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Protein

Cathepsin Z

Gene

CTSZ

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity.By similarity

Catalytic activityi

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei93 – 931PROSITE-ProRule annotation
Active sitei242 – 2421PROSITE-ProRule annotation
Active sitei262 – 2621PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDAi3.4.18.1. 908.

Protein family/group databases

MEROPSiC01.013.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin Z (EC:3.4.18.1)
Gene namesi
Name:CTSZ
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Propeptidei25 – 6238Activation peptideBy similarityPRO_0000284523Add
BLAST
Chaini63 – 304242Cathepsin ZPRO_0000050537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi90 ↔ 133By similarity
Disulfide bondi127 ↔ 165By similarity
Disulfide bondi155 ↔ 171By similarity
Disulfide bondi174 ↔ 180By similarity
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence analysis
Disulfide bondi215 ↔ 297By similarity
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP05689.
PRIDEiP05689.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025007.

Structurei

3D structure databases

ProteinModelPortaliP05689.
SMRiP05689. Positions 31-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000264454.
HOVERGENiHBG004456.
InParanoidiP05689.
KOiK08568.

Family and domain databases

InterProiIPR033157. Cathepsin_X.
IPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF377. PTHR12411:SF377. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSGPLVPP LLLLLVLLAG AARAGLHFRP GRGCYRPLRG DRLTQLGRRT
60 70 80 90 100
YPRPHEYLSP SDLPKSWDWR NVNGVNYASV TRNQHIPQYC GSCWAHGSTS
110 120 130 140 150
AMADRINIKR KGAWPSTLLS VQHVIDCGDA GSCEGGNDLP VWEYAHRHGI
160 170 180 190 200
PDETCNNYQA KDQECDKFNQ CGTCTEFKEC HVIKNYTLWK VGDYGSLSGR
210 220 230 240 250
EKMMAEIYTN GPISCGIMAT EKMSNYTGGI YSEYNDQAFI NHIVSVAGWG
260 270 280 290 300
VSDGMEYWIV RNSWGEPWGE HGWMRIVTST YKGGEGARYN LAIEESCTFG

DPIV
Length:304
Mass (Da):33,886
Last modified:April 17, 2007 - v2
Checksum:iC283E2F0DBC5855E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122603 mRNA. Translation: AAI22604.1.
X01809 mRNA. Translation: CAA25952.1.
PIRiA29172.
RefSeqiNP_001071303.1. NM_001077835.1.
UniGeneiBt.4902.

Genome annotation databases

GeneIDi404187.
KEGGibta:404187.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122603 mRNA. Translation: AAI22604.1.
X01809 mRNA. Translation: CAA25952.1.
PIRiA29172.
RefSeqiNP_001071303.1. NM_001077835.1.
UniGeneiBt.4902.

3D structure databases

ProteinModelPortaliP05689.
SMRiP05689. Positions 31-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000025007.

Protein family/group databases

MEROPSiC01.013.

Proteomic databases

PaxDbiP05689.
PRIDEiP05689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi404187.
KEGGibta:404187.

Organism-specific databases

CTDi1522.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000264454.
HOVERGENiHBG004456.
InParanoidiP05689.
KOiK08568.

Enzyme and pathway databases

BRENDAi3.4.18.1. 908.

Family and domain databases

InterProiIPR033157. Cathepsin_X.
IPR025661. Pept_asp_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PTHR12411:SF377. PTHR12411:SF377. 1 hit.
PfamiPF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00640. THIOL_PROTEASE_ASN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.
  2. "Molecular cloning of a bovine cathepsin."
    Gay N.J., Walker J.E.
    Biochem. J. 225:707-712(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-304.
  3. "Cloning of a bovine protein homologous with cysteine proteinases and identification of the gene."
    Salvesen G., Gay N.J., Walker J.E.
    (In) Turk V. (eds.); Cysteine proteinases and their inhibitors, pp.55-62, Walter de Gruyter, Berlin and New York (1986)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 232-304.

Entry informationi

Entry nameiCATZ_BOVIN
AccessioniPrimary (citable) accession number: P05689
Secondary accession number(s): Q0IIK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 17, 2007
Last modified: June 8, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.