UniProtKB - P05556 (ITB1_HUMAN)
UniProt
P05556 - ITB1_HUMAN
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Protein
Integrin beta-1
Gene
ITGB1
Organism
Homo sapiens (Human)
Status
Functioni
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).11 Publications
Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.By similarity
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).7 Publications
Sites
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Metal bindingi | 152 – 152 | 1 | Magnesium |   | ||
| Metal bindingi | 154 – 154 | 1 | Calcium 1; via carbonyl oxygen | | ||
| Metal bindingi | 156 – 156 | 1 | Calcium 1 | | ||
| Metal bindingi | 157 – 157 | 1 | Calcium 1 | | ||
| Metal bindingi | 189 – 189 | 1 | Calcium 2 | | ||
| Metal bindingi | 244 – 244 | 1 | Calcium 2 | | ||
| Metal bindingi | 246 – 246 | 1 | Calcium 2 | | ||
| Metal bindingi | 248 – 248 | 1 | Calcium 2; via carbonyl oxygen | | ||
| Metal bindingi | 249 – 249 | 1 | Calcium 2 | | ||
| Metal bindingi | 249 – 249 | 1 | Magnesium | | ||
| Metal bindingi | 362 – 362 | 1 | Calcium 1; via carbonyl oxygen | |
GO - Molecular functioni
- actin binding Source: BHF-UCL
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
- cell adhesion molecule binding Source: UniProtKB
- collagen binding involved in cell-matrix adhesion Source: UniProtKB
- coreceptor activity Source: UniProtKB
- fibronectin binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- peptide binding Source: Ensembl
- protease binding Source: UniProtKB
- protein complex binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- axon extension Source: Ensembl
- B cell differentiation Source: BHF-UCL
- bicellular tight junction assembly Source: Ensembl
- calcium-independent cell-matrix adhesion Source: MGI
- cardiac muscle cell differentiation Source: Ensembl
- cell-cell adhesion mediated by integrin Source: BHF-UCL
- cell fate specification Source: Ensembl
- cell-matrix adhesion Source: UniProtKB
- cell migration Source: HGNC
- cell migration involved in sprouting angiogenesis Source: Ensembl
- cell-substrate adhesion Source: UniProtKB
- cellular calcium ion homeostasis Source: Ensembl
- cellular defense response Source: ProtInc
- cellular response to ionizing radiation Source: Ensembl
- cellular response to low-density lipoprotein particle stimulus Source: UniProtKB
- cellular response to mechanical stimulus Source: Ensembl
- cellular response to vitamin D Source: Ensembl
- dendrite morphogenesis Source: Ensembl
- extracellular matrix organization Source: Reactome
- formation of radial glial scaffolds Source: Ensembl
- G1/S transition of mitotic cell cycle Source: Ensembl
- germ cell migration Source: Ensembl
- heterotypic cell-cell adhesion Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: ProtInc
- integrin-mediated signaling pathway Source: UniProtKB
- in utero embryonic development Source: Ensembl
- leukocyte cell-cell adhesion Source: BHF-UCL
- leukocyte migration Source: Reactome
- leukocyte tethering or rolling Source: UniProtKB
- maternal process involved in female pregnancy Source: Ensembl
- mesodermal cell differentiation Source: UniProtKB
- negative regulation of anoikis Source: UniProtKB
- negative regulation of cell projection organization Source: Ensembl
- negative regulation of cell proliferation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of Rho protein signal transduction Source: Ensembl
- positive regulation of apoptotic process Source: MGI
- positive regulation of cell migration Source: Ensembl
