SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P05712

- RAB2A_RAT

UniProt

P05712 - RAB2A_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Ras-related protein Rab-2A
Gene
Rab2a, Rab2
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219GTP By similarity
Nucleotide bindingi61 – 655GTP By similarity
Nucleotide bindingi119 – 1224GTP By similarity
Nucleotide bindingi149 – 1513GTP By similarity

GO - Molecular functioni

  1. GDP binding Source: UniProtKB
  2. GTP binding Source: UniProtKB
  3. GTPase activity Source: UniProtKB

GO - Biological processi

  1. GTP catabolic process Source: GOC
  2. Rab protein signal transduction Source: RGD
  3. protein transport Source: UniProtKB-KW
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2A
Gene namesi
Name:Rab2a
Synonyms:Rab2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi68323. Rab2a.

Subcellular locationi

GO - Cellular componenti

  1. Golgi membrane Source: RGD
  2. endoplasmic reticulum membrane Source: RGD
  3. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  4. melanosome Source: UniProtKB-SubCell
  5. membrane Source: BHF-UCL
  6. neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 212211Ras-related protein Rab-2A
PRO_0000121069Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Lipidationi211 – 2111S-geranylgeranyl cysteine By similarity
Lipidationi212 – 2121S-geranylgeranyl cysteine By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

PaxDbiP05712.
PRIDEiP05712.

2D gel databases

World-2DPAGE0004:P05712.

PTM databases

PhosphoSiteiP05712.

Expressioni

Gene expression databases

GenevestigatoriP05712.

Interactioni

Subunit structurei

Interacts with PRKCI By similarity.

Protein-protein interaction databases

IntActiP05712. 2 interactions.
MINTiMINT-4542729.
STRINGi10116.ENSRNOP00000008522.

Structurei

3D structure databases

ProteinModelPortaliP05712.
SMRiP05712. Positions 2-170.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 1918Required for interaction with PRKCI By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector region By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiP05712.
KOiK07877.
PhylomeDBiP05712.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05712-1 [UniParc]FASTAAdd to Basket

« Hide

MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTMG VEFGARMITI    50
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW 100
LEDARQHSNS NMVIMLIGNK SDLESRREVK KEEGEAFARE HGLIFMETSA 150
KTASNVEEAF INTAKEIYEK IQEGVFDINN EANGIKIGPQ HAATNASHGG 200
NQGGQQAGGG CC 212
Length:212
Mass (Da):23,536
Last modified:November 1, 1988 - v1
Checksum:iB68AAFF894DBE819
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02999 mRNA. Translation: AAA42007.1.
PIRiB39963.
RefSeqiNP_113906.1. NM_031718.1.
UniGeneiRn.44916.

Genome annotation databases

GeneIDi65158.
KEGGirno:65158.
UCSCiRGD:68323. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02999 mRNA. Translation: AAA42007.1 .
PIRi B39963.
RefSeqi NP_113906.1. NM_031718.1.
UniGenei Rn.44916.

3D structure databases

ProteinModelPortali P05712.
SMRi P05712. Positions 2-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P05712. 2 interactions.
MINTi MINT-4542729.
STRINGi 10116.ENSRNOP00000008522.

PTM databases

PhosphoSitei P05712.

2D gel databases

World-2DPAGE 0004:P05712.

Proteomic databases

PaxDbi P05712.
PRIDEi P05712.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 65158.
KEGGi rno:65158.
UCSCi RGD:68323. rat.

Organism-specific databases

CTDi 5862.
RGDi 68323. Rab2a.

Phylogenomic databases

eggNOGi COG1100.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi P05712.
KOi K07877.
PhylomeDBi P05712.

Miscellaneous databases

NextBioi 614017.

Gene expression databases

Genevestigatori P05712.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library."
    Touchot N., Chardin P., Tavitian A.
    Proc. Natl. Acad. Sci. U.S.A. 84:8210-8214(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiRAB2A_RAT
AccessioniPrimary (citable) accession number: P05712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi