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Protein

Leukocyte elastase inhibitor

Gene

SERPINB1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Thought to be involved in the control of intracellular protein turnover.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei344 – 345Reactive bond2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte elastase inhibitor
Short name:
LEI
Alternative name(s):
Serpin B1
Gene namesi
Name:SERPINB1
Synonyms:ELANH2
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 20

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000941001 – 379Leukocyte elastase inhibitorAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei137N6-acetyllysineBy similarity1
Modified residuei177N6-acetyllysineBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP05619.
PeptideAtlasiP05619.
PRIDEiP05619.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with thymosin beta-4/TMSB4.By similarity1 Publication

Protein-protein interaction databases

STRINGi9796.ENSECAP00000008115.

Structurei

Secondary structure

1379
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 22Combined sources21
Beta strandi24 – 26Combined sources3
Beta strandi28 – 30Combined sources3
Helixi32 – 44Combined sources13
Helixi48 – 57Combined sources10
Helixi60 – 62Combined sources3
Helixi66 – 77Combined sources12
Beta strandi83 – 95Combined sources13
Helixi102 – 112Combined sources11
Beta strandi115 – 119Combined sources5
Turni121 – 123Combined sources3
Helixi125 – 139Combined sources15
Turni140 – 142Combined sources3
Beta strandi143 – 145Combined sources3
Beta strandi157 – 173Combined sources17
Helixi177 – 179Combined sources3
Beta strandi181 – 190Combined sources10
Beta strandi192 – 209Combined sources18
Helixi210 – 212Combined sources3
Beta strandi214 – 221Combined sources8
Beta strandi224 – 235Combined sources12
Beta strandi238 – 242Combined sources5
Helixi244 – 248Combined sources5
Helixi252 – 259Combined sources8
Helixi261 – 263Combined sources3
Beta strandi265 – 274Combined sources10
Beta strandi276 – 283Combined sources8
Helixi285 – 291Combined sources7
Helixi295 – 297Combined sources3
Turni299 – 301Combined sources3
Helixi305 – 308Combined sources4
Beta strandi309 – 311Combined sources3
Beta strandi313 – 326Combined sources14
Beta strandi328 – 343Combined sources16
Beta strandi350 – 353Combined sources4
Beta strandi358 – 364Combined sources7
Turni365 – 368Combined sources4
Beta strandi369 – 376Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLEX-ray1.95A1-344[»]
B349-379[»]
ProteinModelPortaliP05619.
SMRiP05619.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05619.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family. Ov-serpin subfamily.Curated

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05619.
KOiK13963.
OMAiRHNPSAN.
OrthoDBiEOG091G0ION.
TreeFamiTF352619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF183. PTHR11461:SF183. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLSTANTH FAVDLFRALN ESDPTGNIFI SPLSISSALA MIFLGTRGNT
60 70 80 90 100
AAQVSKALYF DTVEDIHSRF QSLNADINKP GAPYILKLAN RLYGEKTYNF
110 120 130 140 150
LADFLASTQK MYGAELASVD FQQAPEDARK EINEWVKGQT EGKIPELLVK
160 170 180 190 200
GMVDNMTKLV LVNAIYFKGN WQEKFMKEAT RDAPFRLNKK DTKTVKMMYQ
210 220 230 240 250
KKKFPYNYIE DLKCRVLELP YQGKELSMII LLPDDIEDES TGLEKIEKQL
260 270 280 290 300
TLEKLREWTK PENLYLAEVN VHLPRFKLEE SYDLTSHLAR LGVQDLFNRG
310 320 330 340 350
KADLSGMSGA RDLFVSKIIH KSFVDLNEEG TEAAAATAGT IMLAMLMPEE
360 370
NFNADHPFIF FIRHNPSANI LFLGRFSSP
Length:379
Mass (Da):43,006
Last modified:February 1, 1994 - v3
Checksum:i72DED1999371427A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91161 mRNA. Translation: AAA97513.1.
PIRiA28060.
A42421.
RefSeqiNP_001075416.1. NM_001081947.1.
XP_005603556.1. XM_005603499.2.
XP_005603557.1. XM_005603500.2.
UniGeneiEca.3727.

Genome annotation databases

EnsembliENSECAT00000010506; ENSECAP00000008115; ENSECAG00000009896.
GeneIDi100049797.
KEGGiecb:100049797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M91161 mRNA. Translation: AAA97513.1.
PIRiA28060.
A42421.
RefSeqiNP_001075416.1. NM_001081947.1.
XP_005603556.1. XM_005603499.2.
XP_005603557.1. XM_005603500.2.
UniGeneiEca.3727.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLEX-ray1.95A1-344[»]
B349-379[»]
ProteinModelPortaliP05619.
SMRiP05619.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9796.ENSECAP00000008115.

Protein family/group databases

MEROPSiI04.006.

Proteomic databases

PaxDbiP05619.
PeptideAtlasiP05619.
PRIDEiP05619.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSECAT00000010506; ENSECAP00000008115; ENSECAG00000009896.
GeneIDi100049797.
KEGGiecb:100049797.

Organism-specific databases

CTDi1992.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
GeneTreeiENSGT00760000118789.
HOGENOMiHOG000238519.
HOVERGENiHBG005957.
InParanoidiP05619.
KOiK13963.
OMAiRHNPSAN.
OrthoDBiEOG091G0ION.
TreeFamiTF352619.

Miscellaneous databases

EvolutionaryTraceiP05619.

Family and domain databases

InterProiIPR015557. Serpin_B1.
IPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PTHR11461:SF183. PTHR11461:SF183. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILEU_HORSE
AccessioniPrimary (citable) accession number: P05619
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.