- positive regulation of cell proliferation Source: Ensembl
- positive regulation of cell-substrate adhesion Source: Ensembl
- positive regulation of endocytosis Source: Ensembl
- positive regulation of establishment of protein localization to plasma membrane Source: UniProtKB
- positive regulation of GTPase activity Source: UniProtKB
- positive regulation of MAPK cascade Source: Ensembl
- positive regulation of neuron projection development Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- protein transport within lipid bilayer Source: Ensembl
- receptor internalization Source: UniProtKB
- regulation of cell cycle Source: Ensembl
- regulation of collagen catabolic process Source: UniProtKB
- regulation of G-protein coupled receptor protein signaling pathway Source: Ensembl
- regulation of immune response Source: Reactome
- response to activity Source: Ensembl
- response to drug Source: Ensembl
- response to gonadotropin Source: Ensembl
- response to transforming growth factor beta Source: Ensembl
- sarcomere organization Source: Ensembl
- tissue homeostasis Source: Ensembl
- visual learning Source: Ensembl
Keywords - Molecular functioni
Host cell receptor for virus entry, Integrin, ReceptorKeywords - Biological processi
Cell adhesion, Host-virus interactionKeywords - Ligandi
Calcium, Magnesium, Metal-bindingEnzyme and pathway databases
| Reactomei | R-HSA-1566948. Elastic fibre formation. R-HSA-1566977. Fibronectin matrix formation. R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. R-HSA-202733. Cell surface interactions at the vascular wall. R-HSA-210991. Basigin interactions. R-HSA-2129379. Molecules associated with elastic fibres. R-HSA-216083. Integrin cell surface interactions. R-HSA-3000157. Laminin interactions. R-HSA-3000170. Syndecan interactions. R-HSA-3000178. ECM proteoglycans. R-HSA-416700. Other semaphorin interactions. R-HSA-445144. Signal transduction by L1. R-HSA-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions. R-HSA-447041. CHL1 interactions. R-HSA-5663220. RHO GTPases Activate Formins. R-HSA-75892. Platelet Adhesion to exposed collagen. |
| SABIO-RK | P05556. |
| SignaLinki | P05556. |
| SIGNORi | P05556. |
Protein family/group databases
| TCDBi | 9.B.87.1.8. the selenoprotein p receptor (selp-receptor) family. |
Names & Taxonomyi
| Protein namesi | Recommended name: Integrin beta-1Alternative name(s): Fibronectin receptor subunit beta Glycoprotein IIa Short name: GPIIA VLA-4 subunit beta CD_antigen: CD29 |
| Gene namesi | Name:ITGB1 Synonyms:FNRB, MDF2, MSK12 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| HGNCi | HGNC:6153. ITGB1. |
Subcellular locationi
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Cell projection › invadopodium membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Cell projection › ruffle membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
- Recycling endosome
- Melanosome
- Cleavage furrow
- Cell projection › lamellipodium
- Cell projection › ruffle
Note: Isoform 2 does not localize to focal adhesions. Highly enriched in stage I melanosomes. Located on plasma membrane of neuroblastoma NMB7 cells. In a lung cancer cell line, in prometaphase and metaphase, localizes diffusely at the membrane and in a few intracellular vesicles. In early telophase, detected mainly on the matrix-facing side of the cells. By mid-telophase, concentrated to the ingressing cleavage furrow, mainly to the basal side of the furrow. In late telophase, concentrated to the extending protrusions formed at the opposite ends of the spreading daughter cells, in vesicles at the base of the lamellipodia formed by the separating daughter cells. Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions sites to fibrillar adhesions in a ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner.1 Publication1 Publication
