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Protein

60S ribosomal protein L17-A

Gene

RPL17A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

There are 2 genes for uL22 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • cytoplasmic translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-31946-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L17-A1 Publication
Alternative name(s):
L20A
Large ribosomal subunit protein uL22-A1 Publication
YL17
Gene namesi
Name:RPL17A1 Publication
Synonyms:RPL17, RPL20A
Ordered Locus Names:YKL180W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKL180W.
SGDiS000001663. RPL17A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001253472 – 18460S ribosomal protein L17-AAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki46Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources
Modified residuei70PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP05740.
PRIDEiP05740.

PTM databases

iPTMnetiP05740.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes). uL22 is associated with the polypeptide exit tunnel (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33959. 162 interactors.
DIPiDIP-5529N.
IntActiP05740. 56 interactors.
MINTiMINT-8285293.
STRINGi4932.YKL180W.

Structurei

Secondary structure

1184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 13Combined sources3
Beta strandi14 – 22Combined sources9
Helixi26 – 34Combined sources9
Turni35 – 38Combined sources4
Helixi41 – 52Combined sources12
Beta strandi54 – 56Combined sources3
Beta strandi61 – 63Combined sources3
Helixi71 – 76Combined sources6
Beta strandi79 – 82Combined sources4
Helixi85 – 105Combined sources21
Beta strandi111 – 121Combined sources11
Beta strandi125 – 131Combined sources7
Helixi132 – 134Combined sources3
Beta strandi135 – 141Combined sources7
Beta strandi144 – 152Combined sources9
Helixi170 – 182Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-N6-152[»]
2WW9electron microscopy8.60I1-184[»]
2WWAelectron microscopy8.90I1-184[»]
2WWBelectron microscopy6.48I1-184[»]
3J6Xelectron microscopy6.10571-184[»]
3J6Yelectron microscopy6.10571-184[»]
3J77electron microscopy6.20671-184[»]
3J78electron microscopy6.30671-184[»]
3JCTelectron microscopy3.08P1-184[»]
4U3MX-ray3.00M7/m72-184[»]
4U3NX-ray3.20M7/m72-184[»]
4U3UX-ray2.90M7/m72-184[»]
4U4NX-ray3.10M7/m72-184[»]
4U4OX-ray3.60M7/m72-184[»]
4U4QX-ray3.00M7/m72-184[»]
4U4RX-ray2.80M7/m72-184[»]
4U4UX-ray3.00M7/m72-184[»]
4U4YX-ray3.20M7/m72-184[»]
4U4ZX-ray3.10M7/m72-184[»]
4U50X-ray3.20M7/m72-184[»]
4U51X-ray3.20M7/m72-184[»]
4U52X-ray3.00M7/m72-184[»]
4U53X-ray3.30M7/m72-184[»]
4U55X-ray3.20M7/m72-184[»]
4U56X-ray3.45M7/m72-184[»]
4U6FX-ray3.10M7/m72-184[»]
4V4Belectron microscopy11.70BN2-184[»]
4V6Ielectron microscopy8.80BV1-170[»]
4V7Felectron microscopy8.70U1-184[»]
4V7RX-ray4.00BQ/DQ1-184[»]
4V88X-ray3.00BP/DP1-184[»]
4V8Telectron microscopy8.10P1-184[»]
4V8Yelectron microscopy4.30BP2-184[»]
4V8Zelectron microscopy6.60BP2-184[»]
4V91electron microscopy3.70P1-184[»]
5APNelectron microscopy3.91P1-184[»]
5APOelectron microscopy3.41P1-184[»]
5DATX-ray3.15M7/m72-184[»]
5DC3X-ray3.25M7/m72-184[»]
5DGEX-ray3.45M7/m72-184[»]
5DGFX-ray3.30M7/m72-184[»]
5DGVX-ray3.10M7/m72-184[»]
5FCIX-ray3.40M7/m72-184[»]
5FCJX-ray3.10M7/m72-184[»]
5FL8electron microscopy9.50P1-184[»]
5GAKelectron microscopy3.88R1-184[»]
5H4Pelectron microscopy3.07P1-184[»]
5I4LX-ray3.10M7/m72-184[»]
5JCSelectron microscopy9.50P1-184[»]
5JUOelectron microscopy4.00U1-184[»]
5JUPelectron microscopy3.50U1-184[»]
5JUSelectron microscopy4.20U1-184[»]
5JUTelectron microscopy4.00U1-184[»]
5JUUelectron microscopy4.00U1-184[»]
5LYBX-ray3.25M7/m72-184[»]
5M1Jelectron microscopy3.30P52-184[»]
5MC6electron microscopy3.80AX1-184[»]
5T62electron microscopy3.30c1-184[»]
5T6Relectron microscopy4.50c1-184[»]
5TGAX-ray3.30M7/m72-184[»]
5TGMX-ray3.50M7/m72-184[»]
ProteinModelPortaliP05740.
SMRiP05740.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05740.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000014873.
HOGENOMiHOG000205045.
InParanoidiP05740.
KOiK02880.
OMAiRINPYEG.
OrthoDBiEOG092C4Y4L.

Family and domain databases

CDDicd00336. Ribosomal_L22. 1 hit.
InterProiView protein in InterPro
IPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005721. Ribosomal_L22/L17_euk/arc.
PANTHERiPTHR11593. PTHR11593. 1 hit.
PfamiView protein in Pfam
PF00237. Ribosomal_L22. 1 hit.
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01038. uL22_arch_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00464. RIBOSOMAL_L22. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05740-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARYGATSTN PAKSASARGS YLRVSFKNTR ETAQAINGWE LTKAQKYLEQ
60 70 80 90 100
VLDHQRAIPF RRFNSSIGRT AQGKEFGVTK ARWPAKSVKF VQGLLQNAAA
110 120 130 140 150
NAEAKGLDAT KLYVSHIQVN QAPKQRRRTY RAHGRINKYE SSPSHIELVV
160 170 180
TEKEEAVAKA AEKKVVRLTS RQRGRIAAQK RIAA
Length:184
Mass (Da):20,549
Last modified:January 23, 2007 - v4
Checksum:iB8902DD90714671D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104 – 114AKGLDATKLYV → VCQEYYMFSTR in CAA52258 (PubMed:8154185).CuratedAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28180 Genomic DNA. Translation: CAA82023.1.
Z28179 Genomic DNA. Translation: CAA82022.1.
X74151 Genomic DNA. Translation: CAA52258.1.
BK006944 Genomic DNA. Translation: DAA08987.1.
PIRiS38012.
RefSeqiNP_012741.1. NM_001179746.1.

Genome annotation databases

EnsemblFungiiYKL180W; YKL180W; YKL180W.
GeneIDi853674.
KEGGisce:YKL180W.

Similar proteinsi

Entry informationi

Entry nameiRL17A_YEAST
AccessioniPrimary (citable) accession number: P05740
Secondary accession number(s): D6VX21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 162 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names