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Protein

Vitellogenin-2

Gene

vit-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Storage protein

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin-2
Gene namesi
Name:vit-2
ORF Names:C42D8.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiC42D8.2a; CE06950; WBGene00006926; vit-2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasmic vesicle Source: WormBase
  • extracellular region Source: UniProtKB-SubCell
  • vesicle lumen Source: WormBase
  • yolk granule Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000004153316 – 1613Vitellogenin-2Add BLAST1598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi1268N-linked (GlcNAc...)3 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiP05690.
PaxDbiP05690.
PeptideAtlasiP05690.
PRIDEiP05690.

PTM databases

iPTMnetiP05690.

Expressioni

Tissue specificityi

Synthesized in Caenorhabditis only by 32 cells building the intestine of adult hermaphroditic individuals; they are cotranslationally secreted into the body cavity and subsequently taken up by the gonad.

Gene expression databases

BgeeiWBGene00006926.
ExpressionAtlasiP05690. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi45716. 3 interactors.
DIPiDIP-27283N.
IntActiP05690. 3 interactors.
MINTiMINT-1123593.
STRINGi6239.C42D8.2a.

Structurei

3D structure databases

ProteinModelPortaliP05690.
SMRiP05690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 687VitellogeninPROSITE-ProRule annotationAdd BLAST664
Domaini1308 – 1510VWFDPROSITE-ProRule annotationAdd BLAST203

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation
Contains 1 VWFD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP05690.
OMAiKIRFTCL.
OrthoDBiEOG091G07SB.
PhylomeDBiP05690.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSIIIASLV ALALASSPAF ERTFEPKTDY HYKFDGLVLS GLPSASSELS
60 70 80 90 100
QSRISARARI QAVDDRYIHL QLVNIRMAAS HLPESEQMPS LNSMEQRELS
110 120 130 140 150
EEYKQMLELP LRAQLRNGLI SELQFDKEDA EWSKNMKRAV VNMISFNPIA
160 170 180 190 200
PRNEIEKIES SYDKEEQSEE NTSFFTNEKT LEGDCQVAYT VIREQKKTII
210 220 230 240 250
TKSINFDKCT ERSEIAYGLR YSSECPECEK DTELIRPQTV YTYVLENEEL
260 270 280 290 300
KESEVRSLYT VNVNGQEVMK TETRSKLVLE ENHSIKSHIK KVNGEKESII
310 320 330 340 350
YSSRWEQLVE DFFKNGDKAE FAPFEKFPLD KKMHLIKTIT EQIQEVENNM
360 370 380 390 400
PETSHFLARL VRIFRTTSTS QLKEIHETLY VKADKKIQSL MEHALAIAGT
410 420 430 440 450
KNTIQHILVH MENEDILPLG QILKTIQETP FPSQSIAEAL IKFAESRVAK
460 470 480 490 500
NNLVVRQAAW LAAGSVVRGI VDYKNIRPLV REDKRELKEK FLRVFMQQYK
510 520 530 540 550
DAETTYEKIL ALKTIGNAGL DISVNQLNEI IVDKRQPLPV RKEAIDALRL
560 570 580 590 600
LKDTMPRKIQ KVLLPIYKNR QYEPEIRMLA LWRMMHTRPE ESLLVQVVSQ
610 620 630 640 650
MEKETNQQVA ALTHQMIRHF AMSTNPCYQR VAIVCSKVLS FTRYQPQEQM
660 670 680 690 700
IASSYAQLPL FLQNSFSGAQ FDFAAIFEKN SFLPKDLHAS LDAVFGGNWN
710 720 730 740 750
KYFAQIGFSQ QHMDKYVQMA LEKLESLEKE STTVVRGRRI QTGIKLLKEL
760 770 780 790 800
AQKMNIRARP ATYTEKDAFA MVYLRYKDMD YAFLPIDRQL VENLIEKFTS
810 820 830 840 850
NGKVQFSEIR RLLNQELEFE THHAAYFYEA IRKFPTTLGL PLTISGKIPT
860 870 880 890 900
VISAEGQFSL ELEGTELRLT VEARPSVAAT HVYEMRMFTP LFEQGVKSVQ
910 920 930 940 950
SVRAYTPIKI QAVAGMKRNF EIVYKVVVPE NQKSIVSLTT RPVVFLRFPG
960 970 980 990 1000
FSKFEYIEAE ERTVVVPQWQ QKTQEIEKVF NFLGLEVSTR GNILNQHTLE
1010 1020 1030 1040 1050
NWLLAEQDFE VSVENKNRPA EFTARLTVGQ LEKTELSQIK YNKIFEKEFE
1060 1070 1080 1090 1100
LEQENTESRR EYFNKMVKNI QKEQGYKSVI SLKLEAPRDY TMNTELTTVC
1110 1120 1130 1140 1150
DKQVRMCQWE VEIRRSPILE ETKEWTLRSQ LLVVRPEMPS SLRQLRDQPH
1160 1170 1180 1190 1200
REVQLSLTST WGSQKKSEVT VNAQLQQSKE QKKYERNMDR QFNGMPEYEL
1210 1220 1230 1240 1250
LIKAARLNQI NAVAEYKLTR ETEQVLARYF DLVKTYNYWT VSSRPENNEN
1260 1270 1280 1290 1300
DRVVVQLTVE PMSRQYVNIT MQSPMERIEL KNVQVPRVYL PSIAQRSVKH
1310 1320 1330 1340 1350
QLTEASGSVC KVQKNQIRTF DDVLYNTPLT TCYSLIAKDC SEEPTFAVLS
1360 1370 1380 1390 1400
KKTEKNSEEM IIKVIRGEQE IVAQLQNEEI RVKVDGKKIQ SEDYSAYQIE
1410 1420 1430 1440 1450
RLGESAIVIE LPEGEVRFDG YTIKTQLPSY SRKNQLCGLC GNNDDESTNE
1460 1470 1480 1490 1500
FYTSDNTETE DIEEFHRSYL LKNEECEAEE ERLSEKKNYR KYERDEEQSD
1510 1520 1530 1540 1550
EYSSEETYDY EQENTKKSQK NQRSQKKSDL VEKTQIKEFS HRICFSVEPV
1560 1570 1580 1590 1600
AECRRGYEVE QQQQRKIRFT CLQRHNRDAS RLLKESRQQP LQLDDYPVSF
1610
VESVKVPTAC VAY
Length:1,613
Mass (Da):187,722
Last modified:July 22, 2008 - v5
Checksum:iCD89484814D516A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti656A → V in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti660L → R in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti759R → C in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1063 – 1068FNKMVK → STRWST in CAA39669 (PubMed:1904098).Curated6
Sequence conflicti1127L → V in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1224Q → H in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1302L → F in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1310C → W in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1313 – 1314QK → KR in CAA39669 (PubMed:1904098).Curated2
Sequence conflicti1426 – 1429QLPS → KIPY in CAA39669 (PubMed:1904098).Curated4
Sequence conflicti1447 – 1451STNEF → VHQRV in CAA39669 (PubMed:1904098).Curated5
Sequence conflicti1472K → R in CAA39669 (PubMed:1904098).Curated1
Sequence conflicti1572L → W in CAA39669 (PubMed:1904098).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56212 Genomic DNA. Translation: CAA39669.1.
FO080659 Genomic DNA. Translation: CCD65563.1.
M10105 Genomic DNA. Translation: AAA28162.1.
X02753 Genomic DNA. Translation: CAA26530.1.
PIRiA43081.
F89528.
RefSeqiNP_508868.1. NM_076467.5.
UniGeneiCel.16869.

