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P05712 (RAB2A_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-2A
Gene names
Name:Rab2a
Synonyms:Rab2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length212 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for protein transport from the endoplasmic reticulum to the Golgi complex By similarity.

Subunit structure

Interacts with PRKCI By similarity.

Subcellular location

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor By similarity. Melanosome By similarity. Endoplasmic reticulum membrane; Lipid-anchor By similarity. Golgi apparatus membrane; Lipid-anchor By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 212211Ras-related protein Rab-2A
PRO_0000121069

Regions

Nucleotide binding13 – 219GTP By similarity
Nucleotide binding61 – 655GTP By similarity
Nucleotide binding119 – 1224GTP By similarity
Nucleotide binding149 – 1513GTP By similarity
Region2 – 1918Required for interaction with PRKCI By similarity
Motif35 – 439Effector region By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Lipidation2111S-geranylgeranyl cysteine By similarity
Lipidation2121S-geranylgeranyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
P05712 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: B68AAFF894DBE819

FASTA21223,536
        10         20         30         40         50         60 
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI DGKQIKLQIW 

        70         80         90        100        110        120 
DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK 

       130        140        150        160        170        180 
SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN 

       190        200        210 
EANGIKIGPQ HAATNASHGG NQGGQQAGGG CC 

« Hide

References

[1]"Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library."
Touchot N., Chardin P., Tavitian A.
Proc. Natl. Acad. Sci. U.S.A. 84:8210-8214(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02999 mRNA. Translation: AAA42007.1.
PIRB39963.
RefSeqNP_113906.1. NM_031718.1.
UniGeneRn.44916.

3D structure databases

ProteinModelPortalP05712.
SMRP05712. Positions 2-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP05712. 2 interactions.
MINTMINT-4542729.
STRING10116.ENSRNOP00000008522.

PTM databases

PhosphoSiteP05712.

2D gel databases

World-2DPAGE0004:P05712.

Proteomic databases

PaxDbP05712.
PRIDEP05712.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID65158.
KEGGrno:65158.
UCSCRGD:68323. rat.

Organism-specific databases

CTD5862.
RGD68323. Rab2a.

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidP05712.
KOK07877.
PhylomeDBP05712.

Gene expression databases

GenevestigatorP05712.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614017.

Entry information

Entry nameRAB2A_RAT
AccessionPrimary (citable) accession number: P05712
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families