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Protein

60S ribosomal protein L36-A

Gene

RPL36A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32881-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36-A
Alternative name(s):
L39
YL39
Gene namesi
Name:RPL36A
Synonyms:RPL39A
Ordered Locus Names:YMR194W
ORF Names:YM9646.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR194W.
SGDiS000004807. RPL36A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001950202 – 10060S ribosomal protein L36-AAdd BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP05745.
PRIDEiP05745.
TopDownProteomicsiP05745.

PTM databases

iPTMnetiP05745.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi35372. 46 interactors.
IntActiP05745. 14 interactors.
MINTiMINT-1898050.

Structurei

Secondary structure

1100
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 10Combined sources5
Helixi26 – 29Combined sources4
Helixi35 – 48Combined sources14
Helixi52 – 64Combined sources13
Helixi66 – 76Combined sources11
Beta strandi77 – 79Combined sources3
Helixi80 – 96Combined sources17
Turni97 – 99Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10761-100[»]
3J6Yelectron microscopy6.10761-100[»]
3J77electron microscopy6.20861-100[»]
3J78electron microscopy6.30861-100[»]
3JCTelectron microscopy3.08i1-100[»]
4U3MX-ray3.00O6/o62-100[»]
4U3NX-ray3.20O6/o62-100[»]
4U3UX-ray2.90O6/o62-100[»]
4U4NX-ray3.10O6/o62-100[»]
4U4OX-ray3.60O6/o62-100[»]
4U4QX-ray3.00O6/o62-100[»]
4U4RX-ray2.80O6/o62-100[»]
4U4UX-ray3.00O6/o62-100[»]
4U4YX-ray3.20O6/o62-100[»]
4U4ZX-ray3.10O6/o62-100[»]
4U50X-ray3.20O6/o62-100[»]
4U51X-ray3.20O6/o62-100[»]
4U52X-ray3.00O6/o62-100[»]
4U53X-ray3.30O6/o62-100[»]
4U55X-ray3.20O6/o62-100[»]
4U56X-ray3.45O6/o62-100[»]
4U6FX-ray3.10O6/o62-100[»]
4V6Ielectron microscopy8.80Bk1-100[»]
4V7Felectron microscopy8.70g1-100[»]
4V88X-ray3.00Bi/Di1-100[»]
4V8Telectron microscopy8.10i1-100[»]
4V8Yelectron microscopy4.30Bi2-100[»]
4V8Zelectron microscopy6.60Bi2-100[»]
4V91electron microscopy3.70i1-100[»]
5APNelectron microscopy3.91i1-100[»]
5APOelectron microscopy3.41i1-100[»]
5DATX-ray3.15O6/o62-100[»]
5DC3X-ray3.25O6/o62-100[»]
5FCIX-ray3.40O6/o62-100[»]
5FCJX-ray3.10O6/o62-100[»]
5FL8electron microscopy9.50i1-100[»]
5GAKelectron microscopy3.88k1-100[»]
5I4LX-ray3.10O6/o62-100[»]
5JUOelectron microscopy4.00NA1-100[»]
5JUPelectron microscopy3.50NA1-100[»]
5JUSelectron microscopy4.20NA1-100[»]
5JUTelectron microscopy4.00NA1-100[»]
5JUUelectron microscopy4.00NA1-100[»]
ProteinModelPortaliP05745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L36e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
InParanoidiP05745.
KOiK02920.
OMAiGTHKRAL.
OrthoDBiEOG092C5H47.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVKTGIAIG LNKGKKVTSM TPAPKISYKK GAASNRTKFV RSLVREIAGL
60 70 80 90 100
SPYERRLIDL IRNSGEKRAR KVAKKRLGSF TRAKAKVEEM NNIIAASRRH
Length:100
Mass (Da):11,124
Last modified:January 23, 2007 - v3
Checksum:i9CAA7BFFF33D0C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA. Translation: CAA87815.1.
BK006946 Genomic DNA. Translation: DAA10092.1.
PIRiS11263. S50922.
RefSeqiNP_013920.1. NM_001182701.1.

Genome annotation databases

EnsemblFungiiYMR194W; YMR194W; YMR194W.
GeneIDi855232.
KEGGisce:YMR194W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA. Translation: CAA87815.1.
BK006946 Genomic DNA. Translation: DAA10092.1.
PIRiS11263. S50922.
RefSeqiNP_013920.1. NM_001182701.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10761-100[»]
3J6Yelectron microscopy6.10761-100[»]
3J77electron microscopy6.20861-100[»]
3J78electron microscopy6.30861-100[»]
3JCTelectron microscopy3.08i1-100[»]
4U3MX-ray3.00O6/o62-100[»]
4U3NX-ray3.20O6/o62-100[»]
4U3UX-ray2.90O6/o62-100[»]
4U4NX-ray3.10O6/o62-100[»]
4U4OX-ray3.60O6/o62-100[»]
4U4QX-ray3.00O6/o62-100[»]
4U4RX-ray2.80O6/o62-100[»]
4U4UX-ray3.00O6/o62-100[»]
4U4YX-ray3.20O6/o62-100[»]
4U4ZX-ray3.10O6/o62-100[»]
4U50X-ray3.20O6/o62-100[»]
4U51X-ray3.20O6/o62-100[»]
4U52X-ray3.00O6/o62-100[»]
4U53X-ray3.30O6/o62-100[»]
4U55X-ray3.20O6/o62-100[»]
4U56X-ray3.45O6/o62-100[»]
4U6FX-ray3.10O6/o62-100[»]
4V6Ielectron microscopy8.80Bk1-100[»]
4V7Felectron microscopy8.70g1-100[»]
4V88X-ray3.00Bi/Di1-100[»]
4V8Telectron microscopy8.10i1-100[»]
4V8Yelectron microscopy4.30Bi2-100[»]
4V8Zelectron microscopy6.60Bi2-100[»]
4V91electron microscopy3.70i1-100[»]
5APNelectron microscopy3.91i1-100[»]
5APOelectron microscopy3.41i1-100[»]
5DATX-ray3.15O6/o62-100[»]
5DC3X-ray3.25O6/o62-100[»]
5FCIX-ray3.40O6/o62-100[»]
5FCJX-ray3.10O6/o62-100[»]
5FL8electron microscopy9.50i1-100[»]
5GAKelectron microscopy3.88k1-100[»]
5I4LX-ray3.10O6/o62-100[»]
5JUOelectron microscopy4.00NA1-100[»]
5JUPelectron microscopy3.50NA1-100[»]
5JUSelectron microscopy4.20NA1-100[»]
5JUTelectron microscopy4.00NA1-100[»]
5JUUelectron microscopy4.00NA1-100[»]
ProteinModelPortaliP05745.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35372. 46 interactors.
IntActiP05745. 14 interactors.
MINTiMINT-1898050.

PTM databases

iPTMnetiP05745.

Proteomic databases

MaxQBiP05745.
PRIDEiP05745.
TopDownProteomicsiP05745.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR194W; YMR194W; YMR194W.
GeneIDi855232.
KEGGisce:YMR194W.

Organism-specific databases

EuPathDBiFungiDB:YMR194W.
SGDiS000004807. RPL36A.

Phylogenomic databases

GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
InParanoidiP05745.
KOiK02920.
OMAiGTHKRAL.
OrthoDBiEOG092C5H47.

Enzyme and pathway databases

BioCyciYEAST:G3O-32881-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiP05745.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL36A_YEAST
AccessioniPrimary (citable) accession number: P05745
Secondary accession number(s): D6W018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 31600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L36 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.