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Protein

60S ribosomal protein L7-A

Gene

RPL7A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 101000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for uL30 in yeast.Curated

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of LSU-rRNA Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30577-MONOMER
ReactomeiR-SCE-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-SCE-1799339 SRP-dependent cotranslational protein targeting to membrane
R-SCE-72689 Formation of a pool of free 40S subunits
R-SCE-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-SCE-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-SCE-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-A1 Publication
Alternative name(s):
L6
Large ribosomal subunit protein uL30-A1 Publication
RP11
YL8
Gene namesi
Name:RPL7A1 Publication
Synonyms:RPL6A, RPL8A, YL8A
Ordered Locus Names:YGL076C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL076C
SGDiS000003044 RPL7A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001046512 – 24460S ribosomal protein L7-AAdd BLAST243

Proteomic databases

MaxQBiP05737
PaxDbiP05737
PRIDEiP05737
TopDownProteomicsiP05737

PTM databases

CarbonylDBiP05737
iPTMnetiP05737

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi33174, 89 interactors
IntActiP05737, 130 interactors
MINTiP05737
STRINGi4932.YGL076C

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 72Combined sources61
Beta strandi83 – 88Combined sources6
Beta strandi92 – 94Combined sources3
Helixi97 – 105Combined sources9
Beta strandi113 – 118Combined sources6
Helixi121 – 129Combined sources9
Helixi131 – 133Combined sources3
Beta strandi134 – 137Combined sources4
Helixi141 – 150Combined sources10
Beta strandi153 – 162Combined sources10
Helixi166 – 173Combined sources8
Helixi174 – 176Combined sources3
Helixi181 – 189Combined sources9
Helixi195 – 201Combined sources7
Beta strandi215 – 217Combined sources3
Beta strandi220 – 222Combined sources3
Helixi223 – 225Combined sources3
Beta strandi228 – 233Combined sources6
Helixi236 – 243Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-F83-243[»]
3J6Xelectron microscopy6.10L71-244[»]
3J6Yelectron microscopy6.10L71-244[»]
3J77electron microscopy6.20L71-244[»]
3J78electron microscopy6.30L71-244[»]
3JCTelectron microscopy3.08F1-244[»]
4U3MX-ray3.00L7/l72-244[»]
4U3NX-ray3.20L7/l72-244[»]
4U3UX-ray2.90L7/l72-244[»]
4U4NX-ray3.10L7/l72-244[»]
4U4OX-ray3.60L7/l72-244[»]
4U4QX-ray3.00L7/l72-244[»]
4U4RX-ray2.80L7/l72-244[»]
4U4UX-ray3.00L7/l72-244[»]
4U4YX-ray3.20L7/l72-244[»]
4U4ZX-ray3.10L7/l72-244[»]
4U50X-ray3.20L7/l72-244[»]
4U51X-ray3.20L7/l72-244[»]
4U52X-ray3.00L7/l72-244[»]
4U53X-ray3.30L7/l72-244[»]
4U55X-ray3.20L7/l72-244[»]
4U56X-ray3.45L7/l72-244[»]
4U6FX-ray3.10L7/l72-244[»]
4V4Belectron microscopy11.70BF83-244[»]
4V6Ielectron microscopy8.80Be1-244[»]
4V7Felectron microscopy8.70a1-244[»]
4V7RX-ray4.00BG/DG1-244[»]
4V88X-ray3.00BF/DF1-244[»]
4V8Telectron microscopy8.10F1-244[»]
4V8Yelectron microscopy4.30BF2-244[»]
4V8Zelectron microscopy6.60BF2-244[»]
4V91electron microscopy3.70F1-244[»]
5APNelectron microscopy3.91F1-244[»]
5APOelectron microscopy3.41F1-244[»]
5DATX-ray3.15L7/l72-244[»]
5DC3X-ray3.25L7/l72-244[»]
5DGEX-ray3.45L7/l72-244[»]
5DGFX-ray3.30L7/l72-244[»]
5DGVX-ray3.10L7/l72-244[»]
5FCIX-ray3.40L7/l72-244[»]
5FCJX-ray3.10L7/l72-244[»]
5FL8electron microscopy9.50F1-244[»]
5GAKelectron microscopy3.88J1-244[»]
5H4Pelectron microscopy3.07F1-244[»]
5I4LX-ray3.10L7/l722-244[»]
5JCSelectron microscopy9.50F1-244[»]
5JUOelectron microscopy4.00K1-244[»]
5JUPelectron microscopy3.50K1-244[»]
5JUSelectron microscopy4.20K1-244[»]
5JUTelectron microscopy4.00K1-244[»]
5JUUelectron microscopy4.00K1-244[»]
5LYBX-ray3.25L7/l722-244[»]
5M1Jelectron microscopy3.30F523-244[»]
5MC6electron microscopy3.80BO1-244[»]
5MEIX-ray3.50CI/o23-244[»]
5NDGX-ray3.70L7/l722-244[»]
5NDVX-ray3.30L7/l719-244[»]
5NDWX-ray3.70L7/l722-244[»]
5OBMX-ray3.40L7/l722-244[»]
5ON6X-ray3.10CI/o23-244[»]
5T62electron microscopy3.30I1-244[»]
5T6Relectron microscopy4.50I1-244[»]
5TBWX-ray3.00CI/o23-244[»]
5TGAX-ray3.30L7/l722-244[»]
5TGMX-ray3.50L7/l722-244[»]
5Z3Gelectron microscopy3.65J1-244[»]
6C0Felectron microscopy3.70F1-244[»]
6ELZelectron microscopy3.30F1-244[»]
6EM1electron microscopy3.60F1-244[»]
6EM3electron microscopy3.20F1-244[»]
6EM4electron microscopy4.10F1-244[»]
6EM5electron microscopy4.30F1-244[»]
6FT6electron microscopy3.90F1-244[»]
ProteinModelPortaliP05737
SMRiP05737
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05737

