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Protein

60S ribosomal protein L26-A

Gene

RPL26A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit biogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32420-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L26-A
Alternative name(s):
L33
YL33
Gene namesi
Name:RPL26A
Synonyms:RPL26, RPL33A
Ordered Locus Names:YLR344W
ORF Names:L8300.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR344W.
SGDiS000004336. RPL26A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 12712660S ribosomal protein L26-APRO_0000130801Add
BLAST

Proteomic databases

TopDownProteomicsiP05743.

PTM databases

iPTMnetiP05743.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31607. 33 interactions.
DIPiDIP-5584N.
IntActiP05743. 8 interactions.
MINTiMINT-8285368.

Structurei

Secondary structure

1
127
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83Combined sources
Helixi12 – 209Combined sources
Helixi24 – 307Combined sources
Beta strandi32 – 354Combined sources
Helixi37 – 437Combined sources
Beta strandi47 – 493Combined sources
Beta strandi55 – 584Combined sources
Turni62 – 654Combined sources
Beta strandi67 – 748Combined sources
Helixi75 – 773Combined sources
Beta strandi79 – 835Combined sources
Beta strandi86 – 883Combined sources
Beta strandi90 – 923Combined sources
Beta strandi94 – 963Combined sources
Helixi101 – 1033Combined sources
Beta strandi104 – 1085Combined sources
Helixi113 – 1219Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-U9-123[»]
2WW9electron microscopy8.60L1-127[»]
2WWAelectron microscopy8.90L1-127[»]
2WWBelectron microscopy6.48L1-127[»]
3J6Xelectron microscopy6.10661-127[»]
3J6Yelectron microscopy6.10661-127[»]
3J77electron microscopy6.20761-127[»]
3J78electron microscopy6.30761-127[»]
3JCTelectron microscopy3.08Y1-127[»]
4U3MX-ray3.00N6/n62-127[»]
4U3NX-ray3.20N6/n62-127[»]
4U3UX-ray2.90N6/n62-127[»]
4U4NX-ray3.10N6/n62-127[»]
4U4OX-ray3.60N6/n62-127[»]
4U4QX-ray3.00N6/n62-127[»]
4U4RX-ray2.80N6/n62-127[»]
4U4UX-ray3.00N6/n62-127[»]
4U4YX-ray3.20N6/n62-127[»]
4U4ZX-ray3.10N6/n62-127[»]
4U50X-ray3.20N6/n62-127[»]
4U51X-ray3.20N6/n62-127[»]
4U52X-ray3.00N6/n62-127[»]
4U53X-ray3.30N6/n62-127[»]
4U55X-ray3.20N6/n62-127[»]
4U56X-ray3.45N6/n62-127[»]
4U6FX-ray3.10N6/n62-127[»]
4V4Belectron microscopy11.70BU2-127[»]
4V6Ielectron microscopy8.80BY1-123[»]
4V7Felectron microscopy8.70X1-127[»]
4V7RX-ray4.00BX/DX1-127[»]
4V88X-ray3.00BY/DY1-127[»]
4V8Telectron microscopy8.10Y1-127[»]
4V8Yelectron microscopy4.30BY2-127[»]
4V8Zelectron microscopy6.60BY2-127[»]
4V91electron microscopy3.70Y1-127[»]
5APNelectron microscopy3.91Y1-127[»]
5APOelectron microscopy3.41Y1-127[»]
5DC3X-ray3.25N6/n62-127[»]
5FCIX-ray3.40N6/n62-127[»]
5FCJX-ray3.10N6/n62-127[»]
5FL8electron microscopy9.50Y1-127[»]
5GAKelectron microscopy3.88a1-127[»]
5I4LX-ray3.10N6/n62-127[»]
ProteinModelPortaliP05743.
SMRiP05743. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05743.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L24P family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
InParanoidiP05743.
KOiK02898.
OMAiANIGIHP.
OrthoDBiEOG092C5U93.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQSLDVSS DRRKARKAYF TAPSSQRRVL LSAPLSKELR AQYGIKALPI
60 70 80 90 100
RRDDEVLVVR GSKKGQEGKI SSVYRLKFAV QVDKVTKEKV NGASVPINLH
110 120
PSKLVITKLH LDKDRKALIQ RKGGKLE
Length:127
Mass (Da):14,234
Last modified:January 23, 2007 - v3
Checksum:i3888654AC1587E8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67254.1.
BK006945 Genomic DNA. Translation: DAA09649.1.
PIRiS51347.
RefSeqiNP_013448.1. NM_001182233.1.

