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Protein

60S ribosomal protein L7-A

Gene

RPL7A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: GO_Central
  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • maturation of LSU-rRNA Source: SGD
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • ribosomal large subunit biogenesis Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-30577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7-A
Alternative name(s):
L6
RP11
YL8
Gene namesi
Name:RPL7A
Synonyms:RPL6A, RPL8A, YL8A
Ordered Locus Names:YGL076C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL076C.
SGDiS000003044. RPL7A.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosolic large ribosomal subunit Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00001046512 – 24460S ribosomal protein L7-AAdd BLAST243

Proteomic databases

MaxQBiP05737.
PRIDEiP05737.
TopDownProteomicsiP05737.

PTM databases

iPTMnetiP05737.

Interactioni

Subunit structurei

Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

Protein-protein interaction databases

BioGridi33174. 79 interactors.
IntActiP05737. 130 interactors.
MINTiMINT-4485679.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni23 – 25Combined sources3
Helixi28 – 71Combined sources44
Beta strandi82 – 88Combined sources7
Beta strandi92 – 94Combined sources3
Helixi97 – 105Combined sources9
Beta strandi113 – 118Combined sources6
Helixi121 – 128Combined sources8
Turni129 – 133Combined sources5
Beta strandi134 – 137Combined sources4
Helixi141 – 151Combined sources11
Beta strandi156 – 159Combined sources4
Beta strandi160 – 162Combined sources3
Helixi166 – 173Combined sources8
Helixi174 – 176Combined sources3
Helixi181 – 189Combined sources9
Helixi195 – 201Combined sources7
Beta strandi215 – 217Combined sources3
Beta strandi219 – 222Combined sources4
Helixi223 – 225Combined sources3
Beta strandi227 – 231Combined sources5
Helixi233 – 235Combined sources3
Helixi236 – 243Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-F83-243[»]
3J6Xelectron microscopy6.10L71-244[»]
3J6Yelectron microscopy6.10L71-244[»]
3J77electron microscopy6.20L71-244[»]
3J78electron microscopy6.30L71-244[»]
3JCTelectron microscopy3.08F1-244[»]
4U3MX-ray3.00L7/l72-244[»]
4U3NX-ray3.20L7/l72-244[»]
4U3UX-ray2.90L7/l72-244[»]
4U4NX-ray3.10L7/l72-244[»]
4U4OX-ray3.60L7/l72-244[»]
4U4QX-ray3.00L7/l72-244[»]
4U4RX-ray2.80L7/l72-244[»]
4U4UX-ray3.00L7/l72-244[»]
4U4YX-ray3.20L7/l72-244[»]
4U4ZX-ray3.10L7/l72-244[»]
4U50X-ray3.20L7/l72-244[»]
4U51X-ray3.20L7/l72-244[»]
4U52X-ray3.00L7/l72-244[»]
4U53X-ray3.30L7/l72-244[»]
4U55X-ray3.20L7/l72-244[»]
4U56X-ray3.45L7/l72-244[»]
4U6FX-ray3.10L7/l72-244[»]
4V4Belectron microscopy11.70BF83-244[»]
4V6Ielectron microscopy8.80Be1-244[»]
4V7Felectron microscopy8.70a1-244[»]
4V7RX-ray4.00BG/DG1-244[»]
4V88X-ray3.00BF/DF1-244[»]
4V8Telectron microscopy8.10F1-244[»]
4V8Yelectron microscopy4.30BF2-244[»]
4V8Zelectron microscopy6.60BF2-244[»]
4V91electron microscopy3.70F1-244[»]
5APNelectron microscopy3.91F1-244[»]
5APOelectron microscopy3.41F1-244[»]
5DATX-ray3.15L7/l72-244[»]
5DC3X-ray3.25L7/l72-244[»]
5FCIX-ray3.40L7/l72-244[»]
5FCJX-ray3.10L7/l72-244[»]
5FL8electron microscopy9.50F1-244[»]
5GAKelectron microscopy3.88J1-244[»]
5I4LX-ray3.10L7/l722-244[»]
5JUOelectron microscopy4.00K1-244[»]
5JUPelectron microscopy3.50K1-244[»]
5JUSelectron microscopy4.20K1-244[»]
5JUTelectron microscopy4.00K1-244[»]
5JUUelectron microscopy4.00K1-244[»]
ProteinModelPortaliP05737.
SMRiP05737.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05737.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L30P family.Curated

