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P05714

- RAB4A_RAT

UniProt

P05714 - RAB4A_RAT

Protein

Ras-related protein Rab-4A

Gene

Rab4a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 3 (06 Mar 2013)
      Previous versions | rss
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    Functioni

    Protein transport. Probably involved in vesicular traffic By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 289GTPBy similarity
    Nucleotide bindingi68 – 725GTPBy similarity
    Nucleotide bindingi126 – 1294GTPBy similarity
    Nucleotide bindingi156 – 1583GTPBy similarity

    GO - Molecular functioni

    1. ATPase activator activity Source: RGD
    2. ATPase binding Source: RGD
    3. GDP binding Source: UniProtKB
    4. GTPase activity Source: UniProtKB
    5. GTP binding Source: UniProtKB
    6. ionotropic glutamate receptor binding Source: RGD
    7. protein binding Source: IntAct
    8. syntaxin binding Source: RGD

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. positive regulation of ATPase activity Source: GOC
    3. protein transport Source: UniProtKB-KW
    4. Rab protein signal transduction Source: RGD

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-4A
    Gene namesi
    Name:Rab4a
    Synonyms:Rab4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi3529. Rab4a.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Cytoplasm By similarity
    Note: Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1.

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. insulin-responsive compartment Source: RGD
    3. intracellular membrane-bounded organelle Source: RGD
    4. membrane Source: RGD
    5. plasma membrane Source: RGD
    6. recycling endosome Source: RGD

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 218218Ras-related protein Rab-4APRO_0000121095Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei204 – 2041Phosphoserine; by CDK1By similarity
    Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity
    Modified residuei218 – 2181Cysteine methyl esterBy similarity
    Lipidationi218 – 2181S-geranylgeranyl cysteineBy similarity

    Post-translational modificationi

    Phosphorylated by CDK1 kinase during mitosis.By similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Phosphoprotein, Prenylation

    Proteomic databases

    PaxDbiP05714.
    PRIDEiP05714.

    Expressioni

    Gene expression databases

    GenevestigatoriP05714.

    Interactioni

    Subunit structurei

    Interacts with RAB11FIP1, RABEP1, ZFYVE20 and RUFY1. Interacts with SGSM1, SGSM2 and SGSM3. Interacts (membrane-bound form) with NDRG1; the interaction involves NDRG1 in vesicular recycling of E-cadherin By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NISCHQ9Y2I14EBI-9029299,EBI-2688731From a different organism.

    Protein-protein interaction databases

    IntActiP05714. 1 interaction.
    STRINGi10116.ENSRNOP00000023771.

    Structurei

    3D structure databases

    ProteinModelPortaliP05714.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 509Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP05714.
    KOiK07879.
    TreeFamiTF300032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05714-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQTAMSETY DFLFKFLVIG NAGTGKSCLL HQFIEKKFKD DSNHTIGVEF    50
    GSKIINVGGK YVKLQIWDTA GQERFRSVTR SYYRGAAGAL LVYDITSRET 100
    YNALTNWLTD ARMLASQNIV IILCGNKKDL DADREVTFLE ASRFAQENEL 150
    MFLETSALTG ENVEEAFMQC ARKILNKIES GELDPERMGS GIQYGDAALR 200
    QLRSPRRTQA PSAQECGC 218
    Length:218
    Mass (Da):24,409
    Last modified:March 6, 2013 - v3
    Checksum:iA576827D571CAD01
    GO

    Sequence cautioni

    The sequence CAA30006.1 differs from that shown. Reason: Frameshift at position 3.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521S → Q in CAA30006. (PubMed:3344209)Curated
    Sequence conflicti80 – 801R → T in CAA30006. (PubMed:3344209)Curated
    Sequence conflicti157 – 1571A → P in CAA30006. (PubMed:3344209)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06890 mRNA. Translation: CAA30006.1. Frameshift.
    BC062016 mRNA. Translation: AAH62016.1.
    PIRiS01766.
    RefSeqiNP_037151.2. NM_013019.2.
    UniGeneiRn.3016.

    Genome annotation databases

    GeneIDi25532.
    KEGGirno:25532.
    UCSCiRGD:3529. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X06890 mRNA. Translation: CAA30006.1 . Frameshift.
    BC062016 mRNA. Translation: AAH62016.1 .
    PIRi S01766.
    RefSeqi NP_037151.2. NM_013019.2.
    UniGenei Rn.3016.

    3D structure databases

    ProteinModelPortali P05714.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P05714. 1 interaction.
    STRINGi 10116.ENSRNOP00000023771.

    Proteomic databases

    PaxDbi P05714.
    PRIDEi P05714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25532.
    KEGGi rno:25532.
    UCSCi RGD:3529. rat.

    Organism-specific databases

    CTDi 5867.
    RGDi 3529. Rab4a.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P05714.
    KOi K07879.
    TreeFami TF300032.

    Miscellaneous databases

    NextBioi 607033.
    PROi P05714.

    Gene expression databases

    Genevestigatori P05714.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete coding sequences of the ras related rab 3 and 4 cDNAs."
      Zahraoui A., Touchot N., Chardin P., Tavitian A.
      Nucleic Acids Res. 16:1204-1204(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiRAB4A_RAT
    AccessioniPrimary (citable) accession number: P05714
    Secondary accession number(s): Q6P6U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: March 6, 2013
    Last modified: October 1, 2014
    This is version 128 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3