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Protein

Ras-related protein Rab-4A

Gene

Rab4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 28GTPBy similarity9
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4
Nucleotide bindingi156 – 158GTPBy similarity3

GO - Molecular functioni

  • ATPase activator activity Source: RGD
  • ATPase binding Source: RGD
  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • ionotropic glutamate receptor binding Source: RGD
  • protein transporter activity Source: Ensembl
  • syntaxin binding Source: RGD

GO - Biological processi

  • antigen processing and presentation Source: Ensembl
  • Rab protein signal transduction Source: RGD
  • regulation of endocytosis Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1660499. Synthesis of PIPs at the plasma membrane.
R-RNO-8875656. MET receptor recycling.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:Rab4a
Synonyms:Rab4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi3529. Rab4a.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
  • extracellular exosome Source: Ensembl
  • insulin-responsive compartment Source: RGD
  • intracellular membrane-bounded organelle Source: RGD
  • membrane Source: RGD
  • perinuclear region of cytoplasm Source: Ensembl
  • plasma membrane Source: RGD
  • recycling endosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001210951 – 218Ras-related protein Rab-4AAdd BLAST218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphoserineBy similarity1
Modified residuei204Phosphoserine; by CDK1By similarity1
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP05714.
PRIDEiP05714.

Expressioni

Gene expression databases

ExpressionAtlasiP05714. baseline and differential.
GenevisibleiP05714. RN.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin. Does not interact with HPS4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
NISCHQ9Y2I13EBI-9029299,EBI-2688731From a different organism.

GO - Molecular functioni

  • ATPase binding Source: RGD
  • ionotropic glutamate receptor binding Source: RGD
  • syntaxin binding Source: RGD

Protein-protein interaction databases

IntActiP05714. 1 interactor.
STRINGi10116.ENSRNOP00000048878.

Structurei

3D structure databases

ProteinModelPortaliP05714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05714.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05714-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF
60 70 80 90 100
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET
110 120 130 140 150
YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL
160 170 180 190 200
MFLETSALTG ENVEEAFMQC ARKILNKIES GELDPERMGS GIQYGDAALR
210
QLRSPRRTQA PSAQECGC
Length:218
Mass (Da):24,409
Last modified:March 6, 2013 - v3
Checksum:iA576827D571CAD01
GO

Sequence cautioni

The sequence CAA30006 differs from that shown. Reason: Frameshift at position 3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52S → Q in CAA30006 (PubMed:3344209).Curated1
Sequence conflicti80R → T in CAA30006 (PubMed:3344209).Curated1
Sequence conflicti157A → P in CAA30006 (PubMed:3344209).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06890 mRNA. Translation: CAA30006.1. Frameshift.
BC062016 mRNA. Translation: AAH62016.1.
PIRiS01766.
RefSeqiNP_037151.2. NM_013019.2.
UniGeneiRn.3016.

Genome annotation databases

EnsembliENSRNOT00000049337; ENSRNOP00000048878; ENSRNOG00000017467.
GeneIDi25532.
KEGGirno:25532.
UCSCiRGD:3529. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X06890 mRNA. Translation: CAA30006.1. Frameshift.
BC062016 mRNA. Translation: AAH62016.1.
PIRiS01766.
RefSeqiNP_037151.2. NM_013019.2.
UniGeneiRn.3016.

3D structure databases

ProteinModelPortaliP05714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05714. 1 interactor.
STRINGi10116.ENSRNOP00000048878.

Proteomic databases

PaxDbiP05714.
PRIDEiP05714.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049337; ENSRNOP00000048878; ENSRNOG00000017467.
GeneIDi25532.
KEGGirno:25532.
UCSCiRGD:3529. rat.

Organism-specific databases

CTDi5867.
RGDi3529. Rab4a.

Phylogenomic databases

eggNOGiKOG0086. Eukaryota.
ENOG410XQ9X. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05714.
KOiK07879.
OMAiMVKLQIW.
OrthoDBiEOG091G0QOB.
TreeFamiTF300032.

Enzyme and pathway databases

ReactomeiR-RNO-1660499. Synthesis of PIPs at the plasma membrane.
R-RNO-8875656. MET receptor recycling.

Miscellaneous databases

PROiP05714.

Gene expression databases

ExpressionAtlasiP05714. baseline and differential.
GenevisibleiP05714. RN.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAB4A_RAT
AccessioniPrimary (citable) accession number: P05714
Secondary accession number(s): Q6P6U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 6, 2013
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.