Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vitellogenin-2

Gene

vit-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

Keywordsi

Molecular functionStorage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-2
Gene namesi
Name:vit-2
ORF Names:C42D8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC42D8.2a ; CE06950 ; WBGene00006926 ; vit-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000004153316 – 1613Vitellogenin-2Add BLAST1598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1268N-linked (GlcNAc...) asparagine3 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP05690
PaxDbiP05690
PeptideAtlasiP05690
PRIDEiP05690

PTM databases

iPTMnetiP05690

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Gene expression databases

BgeeiWBGene00006926
ExpressionAtlasiP05690 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi45716, 3 interactors
DIPiDIP-27283N
IntActiP05690, 3 interactors
STRINGi6239.C42D8.2a

Structurei

3D structure databases

ProteinModelPortaliP05690
SMRiP05690
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 687VitellogeninPROSITE-ProRule annotationAdd BLAST664
Domaini1308 – 1510VWFDPROSITE-ProRule annotationAdd BLAST203

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338 Eukaryota
ENOG411104F LUCA
GeneTreeiENSGT00530000064273
HOGENOMiHOG000004768
InParanoidiP05690
OMAiKIRFTCL
OrthoDBiEOG091G07SB
PhylomeDBiP05690

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR015816 Vitellinogen_b-sht_N
IPR015255 Vitellinogen_open_b-sht
IPR001846 VWF_type-D
PfamiView protein in Pfam
PF09172 DUF1943, 1 hit
PF01347 Vitellogenin_N, 1 hit
PF00094 VWD, 1 hit
SMARTiView protein in SMART
SM01169 DUF1943, 1 hit
SM00638 LPD_N, 1 hit
SM00216 VWD, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 2 hits
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
PS51233 VWFD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIIIASLV ALALASSPAF ERTFEPKTDY HYKFDGLVLS GLPSASSELS
60 70 80 90 100
QSRISARARI QAVDDRYIHL QLVNIRMAAS HLPESEQMPS LNSMEQRELS
110 120 130 140 150
EEYKQMLELP LRAQLRNGLI SELQFDKEDA EWSKNMKRAV VNMISFNPIA
160 170 180 190 200
PRNEIEKIES SYDKEEQSEE NTSFFTNEKT LEGDCQVAYT VIREQKKTII
210 220 230 240 250
TKSINFDKCT ERSEIAYGLR YSSECPECEK DTELIRPQTV YTYVLENEEL
260 270 280 290 300
KESEVRSLYT VNVNGQEVMK TETRSKLVLE ENHSIKSHIK KVNGEKESII
310 320 330 340 350
YSSRWEQLVE DFFKNGDKAE FAPFEKFPLD KKMHLIKTIT EQIQEVENNM
360 370 380 390 400
PETSHFLARL VRIFRTTSTS QLKEIHETLY VKADKKIQSL MEHALAIAGT
410 420 430 440 450
KNTIQHILVH MENEDILPLG QILKTIQETP FPSQSIAEAL IKFAESRVAK
460 470 480 490 500
NNLVVRQAAW LAAGSVVRGI VDYKNIRPLV REDKRELKEK FLRVFMQQYK
510 520 530 540 550
DAETTYEKIL ALKTIGNAGL DISVNQLNEI IVDKRQPLPV RKEAIDALRL
560 570 580 590 600
LKDTMPRKIQ KVLLPIYKNR QYEPEIRMLA LWRMMHTRPE ESLLVQVVSQ
610 620 630 640 650
MEKETNQQVA ALTHQMIRHF AMSTNPCYQR VAIVCSKVLS FTRYQPQEQM
660 670 680 690 700
IASSYAQLPL FLQNSFSGAQ FDFAAIFEKN SFLPKDLHAS LDAVFGGNWN
710 720 730 740 750
KYFAQIGFSQ QHMDKYVQMA LEKLESLEKE STTVVRGRRI QTGIKLLKEL
760 770 780 790 800
AQKMNIRARP ATYTEKDAFA MVYLRYKDMD YAFLPIDRQL VENLIEKFTS