Phylogenomic databases

GeneTreeiENSGT00840000131772.
HOGENOMiHOG000170917.
InParanoidiP05737.
KOiK02937.
OMAiMASTAFT.
OrthoDBiEOG092C4MAX.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05737-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAEKILTPE SQLKKSKAQQ KTAEQVAAER AARKAANKEK RAIILERNAA
60 70 80 90 100
YQKEYETAER NIIQAKRDAK AAGSYYVEAQ HKLVFVVRIK GINKIPPKPR
110 120 130 140 150
KVLQLLRLTR INSGTFVKVT KATLELLKLI EPYVAYGYPS YSTIRQLVYK
160 170 180 190 200
RGFGKINKQR VPLSDNAIIE ANLGKYGILS IDDLIHEIIT VGPHFKQANN
210 220 230 240
FLWPFKLSNP SGGWGVPRKF KHFIQGGSFG NREEFINKLV KSMN
Length:244
Mass (Da):27,638
Last modified:January 23, 2007 - v3
Checksum:iF65B24D48459F745
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62627 Genomic DNA. Translation: CAA44495.1.
Z72598 Genomic DNA. Translation: CAA96781.1.
Z72597 Genomic DNA. Translation: CAA96779.2. Sequence problems.
BK006941 Genomic DNA. Translation: DAA08029.1.
PIRiS22789. R5BYL7.
RefSeqiNP_011439.1. NM_001180941.1.

Genome annotation databases

EnsemblFungiiYGL076C; YGL076C; YGL076C.
GeneIDi852804.
KEGGisce:YGL076C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62627 Genomic DNA. Translation: CAA44495.1.
Z72598 Genomic DNA. Translation: CAA96781.1.
Z72597 Genomic DNA. Translation: CAA96779.2. Sequence problems.
BK006941 Genomic DNA. Translation: DAA08029.1.
PIRiS22789. R5BYL7.
RefSeqiNP_011439.1. NM_001180941.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K5Ymodel-F83-243[»]
3J6Xelectron microscopy6.10L71-244[»]
3J6Yelectron microscopy6.10L71-244[»]
3J77electron microscopy6.20L71-244[»]
3J78electron microscopy6.30L71-244[»]
3JCTelectron microscopy3.08F1-244[»]
4U3MX-ray3.00L7/l72-244[»]
4U3NX-ray3.20L7/l72-244[»]
4U3UX-ray2.90L7/l72-244[»]
4U4NX-ray3.10L7/l72-244[»]
4U4OX-ray3.60L7/l72-244[»]
4U4QX-ray3.00L7/l72-244[»]
4U4RX-ray2.80L7/l72-244[»]
4U4UX-ray3.00L7/l72-244[»]
4U4YX-ray3.20L7/l72-244[»]
4U4ZX-ray3.10L7/l72-244[»]
4U50X-ray3.20L7/l72-244[»]
4U51X-ray3.20L7/l72-244[»]
4U52X-ray3.00L7/l72-244[»]
4U53X-ray3.30L7/l72-244[»]
4U55X-ray3.20L7/l72-244[»]
4U56X-ray3.45L7/l72-244[»]
4U6FX-ray3.10L7/l72-244[»]
4V4Belectron microscopy11.70BF83-244[»]
4V6Ielectron microscopy8.80Be1-244[»]
4V7Felectron microscopy8.70a1-244[»]
4V7RX-ray4.00BG/DG1-244[»]
4V88X-ray3.00BF/DF1-244[»]
4V8Telectron microscopy8.10F1-244[»]
4V8Yelectron microscopy4.30BF2-244[»]
4V8Zelectron microscopy6.60BF2-244[»]
4V91electron microscopy3.70F1-244[»]
5APNelectron microscopy3.91F1-244[»]
5APOelectron microscopy3.41F1-244[»]
5DATX-ray3.15L7/l72-244[»]
5DC3X-ray3.25L7/l72-244[»]
5FCIX-ray3.40L7/l72-244[»]
5FCJX-ray3.10L7/l72-244[»]
5FL8electron microscopy9.50F1-244[»]
5GAKelectron microscopy3.88J1-244[»]
5I4LX-ray3.10L7/l722-244[»]
5JUOelectron microscopy4.00K1-244[»]
5JUPelectron microscopy3.50K1-244[»]
5JUSelectron microscopy4.20K1-244[»]
5JUTelectron microscopy4.00K1-244[»]
5JUUelectron microscopy4.00K1-244[»]
ProteinModelPortaliP05737.
SMRiP05737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33174. 79 interactors.
IntActiP05737. 130 interactors.
MINTiMINT-4485679.

PTM databases

iPTMnetiP05737.

Proteomic databases

MaxQBiP05737.
PRIDEiP05737.
TopDownProteomicsiP05737.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL076C; YGL076C; YGL076C.
GeneIDi852804.
KEGGisce:YGL076C.

Organism-specific databases

EuPathDBiFungiDB:YGL076C.
SGDiS000003044. RPL7A.

Phylogenomic databases

GeneTreeiENSGT00840000131772.
HOGENOMiHOG000170917.
InParanoidiP05737.
KOiK02937.
OMAiMASTAFT.
OrthoDBiEOG092C4MAX.

Enzyme and pathway databases

BioCyciYEAST:G3O-30577-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP05737.
PROiP05737.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiIPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
[Graphical view]
PfamiPF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
[Graphical view]
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL7A_YEAST
AccessioniPrimary (citable) accession number: P05737
Secondary accession number(s): D6VU68, P87029
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 169 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 101000 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for L7 in yeast.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.