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P05737

- RL7A_YEAST

UniProt

P05737 - RL7A_YEAST

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Protein

60S ribosomal protein L7-A

Gene

RPL7A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: SGD

GO - Biological processi

  1. cytoplasmic translation Source: SGD
  2. maturation of LSU-rRNA Source: SGD
  3. ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-A
Alternative name(s):
L6
RP11
YL8
Gene namesi
Name:RPL7A
Synonyms:RPL6A, RPL8A, YL8A
Ordered Locus Names:YGL076C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

SGDiS000003044. RPL7A.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 24424360S ribosomal protein L7-APRO_0000104651Add
BLAST

Proteomic databases

MaxQBiP05737.
PeptideAtlasiP05737.

Expressioni

Gene expression databases

GenevestigatoriP05737.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33174. 132 interactions.
IntActiP05737. 130 interactions.
MINTiMINT-4485679.
STRINGi4932.YGL076C.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-F83-243[»]
1S1Ielectron microscopy11.70F83-244[»]
1VW8electron microscopy6.10G1-244[»]
1VWUelectron microscopy6.10G1-244[»]
1VXVelectron microscopy6.20G1-244[»]
1VXYelectron microscopy6.30G1-244[»]
3IZSelectron microscopy-e1-244[»]
3J65electron microscopy8.70a1-244[»]
3O58X-ray4.00G1-244[»]
3O5HX-ray4.00G1-244[»]
3U5EX-ray3.00F1-244[»]
3U5IX-ray3.00F1-244[»]
4B6Aelectron microscopy8.10F1-244[»]
4BYNelectron microscopy4.30F2-244[»]
4BYUelectron microscopy6.60F2-244[»]
4CUWelectron microscopy3.70F1-244[»]
ProteinModelPortaliP05737.
SMRiP05737. Positions 22-244.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05737.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L30P family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000006213.
HOGENOMiHOG000170917.
InParanoidiP05737.
KOiK02937.
OMAiYRTETRM.
OrthoDBiEOG7TBCCW.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. L7. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05737-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAEKILTPE SQLKKSKAQQ KTAEQVAAER AARKAANKEK RAIILERNAA
60 70 80 90 100
YQKEYETAER NIIQAKRDAK AAGSYYVEAQ HKLVFVVRIK GINKIPPKPR
110 120 130 140 150
KVLQLLRLTR INSGTFVKVT KATLELLKLI EPYVAYGYPS YSTIRQLVYK
160 170 180 190 200
RGFGKINKQR VPLSDNAIIE ANLGKYGILS IDDLIHEIIT VGPHFKQANN
210 220 230 240
FLWPFKLSNP SGGWGVPRKF KHFIQGGSFG NREEFINKLV KSMN
Length:244
Mass (Da):27,638
Last modified:January 23, 2007 - v3
Checksum:iF65B24D48459F745
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62627 Genomic DNA. Translation: CAA44495.1.
Z72598 Genomic DNA. Translation: CAA96781.1.
Z72597 Genomic DNA. Translation: CAA96779.2. Sequence problems.
BK006941 Genomic DNA. Translation: DAA08029.1.
PIRiS22789. R5BYL7.
RefSeqiNP_011439.1. NM_001180941.1.

Genome annotation databases

EnsemblFungiiYGL076C; YGL076C; YGL076C.
GeneIDi852804.
KEGGisce:YGL076C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X62627 Genomic DNA. Translation: CAA44495.1 .
Z72598 Genomic DNA. Translation: CAA96781.1 .
Z72597 Genomic DNA. Translation: CAA96779.2 . Sequence problems.
BK006941 Genomic DNA. Translation: DAA08029.1 .
PIRi S22789. R5BYL7.
RefSeqi NP_011439.1. NM_001180941.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1K5Y model - F 83-243 [» ]
1S1I electron microscopy 11.70 F 83-244 [» ]
1VW8 electron microscopy 6.10 G 1-244 [» ]
1VWU electron microscopy 6.10 G 1-244 [» ]
1VXV electron microscopy 6.20 G 1-244 [» ]
1VXY electron microscopy 6.30 G 1-244 [» ]
3IZS electron microscopy - e 1-244 [» ]
3J65 electron microscopy 8.70 a 1-244 [» ]
3O58 X-ray 4.00 G 1-244 [» ]
3O5H X-ray 4.00 G 1-244 [» ]
3U5E X-ray 3.00 F 1-244 [» ]
3U5I X-ray 3.00 F 1-244 [» ]
4B6A electron microscopy 8.10 F 1-244 [» ]
4BYN electron microscopy 4.30 F 2-244 [» ]
4BYU electron microscopy 6.60 F 2-244 [» ]
4CUW electron microscopy 3.70 F 1-244 [» ]
ProteinModelPortali P05737.
SMRi P05737. Positions 22-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33174. 132 interactions.
IntActi P05737. 130 interactions.
MINTi MINT-4485679.
STRINGi 4932.YGL076C.

Proteomic databases

MaxQBi P05737.
PeptideAtlasi P05737.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL076C ; YGL076C ; YGL076C .
GeneIDi 852804.
KEGGi sce:YGL076C.

Organism-specific databases

SGDi S000003044. RPL7A.

Phylogenomic databases

GeneTreei ENSGT00390000006213.
HOGENOMi HOG000170917.
InParanoidi P05737.
KOi K02937.
OMAi YRTETRM.
OrthoDBi EOG7TBCCW.

Enzyme and pathway databases

BioCyci YEAST:G3O-30577-MONOMER.

Miscellaneous databases

EvolutionaryTracei P05737.
NextBioi 972327.

Gene expression databases

Genevestigatori P05737.

Family and domain databases

Gene3Di 3.30.1390.20. 2 hits.
InterProi IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view ]
Pfami PF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view ]
SUPFAMi SSF55129. SSF55129. 1 hit.
TIGRFAMsi TIGR01310. L7. 1 hit.
PROSITEi PS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Yeast ribosomal proteins: XIII. Saccharomyces cerevisiae YL8A gene, interrupted with two introns, encodes a homolog of mammalian L7."
    Mizuta K., Hashimoto T., Otaka E.
    Nucleic Acids Res. 20:1011-1016(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
    Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
    Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
    Otaka E., Higo K., Itoh T.
    Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE OF 2-41, CLEAVAGE OF INITIATOR METHIONINE.
  6. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
    Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
    J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
  7. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
    Planta R.J., Mager W.H.
    Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE, SUBUNIT.
  8. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
    Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
    J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE OF INITIATOR METHIONINE.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
    Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
    Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 83-243, ELECTRON MICROSCOPY.
  13. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
    Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
    EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 83-244, ELECTRON MICROSCOPY.
  14. "Crystal structure of the eukaryotic ribosome."
    Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
    Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
  15. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

Entry informationi

Entry nameiRL7A_YEAST
AccessioniPrimary (citable) accession number: P05737
Secondary accession number(s): D6VU68, P87029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 101000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L7 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3