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Protein

Beta-casein

Gene

CSN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in determination of the surface properties of the casein micelles.

GO - Molecular functioni

  1. calcium ion binding Source: ProtInc
  2. enzyme inhibitor activity Source: ProtInc
  3. transporter activity Source: InterPro

GO - Biological processi

  1. calcium ion transport Source: ProtInc
  2. lactation Source: UniProtKB
  3. negative regulation of catalytic activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Enzyme and pathway databases

ReactomeiREACT_116022. Nuclear signaling by ERBB4.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-casein
Gene namesi
Name:CSN2
Synonyms:CASB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:2447. CSN2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26950.

Protein family/group databases

Allergomei1064. Hom s 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15151 PublicationAdd
BLAST
Chaini16 – 226211Beta-casein1 PublicationPRO_0000004475Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181Phosphothreonine; in form 5-P2 Publications
Modified residuei21 – 211Phosphoserine; in form 4-P and form 5-P2 Publications
Modified residuei23 – 231Phosphoserine; in form 3-P, form 4-P and form 5-P2 Publications
Modified residuei24 – 241Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications
Modified residuei25 – 251Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications

Post-translational modificationi

Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP05814.
PRIDEiP05814.

PTM databases

PhosphoSiteiP05814.

Miscellaneous databases

PMAP-CutDBP05814.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiP05814.
CleanExiHS_CSN2.
ExpressionAtlasiP05814. baseline.
GenevestigatoriP05814.

Organism-specific databases

HPAiHPA041036.

Interactioni

Protein-protein interaction databases

BioGridi107834. 19 interactions.
DIPiDIP-528N.
IntActiP05814. 8 interactions.
MINTiMINT-5010384.
STRINGi9606.ENSP00000341030.

Structurei

3D structure databases

DisProtiDP00199.
ProteinModelPortaliP05814.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG45871.
HOGENOMiHOG000074044.
HOVERGENiHBG004973.
InParanoidiP05814.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG7WQ7VM.
PhylomeDBiP05814.
TreeFamiTF336929.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05814-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE
60 70 80 90 100
HQDKIYPSFQ PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME
110 120 130 140 150
VPKAKDTVYT KGRVMPVLKS PTIPFFDPQI PKLTDLENLH LPLPLLQPLM
160 170 180 190 200
QQVPQPIPQT LALPPQPLWS VPQPKVLPIP QQVVPYPQRA VPVQALLLNQ
210 220
ELLLNPTHQI YPVTQPLAPV HNPISV
Length:226
Mass (Da):25,382
Last modified:August 1, 1992 - v4
Checksum:i2619C524EA1358E8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301T → P AA sequence (PubMed:6715339)Curated
Sequence conflicti34 – 341Missing in CAA39270. (PubMed:2387396)Curated
Sequence conflicti48 – 503EDE → TDQ AA sequence (PubMed:6715339)Curated
Sequence conflicti120 – 1201S → Q AA sequence (PubMed:6715339)Curated
Sequence conflicti133 – 1331L → V in CAA34916. 1 PublicationCurated
Sequence conflicti140 – 1401H → Q in CAA34916. 1 PublicationCurated
Sequence conflicti149 – 1491L → S AA sequence (PubMed:6715339)Curated
Sequence conflicti173 – 1731Q → E AA sequence (PubMed:6715339)Curated
Sequence conflicti182 – 1843QVV → EVL AA sequence (PubMed:6715339)Curated
Sequence conflicti188 – 1881Q → V AA sequence (PubMed:6715339)Curated
Sequence conflicti207 – 2071T → P AA sequence (PubMed:6715339)Curated
Sequence conflicti214 – 2229TQPLAPVHN → PEPSTTZABH AA sequence (PubMed:6715339)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA. Translation: CAA39270.1.
AF027807 Genomic DNA. Translation: AAC82978.1.
X17070 mRNA. Translation: CAA34916.1.
BC069554 mRNA. Translation: AAH69554.1.
BC096194 mRNA. Translation: AAH96194.1.
BC096195 mRNA. Translation: AAH96195.1.
BC096196 mRNA. Translation: AAH96196.1.
BC096197 mRNA. Translation: AAH96197.1.
X13766 mRNA. Translation: CAA32017.1.
CCDSiCCDS3532.1.
PIRiI53730. KBHU.
RefSeqiNP_001882.1. NM_001891.3.
UniGeneiHs.2242.

