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P05745

- RL36A_YEAST

UniProt

P05745 - RL36A_YEAST

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Protein

60S ribosomal protein L36-A

Gene

RPL36A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32881-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L36-A
Alternative name(s):
L39
YL39
Gene namesi
Name:RPL36A
Synonyms:RPL39A
Ordered Locus Names:YMR194W
ORF Names:YM9646.06
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

SGDiS000004807. RPL36A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 1009960S ribosomal protein L36-APRO_0000195020Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine1 Publication

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP05745.
PaxDbiP05745.

Expressioni

Gene expression databases

GenevestigatoriP05745.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi35372. 116 interactions.
IntActiP05745. 13 interactions.
MINTiMINT-1898050.
STRINGi4932.YMR194W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1VW8electron microscopy6.10j1-100[»]
1VWUelectron microscopy6.10j1-100[»]
1VXVelectron microscopy6.20j1-100[»]
1VXYelectron microscopy6.30j1-100[»]
3IZSelectron microscopy-k1-100[»]
3J65electron microscopy8.70g1-100[»]
3U5EX-ray3.00i1-100[»]
3U5IX-ray3.00i1-100[»]
4B6Aelectron microscopy8.10i1-100[»]
4BYNelectron microscopy4.30i2-100[»]
4BYUelectron microscopy6.60i2-100[»]
4CUWelectron microscopy3.70i1-100[»]
ProteinModelPortaliP05745.
SMRiP05745. Positions 2-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L36e family.Curated

Phylogenomic databases

eggNOGiCOG5051.
GeneTreeiENSGT00390000011943.
HOGENOMiHOG000155312.
InParanoidiP05745.
KOiK02920.
OMAiDIPINES.
OrthoDBiEOG712V86.

Family and domain databases

InterProiIPR000509. Ribosomal_L36e.
[Graphical view]
PANTHERiPTHR10114. PTHR10114. 1 hit.
PfamiPF01158. Ribosomal_L36e. 1 hit.
[Graphical view]
PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05745-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVKTGIAIG LNKGKKVTSM TPAPKISYKK GAASNRTKFV RSLVREIAGL
60 70 80 90 100
SPYERRLIDL IRNSGEKRAR KVAKKRLGSF TRAKAKVEEM NNIIAASRRH
Length:100
Mass (Da):11,124
Last modified:January 23, 2007 - v3
Checksum:i9CAA7BFFF33D0C25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA. Translation: CAA87815.1.
BK006946 Genomic DNA. Translation: DAA10092.1.
PIRiS11263. S50922.
RefSeqiNP_013920.1. NM_001182701.1.

Genome annotation databases

EnsemblFungiiYMR194W; YMR194W; YMR194W.
GeneIDi855232.
KEGGisce:YMR194W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z47815 Genomic DNA. Translation: CAA87815.1 .
BK006946 Genomic DNA. Translation: DAA10092.1 .
PIRi S11263. S50922.
RefSeqi NP_013920.1. NM_001182701.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1VW8 electron microscopy 6.10 j 1-100 [» ]
1VWU electron microscopy 6.10 j 1-100 [» ]
1VXV electron microscopy 6.20 j 1-100 [» ]
1VXY electron microscopy 6.30 j 1-100 [» ]
3IZS electron microscopy - k 1-100 [» ]
3J65 electron microscopy 8.70 g 1-100 [» ]
3U5E X-ray 3.00 i 1-100 [» ]
3U5I X-ray 3.00 i 1-100 [» ]
4B6A electron microscopy 8.10 i 1-100 [» ]
4BYN electron microscopy 4.30 i 2-100 [» ]
4BYU electron microscopy 6.60 i 2-100 [» ]
4CUW electron microscopy 3.70 i 1-100 [» ]
ProteinModelPortali P05745.
SMRi P05745. Positions 2-100.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35372. 116 interactions.
IntActi P05745. 13 interactions.
MINTi MINT-1898050.
STRINGi 4932.YMR194W.

Proteomic databases

MaxQBi P05745.
PaxDbi P05745.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR194W ; YMR194W ; YMR194W .
GeneIDi 855232.
KEGGi sce:YMR194W.

Organism-specific databases

SGDi S000004807. RPL36A.

Phylogenomic databases

eggNOGi COG5051.
GeneTreei ENSGT00390000011943.
HOGENOMi HOG000155312.
InParanoidi P05745.
KOi K02920.
OMAi DIPINES.
OrthoDBi EOG712V86.

Enzyme and pathway databases

BioCyci YEAST:G3O-32881-MONOMER.
Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

NextBioi 978774.

Gene expression databases

Genevestigatori P05745.

Family and domain databases

InterProi IPR000509. Ribosomal_L36e.
[Graphical view ]
PANTHERi PTHR10114. PTHR10114. 1 hit.
Pfami PF01158. Ribosomal_L36e. 1 hit.
[Graphical view ]
PROSITEi PS01190. RIBOSOMAL_L36E. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  4. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2 BY NATA.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  8. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL36A_YEAST
AccessioniPrimary (citable) accession number: P05745
Secondary accession number(s): D6W018
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 31600 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L36 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3