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P05745

- RL36A_YEAST

UniProt

P05745 - RL36A_YEAST

Protein

60S ribosomal protein L36-A

Gene

RPL36A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. RNA binding Source: SGD
    2. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32881-MONOMER.
    ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L36-A
    Alternative name(s):
    L39
    YL39
    Gene namesi
    Name:RPL36A
    Synonyms:RPL39A
    Ordered Locus Names:YMR194W
    ORF Names:YM9646.06
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    SGDiS000004807. RPL36A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 1009960S ribosomal protein L36-APRO_0000195020Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine1 Publication

    Post-translational modificationi

    N-terminally acetylated by acetyltransferase NatA.1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP05745.
    PaxDbiP05745.

    Expressioni

    Gene expression databases

    GenevestigatoriP05745.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi35372. 114 interactions.
    IntActiP05745. 13 interactions.
    MINTiMINT-1898050.
    STRINGi4932.YMR194W.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1VW8electron microscopy6.10j1-100[»]
    1VWUelectron microscopy6.10j1-100[»]
    3IZSelectron microscopy-k1-100[»]
    3J65electron microscopy8.70g1-100[»]
    3U5EX-ray3.00i1-100[»]
    3U5IX-ray3.00i1-100[»]
    4B6Aelectron microscopy8.10i1-100[»]
    4BYNelectron microscopy4.30i2-100[»]
    4BYUelectron microscopy6.60i2-100[»]
    4CUWelectron microscopy3.70i1-100[»]
    ProteinModelPortaliP05745.
    SMRiP05745. Positions 2-100.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L36e family.Curated

    Phylogenomic databases

    eggNOGiCOG5051.
    GeneTreeiENSGT00390000011943.
    HOGENOMiHOG000155312.
    KOiK02920.
    OMAiDIPINES.
    OrthoDBiEOG712V86.

    Family and domain databases

    InterProiIPR000509. Ribosomal_L36e.
    [Graphical view]
    PANTHERiPTHR10114. PTHR10114. 1 hit.
    PfamiPF01158. Ribosomal_L36e. 1 hit.
    [Graphical view]
    PROSITEiPS01190. RIBOSOMAL_L36E. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05745-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVKTGIAIG LNKGKKVTSM TPAPKISYKK GAASNRTKFV RSLVREIAGL    50
    SPYERRLIDL IRNSGEKRAR KVAKKRLGSF TRAKAKVEEM NNIIAASRRH 100
    Length:100
    Mass (Da):11,124
    Last modified:January 23, 2007 - v3
    Checksum:i9CAA7BFFF33D0C25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47815 Genomic DNA. Translation: CAA87815.1.
    BK006946 Genomic DNA. Translation: DAA10092.1.
    PIRiS11263. S50922.
    RefSeqiNP_013920.1. NM_001182701.1.

    Genome annotation databases

    EnsemblFungiiYMR194W; YMR194W; YMR194W.
    GeneIDi855232.
    KEGGisce:YMR194W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z47815 Genomic DNA. Translation: CAA87815.1 .
    BK006946 Genomic DNA. Translation: DAA10092.1 .
    PIRi S11263. S50922.
    RefSeqi NP_013920.1. NM_001182701.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1VW8 electron microscopy 6.10 j 1-100 [» ]
    1VWU electron microscopy 6.10 j 1-100 [» ]
    3IZS electron microscopy - k 1-100 [» ]
    3J65 electron microscopy 8.70 g 1-100 [» ]
    3U5E X-ray 3.00 i 1-100 [» ]
    3U5I X-ray 3.00 i 1-100 [» ]
    4B6A electron microscopy 8.10 i 1-100 [» ]
    4BYN electron microscopy 4.30 i 2-100 [» ]
    4BYU electron microscopy 6.60 i 2-100 [» ]
    4CUW electron microscopy 3.70 i 1-100 [» ]
    ProteinModelPortali P05745.
    SMRi P05745. Positions 2-100.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35372. 114 interactions.
    IntActi P05745. 13 interactions.
    MINTi MINT-1898050.
    STRINGi 4932.YMR194W.

    Proteomic databases

    MaxQBi P05745.
    PaxDbi P05745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR194W ; YMR194W ; YMR194W .
    GeneIDi 855232.
    KEGGi sce:YMR194W.

    Organism-specific databases

    SGDi S000004807. RPL36A.

    Phylogenomic databases

    eggNOGi COG5051.
    GeneTreei ENSGT00390000011943.
    HOGENOMi HOG000155312.
    KOi K02920.
    OMAi DIPINES.
    OrthoDBi EOG712V86.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32881-MONOMER.
    Reactomei REACT_188965. SRP-dependent cotranslational protein targeting to membrane.
    REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
    REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_217188. Formation of a pool of free 40S subunits.

    Miscellaneous databases

    NextBioi 978774.

    Gene expression databases

    Genevestigatori P05745.

    Family and domain databases

    InterProi IPR000509. Ribosomal_L36e.
    [Graphical view ]
    PANTHERi PTHR10114. PTHR10114. 1 hit.
    Pfami PF01158. Ribosomal_L36e. 1 hit.
    [Graphical view ]
    PROSITEi PS01190. RIBOSOMAL_L36E. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    4. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2 BY NATA.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    8. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL36A_YEAST
    AccessioniPrimary (citable) accession number: P05745
    Secondary accession number(s): D6W018
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 31600 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L36 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3