Isoform 5 :
- Cell membrane › sarcolemma By similarity
- Cell junction By similarity
Note: In cardiac muscle, isoform 5 is found in costameres and intercalated disks.By similarity
Topology
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Topological domaini | 21 – 728 | 708 | ExtracellularSequence analysis | | Add BLAST | |
| Transmembranei | 729 – 751 | 23 | HelicalSequence analysis | | Add BLAST | |
| Topological domaini | 752 – 798 | 47 | CytoplasmicSequence analysis | | Add BLAST |
GO - Cellular componenti
- acrosomal vesicle Source: Ensembl
- basement membrane Source: Ensembl
- cell-cell adherens junction Source: BHF-UCL
- cell surface Source: UniProtKB
- cleavage furrow Source: UniProtKB-SubCell
- cytoplasm Source: BHF-UCL
- dendritic spine Source: Ensembl
- external side of plasma membrane Source: Ensembl
- extracellular exosome Source: UniProtKB
- filopodium Source: BHF-UCL
- focal adhesion Source: UniProtKB
- hemidesmosome Source: Ensembl
- integrin alpha10-beta1 complex Source: UniProtKB
- integrin alpha11-beta1 complex Source: UniProtKB
- integrin alpha1-beta1 complex Source: UniProtKB
- integrin alpha2-beta1 complex Source: UniProtKB
- integrin alpha3-beta1 complex Source: UniProtKB
- integrin alpha7-beta1 complex Source: Ensembl
- integrin alpha8-beta1 complex Source: BHF-UCL
- integrin alpha9-beta1 complex Source: Ensembl
- integrin complex Source: UniProtKB
- intercalated disc Source: Ensembl
- invadopodium membrane Source: UniProtKB
- lamellipodium Source: UniProtKB-SubCell
- melanosome Source: UniProtKB-SubCell
- membrane Source: UniProtKB
- membrane raft Source: BHF-UCL
- myelin sheath abaxonal region Source: Ensembl
- neuromuscular junction Source: MGI
- perinuclear region of cytoplasm Source: Ensembl
- plasma membrane Source: UniProtKB
- receptor complex Source: MGI
- recycling endosome Source: UniProtKB-SubCell
- ruffle Source: HGNC
- ruffle membrane Source: UniProtKB
- sarcolemma Source: MGI
- synaptic membrane Source: Ensembl
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Endosome, MembranePathology & Biotechi
Mutagenesis
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Mutagenesisi | 760 – 761 | 2 | RR → AA: No effect on interaction with ACAP1. 1 Publication | | ||
| Mutagenesisi | 762 – 767 | 6 | EFAKFE → AAAAAA: Strongly reduces interaction with ACAP1 and ability to recycle; does not affect heterodimerization with ITGA5. 1 Publication | | ||
| Mutagenesisi | 762 – 763 | 2 | EF → AA: Slightly reduces interaction with ACAP1. | | ||
| Mutagenesisi | 765 – 765 | 1 | K → A: Reduces interaction with ACAP1. | | ||
| Mutagenesisi | 766 – 767 | 2 | FE → AA: Slightly reduces interaction with ACAP1. | | ||
| Mutagenesisi | 768 – 769 | 2 | KE → AA: No effect on interaction with ACAP1. 1 Publication | | ||
| Mutagenesisi | 778 – 778 | 1 | G → Q: Loss of beta-1A interaction with FLNA and FLNB. 1 Publication | | ||
| Mutagenesisi | 786 – 791 | 6 | AVTTVV → PINNFK: Does not interact with ITGB1BP1. 1 Publication | | ||
| Mutagenesisi | 786 – 786 | 1 | A → P: Loss of beta-1A interaction with FLNA and FLNB. 1 Publication | | ||
