Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P05748

- RL15A_YEAST

UniProt

P05748 - RL15A_YEAST

Protein

60S ribosomal protein L15-A

Gene

RPL15A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. RNA binding Source: SGD
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32188-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L15-A
    Alternative name(s):
    L13
    RP15R
    YL10
    YP18
    Gene namesi
    Name:RPL15A
    Synonyms:RPL10A, RPL13A, YL10A
    Ordered Locus Names:YLR029C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    SGDiS000004019. RPL15A.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 20420360S ribosomal protein L15-APRO_0000127566Add
    BLAST

    Proteomic databases

    MaxQBiP05748.
    PeptideAtlasiP05748.

    Expressioni

    Gene expression databases

    GenevestigatoriP05748.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi31303. 117 interactions.
    IntActiP05748. 21 interactions.
    MINTiMINT-8285329.
    STRINGi4932.YLR029C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-L3-196[»]
    1S1Ielectron microscopy11.70L2-204[»]
    1VW8electron microscopy6.10O1-204[»]
    1VWUelectron microscopy6.10O1-204[»]
    3IZSelectron microscopy-P1-204[»]
    3J65electron microscopy8.70O1-204[»]
    3O58X-ray4.00O1-204[»]
    3O5HX-ray4.00O1-204[»]
    3U5EX-ray3.00N1-204[»]
    3U5IX-ray3.00N1-204[»]
    4B6Aelectron microscopy8.10N1-204[»]
    4BYNelectron microscopy4.30N2-204[»]
    4BYUelectron microscopy6.60N2-204[»]
    4CUWelectron microscopy3.70N1-204[»]
    ProteinModelPortaliP05748.
    SMRiP05748. Positions 2-204.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05748.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L15e family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000005092.
    HOGENOMiHOG000229584.
    KOiK02877.
    OMAiSRRAAWK.
    OrthoDBiEOG7S4XJ3.

    Family and domain databases

    Gene3Di3.40.1120.10. 1 hit.
    InterProiIPR024794. Rbsml_L15e_core_dom.
    IPR000439. Ribosomal_L15e.
    IPR020925. Ribosomal_L15e_CS.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    [Graphical view]
    PANTHERiPTHR11847. PTHR11847. 1 hit.
    PfamiPF00827. Ribosomal_L15e. 1 hit.
    [Graphical view]
    SUPFAMiSSF54189. SSF54189. 1 hit.
    PROSITEiPS01194. RIBOSOMAL_L15E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05748-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAYKYLEEL QRKKQSDVLR FLQRVRVWEY RQKNVIHRAA RPTRPDKARR    50
    LGYKAKQGFV IYRVRVRRGN RKRPVPKGAT YGKPTNQGVN ELKYQRSLRA 100
    TAEERVGRRA ANLRVLNSYW VNQDSTYKYF EVILVDPQHK AIRRDARYNW 150
    ICDPVHKHRE ARGLTATGKK SRGINKGHKF NNTKAGRRKT WKRQNTLSLW 200
    RYRK 204
    Length:204
    Mass (Da):24,422
    Last modified:January 23, 2007 - v3
    Checksum:i3913F9E4AB9ECA2C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281W → G AA sequence (PubMed:6814480)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14675 Genomic DNA. Translation: BAA03506.1.
    Z73201 Genomic DNA. Translation: CAA97553.1.
    BK006945 Genomic DNA. Translation: DAA09347.1.
    PIRiS48502.
    RefSeqiNP_013129.1. NM_001181916.1.

    Genome annotation databases

    EnsemblFungiiYLR029C; YLR029C; YLR029C.
    GeneIDi850716.
    KEGGisce:YLR029C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D14675 Genomic DNA. Translation: BAA03506.1 .
    Z73201 Genomic DNA. Translation: CAA97553.1 .
    BK006945 Genomic DNA. Translation: DAA09347.1 .
    PIRi S48502.
    RefSeqi NP_013129.1. NM_001181916.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - L 3-196 [» ]
    1S1I electron microscopy 11.70 L 2-204 [» ]
    1VW8 electron microscopy 6.10 O 1-204 [» ]
    1VWU electron microscopy 6.10 O 1-204 [» ]
    3IZS electron microscopy - P 1-204 [» ]
    3J65 electron microscopy 8.70 O 1-204 [» ]
    3O58 X-ray 4.00 O 1-204 [» ]
    3O5H X-ray 4.00 O 1-204 [» ]
    3U5E X-ray 3.00 N 1-204 [» ]
    3U5I X-ray 3.00 N 1-204 [» ]
    4B6A electron microscopy 8.10 N 1-204 [» ]
    4BYN electron microscopy 4.30 N 2-204 [» ]
    4BYU electron microscopy 6.60 N 2-204 [» ]
    4CUW electron microscopy 3.70 N 1-204 [» ]
    ProteinModelPortali P05748.
    SMRi P05748. Positions 2-204.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31303. 117 interactions.
    IntActi P05748. 21 interactions.
    MINTi MINT-8285329.
    STRINGi 4932.YLR029C.

    Proteomic databases

    MaxQBi P05748.
    PeptideAtlasi P05748.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR029C ; YLR029C ; YLR029C .
    GeneIDi 850716.
    KEGGi sce:YLR029C.

    Organism-specific databases

    SGDi S000004019. RPL15A.

    Phylogenomic databases

    GeneTreei ENSGT00390000005092.
    HOGENOMi HOG000229584.
    KOi K02877.
    OMAi SRRAAWK.
    OrthoDBi EOG7S4XJ3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32188-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    EvolutionaryTracei P05748.
    NextBioi 966784.

    Gene expression databases

    Genevestigatori P05748.

    Family and domain databases

    Gene3Di 3.40.1120.10. 1 hit.
    InterProi IPR024794. Rbsml_L15e_core_dom.
    IPR000439. Ribosomal_L15e.
    IPR020925. Ribosomal_L15e_CS.
    IPR012678. Ribosomal_L23/L15e_core_dom.
    [Graphical view ]
    PANTHERi PTHR11847. PTHR11847. 1 hit.
    Pfami PF00827. Ribosomal_L15e. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54189. SSF54189. 1 hit.
    PROSITEi PS01194. RIBOSOMAL_L15E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Tomiyoshi A., Suzuki K., Otaka E.
      Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Isolation of seventeen proteins and amino-terminal amino acid sequences of eight proteins from cytoplasmic ribosomes of yeast."
      Otaka E., Higo K., Osawa S.
      Biochemistry 21:4545-4550(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-44.
    5. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-9.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 3-196, ELECTRON MICROSCOPY.
    8. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
    9. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    10. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    11. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL15A_YEAST
    AccessioniPrimary (citable) accession number: P05748
    Secondary accession number(s): D6VY31
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are 2 genes for L15 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3