Reviewed, UniProtKB/Swiss-Prot P05623 (A70A_DROME)

Names and origin

Protein names

Recommended name:
    Accessory gland-specific peptide 70A
Alternative name(s):
    Paragonial peptide B

Gene names

Name:	Acp70A
Synonyms:	PAPB
ORF Names:	CG17673

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	55 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Represses female sexual receptivity and stimulates oviposition.
Subcellular location	Secreted.
Tissue specificity	Main cells of the accessory glands of males (paragonial gland).

Ontologies

Keywords
Biological process	Behavior
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Hydroxylation
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	adult feeding behavior Inferred from mutant phenotype. Source: FlyBase juvenile hormone biosynthetic process Non-traceable author statement. Source: FlyBase negative regulation of female receptivity, post-mating Inferred from mutant phenotype. Source: FlyBase oogenesis Traceable author statement. Source: FlyBase oviposition Traceable author statement. Source: FlyBase regulation of juvenile hormone biosynthetic process Traceable author statement. Source: FlyBase regulation of post-mating oviposition Inferred from mutant phenotype. Source: FlyBase
Cellular component	extracellular region Traceable author statement. Source: FlyBase
Molecular function	hormone activity Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Dl	P10041	1	EBI-99218,EBI-115346

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Ref.1
	Chain	20 – 55	36	Accessory gland-specific peptide 70A		PRO_0000020587
Amino acid modifications
	Modified residue	28	1	Hydroxyproline Ref.1
	Modified residue	32	1	Hydroxyproline
	Modified residue	33	1	Isoleucine derivative
	Modified residue	34	1	Hydroxyproline Ref.1
	Modified residue	38	1	Hydroxyproline
Natural variations
	Natural variant	19	1	S → A in strain: Berkeley, M2, M26, M36, M40, M55 and SFS 3.4.
	Natural variant	46	1	N → I in strain: SFS 3.4.

Sequences

	Sequence		Length	Mass (Da)
	P05623-1 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: F6827A1F025BF23D	FASTA	55	6,378
	10 20 30 40 50 MKTLALFLVL VCVLGLVQSW EWPWNRKPTK FPIPSPNPRD KWCRLNLGPA WGGRC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A male accessory gland peptide that regulates reproductive behavior of female D. melanogaster." Chen P.S., Stumm-Zollinger E., Aigaki T., Balmer J., Bienz M., Boehlen P. Cell 54:291-298(1988) [PubMed: 3135120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-55. Strain: Oregon-R.
[2]	"Evolutionary history of the sex-peptide (Acp70A) gene region in Drosophila melanogaster." Cirera S., Aguade M.N. Genetics 147:189-197(1997) [PubMed: 9286679] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: M11, M2, M26, M36, M40, M47, M54, M55 and M66.
[3]	"Population genetics of accessory gland proteins and sexual behavior in Drosophila melanogaster populations from Evolution Canyon." Panhuis T.M., Swanson W.J., Nunney L. Evolution 57:2785-2791(2003) [PubMed: 14761057] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: NFS 5.1, NFS 5.2, NFS 5.3, NFS 5.4, NFS 6.1, NFS 6.2, NFS 6.3, NFS 6.4, NFS 7.8, SFS 1.1, SFS 1.2, SFS 1.3, SFS 1.4, SFS 2.2, SFS 2.3, SFS 2.4, SFS 3.1, SFS 3.2, SFS 3.3 and SFS 3.4.
[4]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[5]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M21201 mRNA. Translation: AAA28816.1. X99407 Genomic DNA. Translation: CAA67784.1. X99408 Genomic DNA. Translation: CAA67785.1. X99409 Genomic DNA. Translation: CAA67786.1. X99410 Genomic DNA. Translation: CAA67787.1. X99411 Genomic DNA. Translation: CAA67788.1. X99413 Genomic DNA. Translation: CAA67790.1. X99415 Genomic DNA. Translation: CAA67792.1. X99416 Genomic DNA. Translation: CAA67793.1. X99418 Genomic DNA. Translation: CAA67795.1. AY344285 Genomic DNA. Translation: AAR04600.1. AY344286 Genomic DNA. Translation: AAR04601.1. AY344287 Genomic DNA. Translation: AAR04602.1. AY344288 Genomic DNA. Translation: AAR04603.1. AY344289 Genomic DNA. Translation: AAR04604.1. AY344290 Genomic DNA. Translation: AAR04605.1. AY344291 Genomic DNA. Translation: AAR04606.1. AY344292 Genomic DNA. Translation: AAR04607.1. AY344293 Genomic DNA. Translation: AAR04608.1. AY344294 Genomic DNA. Translation: AAR04609.1. AY344295 Genomic DNA. Translation: AAR04610.1. AY344296 Genomic DNA. Translation: AAR04611.1. AY344297 Genomic DNA. Translation: AAR04612.1. AY344298 Genomic DNA. Translation: AAR04613.1. AY344299 Genomic DNA. Translation: AAR04614.1. AY344300 Genomic DNA. Translation: AAR04615.1. AY344301 Genomic DNA. Translation: AAR04616.1. AY344302 Genomic DNA. Translation: AAR04617.1. AY344303 Genomic DNA. Translation: AAR04618.1. AY344304 Genomic DNA. Translation: AAR04619.1. AE014296 Genomic DNA. Translation: AAF49836.1.
PIR	A28911.
RefSeq	NP_524057.2.
UniGene	Dm.2898
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P05623. 1 interaction.
STRING	P05623.
Proteomic databases
PRIDE	P05623.
Genome annotation databases
Ensembl	FBtr0075836; FBpp0075572; FBgn0003034; Drosophila melanogaster. [Genome view]
GeneID	39494.
KEGG	dme:Dmel_CG17673.
Organism-specific databases
CTD	39494.
FlyBase	FBgn0003034. Acp70A.
Gene expression databases
GermOnline	CG17673. Drosophila melanogaster.
Family and domain databases
InterPro	IPR012608. Sex_peptide. [Graphical view]
Pfam	PF08138. Sex_peptide. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	813935.

Entry information

Entry name

A70A_DROME

Accession

Primary (citable) accession number: P05623
Secondary accession number(s): O18659, Q6VBF8, Q9VU54

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	September 1, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project