| Mutagenesisi | 787 – 787 | 1 | V → T: Reduces interaction with ITGB1BP1, but not with FERMT2 or TLN1. Inhibits fibronectin deposition and mineralized bone nodules formation. 1 Publication | | ||
| Mutagenesisi | 788 – 788 | 1 | T → D: Strongly reduces ITGB1BP1 binding; when associated with D-790. 1 Publication | | ||
| Mutagenesisi | 790 – 790 | 1 | V → D: Strongly reduces ITGB1BP1 binding; when associated with D-788. 1 Publication | | ||
| Mutagenesisi | 792 – 792 | 1 | N → A: Strongly reduces ITGB1BP1 binding; when associated with A-795. 1 Publication | | ||
| Mutagenesisi | 795 – 795 | 1 | Y → A: Strongly reduces ITGB1BP1 binding; when associated with A-792. 1 Publication | |
Organism-specific databases
| PharmGKBi | PA29953. |
Chemistry
| ChEMBLi | CHEMBL3137268. |
| DrugBanki | DB00098. Anti-thymocyte Globulin (Rabbit). |
Polymorphism and mutation databases
| BioMutai | ITGB1. |
| DMDMi | 218563324. |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Signal peptidei | 1 – 20 | 20 | | Add BLAST | ||
| Chaini | 21 – 798 | 778 | Integrin beta-1 | | PRO_0000016334 | Add BLAST |
Amino acid modifications
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Disulfide bondi | 27 ↔ 45 | 1 Publication | | |||
| Disulfide bondi | 35 ↔ 464 | 1 Publication | | |||
| Disulfide bondi | 38 ↔ 64 | 1 Publication | | |||
| Disulfide bondi | 48 ↔ 75 | 1 Publication | | |||
| Glycosylationi | 50 – 50 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Glycosylationi | 94 – 94 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Glycosylationi | 97 – 97 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Disulfide bondi | 207 ↔ 213 | 1 Publication | | |||
| Glycosylationi | 212 – 212 | 1 | N-linked (GlcNAc...)1 Publication | | ||
| Disulfide bondi | 261 ↔ 301 | 1 Publication | | |||
| Glycosylationi | 269 – 269 | 1 | N-linked (GlcNAc...)1 Publication | | ||
| Glycosylationi | 363 – 363 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Disulfide bondi | 401 ↔ 415 | 1 Publication | | |||
| Glycosylationi | 403 – 403 | 1 | N-linked (GlcNAc...); atypical1 Publication | | ||
| Glycosylationi | 406 – 406 | 1 | N-linked (GlcNAc...)3 Publications | | ||
| Glycosylationi | 411 – 411 | 1 | N-linked (GlcNAc...); atypical1 Publication | | ||
| Glycosylationi | 417 – 417 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Disulfide bondi | 435 ↔ 462 | 1 Publication | | |||
| Disulfide bondi | 466 ↔ 691 | 1 Publication | | |||
| Disulfide bondi | 477 ↔ 489 | By similarity | | |||
| Glycosylationi | 481 – 481 | 1 | N-linked (GlcNAc...)1 Publication | | ||
| Disulfide bondi | 486 ↔ 525 | By similarity | | |||
| Disulfide bondi | 491 ↔ 500 | By similarity | | |||
| Disulfide bondi | 502 ↔ 516 | By similarity | | |||
| Glycosylationi | 520 – 520 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Disulfide bondi | 531 ↔ 536 | By similarity | | |||
| Disulfide bondi | 533 ↔ 568 | By similarity | | |||
| Disulfide bondi | 538 ↔ 553 | By similarity | | |||
| Disulfide bondi | 555 ↔ 560 | By similarity | | |||
| Disulfide bondi | 574 ↔ 579 | By similarity | | |||
| Disulfide bondi | 576 ↔ 607 | By similarity | | |||
| Disulfide bondi | 581 ↔ 590 | By similarity | | |||
| Glycosylationi | 584 – 584 | 1 | N-linked (GlcNAc...)Sequence analysis | | ||
| Disulfide bondi | 592 ↔ 599 | By similarity | | |||
| Disulfide bondi | 613 ↔ 618 | By similarity | | |||
| Disulfide bondi | 615 ↔ 661 | By similarity | | |||
| Disulfide bondi | 620 ↔ 630 | By similarity | | |||
| Disulfide bondi | 633 ↔ 636 | By similarity | | |||
