Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P05737

- RL7A_YEAST

UniProt

P05737 - RL7A_YEAST

Protein

60S ribosomal protein L7-A

Gene

RPL7A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 145 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: SGD

    GO - Biological processi

    1. cytoplasmic translation Source: SGD
    2. maturation of LSU-rRNA Source: SGD
    3. ribosomal large subunit biogenesis Source: SGD

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30577-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L7-A
    Alternative name(s):
    L6
    RP11
    YL8
    Gene namesi
    Name:RPL7A
    Synonyms:RPL6A, RPL8A, YL8A
    Ordered Locus Names:YGL076C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VII

    Organism-specific databases

    SGDiS000003044. RPL7A.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. cytosolic large ribosomal subunit Source: SGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 24424360S ribosomal protein L7-APRO_0000104651Add
    BLAST

    Proteomic databases

    MaxQBiP05737.
    PeptideAtlasiP05737.

    Expressioni

    Gene expression databases

    GenevestigatoriP05737.

    Interactioni

    Subunit structurei

    Component of the large ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains 32 different proteins (encoded by 56 genes) and 1 molecule of RNA (18S). The 60S subunit contains 46 different proteins (encoded by 81 genes) and 3 molecules of RNA (25S, 5.8S and 5S).1 Publication

    Protein-protein interaction databases

    BioGridi33174. 131 interactions.
    IntActiP05737. 130 interactions.
    MINTiMINT-4485679.
    STRINGi4932.YGL076C.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1K5Ymodel-F83-243[»]
    1S1Ielectron microscopy11.70F83-244[»]
    1VW8electron microscopy6.10G1-244[»]
    1VWUelectron microscopy6.10G1-244[»]
    3IZSelectron microscopy-e1-244[»]
    3J65electron microscopy8.70a1-244[»]
    3O58X-ray4.00G1-244[»]
    3O5HX-ray4.00G1-244[»]
    3U5EX-ray3.00F1-244[»]
    3U5IX-ray3.00F1-244[»]
    4B6Aelectron microscopy8.10F1-244[»]
    4BYNelectron microscopy4.30F2-244[»]
    4BYUelectron microscopy6.60F2-244[»]
    4CUWelectron microscopy3.70F1-244[»]
    ProteinModelPortaliP05737.
    SMRiP05737. Positions 22-244.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP05737.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L30P family.Curated

    Phylogenomic databases

    GeneTreeiENSGT00390000006213.
    HOGENOMiHOG000170917.
    KOiK02937.
    OMAiYRTETRM.
    OrthoDBiEOG7TBCCW.

    Family and domain databases

    Gene3Di3.30.1390.20. 2 hits.
    InterProiIPR018038. Ribosomal_L30_CS.
    IPR016082. Ribosomal_L30_ferredoxin-like.
    IPR012988. Ribosomal_L30_N.
    IPR005998. Ribosomal_L7_euk.
    [Graphical view]
    PfamiPF00327. Ribosomal_L30. 1 hit.
    PF08079. Ribosomal_L30_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF55129. SSF55129. 1 hit.
    TIGRFAMsiTIGR01310. L7. 1 hit.
    PROSITEiPS00634. RIBOSOMAL_L30. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05737-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAEKILTPE SQLKKSKAQQ KTAEQVAAER AARKAANKEK RAIILERNAA    50
    YQKEYETAER NIIQAKRDAK AAGSYYVEAQ HKLVFVVRIK GINKIPPKPR 100
    KVLQLLRLTR INSGTFVKVT KATLELLKLI EPYVAYGYPS YSTIRQLVYK 150
    RGFGKINKQR VPLSDNAIIE ANLGKYGILS IDDLIHEIIT VGPHFKQANN 200
    FLWPFKLSNP SGGWGVPRKF KHFIQGGSFG NREEFINKLV KSMN 244
    Length:244
    Mass (Da):27,638
    Last modified:January 23, 2007 - v3
    Checksum:iF65B24D48459F745
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62627 Genomic DNA. Translation: CAA44495.1.
    Z72598 Genomic DNA. Translation: CAA96781.1.
    Z72597 Genomic DNA. Translation: CAA96779.2. Sequence problems.
    BK006941 Genomic DNA. Translation: DAA08029.1.
    PIRiS22789. R5BYL7.
    RefSeqiNP_011439.1. NM_001180941.1.

