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Protein

60S ribosomal protein L33-A

Gene

RPL33A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-34040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L33-A
Alternative name(s):
L37
RP47
YL37
Gene namesi
Name:RPL33A
Synonyms:RPL37A
Ordered Locus Names:YPL143W
ORF Names:LPI4W, P2625
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPL143W.
SGDiS000006064. RPL33A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001928072 – 10760S ribosomal protein L33-AAdd BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine; partial1 Publication1
Cross-linki47Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Post-translational modificationi

N-terminally acetylated by acetyltransferase NatA.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP05744.
PRIDEiP05744.
TopDownProteomicsiP05744.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi36040. 37 interactors.
IntActiP05744. 14 interactors.
MINTiMINT-8285485.

Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 18Combined sources11
Beta strandi23 – 32Combined sources10
Helixi38 – 41Combined sources4
Turni42 – 46Combined sources5
Beta strandi48 – 54Combined sources7
Beta strandi59 – 61Combined sources3
Beta strandi63 – 74Combined sources12
Beta strandi76 – 79Combined sources4
Beta strandi81 – 87Combined sources7
Turni92 – 95Combined sources4
Beta strandi97 – 101Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10731-107[»]
3J6Yelectron microscopy6.10731-107[»]
3J77electron microscopy6.20831-107[»]
3J78electron microscopy6.30831-107[»]
3JCTelectron microscopy3.08f1-107[»]
4U3MX-ray3.00O3/o32-107[»]
4U3NX-ray3.20O3/o32-107[»]
4U3UX-ray2.90O3/o32-107[»]
4U4NX-ray3.10O3/o32-107[»]
4U4OX-ray3.60O3/o32-107[»]
4U4QX-ray3.00O3/o32-107[»]
4U4RX-ray2.80O3/o32-107[»]
4U4UX-ray3.00O3/o32-107[»]
4U4YX-ray3.20O3/o32-107[»]
4U4ZX-ray3.10O3/o32-107[»]
4U50X-ray3.20O3/o32-107[»]
4U51X-ray3.20O3/o32-107[»]
4U52X-ray3.00O3/o32-107[»]
4U53X-ray3.30O3/o32-107[»]
4U55X-ray3.20O3/o32-107[»]
4U56X-ray3.45O3/o32-107[»]
4U6FX-ray3.10O3/o32-107[»]
4V6Ielectron microscopy8.80Bj1-107[»]
4V7Felectron microscopy8.70e1-107[»]
4V88X-ray3.00Bf/Df1-107[»]
4V8Telectron microscopy8.10f1-107[»]
4V8Yelectron microscopy4.30Bf2-107[»]
4V8Zelectron microscopy6.60Bf2-107[»]
4V91electron microscopy3.70f1-107[»]
5APNelectron microscopy3.91f1-107[»]
5APOelectron microscopy3.41f1-107[»]
5DATX-ray3.15O3/o32-107[»]
5DC3X-ray3.25O3/o32-107[»]
5FCIX-ray3.40O3/o32-107[»]
5FCJX-ray3.10O3/o32-107[»]
5FL8electron microscopy9.50f1-107[»]
5GAKelectron microscopy3.88h1-107[»]
5I4LX-ray3.10O3/o32-107[»]
5JUOelectron microscopy4.00KA1-107[»]
5JUPelectron microscopy3.50KA1-107[»]
5JUSelectron microscopy4.20KA1-107[»]
5JUTelectron microscopy4.00KA1-107[»]
5JUUelectron microscopy4.00KA1-107[»]
ProteinModelPortaliP05744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L35Ae family.Curated

Phylogenomic databases

HOGENOMiHOG000195636.
InParanoidiP05744.
KOiK02917.
OMAiGERCAYV.
OrthoDBiEOG092C5MJS.

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05744-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAESHRLYVK GKHLSYQRSK RVNNPNVSLI KIEGVATPQD AQFYLGKRIA
60 70 80 90 100
YVYRASKEVR GSKIRVMWGK VTRTHGNSGV VRATFRNNLP AKTFGASVRI

FLYPSNI
Length:107
Mass (Da):12,154
Last modified:January 23, 2007 - v3
Checksum:i263E8389218B5027
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24N → D AA sequence (PubMed:18782943).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57969 Genomic DNA. Translation: CAA41035.1.
U43703 Genomic DNA. Translation: AAB68218.1.
Z73499 Genomic DNA. Translation: CAA97847.1.
BK006949 Genomic DNA. Translation: DAA11292.1.
PIRiS18431.
RefSeqiNP_015182.1. NM_001183957.1.