| Disulfide bondi | 640 ↔ 649 | By similarity | | |||
| Disulfide bondi | 646 ↔ 723 | By similarity | | |||
| Disulfide bondi | 665 ↔ 699 | By similarity | | |||
| Glycosylationi | 669 – 669 | 1 | N-linked (GlcNAc...)1 Publication | | ||
| Modified residuei | 777 – 777 | 1 | PhosphothreonineCombined sources | | ||
| Modified residuei | 783 – 783 | 1 | PhosphotyrosineCombined sources | | ||
| Modified residuei | 785 – 785 | 1 | PhosphoserineCombined sources | | ||
| Modified residuei | 789 – 789 | 1 | PhosphothreonineCombined sources | | ||
| Modified residuei | 794 – 794 | 1 | N6-acetyllysine; alternateCombined sources | | ||
| Cross-linki | 794 – 794 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | |
Post-translational modificationi
The cysteine residues are involved in intrachain disulfide bonds.By similarity
Keywords - PTMi
Acetylation, Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
| EPDi | P05556. |
| MaxQBi | P05556. |
| PaxDbi | P05556. |
| PeptideAtlasi | P05556. |
| PRIDEi | P05556. |
PTM databases
| iPTMneti | P05556. |
| PhosphoSitei | P05556. |
| SwissPalmi | P05556. |
| UniCarbKBi | P05556. |
Miscellaneous databases
| PMAP-CutDB | Q8WUM6. |
Expressioni
Tissue specificityi
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).6 Publications
Gene expression databases
| Bgeei | ENSG00000150093. |
| ExpressionAtlasi | P05556. baseline and differential. |
| Genevisiblei | P05556. HS. |
Organism-specific databases
| HPAi | CAB003434. |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit. Beta-1 associates with either alpha-1, alpha-2, alpha-3, alpha-4, alpha-5, alpha-6, alpha-7, alpha-8, alpha-9, alpha-10, alpha-11 or alpha-V. Interacts with seprase FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane in a collagen-dependent manner. Binds LGALS3BP and NMRK2, when associated with alpha-7, but not with alpha-5. Interacts with FGR and HCK. Interacts (via the cytoplasmic region) with RAB25 (via the hypervariable C-terminal region). Interacts with RAB21. Interacts with KRT1 in the presence of RACK1 and SRC. Interacts with JAML; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization. Interacts with FLNA, FLNB and RANBP9. Isoform 5 interacts with ACE2. Isoform 1 interacts with the C-terminal region of FLNC. Interacts with MYO10. Interacts with DAB2. Interacts with FERMT2; the interaction is inhibited in presence of ITGB1BP1. Interacts with ITGB1BP1 (via C-terminal region); the interaction is a prerequisite for focal adhesion disassembly. Interacts with TLN1; the interaction is prevented by competitive binding of ITGB1BP1. Interacts with ACAP1; required for ITGB1 recycling. Interacts with ASAP3. Isoform 5 interacts with alpha-7A and alpha-7B in adult skeletal muscle. Isoform 5 interacts with alpha-7B in cardiomyocytes of adult heart. Interacts with EMP2; the interaction may be direct or indirect and ITGB1 has an heterodimer form (By similarity). ITGA5:ITGB1 interacts with NOV. ITGA4:ITGB1 is found in a ternary complex with CX3CR1 and CX3CL1 (PubMed:23125415).By similarity24 Publications
(Microbial infection) Integrin ITGA2:ITGB1 interacts with human echoviruses 1 and 8 capsid proteins.1 Publication
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 envelope glycoprotein B/gB.1 Publication
(Microbial infection) Interacts with Epstein-Barr virus/HHV-4 gB protein.1 Publication
(Microbial infection) Integrin ITGA5:ITGB1 interacts with human parvovirus B19 capsid protein.1 Publication
