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P05937

- CALB1_HUMAN

UniProt

P05937 - CALB1_HUMAN

Protein

Calbindin

Gene

CALB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi24 – 35121Add
    BLAST
    Calcium bindingi111 – 122122Add
    BLAST
    Calcium bindingi155 – 166123Add
    BLAST
    Calcium bindingi199 – 210124Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: UniProt
    2. protein binding Source: IntAct
    3. vitamin D binding Source: UniProtKB-KW
    4. zinc ion binding Source: UniProt

    GO - Biological processi

    1. cellular response to organic substance Source: Ensembl
    2. cytosolic calcium ion homeostasis Source: Ensembl
    3. learning or memory Source: Ensembl
    4. locomotory behavior Source: Ensembl
    5. long-term memory Source: UniProt
    6. metanephric collecting duct development Source: Ensembl
    7. metanephric connecting tubule development Source: Ensembl
    8. metanephric distal convoluted tubule development Source: Ensembl
    9. metanephric part of ureteric bud development Source: Ensembl
    10. regulation of synaptic plasticity Source: Ensembl
    11. retina layer formation Source: Ensembl
    12. short-term memory Source: UniProt

    Keywords - Ligandi

    Calcium, Metal-binding, Vitamin D

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calbindin
    Alternative name(s):
    Calbindin D28
    D-28K
    Vitamin D-dependent calcium-binding protein, avian-type
    Gene namesi
    Name:CALB1
    Synonyms:CAB27
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:1434. CALB1.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: UniProt
    2. cytosol Source: Ensembl
    3. dendrite Source: UniProt
    4. extracellular vesicular exosome Source: UniProt
    5. neuronal cell body Source: UniProt
    6. nucleus Source: UniProtKB
    7. synapse Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 261260CalbindinPRO_0000073472Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP05937.
    PaxDbiP05937.
    PeptideAtlasiP05937.
    PRIDEiP05937.

    PTM databases

    PhosphoSiteiP05937.

    Expressioni

    Gene expression databases

    ArrayExpressiP05937.
    BgeeiP05937.
    CleanExiHS_CALB1.
    GenevestigatoriP05937.

    Organism-specific databases

    HPAiCAB002138.
    HPA023099.

    Interactioni

    Subunit structurei

    Interacts with RANBP9.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IKBKGQ9Y6K93EBI-4286943,EBI-81279
    TRPV5Q9NQA54EBI-4286943,EBI-1053443

    Protein-protein interaction databases

    BioGridi107244. 5 interactions.
    IntActiP05937. 5 interactions.
    MINTiMINT-2834520.
    STRINGi9606.ENSP00000265431.

    Structurei

    3D structure databases

    ProteinModelPortaliP05937.
    SMRiP05937. Positions 1-261.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 4636EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini53 – 8836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 13336EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 17736EF-hand 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini186 – 22136EF-hand 5PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 76Interaction with RANBP9

    Domaini

    This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.

    Sequence similaritiesi

    Belongs to the calbindin family.Curated
    Contains 5 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG299305.
    HOGENOMiHOG000231866.
    HOVERGENiHBG000855.
    InParanoidiP05937.
    KOiK14757.
    OMAiEENFLLF.
    OrthoDBiEOG71G9VB.
    PhylomeDBiP05937.
    TreeFamiTF325083.

    Family and domain databases

    Gene3Di1.10.238.10. 3 hits.
    InterProiIPR029634. Calbindin.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PANTHERiPTHR19972:SF3. PTHR19972:SF3. 1 hit.
    PfamiPF13405. EF-hand_6. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P05937-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA    50
    GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC 100
    EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM 150
    LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ 200
    DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT 250
    DLALILCAGD N 261
    Length:261
    Mass (Da):30,025
    Last modified:January 23, 2007 - v2
    Checksum:i8ED7A09BCC5FE5E4
    GO
    Isoform 2 (identifier: P05937-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-57: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:204
    Mass (Da):23,609
    Checksum:i50B8050A3B9210E3
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 5757Missing in isoform 2. 1 PublicationVSP_055508Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06661 mRNA. Translation: CAA29860.1.
    AF068862 Genomic DNA. Translation: AAC62230.1.
    AC004612 Genomic DNA. Translation: AAC14672.1.
    AK054881 mRNA. Translation: BAG51438.1.
    AK312491 mRNA. Translation: BAG35393.1.
    AK315959 mRNA. Translation: BAH14330.1.
    AF049895 Genomic DNA. No translation available.
    AC123779 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91665.1.
    CH471060 Genomic DNA. Translation: EAW91666.1.
    BC006478 mRNA. Translation: AAH06478.1.
    BC020864 mRNA. Translation: AAH20864.1.
    M19878 Genomic DNA. Translation: AAA98991.1.
    M19879 Genomic DNA. Translation: AAA98992.1.
    CCDSiCCDS6251.1.
    PIRiS00234.
    RefSeqiNP_004920.1. NM_004929.2.
    UniGeneiHs.65425.