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222.
GeneIDi1447.
KEGGihsa:1447.
UCSCiuc003hes.4. human.

Polymorphism databases

DMDMi115661.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55739 mRNA. Translation: CAA39270.1.
AF027807 Genomic DNA. Translation: AAC82978.1.
X17070 mRNA. Translation: CAA34916.1.
BC069554 mRNA. Translation: AAH69554.1.
BC096194 mRNA. Translation: AAH96194.1.
BC096195 mRNA. Translation: AAH96195.1.
BC096196 mRNA. Translation: AAH96196.1.
BC096197 mRNA. Translation: AAH96197.1.
X13766 mRNA. Translation: CAA32017.1.
CCDSiCCDS3532.1.
PIRiI53730. KBHU.
RefSeqiNP_001882.1. NM_001891.3.
UniGeneiHs.2242.

3D structure databases

DisProtiDP00199.
ProteinModelPortaliP05814.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107834. 19 interactions.
DIPiDIP-528N.
IntActiP05814. 8 interactions.
MINTiMINT-5010384.
STRINGi9606.ENSP00000341030.

Protein family/group databases

Allergomei1064. Hom s 8.

PTM databases

PhosphoSiteiP05814.

Polymorphism databases

DMDMi115661.

Proteomic databases

PaxDbiP05814.
PRIDEiP05814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000353151; ENSP00000341030; ENSG00000135222.
GeneIDi1447.
KEGGihsa:1447.
UCSCiuc003hes.4. human.

Organism-specific databases

CTDi1447.
GeneCardsiGC04M070869.
HGNCiHGNC:2447. CSN2.
HPAiHPA041036.
MIMi115460. gene.
neXtProtiNX_P05814.
PharmGKBiPA26950.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45871.
HOGENOMiHOG000074044.
HOVERGENiHBG004973.
InParanoidiP05814.
KOiK17107.
OMAiEIMEVPK.
OrthoDBiEOG7WQ7VM.
PhylomeDBiP05814.
TreeFamiTF336929.

Enzyme and pathway databases

ReactomeiREACT_116022. Nuclear signaling by ERBB4.

Miscellaneous databases

GeneWikiiCSN2.
GenomeRNAii1447.
NextBioi5947.
PMAP-CutDBP05814.
PROiP05814.
SOURCEiSearch...

Gene expression databases

BgeeiP05814.
CleanExiHS_CSN2.
ExpressionAtlasiP05814. baseline.
GenevestigatoriP05814.

Family and domain databases

InterProiIPR001588. Casein.
IPR016345. Casein_beta.
[Graphical view]
PANTHERiPTHR11500. PTHR11500. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PIRSFiPIRSF002372. Beta-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of a cDNA encoding human milk beta-casein."
    Loennerdal B., Bergstroem S., Andersson Y., Hjalmarsson K., Sundqvist A.K., Hernell O.
    FEBS Lett. 269:153-156(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  3. Menon R.S.
    Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  4. "A high resolution linkage map of human 9q34.1."
    Kwiatkowski D.J.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Human beta-casein. Amino acid sequence and identification of phosphorylation sites."
    Greenberg R., Groves M.L., Dower H.J.
    J. Biol. Chem. 259:5132-5138(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-226, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25.
  7. "Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms."
    Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.
    J. Proteome Res. 7:5017-5027(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-33, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY.
  8. "Human beta-casein: partial cDNA sequence and apparent polymorphism."
    Menon R.S., Ham R.G.
    Nucleic Acids Res. 17:2869-2869(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-226.
    Tissue: Mammary gland.
  9. Cited for: PROTEIN SEQUENCE OF 176-215.

Entry informationi

Entry nameiCASB_HUMAN
AccessioniPrimary (citable) accession number: P05814
Secondary accession number(s): Q4VAZ9, Q9UCM5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: August 1, 1992
Last modified: February 4, 2015
This is version 134 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.