(Microbial infection) Integrin ITGA2:ITGB1 interacts with human rotavirus VP4 protein.1 Publication
(Microbial infection) Interacts with mammalian reovirus capsid proteins.1 Publication
(Microbial infection) Integrin ITGA5:ITGB1 interacts with HIV-1 Tat.1 Publication
Binary interactionsi
| With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| ANGPTL4 | Q9BY76 | 2 | EBI-703066,EBI-2968146 | |
| BMRF2 | P03192 | 2 | EBI-703066,EBI-9348955 | From a different organism. |
| CSF2RB | P32927 | 5 | EBI-703066,EBI-1809771 | |
| ENG | P17813 | 3 | EBI-703066,EBI-2834630 | |
| FABP3 | P05413 | 2 | EBI-703066,EBI-704216 | |
| FLNA | P21333 | 5 | EBI-703066,EBI-350432 | |
| ITGA2 | P17301 | 3 | EBI-703066,EBI-702960 | |
| ITGA4 | P13612 | 4 | EBI-703066,EBI-703044 | |
| LYN | P07948 | 4 | EBI-703066,EBI-79452 | |
| PTPN1 | P18031 | 2 | EBI-703066,EBI-968788 | |
| PXN | P49023 | 2 | EBI-6082935,EBI-702209 | |
| Rab21 | P35282 | 3 | EBI-703066,EBI-1993555 | From a different organism. |
| TLN1 | Q9Y490 | 2 | EBI-703066,EBI-2462036 |
GO - Molecular functioni
- actin binding Source: BHF-UCL
- cadherin binding involved in cell-cell adhesion Source: BHF-UCL
- cell adhesion molecule binding Source: UniProtKB
- collagen binding involved in cell-matrix adhesion Source: UniProtKB
- fibronectin binding Source: UniProtKB
- protease binding Source: UniProtKB
- protein complex binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
| BioGridi | 109894. 87 interactions. |
| DIPi | DIP-312N. |
| IntActi | P05556. 58 interactions. |
| MINTi | MINT-140089. |
| STRINGi | 9606.ENSP00000303351. |
Chemistry
| BindingDBi | P05556. |
Structurei
Secondary structure
1
798
Legend: HelixTurnBeta strand
Show more details| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Turni | 26 – 31 | 6 | Combined sources | | ||
| Helixi | 35 – 40 | 6 | Combined sources | | ||
| Beta strandi | 45 – 47 | 3 | Combined sources | | ||
| Helixi | 61 – 63 | 3 | Combined sources | | ||
| Beta strandi | 64 – 66 | 3 | Combined sources | | ||
| Helixi | 67 – 71 | 5 | Combined sources | | ||
| Turni | 72 – 74 | 3 | Combined sources | | ||
| Turni | 77 – 79 | 3 | Combined sources | | ||
| Beta strandi | 86 – 91 | 6 | Combined sources | | ||
| Helixi | 108 – 110 | 3 | Combined sources | | ||
| Beta strandi | 118 – 124 | 7 | Combined sources | | ||
| Beta strandi | 129 – 136 | 8 | Combined sources | | ||
| Beta strandi | 143 – 150 | 8 | Combined sources | | ||
| Helixi | 153 – 155 | 3 | Combined sources | | ||
| Helixi | 156 – 161 | 6 | Combined sources | | ||
| Helixi | 162 – 164 | 3 | Combined sources | | ||
| Helixi | 165 – 173 | 9 | Combined sources | | ||
| Turni | 174 – 176 | 3 | Combined sources | | ||
| Beta strandi | 180 – 187 | 8 | Combined sources | | ||
| Turni | 193 – 195 | 3 | Combined sources | | ||
| Helixi | 200 – 204 | 5 | Combined sources | | ||
| Beta strandi | 209 – 211 | 3 | Combined sources | | ||
| Beta strandi | 218 – 227 | 10 | Combined sources | | ||
| Helixi | 229 – 236 | 8 | Combined sources | | ||
| Beta strandi | 245 – 249 | 5 | Combined sources | | ||
| Helixi | 251 – 260 | 10 | Combined sources | | ||
| Helixi | 262 – 264 | 3 | Combined sources | | ||
| Beta strandi | 269 – 280 | 12 | Combined sources | | ||
| Helixi | 287 – 291 | 5 | Combined sources | | ||
| Turni | 311 – 313 | 3 | Combined sources | | ||
| Helixi | 319 – 328 | 10 | Combined sources | | ||
| Beta strandi | 331 – 337 | 7 | Combined sources | | ||
| Helixi | 339 – 341 | 3 | Combined sources | | ||
| Helixi | 342 – 351 | 10 | Combined sources | | ||
