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P05714

- RAB4A_RAT

UniProt

P05714 - RAB4A_RAT

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Protein

Ras-related protein Rab-4A

Gene
Rab4a, Rab4
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Protein transport. Probably involved in vesicular traffic By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 289GTP By similarity
Nucleotide bindingi68 – 725GTP By similarity
Nucleotide bindingi126 – 1294GTP By similarity
Nucleotide bindingi156 – 1583GTP By similarity

GO - Molecular functioni

  1. ATPase activator activity Source: RGD
  2. ATPase binding Source: RGD
  3. GDP binding Source: UniProtKB
  4. GTPase activity Source: UniProtKB
  5. GTP binding Source: UniProtKB
  6. ionotropic glutamate receptor binding Source: RGD
  7. syntaxin binding Source: RGD

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. positive regulation of ATPase activity Source: GOC
  3. protein transport Source: UniProtKB-KW
  4. Rab protein signal transduction Source: RGD
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-4A
Gene namesi
Name:Rab4a
Synonyms:Rab4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi3529. Rab4a.

Subcellular locationi

Membrane; Peripheral membrane protein By similarity. Cytoplasm By similarity
Note: Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

GO - Cellular componenti

  1. cytosol Source: RGD
  2. insulin-responsive compartment Source: RGD
  3. intracellular membrane-bounded organelle Source: RGD
  4. membrane Source: RGD
  5. plasma membrane Source: RGD
  6. recycling endosome Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Ras-related protein Rab-4APRO_0000121095Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine; by CDK1 By similarity
Lipidationi216 – 2161S-geranylgeranyl cysteine By similarity
Modified residuei218 – 2181Cysteine methyl ester By similarity
Lipidationi218 – 2181S-geranylgeranyl cysteine By similarity

Post-translational modificationi

Phosphorylated by CDK1 kinase during mitosis By similarity.

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP05714.
PRIDEiP05714.

Expressioni

Gene expression databases

GenevestigatoriP05714.

Interactioni

Subunit structurei

Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
NISCHQ9Y2I14EBI-9029299,EBI-2688731From a different organism.

Protein-protein interaction databases

IntActiP05714. 1 interaction.
STRINGi10116.ENSRNOP00000023771.

Structurei

3D structure databases

ProteinModelPortaliP05714.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 509Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05714.
KOiK07879.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05714-1 [UniParc]FASTAAdd to Basket

« Hide

MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF    50
GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET 100
YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL 150
MFLETSALTG ENVEEAFMQC ARKILNKIES GELDPERMGS GIQYGDAALR 200
QLRSPRRTQA PSAQECGC 218
Length:218
Mass (Da):24,409
Last modified:March 6, 2013 - v3
Checksum:iA576827D571CAD01
GO

Sequence cautioni

The sequence CAA30006.1 differs from that shown. Reason: Frameshift at position 3.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti52 – 521S → Q in CAA30006. 1 Publication
Sequence conflicti80 – 801R → T in CAA30006. 1 Publication
Sequence conflicti157 – 1571A → P in CAA30006. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06890 mRNA. Translation: CAA30006.1. Frameshift.
BC062016 mRNA. Translation: AAH62016.1.
PIRiS01766.
RefSeqiNP_037151.2. NM_013019.2.
UniGeneiRn.3016.

Genome annotation databases

GeneIDi25532.
KEGGirno:25532.
UCSCiRGD:3529. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06890 mRNA. Translation: CAA30006.1 . Frameshift.
BC062016 mRNA. Translation: AAH62016.1 .
PIRi S01766.
RefSeqi NP_037151.2. NM_013019.2.
UniGenei Rn.3016.

3D structure databases

ProteinModelPortali P05714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P05714. 1 interaction.
STRINGi 10116.ENSRNOP00000023771.

Proteomic databases

PaxDbi P05714.
PRIDEi P05714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 25532.
KEGGi rno:25532.
UCSCi RGD:3529. rat.

Organism-specific databases

CTDi 5867.
RGDi 3529. Rab4a.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P05714.
KOi K07879.
TreeFami TF300032.

Miscellaneous databases

NextBioi 607033.
PROi P05714.

Gene expression databases

Genevestigatori P05714.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequences of the ras related rab 3 and 4 cDNAs."
    Zahraoui A., Touchot N., Chardin P., Tavitian A.
    Nucleic Acids Res. 16:1204-1204(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiRAB4A_RAT
AccessioniPrimary (citable) accession number: P05714
Secondary accession number(s): Q6P6U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: March 6, 2013
Last modified: September 3, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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