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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Synechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi19 – 191Metal cation 1UniRule annotation
Metal bindingi21 – 211Metal cation 1UniRule annotation
Binding sitei21 – 211cAMPUniRule annotation
Metal bindingi59 – 591Metal cation 1UniRule annotation
Metal bindingi59 – 591Metal cation 2UniRule annotation
Binding sitei59 – 591cAMPUniRule annotation
Metal bindingi89 – 891Metal cation 2UniRule annotation
Metal bindingi157 – 1571Metal cation 2UniRule annotation
Metal bindingi196 – 1961Metal cation 2UniRule annotation
Metal bindingi198 – 1981Metal cation 1UniRule annotation
Binding sitei198 – 1981cAMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902cAMPUniRule annotation

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-960-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:syc0937_d
OrganismiSynechococcus sp. (strain ATCC 27144 / PCC 6301 / SAUG 1402/1) (Anacystis nidulans)
Taxonomic identifieri269084 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000001175 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2552553',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000066100Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi269084.syc0937_d.

Structurei

3D structure databases

ProteinModelPortaliP05675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

P05675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEDFAGDAM TLSIAQITDL HLLVDPQAAL RGCVTTPRAA AVFGNLKQRS
60 70 80 90 100
PDLLLLSGDL SEDGSPASYE RLRDWVEELG CPAIAIAGNH DQPERLTEIC
110 120 130 140 150
GRSPFMGEPV YSIQGWRIIA LDSYQPKRID GRLRGDQLDW LDQRLGEDSS
160 170 180 190 200
PTLLMLHHPP VLIGVTKMDA IGLKDGPEFL EVIAHHQQVR LVLSGHAHQA
210 220 230 240 250
FIQGRGLTTF LGCPATAMQF DQPELPAGWR SLELEPDGSW RSQIHWVDTD

SIHFA
Length:255
Mass (Da):28,172
Last modified:February 28, 2005 - v2
Checksum:i1290DCCF13D726E6
GO

Sequence cautioni

The sequence CAA27241.1 differs from that shown. Reason: Frameshift at position 102. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441G → A in CAA27241 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03538 Genomic DNA. Translation: CAA27240.1. Frameshift.
X03538 Genomic DNA. Translation: CAA27241.1. Frameshift.
AP008231 Genomic DNA. Translation: BAD79127.1.
PIRiS10913.
S10914.
RefSeqiWP_011243249.1. NC_006576.1.
YP_171647.1. NC_006576.1.

Genome annotation databases

EnsemblBacteriaiBAD79127; BAD79127; syc0937_d.
KEGGisyc:syc0937_d.
PATRICi32487662. VBISynElo117686_1092.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03538 Genomic DNA. Translation: CAA27240.1. Frameshift.
X03538 Genomic DNA. Translation: CAA27241.1. Frameshift.
AP008231 Genomic DNA. Translation: BAD79127.1.
PIRiS10913.
S10914.
RefSeqiWP_011243249.1. NC_006576.1.
YP_171647.1. NC_006576.1.

3D structure databases

ProteinModelPortaliP05675.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi269084.syc0937_d.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD79127; BAD79127; syc0937_d.
KEGGisyc:syc0937_d.
PATRICi32487662. VBISynElo117686_1092.

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000238351.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Enzyme and pathway databases

BioCyciSELO269084:GCDQ-960-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the promoter region in the rrnA operon from a blue-green alga, Anacystis nidulans 6301."
    Kumano M., Tomioka N., Shinozaki K., Sugiura M.
    Mol. Gen. Genet. 202:173-178(1985)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.
  2. "Complete nucleotide sequence of the freshwater unicellular cyanobacterium Synechococcus elongatus PCC 6301 chromosome: gene content and organization."
    Sugita C., Ogata K., Shikata M., Jikuya H., Takano J., Furumichi M., Kanehisa M., Omata T., Sugiura M., Sugita M.
    Photosyn. Res. 93:55-67(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27144 / PCC 6301 / SAUG 1402/1.

Entry informationi

Entry nameiCPDA_SYNP6
AccessioniPrimary (citable) accession number: P05675
Secondary accession number(s): P05677, Q5N3J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1988
Last sequence update: February 28, 2005
Last modified: March 31, 2015
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.