60S ribosomal protein L22-A - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P05749 (RL22A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 103. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
60S ribosomal protein L22-A

Alternative name(s):
L1c
RP4
YL31

Gene names

Name:	RPL22A
Ordered Locus Names:	YLR061W
ORF Names:	L2168

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	121 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.4
Subcellular location	Cytoplasm Ref.6.
Miscellaneous	Present with 60400 molecules/cell in log phase SD medium. There are 2 genes for L22 in yeast.
Sequence similarities	Belongs to the ribosomal protein L22e family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cytoplasmic translation Inferred from direct assay Ref.3. Source: SGD
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay Ref.3. Source: SGD
Molecular_function	structural constituent of ribosome Inferred from direct assay Ref.3. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.3 Ref.5

Chain

2 – 121

120

60S ribosomal protein L22-A

PRO_0000215514

Amino acid modifications

Modified residue

Phosphoserine Ref.8

Modified residue

Phosphothreonine Ref.8

Modified residue

Phosphoserine Ref.8

Modified residue

111

Phosphothreonine Ref.8

Experimental info

Sequence conflict

N → D AA sequence Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P05749 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AFF542E484A52069
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FASTA

121

13,693

        10         20         30         40         50         60 
MAPNTSRKQK IAKTFTVDVS SPTENGVFDP ASYAKYLIDH IKVEGAVGNL GNAVTVTEDG 

        70         80         90        100        110        120 
TVVTVVSTAK FSGKYLKYLT KKYLKKNQLR DWIRFVSTKT NEYRLAFYQV TPEEDEEEDE 


E

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast." Otaka E., Higo K., Osawa S. Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-52.
[4]	"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, SUBUNIT.
[5]	"The action of N-terminal acetyltransferases on yeast ribosomal proteins." Arnold R.J., Polevoda B., Reilly J.P., Sherman F. J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[6]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[7]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[8]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21; THR-23; SER-32 AND THR-111, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X94607 Genomic DNA. Translation: CAA64308.1.
Z73233 Genomic DNA. Translation: CAA97592.1.
BK006945 Genomic DNA. Translation: DAA09379.1.

PIR

S61635.

RefSeq

NP_013162.1. NM_001181948.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IZS	electron microscopy	-	W	1-121	[»]
3U5E	X-ray	3.00	U	1-121	[»]
3U5I	X-ray	3.00	U	1-121	[»]
4B6A	electron microscopy	8.10	U	1-121	[»]

ProteinModelPortal

P05749.

SMR

P05749. Positions 9-108.

ModBase

Search...

Protein-protein interaction databases

IntAct

P05749. 2 interactions.

STRING

4932.YLR061W.

Proteomic databases

PaxDb

P05749.

PeptideAtlas

P05749.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YLR061W; YLR061W; YLR061W.

GeneID

850750.

KEGG

sce:YLR061W.

Organism-specific databases

SGD

S000004051. RPL22A.

Phylogenomic databases

eggNOG

NOG260326.

GeneTree

ENSGT00390000003719.

HOGENOM

HOG000198396.

K02891.

OrthoDB

EOG4TF3VZ.

Gene expression databases

Genevestigator

P05749.

GermOnline

YLR061W. Saccharomyces cerevisiae.

Family and domain databases

InterPro

IPR002671. Ribosomal_L22e.
[Graphical view]

PANTHER

PTHR10064. PTHR10064. 1 hit.

Pfam

PF01776. Ribosomal_L22e. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

966882.

Entry information

Entry name

RL22A_YEAST

Accession

Primary (citable) accession number: P05749
Secondary accession number(s): D6VY63

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents