Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein E

Gene

APOE

Organism
Papio anubis (Olive baboon)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein E
Short name:
Apo-E
Gene namesi
Name:APOE
OrganismiPapio anubis (Olive baboon)
Taxonomic identifieri9555 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaePapio
Proteomesi
  • UP000028761 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted, VLDL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000000199219 – 317Apolipoprotein EAdd BLAST299

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei143Methionine sulfoxideBy similarity1
Modified residuei147PhosphoserineBy similarity1
Glycosylationi212O-linked (GalNAc...) threonineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Oxidation, Phosphoprotein

Proteomic databases

PRIDEiP05770.

Expressioni

Tissue specificityi

Secreted in plasma.

Structurei

3D structure databases

ProteinModelPortaliP05770.
SMRiP05770.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 1011Add BLAST22
Repeati102 – 1232Add BLAST22
Repeati124 – 1453Add BLAST22
Repeati146 – 1674Add BLAST22
Repeati168 – 1895Add BLAST22
Repeati190 – 2116Add BLAST22
Repeati212 – 2337Add BLAST22
Repeati234 – 2558Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 2558 X 22 AA approximate tandem repeatsAdd BLAST176
Regioni158 – 168LDL receptor bindingBy similarityAdd BLAST11
Regioni162 – 165Heparin-bindingBy similarity4
Regioni229 – 236Heparin-bindingBy similarity8

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00730000111315.
HOVERGENiHBG010582.
OMAiMGSRTRD.
OrthoDBiEOG091G0IA5.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05770-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLWAALLV TFLAGCQAKV EQPVEPETEP ELRQQAEWQS GQPWELALGR
60 70 80 90 100
FWDYLRWVQT LSEQVQEELL SPQVTQELTT LMDETMKELK AYKSELEEQL
110 120 130 140 150
SPVAEETRAR LSKELQAAQA RLGADMEDVR SRLVQYRSEV QAMLGQSTEE
160 170 180 190 200
LRARLASHLR KLRKRLLRDA DDLQKRLAVY QAGAREGAER GVSAIRERLG
210 220 230 240 250
PLVEQGRVRA ATVGSLASQP LQERAQALGE RLRARMEEMG SRTRDRLDEV
260 270 280 290 300
KEQVAEVRAK LEEQAQQISL QAEAFQARLK SWFEPLVEDM QRQWAGLVEK
310
VQAAVGASTA PVPSDNH
Length:317
Mass (Da):36,021
Last modified:June 7, 2017 - v2
Checksum:i3DCF7AEA1F22E48E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31 – 32EL → DV in AAA35381 (PubMed:3220472).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M29322 Genomic DNA. Translation: AAA35381.1.
JH682906 Genomic DNA. No translation available.
PIRiA28792.
RefSeqiXP_003918648.1. XM_003918599.2.

Genome annotation databases

EnsembliENSPANT00000023574; ENSPANP00000019553; ENSPANG00000024325.
GeneIDi101021396.

Similar proteinsi

Entry informationi

Entry nameiAPOE_PAPAN
AccessioniPrimary (citable) accession number: P05770
Secondary accession number(s): A0A096P2H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 7, 2017
Last modified: August 30, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families