Genome annotation databases

EnsemblMetazoaiC42D8.2a.1; C42D8.2a.1; WBGene00006926.
C42D8.2a.2; C42D8.2a.2; WBGene00006926.
GeneIDi180781.
KEGGicel:CELE_C42D8.2.
UCSCiC42D8.2a.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56212 Genomic DNA. Translation: CAA39669.1.
FO080659 Genomic DNA. Translation: CCD65563.1.
M10105 Genomic DNA. Translation: AAA28162.1.
X02753 Genomic DNA. Translation: CAA26530.1.
PIRiA43081.
F89528.
RefSeqiNP_508868.1. NM_076467.5.
UniGeneiCel.16869.

3D structure databases

ProteinModelPortaliP05690.
SMRiP05690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45716. 3 interactors.
DIPiDIP-27283N.
IntActiP05690. 3 interactors.
MINTiMINT-1123593.
STRINGi6239.C42D8.2a.

PTM databases

iPTMnetiP05690.

Proteomic databases

EPDiP05690.
PaxDbiP05690.
PeptideAtlasiP05690.
PRIDEiP05690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC42D8.2a.1; C42D8.2a.1; WBGene00006926.
C42D8.2a.2; C42D8.2a.2; WBGene00006926.
GeneIDi180781.
KEGGicel:CELE_C42D8.2.
UCSCiC42D8.2a.1. c. elegans.

Organism-specific databases

CTDi180781.
WormBaseiC42D8.2a; CE06950; WBGene00006926; vit-2.

Phylogenomic databases

eggNOGiKOG4338. Eukaryota.
ENOG411104F. LUCA.
GeneTreeiENSGT00530000064273.
HOGENOMiHOG000004768.
InParanoidiP05690.
OMAiKIRFTCL.
OrthoDBiEOG091G07SB.
PhylomeDBiP05690.

Miscellaneous databases

PROiP05690.

Gene expression databases

BgeeiWBGene00006926.
ExpressionAtlasiP05690. baseline and differential.

Family and domain databases

Gene3Di1.25.10.20. 1 hit.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
[Graphical view]
PfamiPF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
[Graphical view]
SMARTiSM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SM00216. VWD. 1 hit.
[Graphical view]
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIT2_CAEEL
AccessioniPrimary (citable) accession number: P05690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 128 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.