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Protein

Porin P

Gene

oprP

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Anion specific, the binding site has higher affinity for phosphate than chloride ions. Porin O has a higher affinity for polyphosphates (tripolyphosphate and pyrophosphate) while porin P has a higher affinity for orthophosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi1.B.5.1.1. the pseudomonas oprp porin (pop) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Porin P
Alternative name(s):
Outer membrane protein D1
Gene namesi
Name:oprP
Ordered Locus Names:PA3279
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3279.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 291 PublicationAdd BLAST29
ChainiPRO_000002521230 – 440Porin PAdd BLAST411

Proteomic databases

PaxDbiP05695.

Interactioni

Subunit structurei

Homotrimer. Trimer pore size is 0.6 nM.

Protein-protein interaction databases

DIPiDIP-29262N.
STRINGi208964.PA3279.

Structurei

Secondary structure

1440
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi39 – 42Combined sources4
Beta strandi44 – 51Combined sources8
Beta strandi57 – 73Combined sources17
Beta strandi76 – 80Combined sources5
Beta strandi82 – 98Combined sources17
Turni99 – 101Combined sources3
Beta strandi102 – 109Combined sources8
Beta strandi114 – 116Combined sources3
Turni117 – 119Combined sources3
Beta strandi122 – 129Combined sources8
Turni131 – 134Combined sources4
Beta strandi135 – 141Combined sources7
Helixi148 – 151Combined sources4
Turni154 – 156Combined sources3
Beta strandi158 – 161Combined sources4
Helixi164 – 168Combined sources5
Helixi170 – 173Combined sources4
Beta strandi176 – 186Combined sources11
Turni187 – 189Combined sources3
Beta strandi190 – 203Combined sources14
Beta strandi208 – 223Combined sources16
Beta strandi226 – 238Combined sources13
Helixi255 – 257Combined sources3
Beta strandi260 – 262Combined sources3
Helixi266 – 268Combined sources3
Beta strandi283 – 298Combined sources16
Beta strandi301 – 314Combined sources14
Beta strandi321 – 333Combined sources13
Turni343 – 346Combined sources4
Turni356 – 358Combined sources3
Beta strandi360 – 374Combined sources15
Beta strandi382 – 384Combined sources3
Beta strandi389 – 401Combined sources13
Beta strandi403 – 420Combined sources18
Beta strandi428 – 440Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O4VX-ray1.94A/B/C30-440[»]
ProteinModelPortaliP05695.
SMRiP05695.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05695.

Family & Domainsi

Sequence similaritiesi

Belongs to the OprO/OprP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4108SDF. Bacteria.
COG3746. LUCA.
HOGENOMiHOG000247361.
InParanoidiP05695.
KOiK07221.
OMAiFRWGVSA.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR010870. Porin_O/P.
[Graphical view]
PfamiPF07396. Porin_O_P. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIRRHSCKGV GSSVAWSLLG LAISAQSLAG TVTTDGADIV IKTKGGLEVA
60 70 80 90 100
TTDKEFSFKL GGRLQADYGR FDGYYTNNGN TADAAYFRRA YLEFGGTAYR
110 120 130 140 150
DWKYQINYDL SRNVGNDSAG YFDEASVTYT GFNPVNLKFG RFYTDFGLEK
160 170 180 190 200
ATSSKWVTAL ERNLTYDIAD WVNDNVGTGI QASSVVGGMA FLSGSVFSEN
210 220 230 240 250
NNDTDGDSVK RYNLRGVFAP LHEPGNVVHL GLQYAYRDLE DSAVDTRIRP
260 270 280 290 300
RMGMRGVSTN GGNDAGSNGN RGLFGGSSAV EGLWKDDSVW GLEGAWALGA
310 320 330 340 350
FSAQAEYLRR TVKAERDRED LKASGYYAQL AYTLTGEPRL YKLDGAKFDT
360 370 380 390 400
IKPENKEIGA WELFYRYDSI KVEDDNIVVD SATREVGDAK GKTHTLGVNW
410 420 430 440
YANEAVKVSA NYVKAKTDKI SNANGDDSGD GLVMRLQYVF
Length:440
Mass (Da):48,211
Last modified:December 8, 2000 - v3
Checksum:i840243D11CDC7C26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208S → T in CAA37395 (PubMed:1697017).Curated1
Sequence conflicti208S → T in AAA25913 (PubMed:1697017).Curated1
Sequence conflicti394 – 395HT → RA in CAA37395 (PubMed:1697017).Curated2
Sequence conflicti394 – 395HT → RA in AAA25913 (PubMed:1697017).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53313 Genomic DNA. Translation: CAA37395.1.
M86648 Genomic DNA. Translation: AAA25913.1.
AE004091 Genomic DNA. Translation: AAG06667.1.
Y00553 Genomic DNA. Translation: CAA68631.1.
PIRiF83235.
S11793.
RefSeqiNP_251969.1. NC_002516.2.
WP_003119678.1. NZ_ASJY01000524.1.

Genome annotation databases

EnsemblBacteriaiAAG06667; AAG06667; PA3279.
GeneIDi882442.
KEGGipae:PA3279.
PATRICi19841139. VBIPseAer58763_3428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X53313 Genomic DNA. Translation: CAA37395.1.
M86648 Genomic DNA. Translation: AAA25913.1.
AE004091 Genomic DNA. Translation: AAG06667.1.
Y00553 Genomic DNA. Translation: CAA68631.1.
PIRiF83235.
S11793.
RefSeqiNP_251969.1. NC_002516.2.
WP_003119678.1. NZ_ASJY01000524.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O4VX-ray1.94A/B/C30-440[»]
ProteinModelPortaliP05695.
SMRiP05695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29262N.
STRINGi208964.PA3279.

Protein family/group databases

TCDBi1.B.5.1.1. the pseudomonas oprp porin (pop) family.

Proteomic databases

PaxDbiP05695.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06667; AAG06667; PA3279.
GeneIDi882442.
KEGGipae:PA3279.
PATRICi19841139. VBIPseAer58763_3428.

Organism-specific databases

PseudoCAPiPA3279.

Phylogenomic databases

eggNOGiENOG4108SDF. Bacteria.
COG3746. LUCA.
HOGENOMiHOG000247361.
InParanoidiP05695.
KOiK07221.
OMAiFRWGVSA.

Miscellaneous databases

EvolutionaryTraceiP05695.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR010870. Porin_O/P.
[Graphical view]
PfamiPF07396. Porin_O_P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPORP_PSEAE
AccessioniPrimary (citable) accession number: P05695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: December 8, 2000
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.