    Genome annotation databases

    EnsembliENST00000265431; ENSP00000265431; ENSG00000104327. [P05937-1]
    ENST00000518457; ENSP00000429602; ENSG00000104327. [P05937-2]
    GeneIDi793.
    KEGGihsa:793.
    UCSCiuc003yel.1. human.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Calbindin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06661 mRNA. Translation: CAA29860.1 .
    AF068862 Genomic DNA. Translation: AAC62230.1 .
    AC004612 Genomic DNA. Translation: AAC14672.1 .
    AK054881 mRNA. Translation: BAG51438.1 .
    AK312491 mRNA. Translation: BAG35393.1 .
    AK315959 mRNA. Translation: BAH14330.1 .
    AF049895 Genomic DNA. No translation available.
    AC123779 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91665.1 .
    CH471060 Genomic DNA. Translation: EAW91666.1 .
    BC006478 mRNA. Translation: AAH06478.1 .
    BC020864 mRNA. Translation: AAH20864.1 .
    M19878 Genomic DNA. Translation: AAA98991.1 .
    M19879 Genomic DNA. Translation: AAA98992.1 .
    CCDSi CCDS6251.1.
    PIRi S00234.
    RefSeqi NP_004920.1. NM_004929.2.
    UniGenei Hs.65425.

    3D structure databases

    ProteinModelPortali P05937.
    SMRi P05937. Positions 1-261.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107244. 5 interactions.
    IntActi P05937. 5 interactions.
    MINTi MINT-2834520.
    STRINGi 9606.ENSP00000265431.

    PTM databases

    PhosphoSitei P05937.

    Proteomic databases

    MaxQBi P05937.
    PaxDbi P05937.
    PeptideAtlasi P05937.
    PRIDEi P05937.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000265431 ; ENSP00000265431 ; ENSG00000104327 . [P05937-1 ]
    ENST00000518457 ; ENSP00000429602 ; ENSG00000104327 . [P05937-2 ]
    GeneIDi 793.
    KEGGi hsa:793.
    UCSCi uc003yel.1. human.

    Organism-specific databases

    CTDi 793.
    GeneCardsi GC08M091070.
    HGNCi HGNC:1434. CALB1.
    HPAi CAB002138.
    HPA023099.
    MIMi 114050. gene.
    neXtProti NX_P05937.
    PharmGKBi PA26026.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG299305.
    HOGENOMi HOG000231866.
    HOVERGENi HBG000855.
    InParanoidi P05937.
    KOi K14757.
    OMAi EENFLLF.
    OrthoDBi EOG71G9VB.
    PhylomeDBi P05937.
    TreeFami TF325083.

    Miscellaneous databases

    GenomeRNAii 793.
    NextBioi 3218.
    PROi P05937.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05937.
    Bgeei P05937.
    CleanExi HS_CALB1.
    Genevestigatori P05937.

    Family and domain databases

    Gene3Di 1.10.238.10. 3 hits.
    InterProi IPR029634. Calbindin.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    PANTHERi PTHR19972:SF3. PTHR19972:SF3. 1 hit.
    Pfami PF13405. EF-hand_6. 2 hits.
    PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human 27-kDa calbindin complementary DNA sequence. Evolutionary and functional implications."
      Parmentier M., Lawson D.E.M., Vassart G.
      Eur. J. Biochem. 170:207-215(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Amygdala, Cerebellum and Substantia nigra.
    3. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney and Lung.
    6. "The human calbindin 27-kDa gene: structural organization of the 5' and 3' regions, chromosomal assignment, and restriction fragment length polymorphism."
      Parmentier M., de Vijlder J.J.M., Muir E., Szpirer C., Islam M.Q., Geurts van Kessel A., Lawson D.E.M., Vassart G.
      Genomics 4:309-319(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42 AND 201-261.
      Tissue: Brain.
    7. "Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy."
      Lutz W., Frank E.M., Craig T.A., Thompson R., Venters R.A., Kojetin D., Cavanagh J., Kumar R.
      Biochem. Biophys. Res. Commun. 303:1186-1192(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RANBP9.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCALB1_HUMAN
    AccessioniPrimary (citable) accession number: P05937
    Secondary accession number(s): B2R696, B7Z9J4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3