Reviewed,
UniProtKB/Swiss-Prot P05783 (K1C18_HUMAN)
Last modified
July 7, 2009.
Version 113.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Keratin, type I cytoskeletal 18 Alternative name(s): Cytokeratin-18 Short name=CK-18 Keratin-18 Short name=K18 Cell proliferation-inducing gene 46 protein | ||||||
| Gene names |
| ||||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 430 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Involved in the uptake of thrombin-antithrombin complexes by hepatic cells By similarity. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. |
| Subunit structure | Heterotetramer of two type I and two type II keratins. Keratin-18 associates with keratin-8. Interacts with the thrombin-antithrombin complex By similarity. Interacts with PNN, HCV core protein and mutated CFTR. Interacts with YWHAE, YWHAH and YWHAZ only when phosphorylated. Interacts with DNAJB6, TCHP and TRADD. |
| Subcellular location | |
| Tissue specificity | Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. Ref.1 Ref.7 Ref.8 Ref.27 |
| Induction | By IL-6. Ref.27 |
| Post-translational modification | Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6. Ref.25 Ref.27 Ref.11 Ref.14 Ref.16 Ref.21 Ref.24 Ref.26 Ref.28 Ref.29 Ref.30 Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either caspase-3, caspase-6 or caspase-7. Ref.15 O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. Ref.10 Ref.12 |
| Involvement in disease | Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600]. Ref.32 Ref.33 |
| Miscellaneous | There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). |
| Sequence similarities | Belongs to the intermediate filament family. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| CLEC3B | P05452 | 1 | EBI-297888,EBI-1047626 | |
| DNAJB6 | O75190 | 3 | EBI-297888,EBI-1053164 | |
| KRT8 | P05787 | 2 | EBI-297888,EBI-297852 | |
| MCC | P23508 | 1 | EBI-297888,EBI-307531 | |
| PPM1B | O75688 | 1 | EBI-297888,EBI-1047039 | |
| TRADD | Q15628 | 3 | EBI-297888,EBI-359215 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed | ||||||
| Chain | 2 – 430 | 429 | Keratin, type I cytoskeletal 18 | PRO_0000063666 | |||||
Regions | |||||||||
| Region | 2 – 79 | 78 | Head | ||||||
| Region | 70 – 373 | 304 | Necessary for interaction with PNN | ||||||
| Region | 77 – 128 | 52 | Interaction with TRADD | ||||||
| Region | 80 – 387 | 308 | Rod | ||||||
| Region | 80 – 115 | 36 | Coil 1A | ||||||
| Region | 116 – 132 | 17 | Linker 1 | ||||||
| Region | 133 – 224 | 92 | Coil 1B | ||||||
| Region | 225 – 248 | 24 | Linker 12 | ||||||
| Region | 243 – 391 | 149 | Interaction with DNAJB6 | ||||||
| Region | 249 – 387 | 139 | Coil 2 | ||||||
| Region | 388 – 430 | 43 | Tail | ||||||
Sites | |||||||||
| Site | 238 – 239 | 2 | Cleavage; by caspase-3, caspase-6 or caspase-7 | ||||||
| Site | 271 | 1 | Stutter | ||||||
| Site | 331 | 1 | Stutter | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine | ||||||
| Modified residue | 7 | 1 | Phosphoserine Ref.24 | ||||||
| Modified residue | 8 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 10 | 1 | Phosphoserine Ref.30 | ||||||
| Modified residue | 11 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 13 | 1 | Phosphotyrosine Ref.26 | ||||||
| Modified residue | 15 | 1 | Phosphoserine Ref.28 | ||||||
| Modified residue | 18 | 1 | Phosphoserine Ref.28 | ||||||
| Modified residue | 30 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 31 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 34 | 1 | Phosphoserine; by CDC2 Ref.16 Ref.21 Ref.24 Ref.30 | ||||||
| Modified residue | 36 | 1 | Phosphotyrosine By similarity | ||||||
| Modified residue | 42 | 1 | Phosphoserine Ref.29 Ref.30 | ||||||
