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Protein

60S ribosomal protein L6-B

Gene

RPL6B

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: SGD
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal large subunit assembly Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32503-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6-B
Alternative name(s):
L17
RP18
YL16
Gene namesi
Name:RPL6B
Synonyms:RPL16B, RPL17B, YL16B
Ordered Locus Names:YLR448W
ORF Names:L9324.4
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR448W.
SGDiS000004440. RPL6B.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 17617560S ribosomal protein L6-BPRO_0000171018Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei12 – 121PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP05739.
PeptideAtlasiP05739.
PRIDEiP05739.

PTM databases

iPTMnetiP05739.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi31706. 86 interactions.
DIPiDIP-4591N.
IntActiP05739. 28 interactions.
MINTiMINT-8285377.

Structurei

3D structure databases

ProteinModelPortaliP05739.
SMRiP05739. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6e family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiP05739.
KOiK02934.
OMAiDHINDEY.
OrthoDBiEOG7Q8D0N.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAQQAPKWY PSEDVAAPKK TRKAVRPQKL RASLVPGTVL ILLAGRFRGK
60 70 80 90 100
RVVYLKHLED NTLLVTGPFK VNGVPLRRVN ARYVIATSTK VSVEGVNVEK
110 120 130 140 150
FNVEYFAKEK LTKKEKKEAN LFPEQQTKEI KTERVEDQKV VDKALLAEIK
160 170
KTPLLKQYLS ASFSLKNGDK PHLLKF
Length:176
Mass (Da):19,986
Last modified:January 23, 2007 - v4
Checksum:i451848C3B1953BC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti68 – 681P → L in BAA01078 (PubMed:1390890).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10226 Genomic DNA. Translation: BAA01078.1.
U22382 Genomic DNA. Translation: AAB67529.1.
BK006945 Genomic DNA. Translation: DAA09748.1.
PIRiS55970.
RefSeqiNP_013553.1. NM_001182336.1.

Genome annotation databases

EnsemblFungiiYLR448W; YLR448W; YLR448W.
GeneIDi851169.
KEGGisce:YLR448W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10226 Genomic DNA. Translation: BAA01078.1.
U22382 Genomic DNA. Translation: AAB67529.1.
BK006945 Genomic DNA. Translation: DAA09748.1.
PIRiS55970.
RefSeqiNP_013553.1. NM_001182336.1.

3D structure databases

ProteinModelPortaliP05739.
SMRiP05739. Positions 1-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31706. 86 interactions.
DIPiDIP-4591N.
IntActiP05739. 28 interactions.
MINTiMINT-8285377.

PTM databases

iPTMnetiP05739.

Proteomic databases

MaxQBiP05739.
PeptideAtlasiP05739.
PRIDEiP05739.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR448W; YLR448W; YLR448W.
GeneIDi851169.
KEGGisce:YLR448W.

Organism-specific databases

EuPathDBiFungiDB:YLR448W.
SGDiS000004440. RPL6B.

Phylogenomic databases

GeneTreeiENSGT00390000003682.
HOGENOMiHOG000207317.
InParanoidiP05739.
KOiK02934.
OMAiDHINDEY.
OrthoDBiEOG7Q8D0N.

Enzyme and pathway databases

BioCyciYEAST:G3O-32503-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

NextBioi967975.
PROiP05739.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
InterProiIPR000915. 60S_ribosomal_L6E.
IPR014722. Rib_L2_dom2.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR10715. PTHR10715. 1 hit.
PfamiPF01159. Ribosomal_L6e. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
PROSITEiPS01170. RIBOSOMAL_L6E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16."
    Hashimoto T., Suzuki K., Mizuta K., Otaka E.
    Biochim. Biophys. Acta 1132:195-198(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
    Otaka E., Higo K., Itoh T.
    Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE OF 2-25, CLEAVAGE OF INITIATOR METHIONINE.
  5. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Sites of ubiquitin attachment in Saccharomyces cerevisiae."
    Starita L.M., Lo R.S., Eng J.K., von Haller P.D., Fields S.
    Proteomics 12:236-240(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRL6B_YEAST
AccessioniPrimary (citable) accession number: P05739
Secondary accession number(s): D6VZ82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 38400 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L6 in yeast.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.