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P05814

- CASB_HUMAN

UniProt

P05814 - CASB_HUMAN

Protein

Beta-casein

Gene

CSN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 4 (01 Aug 1992)
      Previous versions | rss
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    Functioni

    Important role in determination of the surface properties of the casein micelles.

    GO - Molecular functioni

    1. calcium ion binding Source: ProtInc
    2. enzyme inhibitor activity Source: ProtInc
    3. transporter activity Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: ProtInc
    2. lactation Source: UniProt
    3. negative regulation of catalytic activity Source: GOC

    Keywords - Molecular functioni

    Milk protein

    Enzyme and pathway databases

    ReactomeiREACT_116022. Nuclear signaling by ERBB4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-casein
    Gene namesi
    Name:CSN2
    Synonyms:CASB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:2447. CSN2.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26950.

    Protein family/group databases

    Allergomei1064. Hom s 8.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15151 PublicationAdd
    BLAST
    Chaini16 – 226211Beta-casein1 PublicationPRO_0000004475Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181Phosphothreonine; in form 5-P2 Publications
    Modified residuei21 – 211Phosphoserine; in form 4-P and form 5-P2 Publications
    Modified residuei23 – 231Phosphoserine; in form 3-P, form 4-P and form 5-P2 Publications
    Modified residuei24 – 241Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications
    Modified residuei25 – 251Phosphoserine; in form 1-P, form 2-P, form 3-P, form 4-P and form 5-P2 Publications

    Post-translational modificationi

    Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP05814.
    PRIDEiP05814.

    PTM databases

    PhosphoSiteiP05814.

    Miscellaneous databases

    PMAP-CutDBP05814.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Gene expression databases

    BgeeiP05814.
    CleanExiHS_CSN2.
    GenevestigatoriP05814.

    Organism-specific databases

    HPAiHPA041036.

    Interactioni

    Protein-protein interaction databases

    BioGridi107834. 18 interactions.
    DIPiDIP-528N.
    IntActiP05814. 8 interactions.
    MINTiMINT-5010384.
    STRINGi9606.ENSP00000341030.

    Structurei

    3D structure databases

    DisProtiDP00199.
    ProteinModelPortaliP05814.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-casein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45871.
    HOGENOMiHOG000074044.
    HOVERGENiHBG004973.
    InParanoidiP05814.
    KOiK17107.
    OMAiEIMEVPK.
    OrthoDBiEOG7WQ7VM.
    PhylomeDBiP05814.
    TreeFamiTF336929.

    Family and domain databases

    InterProiIPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view]
    PANTHERiPTHR11500. PTHR11500. 1 hit.
    PfamiPF00363. Casein. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002372. Beta-casein. 1 hit.
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05814-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLILACLV ALALARETIE SLSSSEESIT EYKQKVEKVK HEDQQQGEDE    50
    HQDKIYPSFQ PQPLIYPFVE PIPYGFLPQN ILPLAQPAVV LPVPQPEIME 100
    VPKAKDTVYT KGRVMPVLKS PTIPFFDPQI PKLTDLENLH LPLPLLQPLM 150
    QQVPQPIPQT LALPPQPLWS VPQPKVLPIP QQVVPYPQRA VPVQALLLNQ 200
    ELLLNPTHQI YPVTQPLAPV HNPISV 226
    Length:226
    Mass (Da):25,382
    Last modified:August 1, 1992 - v4
    Checksum:i2619C524EA1358E8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti30 – 301T → P AA sequence (PubMed:6715339)Curated
    Sequence conflicti34 – 341Missing in CAA39270. (PubMed:2387396)Curated
    Sequence conflicti48 – 503EDE → TDQ AA sequence (PubMed:6715339)Curated
    Sequence conflicti120 – 1201S → Q AA sequence (PubMed:6715339)Curated
    Sequence conflicti133 – 1331L → V in CAA34916. 1 PublicationCurated
    Sequence conflicti140 – 1401H → Q in CAA34916. 1 PublicationCurated
    Sequence conflicti149 – 1491L → S AA sequence (PubMed:6715339)Curated
    Sequence conflicti173 – 1731Q → E AA sequence (PubMed:6715339)Curated
    Sequence conflicti182 – 1843QVV → EVL AA sequence (PubMed:6715339)Curated
    Sequence conflicti188 – 1881Q → V AA sequence (PubMed:6715339)Curated
    Sequence conflicti207 – 2071T → P AA sequence (PubMed:6715339)Curated
    Sequence conflicti214 – 2229TQPLAPVHN → PEPSTTZABH AA sequence (PubMed:6715339)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55739 mRNA. Translation: CAA39270.1.
    AF027807 Genomic DNA. Translation: AAC82978.1.
    X17070 mRNA. Translation: CAA34916.1.
    BC069554 mRNA. Translation: AAH69554.1.
    BC096194 mRNA. Translation: AAH96194.1.
    BC096195 mRNA. Translation: AAH96195.1.
    BC096196 mRNA. Translation: AAH96196.1.
    BC096197 mRNA. Translation: AAH96197.1.
    X13766 mRNA. Translation: CAA32017.1.
    CCDSiCCDS3532.1.
    PIRiI53730. KBHU.
    RefSeqiNP_001882.1. NM_001891.2.
    XP_005265704.1. XM_005265647.1.
    UniGeneiHs.2242.

