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Protein

60S ribosomal protein L6-B

Gene

RPL6B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 38400 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eL6 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32503-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6-B1 Publication
Alternative name(s):
L17
Large ribosomal subunit protein eL6-B1 Publication
RP18
YL16
Gene namesi
Name:RPL6B1 Publication
Synonyms:RPL16B, RPL17B, YL16B
Ordered Locus Names:YLR448W
ORF Names:L9324.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR448W.
SGDiS000004440. RPL6B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001710182 – 17660S ribosomal protein L6-BAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Cross-linki128Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP05739.
PRIDEiP05739.

PTM databases

iPTMnetiP05739.

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi31706. 349 interactors.
DIPiDIP-4591N.
IntActiP05739. 34 interactors.
MINTiMINT-8285377.
STRINGi4932.YLR448W.

Structurei

3D structure databases

ProteinModelPortaliP05739.
SMRiP05739.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiP05739.
KOiK02934.
OMAiRKGDKPH.
OrthoDBiEOG092C5AV0.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiView protein in InterPro
IPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiView protein in Pfam
PF01159. Ribosomal_L6e. 1 hit.
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiView protein in PROSITE
PS01170. RIBOSOMAL_L6E. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQQAPKWY PSEDVAAPKK TRKAVRPQKL RASLVPGTVL ILLAGRFRGK
60 70 80 90 100
RVVYLKHLED NTLLVTGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
110 120 130 140 150
FNVEYFAKEK LTKKEKKEAN LFPEQQTKEI KTERVEDQKV VDKALLAEIK
160 170
KTPLLKQYLS ASFSLKNGDK PHLLKF
Length:176
Mass (Da):19,986
Last modified:January 23, 2007 - v4
Checksum:i451848C3B1953BC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68P → L in BAA01078 (PubMed:1390890).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10226 Genomic DNA. Translation: BAA01078.1.
U22382 Genomic DNA. Translation: AAB67529.1.
BK006945 Genomic DNA. Translation: DAA09748.1.
PIRiS55970.
RefSeqiNP_013553.1. NM_001182336.1.

Genome annotation databases

EnsemblFungiiYLR448W; YLR448W; YLR448W.
GeneIDi851169.
KEGGisce:YLR448W.

Similar proteinsi

Entry informationi

Entry nameiRL6B_YEAST
AccessioniPrimary (citable) accession number: P05739
Secondary accession number(s): D6VZ82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 157 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names