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Protein

HTH-type transcriptional regulator IlvY

Gene

ilvY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:PD00200.
ECOL316407:JW3746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator IlvY
Gene namesi
Name:ilvY
Ordered Locus Names:b3773, JW3746
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10503. ilvY.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056551 – 297HTH-type transcriptional regulator IlvYAdd BLAST297

Proteomic databases

PaxDbiP05827.
PRIDEiP05827.

Interactioni

Protein-protein interaction databases

BioGridi4263332. 4 interactors.
DIPiDIP-10028N.
IntActiP05827. 4 interactors.
STRINGi511145.b3773.

Structurei

3D structure databases

ProteinModelPortaliP05827.
SMRiP05827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 HTH lysR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105EMY. Bacteria.
COG0583. LUCA.
HOGENOMiHOG000269751.
InParanoidiP05827.
KOiK02521.
OMAiTAKAMHI.
PhylomeDBiP05827.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR
60 70 80 90 100
DNRTVTLTEA GEELRVFAQQ TLLQYQQLRH TIDQQGPSLS GELHIFCSVT
110 120 130 140 150
AAYSHLPPIL DRFRAEHPSV EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE
160 170 180 190 200
TLPGAVAFSM LENLAVVLIA PALPCPVRNQ VSVEKPDWST VPFIMADQGP
210 220 230 240 250
VRRRIELWFR RNKISNPMIY ATVGGHEAMV SMVALGCGVA LLPEVVLENS
260 270 280 290
PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIEAFW KILPNHK
Length:297
Mass (Da):33,204
Last modified:November 1, 1988 - v1
Checksum:iE8FA6A0FC52D3815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11689 Genomic DNA. Translation: AAA24028.1.
M87049 Genomic DNA. Translation: AAA67576.1.
U00096 Genomic DNA. Translation: AAC77493.1.
AP009048 Genomic DNA. Translation: BAE77524.1.
M32253 Genomic DNA. Translation: AAA24025.1.
PIRiB26287. RGECIY.
RefSeqiNP_418221.1. NC_000913.3.
WP_000365791.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC77493; AAC77493; b3773.
BAE77524; BAE77524; BAE77524.
GeneIDi948284.
KEGGiecj:JW3746.
eco:b3773.
PATRICi32123041. VBIEscCol129921_3890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11689 Genomic DNA. Translation: AAA24028.1.
M87049 Genomic DNA. Translation: AAA67576.1.
U00096 Genomic DNA. Translation: AAC77493.1.
AP009048 Genomic DNA. Translation: BAE77524.1.
M32253 Genomic DNA. Translation: AAA24025.1.
PIRiB26287. RGECIY.
RefSeqiNP_418221.1. NC_000913.3.
WP_000365791.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP05827.
SMRiP05827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263332. 4 interactors.
DIPiDIP-10028N.
IntActiP05827. 4 interactors.
STRINGi511145.b3773.

Proteomic databases

PaxDbiP05827.
PRIDEiP05827.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC77493; AAC77493; b3773.
BAE77524; BAE77524; BAE77524.
GeneIDi948284.
KEGGiecj:JW3746.
eco:b3773.
PATRICi32123041. VBIEscCol129921_3890.

Organism-specific databases

EchoBASEiEB0498.
EcoGeneiEG10503. ilvY.

Phylogenomic databases

eggNOGiENOG4105EMY. Bacteria.
COG0583. LUCA.
HOGENOMiHOG000269751.
InParanoidiP05827.
KOiK02521.
OMAiTAKAMHI.
PhylomeDBiP05827.

Enzyme and pathway databases

BioCyciEcoCyc:PD00200.
ECOL316407:JW3746-MONOMER.

Miscellaneous databases

PROiP05827.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005119. LysR_subst-bd.
IPR000847. Tscrpt_reg_HTH_LysR.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00126. HTH_1. 1 hit.
PF03466. LysR_substrate. 1 hit.
[Graphical view]
PRINTSiPR00039. HTHLYSR.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS50931. HTH_LYSR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILVY_ECOLI
AccessioniPrimary (citable) accession number: P05827
Secondary accession number(s): Q2M882
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.