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Protein

Beta-casein

Gene

CSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in determination of the surface properties of the casein micelles.

GO - Molecular functioni

  • calcium ion binding Source: ProtInc
  • enzyme inhibitor activity Source: ProtInc
  • transporter activity Source: InterPro

GO - Biological processi

  • calcium ion transport Source: ProtInc
  • lactation Source: UniProtKB
  • negative regulation of lactation Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135222-MONOMER.
ReactomeiR-HSA-1251985. Nuclear signaling by ERBB4.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-casein
Gene namesi
Name:CSN2
Synonyms:CASB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:2447. CSN2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1447.
OpenTargetsiENSG00000135222.
ENSG00000283030.
PharmGKBiPA26950.

Protein family/group databases

Allergomei1064. Hom s 8.

Polymorphism and mutation databases

BioMutaiCSN2.
DMDMi115661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000000447516 – 226Beta-casein1 PublicationAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Phosphothreonine; in form 5-P2 Publications1
Modified residuei21Phosphoserine; in form 4-P and form 5-P2 Publications1
Modified residuei23Phosphoserine; in form 3-P, form 4-P and form 5-P2 Publications1
Modified residuei24Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications1
Modified residuei25Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications1

Post-translational modificationi

Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05814.
PeptideAtlasiP05814.
PRIDEiP05814.

PTM databases

iPTMnetiP05814.
PhosphoSitePlusiP05814.

Miscellaneous databases

PMAP-CutDBP05814.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSG00000135222.
CleanExiHS_CSN2.
ExpressionAtlasiP05814. baseline and differential.
GenevisibleiP05814. HS.

Organism-specific databases

HPAiHPA041036.

Interactioni

Protein-protein interaction databases

BioGridi107834. 21 interactors.
IntActiP05814. 10 interactors.
MINTiMINT-5010384.
STRINGi9606.ENSP00000341030.

Structurei

3D structure databases

DisProtiDP00199.
ProteinModelPortaliP05814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYJE. Eukaryota.
ENOG411197Z. LUCA.
GeneTreeiENSGT00390000001890.
HOGENOMiHOG000074044.
HOVERGENiHBG004973.
InParanoidiP05814.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG091G0XI8.
PhylomeDBiP05814.
TreeFamiTF336929.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05814-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE
60 70 80 90 100
HQDKIYPSFQ PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME
110 120 130 140 150
VPKAKDTVYT KGRVMPVLKS PTIPFFDPQI PKLTDLENLH LPLPLLQPLM
160 170 180 190 200
QQVPQPIPQT LALPPQPLWS VPQPKVLPIP QQVVPYPQRA VPVQALLLNQ
210 220
ELLLNPTHQI YPVTQPLAPV HNPISV
Length:226
Mass (Da):25,382
Last modified:August 1, 1992 - v4
Checksum:i2619C524EA1358E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30T → P AA sequence (PubMed:6715339).Curated1
Sequence conflicti34Missing in CAA39270 (PubMed:2387396).Curated1
Sequence conflicti48 – 50EDE → TDQ AA sequence (PubMed:6715339).Curated3
Sequence conflicti120S → Q AA sequence (PubMed:6715339).Curated1
Sequence conflicti133L → V in CAA34916 (Ref. 3) Curated1
Sequence conflicti140H → Q in CAA34916 (Ref. 3) Curated1
Sequence conflicti149L → S AA sequence (PubMed:6715339).Curated1
Sequence conflicti173Q → E AA sequence (PubMed:6715339).Curated1
Sequence conflicti182 – 184QVV → EVL AA sequence (PubMed:6715339).Curated3
Sequence conflicti188Q → V AA sequence (PubMed:6715339).Curated1
Sequence conflicti207T → P AA sequence (PubMed:6715339).Curated1
Sequence conflicti214 – 222TQPLAPVHN → PEPSTTZABH AA sequence (PubMed:6715339).Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA. Translation: CAA39270.1.
AF027807 Genomic DNA. Translation: AAC82978.1.
X17070 mRNA. Translation: CAA34916.1.
BC069554 mRNA. Translation: AAH69554.1.
BC096194 mRNA. Translation: AAH96194.1.
BC096195 mRNA. Translation: AAH96195.1.
BC096196 mRNA. Translation: AAH96196.1.
BC096197 mRNA. Translation: AAH96197.1.
X13766 mRNA. Translation: CAA32017.1.
CCDSiCCDS3532.1.
PIRiI53730. KBHU.
RefSeqiNP_001289699.1. NM_001302770.1.
NP_001882.1. NM_001891.3.
XP_016863249.1. XM_017007760.1.
UniGeneiHs.2242.

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222.
ENST00000635174; ENSP00000489488; ENSG00000283030.
GeneIDi1447.
KEGGihsa:1447.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA. Translation: CAA39270.1.
AF027807 Genomic DNA. Translation: AAC82978.1.
X17070 mRNA. Translation: CAA34916.1.
BC069554 mRNA. Translation: AAH69554.1.
BC096194 mRNA. Translation: AAH96194.1.
BC096195 mRNA. Translation: AAH96195.1.
BC096196 mRNA. Translation: AAH96196.1.
BC096197 mRNA. Translation: AAH96197.1.
X13766 mRNA. Translation: CAA32017.1.
CCDSiCCDS3532.1.
PIRiI53730. KBHU.
RefSeqiNP_001289699.1. NM_001302770.1.
NP_001882.1. NM_001891.3.
XP_016863249.1. XM_017007760.1.
UniGeneiHs.2242.

3D structure databases

DisProtiDP00199.
ProteinModelPortaliP05814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107834. 21 interactors.
IntActiP05814. 10 interactors.
MINTiMINT-5010384.
STRINGi9606.ENSP00000341030.

Protein family/group databases

Allergomei1064. Hom s 8.

PTM databases

iPTMnetiP05814.
PhosphoSitePlusiP05814.

Polymorphism and mutation databases

BioMutaiCSN2.
DMDMi115661.

Proteomic databases

PaxDbiP05814.
PeptideAtlasiP05814.
PRIDEiP05814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222.
ENST00000635174; ENSP00000489488; ENSG00000283030.
GeneIDi1447.
KEGGihsa:1447.

Organism-specific databases

CTDi1447.
DisGeNETi1447.
GeneCardsiCSN2.
HGNCiHGNC:2447. CSN2.
HPAiHPA041036.
MIMi115460. gene.
neXtProtiNX_P05814.
OpenTargetsiENSG00000135222.
ENSG00000283030.
PharmGKBiPA26950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYJE. Eukaryota.
ENOG411197Z. LUCA.
GeneTreeiENSGT00390000001890.
HOGENOMiHOG000074044.
HOVERGENiHBG004973.
InParanoidiP05814.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG091G0XI8.
PhylomeDBiP05814.
TreeFamiTF336929.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135222-MONOMER.
ReactomeiR-HSA-1251985. Nuclear signaling by ERBB4.

Miscellaneous databases

GeneWikiiCSN2.
GenomeRNAii1447.
PMAP-CutDBP05814.
PROiP05814.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135222.
CleanExiHS_CSN2.
ExpressionAtlasiP05814. baseline and differential.
GenevisibleiP05814. HS.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASB_HUMAN
AccessioniPrimary (citable) accession number: P05814
Secondary accession number(s): Q4VAZ9, Q9UCM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: August 1, 1992
Last modified: November 30, 2016
This is version 151 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.