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Protein

Leukocyte elastase inhibitor

Gene

SERPINB1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thought to be involved in the control of intracellular protein turnover.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344 – 345Reactive bond2

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.006

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor
Short name:
LEI
Alternative name(s):
Serpin B1
Gene namesi
Name:SERPINB1
Synonyms:ELANH2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 20

Organism-specific databases

VGNCiVGNC:22847 SERPINB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941001 – 379Leukocyte elastase inhibitorAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05619
PeptideAtlasiP05619
PRIDEiP05619

Expressioni

Gene expression databases

BgeeiENSECAG00000009896

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with thymosin beta-4/TMSB4.By similarity1 Publication

Protein-protein interaction databases

STRINGi9796.ENSECAP00000008115

Structurei

Secondary structure

1379
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 22Combined sources21
Beta strandi24 – 26Combined sources3
Beta strandi28 – 30Combined sources3
Helixi32 – 44Combined sources13
Helixi48 – 57Combined sources10
Helixi60 – 62Combined sources3
Helixi66 – 77Combined sources12
Beta strandi83 – 95Combined sources13
Helixi102 – 112Combined sources11
Beta strandi115 – 119Combined sources5
Turni121 – 123Combined sources3
Helixi125 – 139Combined sources15
Turni140 – 142Combined sources3
Beta strandi143 – 145Combined sources3
Beta strandi157 – 173Combined sources17
Helixi177 – 179Combined sources3
Beta strandi181 – 190Combined sources10
Beta strandi192 – 209Combined sources18
Helixi210 – 212Combined sources3
Beta strandi214 – 221Combined sources8
Beta strandi224 – 235Combined sources12
Beta strandi238 – 242Combined sources5
Helixi244 – 248Combined sources5
Helixi252 – 259Combined sources8
Helixi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Beta strandi276 – 283Combined sources8
Helixi285 – 291Combined sources7
Helixi295 – 297Combined sources3
Turni299 – 301Combined sources3
Helixi305 – 308Combined sources4
Beta strandi309 – 311Combined sources3
Beta strandi313 – 326Combined sources14
Beta strandi328 – 343Combined sources16
Beta strandi350 – 353Combined sources4
Beta strandi358 – 364Combined sources7
Turni365 – 368Combined sources4
Beta strandi369 – 376Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLEX-ray1.95A1-344[»]
B349-379[»]
ProteinModelPortaliP05619
SMRiP05619
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05619

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392 Eukaryota
COG4826 LUCA
GeneTreeiENSGT00760000118789
HOGENOMiHOG000238519
HOVERGENiHBG005957
InParanoidiP05619
KOiK13963
OMAiAESFHQV
OrthoDBiEOG091G0ION
TreeFamiTF352619

Family and domain databases

InterProiView protein in InterPro
IPR015557 Serpin_B1
IPR023795 Serpin_CS
IPR023796 Serpin_dom
IPR000215 Serpin_fam
IPR036186 Serpin_sf
PANTHERiPTHR11461 PTHR11461, 1 hit
PTHR11461:SF180 PTHR11461:SF180, 1 hit
PfamiView protein in Pfam
PF00079 Serpin, 1 hit
SMARTiView protein in SMART
SM00093 SERPIN, 1 hit
SUPFAMiSSF56574 SSF56574, 1 hit
PROSITEiView protein in PROSITE
PS00284 SERPIN, 1 hit

Sequencei

Sequence statusi: Complete.

P05619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSTANTH FAVDLFRALN ESDPTGNIFI SPLSISSALA MIFLGTRGNT
60 70 80 90 100
AAQVSKALYF DTVEDIHSRF QSLNADINKP GAPYILKLAN RLYGEKTYNF
110 120 130 140 150
LADFLASTQK MYGAELASVD FQQAPEDARK EINEWVKGQT EGKIPELLVK
160 170 180 190 200
GMVDNMTKLV LVNAIYFKGN WQEKFMKEAT RDAPFRLNKK DTKTVKMMYQ
210 220 230 240 250
KKKFPYNYIE DLKCRVLELP YQGKELSMII LLPDDIEDES TGLEKIEKQL
260 270 280 290 300
TLEKLREWTK PENLYLAEVN VHLPRFKLEE SYDLTSHLAR LGVQDLFNRG
310 320 330 340 350
KADLSGMSGA RDLFVSKIIH KSFVDLNEEG TEAAAATAGT IMLAMLMPEE
360 370
NFNADHPFIF FIRHNPSANI LFLGRFSSP
Length:379
Mass (Da):43,006
Last modified:February 1, 1994 - v3
Checksum:i72DED1999371427A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91161 mRNA Translation: AAA97513.1
PIRiA28060
A42421
RefSeqiNP_001075416.1, NM_001081947.1
XP_005603556.1, XM_005603499.2
XP_005603557.1, XM_005603500.2
UniGeneiEca.3727

Genome annotation databases

EnsembliENSECAT00000010506; ENSECAP00000008115; ENSECAG00000009896
GeneIDi100049797
KEGGiecb:100049797

Similar proteinsi

Entry informationi

Entry nameiILEU_HORSE
AccessioniPrimary (citable) accession number: P05619
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health