Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 21GTPBy similarity9
Nucleotide bindingi61 – 65GTPBy similarity5
Nucleotide bindingi119 – 122GTPBy similarity4
Nucleotide bindingi149 – 151GTPBy similarity3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: RGD

GO - Biological processi

  • protein transport Source: UniProtKB-KW
  • Rab protein signal transduction Source: RGD
  • vesicle-mediated transport Source: UniProtKB-KW

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68323 Rab2a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001210692 – 212Ras-related protein Rab-2AAdd BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi211S-geranylgeranyl cysteineBy similarity1
Lipidationi212S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

PaxDbiP05712
PRIDEiP05712

2D gel databases

World-2DPAGE0004:P05712

PTM databases

iPTMnetiP05712
PhosphoSitePlusiP05712
SwissPalmiP05712

Interactioni

Subunit structurei

Interacts with PRKCI.By similarity

Protein-protein interaction databases

BioGridi249274, 1 interactor
IntActiP05712, 2 interactors
MINTiP05712
STRINGi10116.ENSRNOP00000008522

Structurei

3D structure databases

ProteinModelPortaliP05712
SMRiP05712
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 19Required for interaction with PRKCIBy similarityAdd BLAST18

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 43Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0098 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiP05712
KOiK07877
PhylomeDBiP05712

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05712-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW
110 120 130 140 150
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA
160 170 180 190 200
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGG
210
NQGGQQAGGG CC
Length:212
Mass (Da):23,536
Last modified:November 1, 1988 - v1
Checksum:iB68AAFF894DBE819
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02999 mRNA Translation: AAA42007.1
PIRiB39963
RefSeqiNP_113906.1, NM_031718.1
UniGeneiRn.44916

Genome annotation databases

GeneIDi65158
KEGGirno:65158
UCSCiRGD:68323 rat

Similar proteinsi

Entry informationi

Entry nameiRAB2A_RAT
AccessioniPrimary (citable) accession number: P05712
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health