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Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219GTPBy similarity
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTPBy similarity
Nucleotide bindingi149 – 1513GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTPase activity Source: UniProtKB
  3. GTP binding Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. Rab protein signal transduction Source: GO_Central
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68323. Rab2a.

Subcellular locationi

Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Lipid-anchor By similarity. Melanosome By similarity. Endoplasmic reticulum membrane By similarity; Lipid-anchor By similarity. Golgi apparatus membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum membrane Source: RGD
  3. Golgi membrane Source: RGD
  4. melanosome Source: UniProtKB-SubCell
  5. membrane Source: BHF-UCL
  6. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 212211Ras-related protein Rab-2APRO_0000121069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Lipidationi211 – 2111S-geranylgeranyl cysteineBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

PaxDbiP05712.
PRIDEiP05712.

2D gel databases

World-2DPAGE0004:P05712.

PTM databases

PhosphoSiteiP05712.

Expressioni

Gene expression databases

GenevestigatoriP05712.

Interactioni

Subunit structurei

Interacts with PRKCI.By similarity

Protein-protein interaction databases

IntActiP05712. 2 interactions.
MINTiMINT-4542729.
STRINGi10116.ENSRNOP00000008522.

Structurei

3D structure databases

ProteinModelPortaliP05712.
SMRiP05712. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1918Required for interaction with PRKCIBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05712.
KOiK07877.
PhylomeDBiP05712.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGG
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,536
Last modified:November 1, 1988 - v1
Checksum:iB68AAFF894DBE819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02999 mRNA. Translation: AAA42007.1.
PIRiB39963.
RefSeqiNP_113906.1. NM_031718.1.
UniGeneiRn.44916.

Genome annotation databases

GeneIDi65158.
KEGGirno:65158.
UCSCiRGD:68323. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02999 mRNA. Translation: AAA42007.1.
PIRiB39963.
RefSeqiNP_113906.1. NM_031718.1.
UniGeneiRn.44916.

3D structure databases

ProteinModelPortaliP05712.
SMRiP05712. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP05712. 2 interactions.
MINTiMINT-4542729.
STRINGi10116.ENSRNOP00000008522.

PTM databases

PhosphoSiteiP05712.

2D gel databases

World-2DPAGE0004:P05712.

Proteomic databases

PaxDbiP05712.
PRIDEiP05712.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi65158.
KEGGirno:65158.
UCSCiRGD:68323. rat.

Organism-specific databases

CTDi5862.
RGDi68323. Rab2a.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05712.
KOiK07877.
PhylomeDBiP05712.

Miscellaneous databases

NextBioi614017.

Gene expression databases

GenevestigatoriP05712.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library."
    Touchot N., Chardin P., Tavitian A.
    Proc. Natl. Acad. Sci. U.S.A. 84:8210-8214(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRAB2A_RAT
AccessioniPrimary (citable) accession number: P05712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 4, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.