Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S ribosomal protein L26-A

Gene

RPL26A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. RNA binding Source: SGD
  2. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32420-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-A
Alternative name(s):
L33
YL33
Gene namesi
Name:RPL26A
Synonyms:RPL26, RPL33A
Ordered Locus Names:YLR344W
ORF Names:L8300.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

SGDiS000004336. RPL26A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 12712660S ribosomal protein L26-APRO_0000130801Add
BLAST

Proteomic databases

PeptideAtlasiP05743.

Expressioni

Gene expression databases

GenevestigatoriP05743.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31607. 40 interactions.
DIPiDIP-5584N.
IntActiP05743. 8 interactions.
MINTiMINT-8285368.
STRINGi4932.YLR344W.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Helixi12 – 209Combined sources
Helixi24 – 307Combined sources
Beta strandi32 – 354Combined sources
Helixi37 – 437Combined sources
Beta strandi47 – 493Combined sources
Beta strandi55 – 584Combined sources
Turni62 – 654Combined sources
Beta strandi67 – 748Combined sources
Helixi75 – 773Combined sources
Beta strandi79 – 835Combined sources
Beta strandi86 – 883Combined sources
Beta strandi90 – 923Combined sources
Beta strandi94 – 963Combined sources
Helixi101 – 1033Combined sources
Beta strandi104 – 1085Combined sources
Helixi113 – 1219Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-U9-123[»]
2WW9electron microscopy8.60L1-127[»]
2WWAelectron microscopy8.90L1-127[»]
2WWBelectron microscopy6.48L1-127[»]
3J6Xelectron microscopy6.10661-127[»]
3J6Yelectron microscopy6.10661-127[»]
3J77electron microscopy6.20761-127[»]
3J78electron microscopy6.30761-127[»]
4U3MX-ray3.00N6/n62-127[»]
4U3NX-ray3.20N6/n62-127[»]
4U3UX-ray2.90N6/n62-127[»]
4U4NX-ray3.10N6/n62-127[»]
4U4OX-ray3.60N6/n62-127[»]
4U4QX-ray3.00N6/n62-127[»]
4U4RX-ray2.80N6/n62-127[»]
4U4UX-ray3.00N6/n62-127[»]
4U4YX-ray3.20N6/n62-127[»]
4U4ZX-ray3.10N6/n62-127[»]
4U50X-ray3.20N6/n62-127[»]
4U51X-ray3.20N6/n62-127[»]
4U52X-ray3.00N6/n62-127[»]
4U53X-ray3.30N6/n62-127[»]
4U55X-ray3.20N6/n62-127[»]
4U56X-ray3.45N6/n62-127[»]
4U6FX-ray3.10N6/n62-127[»]
4V4Belectron microscopy11.70BU2-127[»]
4V6Ielectron microscopy8.80BY1-123[»]
4V7Felectron microscopy8.70X1-127[»]
4V7RX-ray4.00BX/DX1-127[»]
4V88X-ray3.00BY/DY1-127[»]
4V8Telectron microscopy8.10Y1-127[»]
4V8Yelectron microscopy4.30BY2-127[»]
4V8Zelectron microscopy6.60BY2-127[»]
4V91electron microscopy3.70Y1-127[»]
ProteinModelPortaliP05743.
SMRiP05743. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05743.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
InParanoidiP05743.
KOiK02898.
OMAiVRIMRGD.
OrthoDBiEOG747PX1.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQSLDVSS DRRKARKAYF TAPSSQRRVL LSAPLSKELR AQYGIKALPI
60 70 80 90 100
RRDDEVLVVR GSKKGQEGKI SSVYRLKFAV QVDKVTKEKV NGASVPINLH
110 120
PSKLVITKLH LDKDRKALIQ RKGGKLE
Length:127
Mass (Da):14,234
Last modified:January 23, 2007 - v3
Checksum:i3888654AC1587E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67254.1.
BK006945 Genomic DNA. Translation: DAA09649.1.
PIRiS51347.
RefSeqiNP_013448.1. NM_001182233.1.

Genome annotation databases

EnsemblFungiiYLR344W; YLR344W; YLR344W.
GeneIDi851058.
KEGGisce:YLR344W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67254.1.
BK006945 Genomic DNA. Translation: DAA09649.1.
PIRiS51347.
RefSeqiNP_013448.1. NM_001182233.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-U9-123[»]
2WW9electron microscopy8.60L1-127[»]
2WWAelectron microscopy8.90L1-127[»]
2WWBelectron microscopy6.48L1-127[»]
3J6Xelectron microscopy6.10661-127[»]
3J6Yelectron microscopy6.10661-127[»]
3J77electron microscopy6.20761-127[»]
3J78electron microscopy6.30761-127[»]
4U3MX-ray3.00N6/n62-127[»]
4U3NX-ray3.20N6/n62-127[»]
4U3UX-ray2.90N6/n62-127[»]
4U4NX-ray3.10N6/n62-127[»]
4U4OX-ray3.60N6/n62-127[»]
4U4QX-ray3.00N6/n62-127[»]
4U4RX-ray2.80N6/n62-127[»]
4U4UX-ray3.00N6/n62-127[»]
4U4YX-ray3.20N6/n62-127[»]
4U4ZX-ray3.10N6/n62-127[»]
4U50X-ray3.20N6/n62-127[»]
4U51X-ray3.20N6/n62-127[»]
4U52X-ray3.00N6/n62-127[»]
4U53X-ray3.30N6/n62-127[»]
4U55X-ray3.20N6/n62-127[»]
4U56X-ray3.45N6/n62-127[»]
4U6FX-ray3.10N6/n62-127[»]
4V4Belectron microscopy11.70BU2-127[»]
4V6Ielectron microscopy8.80BY1-123[»]
4V7Felectron microscopy8.70X1-127[»]
4V7RX-ray4.00BX/DX1-127[»]
4V88X-ray3.00BY/DY1-127[»]
4V8Telectron microscopy8.10Y1-127[»]
4V8Yelectron microscopy4.30BY2-127[»]
4V8Zelectron microscopy6.60BY2-127[»]
4V91electron microscopy3.70Y1-127[»]
ProteinModelPortaliP05743.
SMRiP05743. Positions 2-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31607. 40 interactions.
DIPiDIP-5584N.
IntActiP05743. 8 interactions.
MINTiMINT-8285368.
STRINGi4932.YLR344W.

Proteomic databases

PeptideAtlasiP05743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR344W; YLR344W; YLR344W.
GeneIDi851058.
KEGGisce:YLR344W.

Organism-specific databases

SGDiS000004336. RPL26A.

Phylogenomic databases

GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
InParanoidiP05743.
KOiK02898.
OMAiVRIMRGD.
OrthoDBiEOG747PX1.

Enzyme and pathway databases

BioCyciYEAST:G3O-32420-MONOMER.
ReactomeiREACT_188965. SRP-dependent cotranslational protein targeting to membrane.
REACT_189050. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_189183. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_217188. Formation of a pool of free 40S subunits.
REACT_232946. GTP hydrolysis and joining of the 60S ribosomal subunit.
REACT_252688. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_257951. Peptide chain elongation.

Miscellaneous databases

EvolutionaryTraceiP05743.
NextBioi967681.

Gene expression databases

GenevestigatoriP05743.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
    Otaka E., Higo K., Itoh T.
    Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE OF 2-41, CLEAVAGE OF INITIATOR METHIONINE.
  4. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 9-123, ELECTRON MICROSCOPY.
  7. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
  8. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL26A_YEAST
AccessioniPrimary (citable) accession number: P05743
Secondary accession number(s): D6VYY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 136 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L26 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.