Genome annotation databases

EnsemblFungiiYLR344W; YLR344W; YLR344W.
GeneIDi851058.
KEGGisce:YLR344W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19028 Genomic DNA. Translation: AAB67254.1.
BK006945 Genomic DNA. Translation: DAA09649.1.
PIRiS51347.
RefSeqiNP_013448.1. NM_001182233.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-U9-123[»]
2WW9electron microscopy8.60L1-127[»]
2WWAelectron microscopy8.90L1-127[»]
2WWBelectron microscopy6.48L1-127[»]
3J6Xelectron microscopy6.10661-127[»]
3J6Yelectron microscopy6.10661-127[»]
3J77electron microscopy6.20761-127[»]
3J78electron microscopy6.30761-127[»]
3JCTelectron microscopy3.08Y1-127[»]
4U3MX-ray3.00N6/n62-127[»]
4U3NX-ray3.20N6/n62-127[»]
4U3UX-ray2.90N6/n62-127[»]
4U4NX-ray3.10N6/n62-127[»]
4U4OX-ray3.60N6/n62-127[»]
4U4QX-ray3.00N6/n62-127[»]
4U4RX-ray2.80N6/n62-127[»]
4U4UX-ray3.00N6/n62-127[»]
4U4YX-ray3.20N6/n62-127[»]
4U4ZX-ray3.10N6/n62-127[»]
4U50X-ray3.20N6/n62-127[»]
4U51X-ray3.20N6/n62-127[»]
4U52X-ray3.00N6/n62-127[»]
4U53X-ray3.30N6/n62-127[»]
4U55X-ray3.20N6/n62-127[»]
4U56X-ray3.45N6/n62-127[»]
4U6FX-ray3.10N6/n62-127[»]
4V4Belectron microscopy11.70BU2-127[»]
4V6Ielectron microscopy8.80BY1-123[»]
4V7Felectron microscopy8.70X1-127[»]
4V7RX-ray4.00BX/DX1-127[»]
4V88X-ray3.00BY/DY1-127[»]
4V8Telectron microscopy8.10Y1-127[»]
4V8Yelectron microscopy4.30BY2-127[»]
4V8Zelectron microscopy6.60BY2-127[»]
4V91electron microscopy3.70Y1-127[»]
5APNelectron microscopy3.91Y1-127[»]
5APOelectron microscopy3.41Y1-127[»]
5DC3X-ray3.25N6/n62-127[»]
5FCIX-ray3.40N6/n62-127[»]
5FCJX-ray3.10N6/n62-127[»]
5FL8electron microscopy9.50Y1-127[»]
5GAKelectron microscopy3.88a1-127[»]
5I4LX-ray3.10N6/n62-127[»]
ProteinModelPortaliP05743.
SMRiP05743. Positions 1-127.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31607. 33 interactions.
DIPiDIP-5584N.
IntActiP05743. 8 interactions.
MINTiMINT-8285368.

PTM databases

iPTMnetiP05743.

Proteomic databases

TopDownProteomicsiP05743.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR344W; YLR344W; YLR344W.
GeneIDi851058.
KEGGisce:YLR344W.

Organism-specific databases

EuPathDBiFungiDB:YLR344W.
SGDiS000004336. RPL26A.

Phylogenomic databases

GeneTreeiENSGT00390000014165.
HOGENOMiHOG000216571.
InParanoidiP05743.
KOiK02898.
OMAiANIGIHP.
OrthoDBiEOG092C5U93.

Enzyme and pathway databases

BioCyciYEAST:G3O-32420-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

EvolutionaryTraceiP05743.
PROiP05743.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR005825. Ribosomal_L24/26_CS.
IPR005756. Ribosomal_L26/L24P_euk/arc.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR11143. PTHR11143. 1 hit.
PfamiPF00467. KOW. 1 hit.
PF16906. Ribosomal_L26. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01080. rplX_A_E. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL26A_YEAST
AccessioniPrimary (citable) accession number: P05743
Secondary accession number(s): D6VYY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 2 genes for L26 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.