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P05749

- RL22A_YEAST

UniProt

P05749 - RL22A_YEAST

Protein

60S ribosomal protein L22-A

Gene

RPL22A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32215-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L22-A
    Alternative name(s):
    L1c
    RP4
    YL31
    Gene namesi
    Name:RPL22A
    Ordered Locus Names:YLR061W
    ORF Names:L2168
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    SGDiS000004051. RPL22A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 12112060S ribosomal protein L22-APRO_0000215514Add
    BLAST

    Proteomic databases

    MaxQBiP05749.
    PaxDbiP05749.
    PeptideAtlasiP05749.

    Expressioni

    Gene expression databases

    GenevestigatoriP05749.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31336. 90 interactions.
    IntActiP05749. 4 interactions.
    MINTiMINT-4494605.
    STRINGi4932.YLR061W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10V1-121[»]
    1VWUelectron microscopy6.10V1-121[»]
    3IZSelectron microscopy-W1-121[»]
    3J65electron microscopy8.70V1-121[»]
    3U5EX-ray3.00U1-121[»]
    3U5IX-ray3.00U1-121[»]
    4B6Aelectron microscopy8.10U1-121[»]
    4BYNelectron microscopy4.30U2-121[»]
    4BYUelectron microscopy6.60U2-121[»]
    4CUWelectron microscopy3.70U1-121[»]
    ProteinModelPortaliP05749.
    SMRiP05749. Positions 9-108.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L22e family.Curated

    Phylogenomic databases

    eggNOGiNOG260326.
    GeneTreeiENSGT00390000003719.
    HOGENOMiHOG000198396.
    KOiK02891.
    OrthoDBiEOG7673PN.

    Family and domain databases

    InterProiIPR002671. Ribosomal_L22e.
    [Graphical view]
    PANTHERiPTHR10064. PTHR10064. 1 hit.
    PfamiPF01776. Ribosomal_L22e. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05749-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPNTSRKQK IAKTFTVDVS SPTENGVFDP ASYAKYLIDH IKVEGAVGNL    50
    GNAVTVTEDG TVVTVVSTAK FSGKYLKYLT KKYLKKNQLR DWIRFVSTKT 100
    NEYRLAFYQV TPEEDEEEDE E 121
    Length:121
    Mass (Da):13,693
    Last modified:January 23, 2007 - v3
    Checksum:iAFF542E484A52069
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 491N → D AA sequence (PubMed:6814480)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94607 Genomic DNA. Translation: CAA64308.1.
    Z73233 Genomic DNA. Translation: CAA97592.1.
    BK006945 Genomic DNA. Translation: DAA09379.1.
    PIRiS61635.
    RefSeqiNP_013162.1. NM_001181948.1.

    Genome annotation databases

    EnsemblFungiiYLR061W; YLR061W; YLR061W.
    GeneIDi850750.
    KEGGisce:YLR061W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X94607 Genomic DNA. Translation: CAA64308.1 .
    Z73233 Genomic DNA. Translation: CAA97592.1 .
    BK006945 Genomic DNA. Translation: DAA09379.1 .
    PIRi S61635.
    RefSeqi NP_013162.1. NM_001181948.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 V 1-121 [» ]
    1VWU electron microscopy 6.10 V 1-121 [» ]
    3IZS electron microscopy - W 1-121 [» ]
    3J65 electron microscopy 8.70 V 1-121 [» ]
    3U5E X-ray 3.00 U 1-121 [» ]
    3U5I X-ray 3.00 U 1-121 [» ]
    4B6A electron microscopy 8.10 U 1-121 [» ]
    4BYN electron microscopy 4.30 U 2-121 [» ]
    4BYU electron microscopy 6.60 U 2-121 [» ]
    4CUW electron microscopy 3.70 U 1-121 [» ]
    ProteinModelPortali P05749.
    SMRi P05749. Positions 9-108.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31336. 90 interactions.
    IntActi P05749. 4 interactions.
    MINTi MINT-4494605.
    STRINGi 4932.YLR061W.

    Proteomic databases

    MaxQBi P05749.
    PaxDbi P05749.
    PeptideAtlasi P05749.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR061W ; YLR061W ; YLR061W .
    GeneIDi 850750.
    KEGGi sce:YLR061W.

    Organism-specific databases

    SGDi S000004051. RPL22A.

    Phylogenomic databases

    eggNOGi NOG260326.
    GeneTreei ENSGT00390000003719.
    HOGENOMi HOG000198396.
    KOi K02891.
    OrthoDBi EOG7673PN.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32215-MONOMER.

    Miscellaneous databases

    NextBioi 966882.
    PROi P05749.

    Gene expression databases

    Genevestigatori P05749.

    Family and domain databases

    InterProi IPR002671. Ribosomal_L22e.
    [Graphical view ]
    PANTHERi PTHR10064. PTHR10064. 1 hit.
    Pfami PF01776. Ribosomal_L22e. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
      Otaka E., Higo K., Osawa S.
      Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-52.
    4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    5. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    10. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL22A_YEAST
    AccessioniPrimary (citable) accession number: P05749
    Secondary accession number(s): D6VY63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 60400 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L22 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3