    Genome annotation databases

    EnsemblFungiiYGL076C; YGL076C; YGL076C.
    GeneIDi852804.
    KEGGisce:YGL076C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X62627 Genomic DNA. Translation: CAA44495.1 .
    Z72598 Genomic DNA. Translation: CAA96781.1 .
    Z72597 Genomic DNA. Translation: CAA96779.2 . Sequence problems.
    BK006941 Genomic DNA. Translation: DAA08029.1 .
    PIRi S22789. R5BYL7.
    RefSeqi NP_011439.1. NM_001180941.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1K5Y model - F 83-243 [» ]
    1S1I electron microscopy 11.70 F 83-244 [» ]
    1VW8 electron microscopy 6.10 G 1-244 [» ]
    1VWU electron microscopy 6.10 G 1-244 [» ]
    3IZS electron microscopy - e 1-244 [» ]
    3J65 electron microscopy 8.70 a 1-244 [» ]
    3O58 X-ray 4.00 G 1-244 [» ]
    3O5H X-ray 4.00 G 1-244 [» ]
    3U5E X-ray 3.00 F 1-244 [» ]
    3U5I X-ray 3.00 F 1-244 [» ]
    4B6A electron microscopy 8.10 F 1-244 [» ]
    4BYN electron microscopy 4.30 F 2-244 [» ]
    4BYU electron microscopy 6.60 F 2-244 [» ]
    4CUW electron microscopy 3.70 F 1-244 [» ]
    ProteinModelPortali P05737.
    SMRi P05737. Positions 22-244.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 33174. 131 interactions.
    IntActi P05737. 130 interactions.
    MINTi MINT-4485679.
    STRINGi 4932.YGL076C.

    Proteomic databases

    MaxQBi P05737.
    PeptideAtlasi P05737.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YGL076C ; YGL076C ; YGL076C .
    GeneIDi 852804.
    KEGGi sce:YGL076C.

    Organism-specific databases

    SGDi S000003044. RPL7A.

    Phylogenomic databases

    GeneTreei ENSGT00390000006213.
    HOGENOMi HOG000170917.
    KOi K02937.
    OMAi YRTETRM.
    OrthoDBi EOG7TBCCW.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30577-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P05737.
    NextBioi 972327.

    Gene expression databases

    Genevestigatori P05737.

    Family and domain databases

    Gene3Di 3.30.1390.20. 2 hits.
    InterProi IPR018038. Ribosomal_L30_CS.
    IPR016082. Ribosomal_L30_ferredoxin-like.
    IPR012988. Ribosomal_L30_N.
    IPR005998. Ribosomal_L7_euk.
    [Graphical view ]
    Pfami PF00327. Ribosomal_L30. 1 hit.
    PF08079. Ribosomal_L30_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55129. SSF55129. 1 hit.
    TIGRFAMsi TIGR01310. L7. 1 hit.
    PROSITEi PS00634. RIBOSOMAL_L30. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Yeast ribosomal proteins: XIII. Saccharomyces cerevisiae YL8A gene, interrupted with two introns, encodes a homolog of mammalian L7."
      Mizuta K., Hashimoto T., Otaka E.
      Nucleic Acids Res. 20:1011-1016(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Sequence analysis of 203 kilobases from Saccharomyces cerevisiae chromosome VII."
      Rieger M., Brueckner M., Schaefer M., Mueller-Auer S.
      Yeast 13:1077-1090(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
      Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
      , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
      Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    5. "Yeast ribosomal proteins. VIII. Isolation of two proteins and sequence characterization of twenty-four proteins from cytoplasmic ribosomes."
      Otaka E., Higo K., Itoh T.
      Mol. Gen. Genet. 195:544-546(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE OF 2-41, CLEAVAGE OF INITIATOR METHIONINE.
    6. "NH2-terminal acetylation of ribosomal proteins of Saccharomyces cerevisiae."
      Takakura H., Tsunasawa S., Miyagi M., Warner J.R.
      J. Biol. Chem. 267:5442-5445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-21.
    7. "The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae."
      Planta R.J., Mager W.H.
      Yeast 14:471-477(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE, SUBUNIT.
    8. "The action of N-terminal acetyltransferases on yeast ribosomal proteins."
      Arnold R.J., Polevoda B., Reilly J.P., Sherman F.
      J. Biol. Chem. 274:37035-37040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE OF INITIATOR METHIONINE.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    10. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Structure of the 80S ribosome from Saccharomyces cerevisiae -- tRNA-ribosome and subunit-subunit interactions."
      Spahn C.M.T., Beckmann R., Eswar N., Penczek P.A., Sali A., Blobel G., Frank J.
      Cell 107:373-386(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 83-243, ELECTRON MICROSCOPY.
    13. "Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation."
      Spahn C.M.T., Gomez-Lorenzo M.G., Grassucci R.A., Joergensen R., Andersen G.R., Beckmann R., Penczek P.A., Ballesta J.P.G., Frank J.
      EMBO J. 23:1008-1019(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING OF 83-244, ELECTRON MICROSCOPY.
    14. "Crystal structure of the eukaryotic ribosome."
      Ben-Shem A., Jenner L., Yusupova G., Yusupov M.
      Science 330:1203-1209(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 80S RIBOSOME.
    15. Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 80S RIBOSOME.

    Entry informationi

    Entry nameiRL7A_YEAST
    AccessioniPrimary (citable) accession number: P05737
    Secondary accession number(s): D6VU68, P87029
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 145 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 101000 molecules/cell in log phase SD medium.1 Publication
    There are 2 genes for L7 in yeast.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families
    4. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    5. Yeast chromosome VII
      Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

    External Data

    Dasty 3