    Genome annotation databases

    EnsembliENST00000353151; ENSP00000341030; ENSG00000135222.
    GeneIDi1447.
    KEGGihsa:1447.
    UCSCiuc003hes.4. human.

    Polymorphism databases

    DMDMi115661.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X55739 mRNA. Translation: CAA39270.1 .
    AF027807 Genomic DNA. Translation: AAC82978.1 .
    X17070 mRNA. Translation: CAA34916.1 .
    BC069554 mRNA. Translation: AAH69554.1 .
    BC096194 mRNA. Translation: AAH96194.1 .
    BC096195 mRNA. Translation: AAH96195.1 .
    BC096196 mRNA. Translation: AAH96196.1 .
    BC096197 mRNA. Translation: AAH96197.1 .
    X13766 mRNA. Translation: CAA32017.1 .
    CCDSi CCDS3532.1.
    PIRi I53730. KBHU.
    RefSeqi NP_001882.1. NM_001891.2.
    XP_005265704.1. XM_005265647.1.
    UniGenei Hs.2242.

    3D structure databases

    DisProti DP00199.
    ProteinModelPortali P05814.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107834. 18 interactions.
    DIPi DIP-528N.
    IntActi P05814. 8 interactions.
    MINTi MINT-5010384.
    STRINGi 9606.ENSP00000341030.

    Protein family/group databases

    Allergomei 1064. Hom s 8.

    PTM databases

    PhosphoSitei P05814.

    Polymorphism databases

    DMDMi 115661.

    Proteomic databases

    PaxDbi P05814.
    PRIDEi P05814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000353151 ; ENSP00000341030 ; ENSG00000135222 .
    GeneIDi 1447.
    KEGGi hsa:1447.
    UCSCi uc003hes.4. human.

    Organism-specific databases

    CTDi 1447.
    GeneCardsi GC04M070869.
    HGNCi HGNC:2447. CSN2.
    HPAi HPA041036.
    MIMi 115460. gene.
    neXtProti NX_P05814.
    PharmGKBi PA26950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45871.
    HOGENOMi HOG000074044.
    HOVERGENi HBG004973.
    InParanoidi P05814.
    KOi K17107.
    OMAi EIMEVPK.
    OrthoDBi EOG7WQ7VM.
    PhylomeDBi P05814.
    TreeFami TF336929.

    Enzyme and pathway databases

    Reactomei REACT_116022. Nuclear signaling by ERBB4.

    Miscellaneous databases

    GeneWikii CSN2.
    GenomeRNAii 1447.
    NextBioi 5947.
    PMAP-CutDB P05814.
    PROi P05814.
    SOURCEi Search...

    Gene expression databases

    Bgeei P05814.
    CleanExi HS_CSN2.
    Genevestigatori P05814.

    Family and domain databases

    InterProi IPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view ]
    PANTHERi PTHR11500. PTHR11500. 1 hit.
    Pfami PF00363. Casein. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002372. Beta-casein. 1 hit.
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of a cDNA encoding human milk beta-casein."
      Loennerdal B., Bergstroem S., Andersson Y., Hjalmarsson K., Sundqvist A.K., Hernell O.
      FEBS Lett. 269:153-156(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    3. Menon R.S.
      Submitted (OCT-1989) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    4. "A high resolution linkage map of human 9q34.1."
      Kwiatkowski D.J.
      Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Placenta.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Human beta-casein. Amino acid sequence and identification of phosphorylation sites."
      Greenberg R., Groves M.L., Dower H.J.
      J. Biol. Chem. 259:5132-5138(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-226, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25.
    7. "Analysis of the human casein phosphoproteome by 2-D electrophoresis and MALDI-TOF/TOF MS reveals new phosphoforms."
      Poth A.G., Deeth H.C., Alewood P.F., Holland J.W.
      J. Proteome Res. 7:5017-5027(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 18-33, PHOSPHORYLATION AT THR-18; SER-21; SER-23; SER-24 AND SER-25, IDENTIFICATION BY MASS SPECTROMETRY.
    8. "Human beta-casein: partial cDNA sequence and apparent polymorphism."
      Menon R.S., Ham R.G.
      Nucleic Acids Res. 17:2869-2869(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 161-226.
      Tissue: Mammary gland.
    9. Cited for: PROTEIN SEQUENCE OF 176-215.

    Entry informationi

    Entry nameiCASB_HUMAN
    AccessioniPrimary (citable) accession number: P05814
    Secondary accession number(s): Q4VAZ9, Q9UCM5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: August 1, 1992
    Last modified: October 1, 2014
    This is version 131 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3