 201-261.
    Tissue: Brain.
  7. "Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy."
    Lutz W., Frank E.M., Craig T.A., Thompson R., Venters R.A., Kojetin D., Cavanagh J., Kumar R.
    Biochem. Biophys. Res. Commun. 303:1186-1192(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RANBP9.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCALB1_HUMAN
AccessioniPrimary (citable) accession number: P05937
Secondary accession number(s): B2R696, B7Z9J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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