810 820 830 840 850
NGKVQFSEIR RLLNQELEFE THHAAYFYEA IRKFPTTLGL PLTISGKIPT
860 870 880 890 900
VISAEGQFSL ELEGTELRLT VEARPSVAAT HVYEMRMFTP LFEQGVKSVQ
910 920 930 940 950
SVRAYTPIKI QAVAGMKRNF EIVYKVVVPE NQKSIVSLTT RPVVFLRFPG
960 970 980 990 1000
FSKFEYIEAE ERTVVVPQWQ QKTQEIEKVF NFLGLEVSTR GNILNQHTLE
1010 1020 1030 1040 1050
NWLLAEQDFE VSVENKNRPA EFTARLTVGQ LEKTELSQIK YNKIFEKEFE
1060 1070 1080 1090 1100
LEQENTESRR EYFNKMVKNI QKEQGYKSVI SLKLEAPRDY TMNTELTTVC
1110 1120 1130 1140 1150
DKQVRMCQWE VEIRRSPILE ETKEWTLRSQ LLVVRPEMPS SLRQLRDQPH
1160 1170 1180 1190 1200
REVQLSLTST WGSQKKSEVT VNAQLQQSKE QKKYERNMDR QFNGMPEYEL
1210 1220 1230 1240 1250
LIKAARLNQI NAVAEYKLTR ETEQVLARYF DLVKTYNYWT VSSRPENNEN
1260 1270 1280 1290 1300
DRVVVQLTVE PMSRQYVNIT MQSPMERIEL KNVQVPRVYL PSIAQRSVKH
1310 1320 1330 1340 1350
QLTEASGSVC KVQKNQIRTF DDVLYNTPLT TCYSLIAKDC SEEPTFAVLS
1360 1370 1380 1390 1400
KKTEKNSEEM IIKVIRGEQE IVAQLQNEEI RVKVDGKKIQ SEDYSAYQIE
1410 1420 1430 1440 1450
RLGESAIVIE LPEGEVRFDG YTIKTQLPSY SRKNQLCGLC GNNDDESTNE
1460 1470 1480 1490 1500
FYTSDNTETE DIEEFHRSYL LKNEECEAEE ERLSEKKNYR KYERDEEQSD
1510 1520 1530 1540 1550
EYSSEETYDY EQENTKKSQK NQRSQKKSDL VEKTQIKEFS HRICFSVEPV
1560 1570 1580 1590 1600
AECRRGYEVE QQQQRKIRFT CLQRHNRDAS RLLKESRQQP LQLDDYPVSF
1610
VESVKVPTAC VAY
Length:1,613
Mass (Da):187,722
Last modified:July 22, 2008 - v5
Checksum:iCD89484814D516A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti656A → V in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti660L → R in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti759R → C in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1063 – 1068FNKMVK → STRWST in CAA39669 (PubMed:1904098).Curated6
Sequence conflicti1127L → V in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1224Q → H in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1302L → F in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1310C → W in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1313 – 1314QK → KR in CAA39669 (PubMed:1904098).Curated2
Sequence conflicti1426 – 1429QLPS → KIPY in CAA39669 (PubMed:1904098).Curated4
Sequence conflicti1447 – 1451STNEF → VHQRV in CAA39669 (PubMed:1904098).Curated5
Sequence conflicti1472K → R in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1572L → W in CAA39669 (PubMed:1904098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56212 Genomic DNA Translation: CAA39669.1
FO080659 Genomic DNA Translation: CCD65563.1
M10105 Genomic DNA Translation: AAA28162.1
X02753 Genomic DNA Translation: CAA26530.1
PIRiA43081
F89528
RefSeqiNP_508868.1, NM_076467.5
UniGeneiCel.16869

Genome annotation databases

EnsemblMetazoaiC42D8.2a.1; C42D8.2a.1; WBGene00006926
C42D8.2a.2; C42D8.2a.2; WBGene00006926
GeneIDi180781
KEGGicel:CELE_C42D8.2
UCSCiC42D8.2a.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiVIT2_CAEEL
AccessioniPrimary (citable) accession number: P05690
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 22, 2008
Last modified: May 23, 2018
This is version 138 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health