| Modified residue | 53 | 1 | Phosphoserine; by CAMK, PKC/PRKCE and STK6 Ref.25 Ref.11 Ref.21 Ref.28 Ref.30 | ||||||
| Modified residue | 60 | 1 | Phosphoserine Ref.28 Ref.29 Ref.30 | ||||||
| Modified residue | 302 | 1 | Phosphothreonine Ref.30 | ||||||
| Modified residue | 399 | 1 | Phosphoserine Ref.29 Ref.30 | ||||||
| Modified residue | 401 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 404 | 1 | Phosphothreonine By similarity | ||||||
| Glycosylation | 30 | 1 | O-linked (GlcNAc) Ref.12 | CAR_000175 | |||||
| Glycosylation | 31 | 1 | O-linked (GlcNAc) Ref.12 | CAR_000193 | |||||
| Glycosylation | 49 | 1 | O-linked (GlcNAc) Ref.12 | CAR_000194 | |||||
Natural variations | |||||||||
| Natural variant | 103 | 1 | T → A in cryptogenic cirrhosis. Ref.33 | VAR_023054 | |||||
| Natural variant | 128 | 1 | H → L in cryptogenic cirrhosis; interfers with the ability to form normal filaments. Ref.32 Ref.33 | VAR_003852 | |||||
| Natural variant | 230 | 1 | S → T Ref.33 | VAR_023055 | |||||
| Natural variant | 261 | 1 | R → Q in cryptogenic cirrhosis. Ref.33 | VAR_023056 | |||||
| Natural variant | 340 | 1 | G → R in cryptogenic cirrhosis. Ref.33 | VAR_023057 | |||||
Experimental info | |||||||||
| Mutagenesis | 2 | 1 | S → A: No effect on phosphorylation; when associated with A-7 and A-10. Ref.11 | ||||||
| Mutagenesis | 7 | 1 | S → A: No effect on phosphorylation; when associated with A-2 and A-10. Ref.11 | ||||||
| Mutagenesis | 10 | 1 | S → A: No effect on phosphorylation; when associated with A-2 and A-7. Ref.11 | ||||||
| Mutagenesis | 15 | 1 | S → A: No effect on phosphorylation; when associated with A-18 and A-23. Abolishes phosphorylation; when associated with A-18; A-34; A-47; A-49; A-51 and A-53. Ref.11 | ||||||
| Mutagenesis | 18 | 1 | S → A: No effect on phosphorylation; when associated with A-15 and A-23. Abolishes phosphorylation; when associated with A-15; A-34; A-47; A-49; A-51 and A-53. Ref.11 | ||||||
| Mutagenesis | 23 | 1 | S → A: No effect on phosphorylation; when associated with A-15 and A-18. Ref.11 | ||||||
| Mutagenesis | 30 | 1 | S → A: No effect on phosphorylation; when associated with A-31 and A-34, or with A-31; A-44 and A-51. Abolishes glycosylation but does not affect binding to YWHAE and YWHAZ; when associated with A-31 and A-49. Ref.11 Ref.12 | ||||||
| Mutagenesis | 31 | 1 | S → A: No effect on phosphorylation; when associated with A-30 and A-34, or with A-30; A-44 and A-51. Abolishes glycosylation but does not affect binding to YWHAE and YWHAZ; when associated with A-30 and A-49. Ref.11 Ref.12 | ||||||
| Mutagenesis | 34 | 1 | S → A: No effect on phosphorylation; when associated with A-30 and A-31. Abolishes phosphorylation; when associated with A-15; A-18; A-47; A-49; A-51 and A-53. Abolishes binding to YWHAE and YWHAZ; and when associated with A-53. Ref.11 Ref.16 | ||||||
| Mutagenesis | 34 | 1 | S → D or E: Abolishes binding to YWHAE and YWHAZ. Ref.11 Ref.16 | ||||||
| Mutagenesis | 42 | 1 | S → A: No effect on phosphorylation; when associated with A-44. Ref.11 | ||||||
| Mutagenesis | 44 | 1 | S → A: No effect on phosphorylation; when associated with A-42, or with A-30; A-31 and A-51. Ref.11 | ||||||
| Mutagenesis | 47 | 1 | S → A: No effect on phosphorylation; when associated with A-49. Abolishes phosphorylation; when associated with A-49; A-51 and A-53, or with A-15; A-18; A-34; A-49; A-51 and A-53. Ref.11 | ||||||
| Mutagenesis | 49 | 1 | S → A: No effect on phosphorylation; when associated with A-47. Abolishes phosphorylation; when associated with A-47; A-51 and A-53, or with A-15; A-18; A-34; A-47; A-51 and A-53. Abolishes glycosylation but does not affect binding to YWHAE and YWHAZ; when associated with A-30 and A-31. Ref.11 Ref.12 | ||||||
