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Protein

60S ribosomal protein L26-A

Gene

RPL26A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for uL24 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit biogenesis Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32420-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-A1 Publication
Alternative name(s):
L33
Large ribosomal subunit protein uL24-A1 Publication
YL33
Gene namesi
Name:RPL26A1 Publication
Synonyms:RPL26, RPL33A
Ordered Locus Names:YLR344W
ORF Names:L8300.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR344W
SGDiS000004336 RPL26A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001308012 – 12760S ribosomal protein L26-AAdd BLAST126

Proteomic databases

MaxQBiP05743
PaxDbiP05743
PRIDEiP05743
TopDownProteomicsiP05743

PTM databases

iPTMnetiP05743

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31607, 97 interactors
DIPiDIP-5584N
IntActiP05743, 8 interactors
MINTiP05743
STRINGi4932.YLR344W

Structurei

Secondary structure

1127
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Helixi12 – 20Combined sources9
Helixi24 – 30Combined sources7
Beta strandi31 – 35Combined sources5
Helixi37 – 43Combined sources7
Beta strandi46 – 49Combined sources4
Beta strandi55 – 58Combined sources4
Beta strandi60 – 63Combined sources4
Beta strandi67 – 74Combined sources8
Turni75 – 78Combined sources4
Beta strandi79 – 88Combined sources10
Beta strandi94 – 99Combined sources6
Turni101 – 103Combined sources3
Beta strandi104 – 108Combined sources5
Helixi113 – 121Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-U9-123[»]
2WW9electron microscopy8.60L1-127[»]
2WWAelectron microscopy8.90L1-127[»]
2WWBelectron microscopy6.48L1-127[»]
3J6Xelectron microscopy6.10661-127[»]
3J6Yelectron microscopy6.10661-127[»]
3J77electron microscopy6.20761-127[»]
3J78electron microscopy6.30761-127[»]
3JCTelectron microscopy3.08Y1-127[»]
4U3MX-ray3.00N6/n62-127[»]
4U3NX-ray3.20N6/n62-127[»]
4U3UX-ray2.90N6/n62-127[»]
4U4NX-ray3.10N6/n62-127[»]
4U4OX-ray3.60N6/n62-127[»]
4U4QX-ray3.00N6/n62-127[»]
4U4RX-ray2.80N6/n62-127[»]
4U4UX-ray3.00N6/n62-127[»]
4U4YX-ray3.20N6/n62-127[»]
4U4ZX-ray3.10N6/n62-127[»]
4U50X-ray3.20N6/n62-127[»]
4U51X-ray3.20N6/n62-127[»]
4U52X-ray3.00N6/n62-127[»]
4U53X-ray3.30N6/n62-127[»]
4U55X-ray3.20N6/n62-127[»]
4U56X-ray3.45N6/n62-127[»]
4U6FX-ray3.10N6/n62-127[»]
4V4Belectron microscopy11.70BU2-127[»]
4V6Ielectron microscopy8.80BY1-123[»]
4V7Felectron microscopy8.70X1-127[»]
4V7RX-ray4.00BX/DX1-127[»]
4V88X-ray3.00BY/DY1-127[»]
4V8Telectron microscopy8.10Y1-127[»]
4V8Yelectron microscopy4.30BY2-127[»]
4V8Zelectron microscopy6.60BY2-127[»]
4V91electron microscopy3.70Y1-127[»]
5APNelectron microscopy3.91Y1-127[»]
5APOelectron microscopy3.41Y1-127[»]
5DATX-ray3.15N6/n62-127[»]
5DC3X-ray3.25N6/n62-127[»]
5DGEX-ray3.45N6/n62-127[»]
5DGFX-ray3.30N6/n62-127[»]
5DGVX-ray3.10N6/n62-127[»]
5FCIX-ray3.40N6/n62-127[»]
5FCJX-ray3.10N6/n62-127[»]
5FL8electron microscopy9.50Y1-127[»]
5GAKelectron microscopy3.88a1-127[»]
5H4Pelectron microscopy3.07Y1-127[»]
5I4LX-ray3.10N6/n62-127[»]
5JCSelectron microscopy9.50Y1-127[»]
5JUOelectron microscopy4.00DA1-127[»]
5JUPelectron microscopy3.50DA1-127[»]
5JUSelectron microscopy4.20DA1-127[»]
5JUTelectron microscopy4.00DA1-127[»]
5JUUelectron microscopy4.00DA1-127[»]
5LYBX-ray3.25N6/n62-127[»]
5M1Jelectron microscopy3.30Y52-127[»]
5MC6electron microscopy3.80AK1-127[»]
5MEIX-ray3.509/DA2-127[»]
5NDGX-ray3.70N6/n62-127[»]
5NDVX-ray3.30N6/n62-126[»]
5NDWX-ray3.70N6/n62-127[»]
5OBMX-ray3.40N6/n62-127[»]
5ON6X-ray3.109/DA2-127[»]
5T62electron microscopy3.30l1-127[»]
5T6Relectron microscopy4.50l1-127[»]
5TBWX-ray3.009/DA2-127[»]
5TGAX-ray3.30N6/n62-127[»]
5TGMX-ray3.50N6/n62-127[»]
5Z3Gelectron microscopy3.65c1-127[»]
6C0Felectron microscopy3.70Y1-127[»]
6CB1electron microscopy4.60Y1-127[»]
6ELZelectron microscopy3.30Y1-127[»]
6EM1electron microscopy3.60Y1-127[»]
6EM3electron microscopy3.20Y1-127[»]
6EM4electron microscopy4.10Y1-127[»]
6EM5electron microscopy4.30Y1-127[»]
6FT6electron microscopy3.90Y1-127[»]
ProteinModelPortaliP05743
SMRiP05743
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05743

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014165
HOGENOMiHOG000216571
InParanoidiP05743
KOiK02898
OMAiKICVEGI
OrthoDBiEOG092C5U93

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR005824 KOW
IPR014722 Rib_L2_dom2
IPR005825 Ribosomal_L24/26_CS
IPR005756 Ribosomal_L26/L24P_euk/arc
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR11143 PTHR11143, 1 hit
PfamiView protein in Pfam
PF00467 KOW, 1 hit
PF16906 Ribosomal_L26, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
TIGRFAMsiTIGR01080 rplX_A_E, 1 hit
PROSITEiView protein in PROSITE
PS01108 RIBOSOMAL_L24, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQSLDVSS DRRKARKAYF TAPSSQRRVL LSAPLSKELR AQYGIKALPI
60 70 80 90 100
RRDDEVLVVR GSKKGQEGKI SSVYRLKFAV QVDKVTKEKV NGASVPINLH
110 120
PSKLVITKLH LDKDRKALIQ RKGGKLE
Length:127
Mass (Da):14,234
Last modified:January 23, 2007 - v3
Checksum:i3888654AC1587E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA Translation: AAB67254.1
BK006945 Genomic DNA Translation: DAA09649.1
PIRiS51347
RefSeqiNP_013448.1, NM_001182233.1

Genome annotation databases

EnsemblFungiiYLR344W; YLR344W; YLR344W
GeneIDi851058
KEGGisce:YLR344W

Similar proteinsi

Entry informationi

Entry nameiRL26A_YEAST
AccessioniPrimary (citable) accession number: P05743
Secondary accession number(s): D6VYY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 170 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

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