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000006213
HOGENOMiHOG000170917
InParanoidiP05737
KOiK02937
OMAiYQKEYTE
OrthoDBiEOG092C4MAX

Family and domain databases

CDDicd01657 Ribosomal_L7_archeal_euk, 1 hit
Gene3Di1.10.15.30, 1 hit
3.30.1390.20, 2 hits
InterProiView protein in InterPro
IPR036919 L30_ferredoxin-like_sf
IPR023106 Ribosomal_L30_central_dom_arc
IPR018038 Ribosomal_L30_CS
IPR016082 Ribosomal_L30_ferredoxin-like
IPR012988 Ribosomal_L30_N
IPR005998 Ribosomal_L7_euk
IPR035808 Ribosomal_L7_euk_arc
PfamiView protein in Pfam
PF00327 Ribosomal_L30, 1 hit
PF08079 Ribosomal_L30_N, 1 hit
SUPFAMiSSF55129 SSF55129, 1 hit
TIGRFAMsiTIGR01310 uL30_euk, 1 hit
PROSITEiView protein in PROSITE
PS00634 RIBOSOMAL_L30, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEKILTPE SQLKKSKAQQ KTAEQVAAER AARKAANKEK RAIILERNAA
60 70 80 90 100
YQKEYETAER NIIQAKRDAK AAGSYYVEAQ HKLVFVVRIK GINKIPPKPR
110 120 130 140 150
KVLQLLRLTR INSGTFVKVT KATLELLKLI EPYVAYGYPS YSTIRQLVYK
160 170 180 190 200
RGFGKINKQR VPLSDNAIIE ANLGKYGILS IDDLIHEIIT VGPHFKQANN
210 220 230 240
FLWPFKLSNP SGGWGVPRKF KHFIQGGSFG NREEFINKLV KSMN
Length:244
Mass (Da):27,638
Last modified:January 23, 2007 - v3
Checksum:iF65B24D48459F745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62627 Genomic DNA Translation: CAA44495.1
Z72598 Genomic DNA Translation: CAA96781.1
Z72597 Genomic DNA Translation: CAA96779.2 Sequence problems.
BK006941 Genomic DNA Translation: DAA08029.1
PIRiS22789 R5BYL7
RefSeqiNP_011439.1, NM_001180941.1

Genome annotation databases

EnsemblFungiiYGL076C; YGL076C; YGL076C
GeneIDi852804
KEGGisce:YGL076C

Similar proteinsi

Entry informationi

Entry nameiRL7A_YEAST
AccessioniPrimary (citable) accession number: P05737
Secondary accession number(s): D6VU68, P87029
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names
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