| Beta strandi | 352 – 359 | 8 | Combined sources | | ||
| Beta strandi | 362 – 364 | 3 | Combined sources | | ||
| Helixi | 367 – 379 | 13 | Combined sources | | ||
| Beta strandi | 382 – 386 | 5 | Combined sources | | ||
| Beta strandi | 393 – 400 | 8 | Combined sources | | ||
| Helixi | 402 – 404 | 3 | Combined sources | | ||
| Beta strandi | 406 – 408 | 3 | Combined sources | | ||
| Helixi | 409 – 413 | 5 | Combined sources | | ||
| Beta strandi | 423 – 432 | 10 | Combined sources | | ||
| Beta strandi | 437 – 439 | 3 | Combined sources | | ||
| Beta strandi | 441 – 447 | 7 | Combined sources | | ||
| Beta strandi | 454 – 461 | 8 | Combined sources | | ||
| Helixi | 752 – 769 | 18 | Combined sources | | ||
| Helixi | 770 – 772 | 3 | Combined sources | |
3D structure databases
|
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ProteinModelPortali | P05556. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMRi | P05556. Positions 24-787. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ModBasei | Search... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MobiDBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P05556. |
Family & Domainsi
Domains and Repeats
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Domaini | 140 – 378 | 239 | VWFA | | Add BLAST | |
| Repeati | 466 – 515 | 50 | I | | Add BLAST | |
| Repeati | 516 – 559 | 44 | II | | Add BLAST | |
| Repeati | 560 – 598 | 39 | III | | Add BLAST | |
| Repeati | 599 – 635 | 37 | IV | | Add BLAST |
Region
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Regioni | 207 – 213 | 7 | CX3CL1-binding1 Publication | | ||
| Regioni | 295 – 314 | 20 | CX3CL1-binding1 Publication | | Add BLAST | |
| Regioni | 466 – 635 | 170 | Cysteine-rich tandem repeats | | Add BLAST | |
| Regioni | 762 – 767 | 6 | Signal for sorting from recycling endosomes; interaction with ACAP1 | | ||
| Regioni | 785 – 792 | 8 | Interaction with ITGB1BP1 | |
Sequence similaritiesi
Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
| eggNOGi | KOG1226. Eukaryota. ENOG410XP60. LUCA. |
| GeneTreei | ENSGT00760000119064. |
| HOVERGENi | HBG006190. |
| InParanoidi | P05556. |
| KOi | K05719. |
| OMAi | SSVCCVF. |
| OrthoDBi | EOG091G029W. |
| PhylomeDBi | P05556. |
| TreeFami | TF105392. |
Family and domain databases
| Gene3Di | 1.20.5.630. 1 hit. 3.40.50.410. 1 hit. |
| InterProi | IPR013111. EGF_extracell. IPR027071. Integrin_beta-1. IPR015812. Integrin_bsu. IPR014836. Integrin_bsu_cyt_dom. IPR002369. Integrin_bsu_N. IPR012896. Integrin_bsu_tail. IPR032695. Integrin_dom. IPR016201. Plexin-like_fold. IPR002035. VWF_A. [Graphical view] |
| PANTHERi | PTHR10082. PTHR10082. 1 hit. PTHR10082:SF28. PTHR10082:SF28. 1 hit. |
| Pfami | PF07974. EGF_2. 1 hit. PF08725. Integrin_b_cyt. 1 hit. PF07965. Integrin_B_tail. 1 hit. PF00362. Integrin_beta. 1 hit. [Graphical view] |
| PIRSFi | PIRSF002512. Integrin_B. 1 hit. |
| PRINTSi | PR01186. INTEGRINB. |
| SMARTi | SM00187. INB. 1 hit. SM01241. Integrin_b_cyt. 1 hit. SM01242. Integrin_B_tail. 1 hit. SM00423. PSI. 1 hit. [Graphical view] |
| SUPFAMi | SSF103575. SSF103575. 1 hit. SSF53300. SSF53300. 1 hit. SSF69179. SSF69179. 1 hit. SSF69687. SSF69687. 1 hit. |
| PROSITEi | PS00022. EGF_1. 2 hits. PS00243. INTEGRIN_BETA. 3 hits. [Graphical view] |
Sequences (5)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P05556-1) [UniParc]FASTAAdd to basket
Also known as: Beta-1A
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNLQPIFWIG LISSVCCVFA QTDENRCLKA NAKSCGECIQ AGPNCGWCTN
