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Protein

Leukocyte elastase inhibitor

Gene

SERPINB1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be involved in the control of intracellular protein turnover.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei344 – 3452Reactive bond

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor
Short name:
LEI
Alternative name(s):
Serpin B1
Gene namesi
Name:SERPINB1
Synonyms:ELANH2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 20

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Leukocyte elastase inhibitorPRO_0000094100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei137 – 1371N6-acetyllysineBy similarity
Modified residuei177 – 1771N6-acetyllysineBy similarity

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05619.
PeptideAtlasiP05619.
PRIDEiP05619.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with thymosin beta-4/TMSB4.By similarity1 Publication

Protein-protein interaction databases

STRINGi9796.ENSECAP00000008115.

Structurei

Secondary structure

1
379
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 2221Combined sources
Beta strandi24 – 263Combined sources
Beta strandi28 – 303Combined sources
Helixi32 – 4413Combined sources
Helixi48 – 5710Combined sources
Helixi60 – 623Combined sources
Helixi66 – 7712Combined sources
Beta strandi83 – 9513Combined sources
Helixi102 – 11211Combined sources
Beta strandi115 – 1195Combined sources
Turni121 – 1233Combined sources
Helixi125 – 13915Combined sources
Turni140 – 1423Combined sources
Beta strandi143 – 1453Combined sources
Beta strandi157 – 17317Combined sources
Helixi177 – 1793Combined sources
Beta strandi181 – 19010Combined sources
Beta strandi192 – 20918Combined sources
Helixi210 – 2123Combined sources
Beta strandi214 – 2218Combined sources
Beta strandi224 – 23512Combined sources
Beta strandi238 – 2425Combined sources
Helixi244 – 2485Combined sources
Helixi252 – 2598Combined sources
Helixi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Beta strandi276 – 2838Combined sources
Helixi285 – 2917Combined sources
Helixi295 – 2973Combined sources
Turni299 – 3013Combined sources
Helixi305 – 3084Combined sources
Beta strandi309 – 3113Combined sources
Beta strandi313 – 32614Combined sources
Beta strandi328 – 34316Combined sources
Beta strandi350 – 3534Combined sources
Beta strandi358 – 3647Combined sources
Turni365 – 3684Combined sources
Beta strandi369 – 3768Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLEX-ray1.95A1-344[»]
B349-379[»]
ProteinModelPortaliP05619.
SMRiP05619. Positions 1-344, 349-379.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05619.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05619.
KOiK13963.
OMAiRHNPSAN.
OrthoDBiEOG091G0ION.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF183. PTHR11461:SF183. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSTANTH FAVDLFRALN ESDPTGNIFI SPLSISSALA MIFLGTRGNT
60 70 80 90 100
AAQVSKALYF DTVEDIHSRF QSLNADINKP GAPYILKLAN RLYGEKTYNF
110 120 130 140 150
LADFLASTQK MYGAELASVD FQQAPEDARK EINEWVKGQT EGKIPELLVK
160 170 180 190 200
GMVDNMTKLV LVNAIYFKGN WQEKFMKEAT RDAPFRLNKK DTKTVKMMYQ
210 220 230 240 250
KKKFPYNYIE DLKCRVLELP YQGKELSMII LLPDDIEDES TGLEKIEKQL
260 270 280 290 300
TLEKLREWTK PENLYLAEVN VHLPRFKLEE SYDLTSHLAR LGVQDLFNRG
310 320 330 340 350
KADLSGMSGA RDLFVSKIIH KSFVDLNEEG TEAAAATAGT IMLAMLMPEE
360 370
NFNADHPFIF FIRHNPSANI LFLGRFSSP
Length:379
Mass (Da):43,006
Last modified:February 1, 1994 - v3
Checksum:i72DED1999371427A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91161 mRNA. Translation: AAA97513.1.
PIRiA28060.
A42421.
RefSeqiNP_001075416.1. NM_001081947.1.
XP_005603556.1. XM_005603499.2.
XP_005603557.1. XM_005603500.2.
UniGeneiEca.3727.

Genome annotation databases

EnsembliENSECAT00000010506; ENSECAP00000008115; ENSECAG00000009896.
GeneIDi100049797.
KEGGiecb:100049797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91161 mRNA. Translation: AAA97513.1.
PIRiA28060.
A42421.
RefSeqiNP_001075416.1. NM_001081947.1.
XP_005603556.1. XM_005603499.2.
XP_005603557.1. XM_005603500.2.
UniGeneiEca.3727.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HLEX-ray1.95A1-344[»]
B349-379[»]
ProteinModelPortaliP05619.
SMRiP05619. Positions 1-344, 349-379.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000008115.

Protein family/group databases

MEROPSiI04.006.

Proteomic databases

PaxDbiP05619.
PeptideAtlasiP05619.
PRIDEiP05619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000010506; ENSECAP00000008115; ENSECAG00000009896.
GeneIDi100049797.
KEGGiecb:100049797.

Organism-specific databases

CTDi1992.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05619.
KOiK13963.
OMAiRHNPSAN.
OrthoDBiEOG091G0ION.
TreeFamiTF352619.

Miscellaneous databases

EvolutionaryTraceiP05619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF183. PTHR11461:SF183. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILEU_HORSE
AccessioniPrimary (citable) accession number: P05619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.