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P05814 (CASB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-casein
Gene names
Name:CSN2
Synonyms:CASB
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Important role in determination of the surface properties of the casein micelles.

Subcellular location

Secreted.

Tissue specificity

Mammary gland specific. Secreted in milk.

Post-translational modification

Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25. Ref.6 Ref.7

Sequence similarities

Belongs to the beta-casein family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Ref.6
Chain16 – 226211Beta-casein Ref.6
PRO_0000004475

Amino acid modifications

Modified residue181Phosphothreonine; in form 5-P Ref.6 Ref.7
Modified residue211Phosphoserine; in form 4-P and form 5-P Ref.6 Ref.7
Modified residue231Phosphoserine; in form 3-P, form 4-P and form 5-P Ref.6 Ref.7
Modified residue241Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P Ref.6 Ref.7
Modified residue251Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P Ref.6 Ref.7

Experimental info

Sequence conflict301T → P AA sequence Ref.6
Sequence conflict341Missing in CAA39270. Ref.1
Sequence conflict48 – 503EDE → TDQ AA sequence Ref.6
Sequence conflict1201S → Q AA sequence Ref.6
Sequence conflict1331L → V in CAA34916. Ref.3
Sequence conflict1401H → Q in CAA34916. Ref.3
Sequence conflict1491L → S AA sequence Ref.6
Sequence conflict1731Q → E AA sequence Ref.6
Sequence conflict182 – 1843QVV → EVL AA sequence Ref.6
Sequence conflict1881Q → V AA sequence Ref.6
Sequence conflict2071T → P AA sequence Ref.6
Sequence conflict214 – 2229TQPLAPVHN → PEPSTTZABH AA sequence Ref.6

Sequences

Sequence LengthMass (Da)Tools
P05814 [UniParc].

Last modified August 1, 1992. Version 4.
Checksum: 2619C524EA1358E8

FASTA22625,382
        10         20         30         40         50         60 
MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE HQDKIYPSFQ 

        70         80         90        100        110        120 
PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME VPKAKDTVYT KGRVMPVLKS 

       130        140        150        160        170        180 
PTIPFFDPQI PKLTDLENLH LPLPLLQPLM QQVPQPIPQT LALPPQPLWS VPQPKVLPIP 

       190        200        210        220 
QQVVPYPQRA VPVQALLLNQ ELLLNPTHQI YPVTQPLAPV HNPISV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of a cDNA encoding human milk beta-casein."
Loennerdal B., Bergstroem S., Andersson Y., Hjalmarsson K., Sundqvist A.K., Hernell O.
FEBS Lett. 269:153-156(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Structure of the human beta-casein encoding gene."
Hansson L., Edlund A., Johansson T., Hernell O., Stroemqvist M., Lindquist S., Loennerdal B., Bergstroem S.
Gene 139:193-199(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[3]Menon R.S.
Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Mammary gland.
[4]"A high resolution linkage map of human 9q34.1."
Kwiatkowski D.J.
Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: Placenta.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Human beta-casein. Amino acid sequence and identification of phosphorylation sites."
Greenberg R., Groves M.L., Dower H.J.
J. Biol. Chem. 259:5132-5138(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-226, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25.
[7]"Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms."
Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.
J. Proteome Res. 7:5017-5027(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 18-33, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY.
[8]"Human beta-casein: partial cDNA sequence and apparent polymorphism."
Menon R.S., Ham R.G.
Nucleic Acids Res. 17:2869-2869(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-226.
Tissue: Mammary gland.
[9]"Plasmin cleavage of human beta-casein."
Azuma N., Yamauchi K.
Biosci. Biotechnol. Biochem. 56:1140-1141(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 176-215.
+Additional computationally mapped references.

Web resources

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X55739 mRNA. Translation: CAA39270.1.
AF027807 Genomic DNA. Translation: AAC82978.1.
X17070 mRNA. Translation: CAA34916.1.
BC069554 mRNA. Translation: AAH69554.1.
BC096194 mRNA. Translation: AAH96194.1.
BC096195 mRNA. Translation: AAH96195.1.
BC096196 mRNA. Translation: AAH96196.1.
BC096197 mRNA. Translation: AAH96197.1.
X13766 mRNA. Translation: CAA32017.1.
CCDSCCDS3532.1.
PIRKBHU. I53730.
RefSeqNP_001882.1. NM_001891.2.
XP_005265704.1. XM_005265647.1.
UniGeneHs.2242.

3D structure databases

DisProtDP00199.
ProteinModelPortalP05814.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107834. 18 interactions.
DIPDIP-528N.
IntActP05814. 8 interactions.
MINTMINT-5010384.
STRING9606.ENSP00000341030.

Protein family/group databases

Allergome1064. Hom s 8.

PTM databases

PhosphoSiteP05814.

Polymorphism databases

DMDM115661.

Proteomic databases

PaxDbP05814.
PRIDEP05814.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000353151; ENSP00000341030; ENSG00000135222.
GeneID1447.
KEGGhsa:1447.
UCSCuc003hes.4. human.

Organism-specific databases

CTD1447.
GeneCardsGC04M070869.
HGNCHGNC:2447. CSN2.
HPAHPA041036.
MIM115460. gene.
neXtProtNX_P05814.
PharmGKBPA26950.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45871.
HOGENOMHOG000074044.
HOVERGENHBG004973.
InParanoidP05814.
KOK17107.
OMAEIMEVPK.
OrthoDBEOG7WQ7VM.
PhylomeDBP05814.
TreeFamTF336929.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeP05814.
CleanExHS_CSN2.
GenevestigatorP05814.

Family and domain databases

InterProIPR001588. Casein.
IPR016345. Casein_beta.
[Graphical view]
PANTHERPTHR11500. PTHR11500. 1 hit.
PfamPF00363. Casein. 1 hit.
[Graphical view]
PIRSFPIRSF002372. Beta-casein. 1 hit.
PROSITEPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCSN2.
GenomeRNAi1447.
NextBio5947.
PMAP-CutDBP05814.
PROP05814.
SOURCESearch...

Entry information

Entry nameCASB_HUMAN
AccessionPrimary (citable) accession number: P05814
Secondary accession number(s): Q4VAZ9, Q9UCM5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: August 1, 1992
Last modified: July 9, 2014
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM