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P05748

- RL15A_YEAST

UniProt

P05748 - RL15A_YEAST

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Protein

60S ribosomal protein L15-A

Gene

RPL15A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32188-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L15-A
Alternative name(s):
L13
RP15R
YL10
YP18
Gene namesi
Name:RPL15A
Synonyms:RPL10A, RPL13A, YL10A
Ordered Locus Names:YLR029C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

SGDiS000004019. RPL15A.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 20420360S ribosomal protein L15-APRO_0000127566Add
BLAST

Proteomic databases

MaxQBiP05748.
PeptideAtlasiP05748.

Expressioni

Gene expression databases

GenevestigatoriP05748.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31303. 118 interactions.
IntActiP05748. 21 interactions.
MINTiMINT-8285329.
STRINGi4932.YLR029C.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-L3-196[»]
1S1Ielectron microscopy11.70L2-204[»]
1VW8electron microscopy6.10O1-204[»]
1VWUelectron microscopy6.10O1-204[»]
1VXVelectron microscopy6.20O1-204[»]
1VXYelectron microscopy6.30O1-204[»]
3IZSelectron microscopy-P1-204[»]
3J65electron microscopy8.70O1-204[»]
3O58X-ray4.00O1-204[»]
3O5HX-ray4.00O1-204[»]
3U5EX-ray3.00N1-204[»]
3U5IX-ray3.00N1-204[»]
4B6Aelectron microscopy8.10N1-204[»]
4BYNelectron microscopy4.30N2-204[»]
4BYUelectron microscopy6.60N2-204[»]
4CUWelectron microscopy3.70N1-204[»]
ProteinModelPortaliP05748.
SMRiP05748. Positions 2-204.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05748.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L15e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000005092.
HOGENOMiHOG000229584.
InParanoidiP05748.
KOiK02877.
OMAiSRRAAWK.
OrthoDBiEOG7S4XJ3.

Family and domain databases

Gene3Di3.40.1120.10. 1 hit.
InterProiIPR024794. Rbsml_L15e_core_dom.
IPR000439. Ribosomal_L15e.
IPR020925. Ribosomal_L15e_CS.
IPR012678. Ribosomal_L23/L15e_core_dom.
[Graphical view]
PANTHERiPTHR11847. PTHR11847. 1 hit.
PfamiPF00827. Ribosomal_L15e. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS01194. RIBOSOMAL_L15E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAYKYLEEL QRKKQSDVLR FLQRVRVWEY RQKNVIHRAA RPTRPDKARR
60 70 80 90 100
LGYKAKQGFV IYRVRVRRGN RKRPVPKGAT YGKPTNQGVN ELKYQRSLRA
110 120 130 140 150
TAEERVGRRA ANLRVLNSYW VNQDSTYKYF EVILVDPQHK AIRRDARYNW
160 170 180 190 200
ICDPVHKHRE ARGLTATGKK SRGINKGHKF NNTKAGRRKT WKRQNTLSLW

RYRK
Length:204
Mass (Da):24,422
Last modified:January 23, 2007 - v3
Checksum:i3913F9E4AB9ECA2C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281W → G AA sequence (PubMed:6814480)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14675 Genomic DNA. Translation: BAA03506.1.
Z73201 Genomic DNA. Translation: CAA97553.1.
BK006945 Genomic DNA. Translation: DAA09347.1.
PIRiS48502.
RefSeqiNP_013129.1. NM_001181916.1.

Genome annotation databases

EnsemblFungiiYLR029C; YLR029C; YLR029C.
GeneIDi850716.
KEGGisce:YLR029C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14675 Genomic DNA. Translation: BAA03506.1 .
Z73201 Genomic DNA. Translation: CAA97553.1 .
BK006945 Genomic DNA. Translation: DAA09347.1 .
PIRi S48502.
RefSeqi NP_013129.1. NM_001181916.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - L 3-196 [» ]
1S1I electron microscopy 11.70 L 2-204 [» ]
1VW8 electron microscopy 6.10 O 1-204 [» ]
1VWU electron microscopy 6.10 O 1-204 [» ]
1VXV electron microscopy 6.20 O 1-204 [» ]
1VXY electron microscopy 6.30 O 1-204 [» ]
3IZS electron microscopy - P 1-204 [» ]
3J65 electron microscopy 8.70 O 1-204 [» ]
3O58 X-ray 4.00 O 1-204 [» ]
3O5H X-ray 4.00 O 1-204 [» ]
3U5E X-ray 3.00 N 1-204 [» ]
3U5I X-ray 3.00 N 1-204 [» ]
4B6A electron microscopy 8.10 N 1-204 [» ]
4BYN electron microscopy 4.30 N 2-204 [» ]
4BYU electron microscopy 6.60 N 2-204 [» ]
4CUW electron microscopy 3.70 N 1-204 [» ]
ProteinModelPortali P05748.
SMRi P05748. Positions 2-204.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31303. 118 interactions.
IntActi P05748. 21 interactions.
MINTi MINT-8285329.
STRINGi 4932.YLR029C.

Proteomic databases

MaxQBi P05748.
PeptideAtlasi P05748.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR029C ; YLR029C ; YLR029C .
GeneIDi 850716.
KEGGi sce:YLR029C.

Organism-specific databases

SGDi S000004019. RPL15A.

Phylogenomic databases

GeneTreei ENSGT00390000005092.
HOGENOMi HOG000229584.
InParanoidi P05748.
KOi K02877.
OMAi SRRAAWK.
OrthoDBi EOG7S4XJ3.

Enzyme and pathway databases

BioCyci YEAST:G3O-32188-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

EvolutionaryTracei P05748.
NextBioi 966784.

Gene expression databases

Genevestigatori P05748.

Family and domain databases

Gene3Di 3.40.1120.10. 1 hit.
InterProi IPR024794. Rbsml_L15e_core_dom.
IPR000439. Ribosomal_L15e.
IPR020925. Ribosomal_L15e_CS.
IPR012678. Ribosomal_L23/L15e_core_dom.
[Graphical view ]
PANTHERi PTHR11847. PTHR11847. 1 hit.
Pfami PF00827. Ribosomal_L15e. 1 hit.
[Graphical view ]
SUPFAMi SSF54189. SSF54189. 1 hit.
PROSITEi PS01194. RIBOSOMAL_L15E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Tomiyoshi A., Suzuki K., Otaka E.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
    Otaka E., Higo K., Osawa S.
    Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-44.
  5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
    Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
    J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-9.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 3-196, ELECTRON MICROSCOPY.
  8. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
  9. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  10. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL15A_YEAST
AccessioniPrimary (citable) accession number: P05748
Secondary accession number(s): D6VY31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L15 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3