| Mutagenesis | 51 | 1 | S → A: No effect on phosphorylation; when associated with A-30; A-31 and A-47. Abolishes phosphorylation; when associated with A-47; A-49 and A-53, or with A-15; A-18; A-34; A-47; A-49 and A-53. Ref.11 | ||||||
| Mutagenesis | 53 | 1 | S → A: Abolishes phosphorylation; when associated with A-47; A-49 and A-51, or with A-15; A-18; A-34; A-47; A-49 and A-51. Abolishes binding to YWHAE and YWHAZ; when associated with A-34. No effect on caspase cleavage during apoptosis. Ref.11 Ref.16 Ref.15 | ||||||
| Mutagenesis | 90 | 1 | R → C or H in transgenic mice, induces marked disruption of liver and pancreas keratin filament network. Increases phosphorylation and glycosylation. Ref.13 | ||||||
| Mutagenesis | 238 | 1 | D → E: Prevents cleavage by caspase-6 during apoptosis. Induces aggregates of keratin filaments in an altered organization. Ref.15 | ||||||
| Sequence conflict | 168 | 1 | Y → H in AAH00698. Ref.5 | ||||||
| Sequence conflict | 202 | 1 | E → Q in CAA31369. Ref.8 | ||||||
| Sequence conflict | 208 | 1 | E → G in BAD96813. Ref.3 | ||||||
| Sequence conflict | 246 | 1 | A → S in CAA31369. Ref.8 | ||||||
| Sequence conflict | 309 | 1 | D → R in CAA31369. Ref.8 | ||||||
| Sequence conflict | 312 | 1 | S → R in CAA31369. Ref.8 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation." Oshima R.G., Millan J.L., Cecena G. Differentiation 33:61-68(1986) [PubMed: 2434380] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Placenta. |
| [2] | "Identification of a cell proliferation-inducing gene." Kim J.W. Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix, Colon, Pancreas, Placenta and Uterus. |
| [6] | "Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells." Kulesh D.A., Oshima R.G. Mol. Cell. Biol. 8:1540-1550(1988) [PubMed: 2454392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-167. |
| [7] | "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ." Leube R.E., Bosch F.X., Romano V., Zimbelmann R., Hofler H., Franke W.W. Differentiation 33:69-85(1986) [PubMed: 2434381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-430, TISSUE SPECIFICITY. Tissue: Vulva. |
| [8] | "Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone." Romano V., Hatzfeld M., Magin T.M., Zimbelmann R., Franke W.W., Maier G., Ponstingl H. Differentiation 30:244-253(1986) [PubMed: 2422083] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-430, TISSUE SPECIFICITY. Tissue: Liver. |
| [9] | "A two-dimensional gel database of human colon carcinoma proteins." Ji H., Reid G.E., Moritz R.L., Eddes J.S., Burgess A.W., Simpson R.J. Electrophoresis 18:605-613(1997) [PubMed: 9150948] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Colon carcinoma. |
| [10] | "Characterization and dynamics of O-linked glycosylation of human cytokeratin 8 and 18." Chou C.F., Smith A.J., Omary M.B. J. Biol. Chem. 267:3901-3906(1992) [PubMed: 1371281] [Abstract] Cited for: GLYCOSYLATION. |
| [11] | "Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization." Ku N.O., Omary M.B. J. Cell Biol. 127:161-171(1994) [PubMed: 7523419] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION AT SER-53, MUTAGENESIS OF SER-2; SER-7; SER-10; SER-15; SER-18; SER-23; SER-30; SER-31; SER-34; SER-42; SER-44; SER-47; SER-49; SER-51 AND SER-53. |
| [12] | "Identification and mutational analysis of the glycosylation sites of human keratin 18." Ku N.-O., Omary M.B. J. Biol. Chem. 270:11820-11827(1995) [PubMed: 7538124] [Abstract] Cited for: GLYCOSYLATION AT SER-30; SER-31 AND SER-49, MUTAGENESIS OF SER-30; SER-31 AND SER-49. |
| [13] | "Chronic hepatitis, hepatocyte fragility, and increased soluble phosphoglycokeratins in transgenic mice expressing a keratin 18 conserved arginine mutant." Ku N.O., Michie S., Oshima R.G., Omary M.B. J. Cell Biol. 131:1303-1314(1995) [PubMed: 8522591] [Abstract] Cited for: FUNCTION, MUTAGENESIS OF ARG-90. |
| [14] | "14-3-3 proteins associate with phosphorylated simple epithelial keratins during cell cycle progression and act as a solubility cofactor." Liao J., Omary M.B. J. Cell Biol. 133:345-357(1996) [PubMed: 8609167] [Abstract] Cited for: PHOSPHORYLATION, INTERACTION WITH YWHAE, YWHAH AND YWHAZ. |
| [15] | "Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis." Caulin C., Salvesen G.S., Oshima R.G. J. Cell Biol. 138:1379-1394(1997) [PubMed: 9298992] [Abstract] Cited for: FUNCTION, CLEAVAGE BY CASPASES, MUTAGENESIS OF SER-53 AND ASP-238. |
| [16] | "Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins." Ku N.O., Liao J., Omary M.B. EMBO J. 17:1892-1906(1998) [PubMed: 9524113] [Abstract] Cited for: FUNCTION, INTERACTION WITH YWHAE AND YWHAZ, PHOSPHORYLATION AT SER-34, MUTAGENESIS OF SER-34 AND SER-53. |
| [17] | "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus." Shi J., Sugrue S.P. J. Biol. Chem. 275:14910-14915(2000) [PubMed: 10809736] [Abstract] Cited for: INTERACTION WITH PNN. |
| [18] | "Identification of Mrj, a DnaJ/Hsp40 family protein, as a keratin 8/18 filament regulatory protein." Izawa I., Nishizawa M., Ohtakara K., Ohtsuka K., Inada H., Inagaki M. J. Biol. Chem. 275:34521-34527(2000) [PubMed: 10954706] [Abstract] Cited for: INTERACTION WITH DNAJB6. |
| [19] | "Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD." Inada H., Izawa I., Nishizawa M., Fujita E., Kiyono T., Takahashi T., Momoi T., Inagaki M. J. Cell Biol. 155:415-426(2001) [PubMed: 11684708] [Abstract] Cited for: INTERACTION WITH TRADD. |
| [20] | "Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability." Waseem A., Karsten U., Leigh I.M., Purkis P., Waseem N.H., Lane E.B. Biochemistry 43:1283-1295(2004) [PubMed: 14756564] [Abstract] Cited for: ASSOCIATION WITH KRT8. |
| [21] | "Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease." Toivola D.M., Ku N.O., Resurreccion E.Z., Nelson D.R., Wright T.L., Omary M.B. Hepatology 40:459-466(2004) [PubMed: 15368451] [Abstract] Cited for: PHOSPHORYLATION AT SER-34 AND SER-53. |
| [22] | "Global proteomic approach unmasks involvement of keratins 8 and 18 in the delivery of cystic fibrosis transmembrane conductance regulator (CFTR)/deltaF508-CFTR to the plasma membrane." Davezac N., Tondelier D., Lipecka J., Fanen P., Demaugre F., Debski J., Dadlez M., Schrattenholz A., Cahill M.A., Edelman A. Proteomics 4:3833-3844(2004) [PubMed: 15529338] [Abstract] Cited for: FUNCTION, INTERACTION WITH MUTATED CFTR, SUBCELLULAR LOCATION. |
| [23] | "Identification of trichoplein, a novel keratin filament-binding protein." Nishizawa M., Izawa I., Inoko A., Hayashi Y., Nagata K., Yokoyama T., Usukura J., Inagaki M. J. Cell Sci. 118:1081-1090(2005) [PubMed: 15731013] [Abstract] Cited for: INTERACTION WITH TCHP. |
| [24] | "Global phosphoproteome of HT-29 human colon adenocarcinoma cells." Kim J.-E., Tannenbaum S.R., White F.M. J. Proteome Res. 4:1339-1346(2005) [PubMed: 16083285] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7 AND SER-34, MASS SPECTROMETRY. |
| [25] | "Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network." Lipecka J., Norez C., Bensalem N., Baudouin-Legros M., Planelles G., Becq F., Edelman A., Davezac N. J. Pharmacol. Exp. Ther. 317:500-505(2006) [PubMed: 16424149] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-53. |
| [26] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-13, MASS SPECTROMETRY. |
| [27] | "Interleukin-6 induces keratin expression in intestinal epithelial cells: potential role of keratin-8 in interleukin-6-induced barrier function alterations." Wang L., Srinivasan S., Theiss A.L., Merlin D., Sitaraman S.V. J. Biol. Chem. 282:8219-8227(2007) [PubMed: 17213200] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, PHOSPHORYLATION, INDUCTION. |
| [28] | "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-15; SER-18; SER-53 AND SER-60, MASS SPECTROMETRY. Tissue: Epithelium. |
| [29] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42; SER-60 AND SER-399, MASS SPECTROMETRY. |
| [30] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-34; SER-42; SER-53; SER-60; THR-302 AND SER-399, MASS SPECTROMETRY. |
| [31] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [32] | "Mutation of human keratin 18 in association with cryptogenic cirrhosis." Ku N.-O., Wright T.L., Terrault N.A., Gish R., Omary M.B. J. Clin. Invest. 99:19-23(1997) [PubMed: 9011570] [Abstract] Cited for: VARIANT CRYPTOGENIC CIRRHOSIS LEU-128. |
| [33] | "Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies." Ku N.-O., Darling J.M., Krams S.M., Esquivel C.O., Keeffe E.B., Sibley R.K., Lee Y.M., Wright T.L., Omary M.B. Proc. Natl. Acad. Sci. U.S.A. 100:6063-6068(2003) [PubMed: 12724528] [Abstract] Cited for: VARIANTS CRYPTOGENIC CIRRHOSIS ALA-103; LEU-128; GLN-261 AND ARG-340, VARIANT THR-230. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X12881 mRNA. Translation: CAA31375.1. AY762101 mRNA. Translation: AAX07828.1. BT019412 mRNA. Translation: AAV38219.1. AK223093 mRNA. Translation: BAD96813.1. BC000180 mRNA. Translation: AAH00180.1. BC000698 mRNA. Translation: AAH00698.1. BC004253 mRNA. Translation: AAH04253.1. BC008636 mRNA. Translation: AAH08636.1. BC020982 mRNA. Translation: AAH20982.1. BC072017 mRNA. Translation: AAH72017.1. AF179904 Genomic DNA. Translation: AAA59461.1. X12883 mRNA. Translation: CAA31377.1. X12876 mRNA. Translation: CAA31369.1. | |
| IPI | IPI00554788. |
| PIR | S05481. |
| RefSeq | NP_000215.1. NP_954657.1. |
| UniGene | Hs.406013 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GK7 based on UniProtKB P08670. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:633N. |
| IntAct | P05783. 22 interactions. |
PTM databases | |
| GlycoSuiteDB | P05783. |
| PhosphoSite | P05783. |
2-D gel databases | |
| SWISS-2DPAGE | P05783. |
| PMMA-2DPAGE | P05783. |
| Siena-2DPAGE | P05783. |
Proteomic databases | |
| PRIDE | P05783. |
Genome annotation databases | |
| Ensembl | ENSG00000111057. Homo sapiens. [Contig view] |
| GeneID | 3875. |
| KEGG | hsa:3875. |
| UCSC | uc001sbe.1. human. |
Organism-specific databases | |
| GeneCards | GC12P051632. |
| H-InvDB | HIX0010657. HIX0029655. HIX0030618. HIX0040371. HIX0056530. HIX0056886. HIX0058984. |
| HGNC | HGNC:6430. KRT18. |
| HPA | CAB000008. CAB000030. CAB000092. HPA001605. |
| MIM | 148070. gene. 215600. phenotype. |
| PharmGKB | PA30217. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | P05783. |
| OMA | P05783. KGLQNQI. |
Enzyme and pathway databases | |
| Pathway_Interaction_DB | caspase_pathway. Caspase cascade in apoptosis. |
Gene expression databases | |
| CleanEx | HS_KRT18. |
| GermOnline | ENSG00000111057. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view] |
| PANTHER | PTHR23239. IF. 1 hit. |
| Pfam | PF00038. Filament. 1 hit. [Graphical view] |
| PRINTS | PR01248. TYPE1KERATIN. |
| PROSITE | PS00226. IF. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 15217. |
| PMAP-CutDB | P05783. |
| SOURCE | Search... |
Entry information
| Entry name | K1C18_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P05783 Secondary accession number(s): Q53G38, Q5U0N8, Q9BW26 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 12 Human chromosome 12: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


