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Protein

Colicin-M

Gene

cma

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Colicins are polypeptide toxins produced by and active against E.coli and closely related bacteria.
This is a calcium-requiring inhibitor for murein biosynthesis; it causes lysis of sensitive cells accompanied by murein degradation. The target site is possibly the cytoplasmic membrane.

Miscellaneous

This colicin requires TonB for its uptake.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin

Names & Taxonomyi

Protein namesi
Recommended name:
Colicin-M
Gene namesi
Name:cma
Encoded oniPlasmid ColBM-Cl1390 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002186891 – 271Colicin-MAdd BLAST271

Proteomic databases

PRIDEiP05820

Interactioni

Protein-protein interaction databases

IntActiP05820, 1 interactor

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 13Combined sources3
Helixi18 – 21Combined sources4
Helixi38 – 45Combined sources8
Helixi49 – 65Combined sources17
Beta strandi67 – 69Combined sources3
Helixi70 – 92Combined sources23
Helixi98 – 104Combined sources7
Helixi109 – 111Combined sources3
Helixi114 – 117Combined sources4
Beta strandi120 – 122Combined sources3
Helixi128 – 138Combined sources11
Beta strandi144 – 146Combined sources3
Helixi148 – 150Combined sources3
Helixi157 – 159Combined sources3
Helixi161 – 168Combined sources8
Beta strandi173 – 184Combined sources12
Helixi185 – 187Combined sources3
Helixi190 – 195Combined sources6
Beta strandi198 – 209Combined sources12
Beta strandi213 – 231Combined sources19
Turni232 – 234Combined sources3
Helixi237 – 249Combined sources13
Beta strandi255 – 258Combined sources4
Beta strandi263 – 270Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XMXX-ray1.67A/B1-271[»]
2XTQX-ray2.31A/B/C/D/E/F/G/H1-271[»]
2XTRX-ray2.14A/B1-271[»]
3DA3X-ray2.50A/B1-271[»]
3DA4X-ray1.70A/B1-271[»]
ProteinModelPortaliP05820
SMRiP05820
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05820

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi2 – 9TonB box8

Keywords - Domaini

TonB box

Family and domain databases

InterProiView protein in InterPro
IPR028056 Colicin_M
PfamiView protein in Pfam
PF14859 Colicin_M, 1 hit

Sequencei

Sequence statusi: Complete.

P05820-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLTVHAPS PSTNLPSYGN GAFSLSAPHV PGAGPLLVQV VYSFFQSPNM
60 70 80 90 100
CLQALTQLED YIKKHGASNP LTLQIISTNI GYFCNADRNL VLHPGISVYD
110 120 130 140 150
AYHFAKPAPS QYDYRSMNMK QMSGNVTTPI VALAHYLWGN GAERSVNIAN
160 170 180 190 200
IGLKISPMKI NQIKDIIKSG VVGTFPVSTK FTHATGDYNV ITGAYLGNIT
210 220 230 240 250
LKTEGTLTIS ANGSWTYNGV VRSYDDKYDF NASTHRGIIG ESLTRLGAMF
260 270
SGKEYQILLP GEIHIKESGK R
Length:271
Mass (Da):29,483
Last modified:November 1, 1988 - v1
Checksum:iB41B7BE107EC1DBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16754 Genomic DNA Translation: AAA23589.1
PIRiA27090 IKECM
RefSeqiWP_000449473.1, NZ_PIIY01000206.1
YP_008998009.1, NC_023315.1

Genome annotation databases

GeneIDi18194796

Similar proteinsi

Entry informationi

Entry nameiCEAM_ECOLX
AccessioniPrimary (citable) accession number: P05820
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid
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Main funding by: National Institutes of Health