Genome annotation databases

EnsemblFungiiYPL143W; YPL143W; YPL143W.
GeneIDi855960.
KEGGisce:YPL143W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X57969 Genomic DNA. Translation: CAA41035.1.
U43703 Genomic DNA. Translation: AAB68218.1.
Z73499 Genomic DNA. Translation: CAA97847.1.
BK006949 Genomic DNA. Translation: DAA11292.1.
PIRiS18431.
RefSeqiNP_015182.1. NM_001183957.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10731-107[»]
3J6Yelectron microscopy6.10731-107[»]
3J77electron microscopy6.20831-107[»]
3J78electron microscopy6.30831-107[»]
3JCTelectron microscopy3.08f1-107[»]
4U3MX-ray3.00O3/o32-107[»]
4U3NX-ray3.20O3/o32-107[»]
4U3UX-ray2.90O3/o32-107[»]
4U4NX-ray3.10O3/o32-107[»]
4U4OX-ray3.60O3/o32-107[»]
4U4QX-ray3.00O3/o32-107[»]
4U4RX-ray2.80O3/o32-107[»]
4U4UX-ray3.00O3/o32-107[»]
4U4YX-ray3.20O3/o32-107[»]
4U4ZX-ray3.10O3/o32-107[»]
4U50X-ray3.20O3/o32-107[»]
4U51X-ray3.20O3/o32-107[»]
4U52X-ray3.00O3/o32-107[»]
4U53X-ray3.30O3/o32-107[»]
4U55X-ray3.20O3/o32-107[»]
4U56X-ray3.45O3/o32-107[»]
4U6FX-ray3.10O3/o32-107[»]
4V6Ielectron microscopy8.80Bj1-107[»]
4V7Felectron microscopy8.70e1-107[»]
4V88X-ray3.00Bf/Df1-107[»]
4V8Telectron microscopy8.10f1-107[»]
4V8Yelectron microscopy4.30Bf2-107[»]
4V8Zelectron microscopy6.60Bf2-107[»]
4V91electron microscopy3.70f1-107[»]
5APNelectron microscopy3.91f1-107[»]
5APOelectron microscopy3.41f1-107[»]
5DATX-ray3.15O3/o32-107[»]
5DC3X-ray3.25O3/o32-107[»]
5FCIX-ray3.40O3/o32-107[»]
5FCJX-ray3.10O3/o32-107[»]
5FL8electron microscopy9.50f1-107[»]
5GAKelectron microscopy3.88h1-107[»]
5I4LX-ray3.10O3/o32-107[»]
5JUOelectron microscopy4.00KA1-107[»]
5JUPelectron microscopy3.50KA1-107[»]
5JUSelectron microscopy4.20KA1-107[»]
5JUTelectron microscopy4.00KA1-107[»]
5JUUelectron microscopy4.00KA1-107[»]
ProteinModelPortaliP05744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36040. 37 interactors.
IntActiP05744. 14 interactors.
MINTiMINT-8285485.

Proteomic databases

MaxQBiP05744.
PRIDEiP05744.
TopDownProteomicsiP05744.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPL143W; YPL143W; YPL143W.
GeneIDi855960.
KEGGisce:YPL143W.

Organism-specific databases

EuPathDBiFungiDB:YPL143W.
SGDiS000006064. RPL33A.

Phylogenomic databases

HOGENOMiHOG000195636.
InParanoidiP05744.
KOiK02917.
OMAiGERCAYV.
OrthoDBiEOG092C5MJS.

Enzyme and pathway databases

BioCyciYEAST:G3O-34040-MONOMER.

Miscellaneous databases

PROiP05744.

Family and domain databases

InterProiIPR001780. Ribosomal_L35A.
IPR018266. Ribosomal_L35Ae_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR10902. PTHR10902. 1 hit.
PfamiPF01247. Ribosomal_L35Ae. 1 hit.
[Graphical view]
ProDomiPD012670. Ribosomal_L35Ae. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF50447. SSF50447. 1 hit.
PROSITEiPS01105. RIBOSOMAL_L35AE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL33A_YEAST
AccessioniPrimary (citable) accession number: P05744
Secondary accession number(s): D6W3M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L33 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.