60S ribosomal protein L17-A - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P05740 (RL17A_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 123. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
60S ribosomal protein L17-A

Alternative name(s):
L20A
YL17

Gene names

Name:	RPL17A
Synonyms:	RPL17, RPL20A
Ordered Locus Names:	YKL180W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S). Ref.5
Subcellular location	Cytoplasm Ref.7.
Miscellaneous	There are 2 genes for L17 in yeast.
Sequence similarities	Belongs to the ribosomal protein L22P family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cytoplasmic translation Inferred from direct assay PubMed 18782943. Source: SGD
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 18782943. Source: SGD
Molecular_function	structural constituent of ribosome Inferred from direct assay PubMed 18782943. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Ref.4 Ref.6

Chain

2 – 184

183

60S ribosomal protein L17-A

PRO_0000125347

Amino acid modifications

Modified residue

Phosphoserine Ref.9

Modified residue

Phosphoserine Ref.8 Ref.9

Modified residue

Phosphoserine Ref.9

Experimental info

Sequence conflict

104 – 114

AKGLDATKLYV → VCQEYYMFSTR in CAA52258. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

P05740 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: B8902DD90714671D
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FASTA

184

20,549

        10         20         30         40         50         60 
MARYGATSTN PAKSASARGS YLRVSFKNTR ETAQAINGWE LTKAQKYLEQ VLDHQRAIPF 

        70         80         90        100        110        120 
RRFNSSIGRT AQGKEFGVTK ARWPAKSVKF VQGLLQNAAA NAEAKGLDAT KLYVSHIQVN 

       130        140        150        160        170        180 
QAPKQRRRTY RAHGRINKYE SSPSHIELVV TEKEEAVAKA AEKKVVRLTS RQRGRIAAQK 


RIAA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete DNA sequence of yeast chromosome XI." Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V., Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P., Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L., Daignan-Fornier B., del Rey F., Dion C. Mewes H.-W. Nature 369:371-378(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 96604 / S288c / FY1679.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Sequencing and analysis of 51.6 kilobases on the left arm of chromosome XI from Saccharomyces cerevisiae reveals 23 open reading frames including the FAS1 gene." Wiemann S., Voss H., Schwager C., Rupp T., Stegemann J., Zimmermann J., Grothues D., Sensen C., Erfle H., Hewitt N., Banrevi A., Ansorge W. Yeast 9:1343-1348(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-114.
[4]	"Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes." Otaka E., Higo K., Itoh T. Mol. Gen. Genet. 195:544-546(1984) Cited for: PRELIMINARY PROTEIN SEQUENCE OF 2-41.
[5]	"The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae." Planta R.J., Mager W.H. Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE, SUBUNIT.
[6]	"The action of N-terminal acetyltransferases on yeast ribosomal proteins." Arnold R.J., Polevoda B., Reilly J.P., Sherman F. J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract] Cited for: CLEAVAGE OF INITIATOR METHIONINE.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway." Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N. Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-65, MASS SPECTROMETRY. Strain: YAL6B.
[9]	"Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry." Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L., Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F. Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-65 AND SER-66, MASS SPECTROMETRY.
[10]	"Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions." Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J. Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 6-152, ELECTRON MICROSCOPY.
[11]	"Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation." Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J. EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract] Cited for: 3D-STRUCTURE MODELING, ELECTRON MICROSCOPY.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z28180 Genomic DNA. Translation: CAA82023.1.
Z28179 Genomic DNA. Translation: CAA82022.1.
X74151 Genomic DNA. Translation: CAA52258.1.
BK006944 Genomic DNA. Translation: DAA08987.1.

PIR

S38012.

RefSeq

NP_012741.1. NM_001179746.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1K5Y	model	-	N	6-152	[»]
1S1I	electron microscopy	11.70	N	2-184	[»]
2WW9	electron microscopy	8.60	I	1-184	[»]
2WWA	electron microscopy	8.90	I	1-184	[»]
3IZS	electron microscopy	-	V	1-170	[»]
3O58	X-ray	4.00	Q	1-184	[»]
3O5H	X-ray	4.00	Q	1-184	[»]
3U5E	X-ray	3.00	P	1-184	[»]
3U5I	X-ray	3.00	P	1-184	[»]
4B6A	electron microscopy	8.10	P	1-184	[»]

ProteinModelPortal

P05740.

SMR

P05740. Positions 2-184.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-5529N.

IntAct

P05740. 49 interactions.

MINT

MINT-8285293.

STRING

4932.YKL180W.

Proteomic databases

PeptideAtlas

P05740.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblFungi

YKL180W; YKL180W; YKL180W.

GeneID

853674.

KEGG

sce:YKL180W.

Organism-specific databases

SGD

S000001663. RPL17A.

Phylogenomic databases

GeneTree

ENSGT00390000014873.

HOGENOM

HOG000205045.

K02880.

OMA

ANAEYKG.

OrthoDB

EOG4M68SV.

Enzyme and pathway databases

BioCyc

YEAST:G3O-31946-MONOMER.

Gene expression databases

Genevestigator

P05740.

GermOnline

YKL180W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D

3.90.470.10. 1 hit.

InterPro

IPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005721. Ribosomal_L22/L17_euk/arc.
[Graphical view]

PANTHER

PTHR11593. PTHR11593. 1 hit.

Pfam

PF00237. Ribosomal_L22. 1 hit.
[Graphical view]

SUPFAM

SSF54843. Ribosomal_L22. 1 hit.

TIGRFAMs

TIGR01038. L22_arch. 1 hit.

PROSITE

PS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P05740.

NextBio

974625.

Entry information

Entry name

RL17A_YEAST

Accession

Primary (citable) accession number: P05740
Secondary accession number(s): D6VX21

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2007
Last modified:	May 29, 2013
This is version 123 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XI

Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents