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Protein

HTH-type transcriptional regulator IlvY

Gene

ilvY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

This protein activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate. IlvY is also a negative regulator of its own expression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 37H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:PD00200

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator IlvY
Gene namesi
Name:ilvY
Ordered Locus Names:b3773, JW3746
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG10503 ilvY

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056551 – 297HTH-type transcriptional regulator IlvYAdd BLAST297

Proteomic databases

PaxDbiP05827
PRIDEiP05827

Interactioni

Protein-protein interaction databases

BioGridi4263332, 4 interactors
DIPiDIP-10028N
IntActiP05827, 4 interactors
STRINGi316385.ECDH10B_3962

Structurei

3D structure databases

ProteinModelPortaliP05827
SMRiP05827
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 58HTH lysR-typePROSITE-ProRule annotationAdd BLAST58

Phylogenomic databases

eggNOGiENOG4105EMY Bacteria
COG0583 LUCA
HOGENOMiHOG000269751
InParanoidiP05827
KOiK02521
OMAiFERDNRS
PhylomeDBiP05827

Family and domain databases

CDDicd08430 PBP2_IlvY, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR037404 IlvY_PBP2
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P05827-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLRDLKTFL HLAESRHFGR SARAMHVSPS TLSRQIQRLE EDLGQPLFVR
60 70 80 90 100
DNRTVTLTEA GEELRVFAQQ TLLQYQQLRH TIDQQGPSLS GELHIFCSVT
110 120 130 140 150
AAYSHLPPIL DRFRAEHPSV EIKLTTGDAA DAMEKVVTGE ADLAIAGKPE
160 170 180 190 200
TLPGAVAFSM LENLAVVLIA PALPCPVRNQ VSVEKPDWST VPFIMADQGP
210 220 230 240 250
VRRRIELWFR RNKISNPMIY ATVGGHEAMV SMVALGCGVA LLPEVVLENS
260 270 280 290
PEPVRNRVMI LERSDEKTPF ELGVCAQKKR LHEPLIEAFW KILPNHK
Length:297
Mass (Da):33,204
Last modified:November 1, 1988 - v1
Checksum:iE8FA6A0FC52D3815
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11689 Genomic DNA Translation: AAA24028.1
M87049 Genomic DNA Translation: AAA67576.1
U00096 Genomic DNA Translation: AAC77493.1
AP009048 Genomic DNA Translation: BAE77524.1
M32253 Genomic DNA Translation: AAA24025.1
PIRiB26287 RGECIY
RefSeqiNP_418221.1, NC_000913.3
WP_000365791.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC77493; AAC77493; b3773
BAE77524; BAE77524; BAE77524
GeneIDi948284
KEGGiecj:JW3746
eco:b3773
PATRICifig|511145.12.peg.3890

Entry informationi

Entry nameiILVY_ECOLI
AccessioniPrimary (citable) accession number: P05827
Secondary accession number(s): Q2M882
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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