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P05712

- RAB2A_RAT

UniProt

P05712 - RAB2A_RAT

Protein

Ras-related protein Rab-2A

Gene

Rab2a

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Required for protein transport from the endoplasmic reticulum to the Golgi complex.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 219GTPBy similarity
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi119 – 1224GTPBy similarity
    Nucleotide bindingi149 – 1513GTPBy similarity

    GO - Molecular functioni

    1. GDP binding Source: UniProtKB
    2. GTPase activity Source: UniProtKB
    3. GTP binding Source: UniProtKB

    GO - Biological processi

    1. GTP catabolic process Source: GOC
    2. protein transport Source: UniProtKB-KW
    3. Rab protein signal transduction Source: RGD
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-2A
    Gene namesi
    Name:Rab2a
    Synonyms:Rab2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi68323. Rab2a.

    Subcellular locationi

    Endoplasmic reticulum-Golgi intermediate compartment membrane By similarity; Lipid-anchor By similarity. Melanosome By similarity. Endoplasmic reticulum membrane By similarity; Lipid-anchor By similarity. Golgi apparatus membrane By similarity; Lipid-anchor By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RGD
    3. Golgi membrane Source: RGD
    4. melanosome Source: UniProtKB-SubCell
    5. membrane Source: BHF-UCL
    6. neuronal cell body Source: RGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 212211Ras-related protein Rab-2APRO_0000121069Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Lipidationi211 – 2111S-geranylgeranyl cysteineBy similarity
    Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiP05712.
    PRIDEiP05712.

    2D gel databases

    World-2DPAGE0004:P05712.

    PTM databases

    PhosphoSiteiP05712.

    Expressioni

    Gene expression databases

    GenevestigatoriP05712.

    Interactioni

    Subunit structurei

    Interacts with PRKCI.By similarity

    Protein-protein interaction databases

    IntActiP05712. 2 interactions.
    MINTiMINT-4542729.
    STRINGi10116.ENSRNOP00000008522.

    Structurei

    3D structure databases

    ProteinModelPortaliP05712.
    SMRiP05712. Positions 2-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 1918Required for interaction with PRKCIBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiP05712.
    KOiK07877.
    PhylomeDBiP05712.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P05712-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI    50
    DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW 100
    LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA 150
    KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGG 200
    NQGGQQAGGG CC 212
    Length:212
    Mass (Da):23,536
    Last modified:November 1, 1988 - v1
    Checksum:iB68AAFF894DBE819
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02999 mRNA. Translation: AAA42007.1.
    PIRiB39963.
    RefSeqiNP_113906.1. NM_031718.1.
    UniGeneiRn.44916.

    Genome annotation databases

    GeneIDi65158.
    KEGGirno:65158.
    UCSCiRGD:68323. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02999 mRNA. Translation: AAA42007.1 .
    PIRi B39963.
    RefSeqi NP_113906.1. NM_031718.1.
    UniGenei Rn.44916.

    3D structure databases

    ProteinModelPortali P05712.
    SMRi P05712. Positions 2-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P05712. 2 interactions.
    MINTi MINT-4542729.
    STRINGi 10116.ENSRNOP00000008522.

    PTM databases

    PhosphoSitei P05712.

    2D gel databases

    World-2DPAGE 0004:P05712.

    Proteomic databases

    PaxDbi P05712.
    PRIDEi P05712.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 65158.
    KEGGi rno:65158.
    UCSCi RGD:68323. rat.

    Organism-specific databases

    CTDi 5862.
    RGDi 68323. Rab2a.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi P05712.
    KOi K07877.
    PhylomeDBi P05712.

    Miscellaneous databases

    NextBioi 614017.

    Gene expression databases

    Genevestigatori P05712.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library."
      Touchot N., Chardin P., Tavitian A.
      Proc. Natl. Acad. Sci. U.S.A. 84:8210-8214(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiRAB2A_RAT
    AccessioniPrimary (citable) accession number: P05712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 122 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3