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P05675

- CPDA_SYNP6

UniProt

P05675 - CPDA_SYNP6

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 2 (01 Mar 2005)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi19 – 191Metal cation 1UniRule annotation
    Metal bindingi21 – 211Metal cation 1UniRule annotation
    Binding sitei21 – 211cAMPUniRule annotation
    Metal bindingi59 – 591Metal cation 1UniRule annotation
    Metal bindingi59 – 591Metal cation 2UniRule annotation
    Binding sitei59 – 591cAMPUniRule annotation
    Metal bindingi89 – 891Metal cation 2UniRule annotation
    Metal bindingi157 – 1571Metal cation 2UniRule annotation
    Metal bindingi196 – 1961Metal cation 2UniRule annotation
    Metal bindingi198 – 1981Metal cation 1UniRule annotation
    Binding sitei198 – 1981cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSELO269084:GCDQ-960-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:syc0937_d
    OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
    Taxonomic identifieri269084 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000001175: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2552553',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000066100Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi269084.syc0937_d.

    Structurei

    3D structure databases

    ProteinModelPortaliP05675.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000238351.
    KOiK03651.
    OMAiWQIIMLD.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P05675-1 [UniParc]FASTAAdd to Basket

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    MVEDFAGDAM TLSIAQITDL HLLVDPQAAL RGCVTTPRAA AVFGNLKQRS    50
    PDLLLLSGDL SEDGSPASYE RLRDWVEELG CPAIAIAGNH DQPERLTEIC 100
    GRSPFMGEPV YSIQGWRIIA LDSYQPKRID GRLRGDQLDW LDQRLGEDSS 150
    PTLLMLHHPP VLIGVTKMDA IGLKDGPEFL EVIAHHQQVR LVLSGHAHQA 200
    FIQGRGLTTF LGCPATAMQF DQPELPAGWR SLELEPDGSW RSQIHWVDTD 250
    SIHFA 255
    Length:255
    Mass (Da):28,172
    Last modified:March 1, 2005 - v2
    Checksum:i1290DCCF13D726E6
    GO

    Sequence cautioni

    The sequence CAA27241.1 differs from that shown. Reason: Frameshift at position 102.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441G → A in CAA27241. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03538 Genomic DNA. Translation: CAA27240.1. Frameshift.
    X03538 Genomic DNA. Translation: CAA27241.1. Frameshift.
    AP008231 Genomic DNA. Translation: BAD79127.1.
    PIRiS10913.
    S10914.
    RefSeqiWP_011243249.1. NC_006576.1.
    YP_171647.1. NC_006576.1.

    Genome annotation databases

    EnsemblBacteriaiBAD79127; BAD79127; syc0937_d.
    GeneIDi3198083.
    KEGGisyc:syc0937_d.
    PATRICi32487662. VBISynElo117686_1092.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X03538 Genomic DNA. Translation: CAA27240.1 . Frameshift.
    X03538 Genomic DNA. Translation: CAA27241.1 . Frameshift.
    AP008231 Genomic DNA. Translation: BAD79127.1 .
    PIRi S10913.
    S10914.
    RefSeqi WP_011243249.1. NC_006576.1.
    YP_171647.1. NC_006576.1.

    3D structure databases

    ProteinModelPortali P05675.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 269084.syc0937_d.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD79127 ; BAD79127 ; syc0937_d .
    GeneIDi 3198083.
    KEGGi syc:syc0937_d.
    PATRICi 32487662. VBISynElo117686_1092.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000238351.
    KOi K03651.
    OMAi WQIIMLD.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci SELO269084:GCDQ-960-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the promoter region in the rrnA operon from a blue-green alga, Anacystis nidulans 6301."
      Kumano M., Tomioka N., Shinozaki K., Sugiura M.
      Mol. Gen. Genet. 202:173-178(1986)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.
    2. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
      Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
      Photosyn. Res. 93:55-67(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

    Entry informationi

    Entry nameiCPDA_SYNP6
    AccessioniPrimary (citable) accession number: P05675
    Secondary accession number(s): P05677, Q5N3J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: March 1, 2005
    Last modified: October 1, 2014
    This is version 80 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3