60 70 80 90 100
STFLQEGMPT SARCDDLEAL KKKGCPPDDI ENPRGSKDIK KNKNVTNRSK
110 120 130 140 150
GTAEKLKPED ITQIQPQQLV LRLRSGEPQT FTLKFKRAED YPIDLYYLMD
160 170 180 190 200
LSYSMKDDLE NVKSLGTDLM NEMRRITSDF RIGFGSFVEK TVMPYISTTP
210 220 230 240 250
AKLRNPCTSE QNCTSPFSYK NVLSLTNKGE VFNELVGKQR ISGNLDSPEG
260 270 280 290 300
GFDAIMQVAV CGSLIGWRNV TRLLVFSTDA GFHFAGDGKL GGIVLPNDGQ
310 320 330 340 350
CHLENNMYTM SHYYDYPSIA HLVQKLSENN IQTIFAVTEE FQPVYKELKN
360 370 380 390 400
LIPKSAVGTL SANSSNVIQL IIDAYNSLSS EVILENGKLS EGVTISYKSY
410 420 430 440 450
CKNGVNGTGE NGRKCSNISI GDEVQFEISI TSNKCPKKDS DSFKIRPLGF
460 470 480 490 500
TEEVEVILQY ICECECQSEG IPESPKCHEG NGTFECGACR CNEGRVGRHC
510 520 530 540 550
ECSTDEVNSE DMDAYCRKEN SSEICSNNGE CVCGQCVCRK RDNTNEIYSG
560 570 580 590 600
KFCECDNFNC DRSNGLICGG NGVCKCRVCE CNPNYTGSAC DCSLDTSTCE
610 620 630 640 650
ASNGQICNGR GICECGVCKC TDPKFQGQTC EMCQTCLGVC AEHKECVQCR
660 670 680 690 700
AFNKGEKKDT CTQECSYFNI TKVESRDKLP QPVQPDPVSH CKEKDVDDCW
710 720 730 740 750
FYFTYSVNGN NEVMVHVVEN PECPTGPDII PIVAGVVAGI VLIGLALLLI
760 770 780 790
WKLLMIIHDR REFAKFEKEK MNAKWDTGEN PIYKSAVTTV VNPKYEGK
Sequence cautioni
The sequence CAD97649 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
Experimental Info
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Sequence conflicti | 112 – 112 | 1 | T → H in CAA30790 (PubMed:2958481).Curated | | ||
| Sequence conflicti | 215 – 215 | 1 | S → T in CAA30790 (PubMed:2958481).Curated | | ||
| Sequence conflicti | 261 – 265 | 5 | CGSLI → VWMLL in AAI13902 (PubMed:15489334).Curated | | ||
| Sequence conflicti | 385 – 386 | 2 | EN → DG in AAI13902 (PubMed:15489334).Curated | | ||
| Sequence conflicti | 463 – 463 | 1 | E → V in BAF84386 (PubMed:14702039).Curated | |
Alternative sequence
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | Actions |
|---|---|---|---|---|---|---|
| Alternative sequencei | 778 – 798 | 21 | GENPI…KYEGK → VSYKTSKKQSGL in isoform 2. Curated | | VSP_002741 | Add BLAST |
| Alternative sequencei | 778 – 798 | 21 | GENPI…KYEGK → SLSVAQPGVQWCDISSLQPL TSRFQQFSCLSLPSTWDYRV KILFIRVP in isoform 3. Curated | | VSP_002742 | Add BLAST |
| Alternative sequencei | 778 – 798 | 21 | GENPI…KYEGK → PGVQWCDISSLQPLTSRFQQ FSCLSLPSTWDYRVKILFIR VP in isoform 4. Curated | | VSP_002743 | Add BLAST |
| Alternative sequencei | 778 – 798 | 21 | GENPI…KYEGK → QENPIYKSPINNFKNPNYGR KAGL in isoform 5. Curated | | VSP_002744 | Add BLAST |
Sequence databases
|
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07979 mRNA. Translation: CAA30790.1. AK291697 mRNA. Translation: BAF84386.1. BX537407 mRNA. Translation: CAD97649.1. Different initiation. AL365203 Genomic DNA. Translation: CAI14426.1. CH471072 Genomic DNA. Translation: EAW85948.1. CH471072 Genomic DNA. Translation: EAW85949.1. CH471072 Genomic DNA. Translation: EAW85950.1. CH471072 Genomic DNA. Translation: EAW85951.1. CH471072 Genomic DNA. Translation: EAW85952.1. CH471072 Genomic DNA. Translation: EAW85953.1. CH471072 Genomic DNA. Translation: EAW85954.1. CH471072 Genomic DNA. Translation: EAW85955.1. CH471072 Genomic DNA. Translation: EAW85957.1. CH471072 Genomic DNA. Translation: EAW85958.1. CH471072 Genomic DNA. Translation: EAW85959.1. BC020057 mRNA. Translation: AAH20057.1. BC113901 mRNA. Translation: AAI13902.1. U33879 Genomic DNA. Translation: AAA79832.1. U33880, U33879 Genomic DNA. Translation: AAA79833.1. U33882, U33879, U33881 Genomic DNA. Translation: AAA79834.1. U33882, U33879 Genomic DNA. Translation: AAA79835.1. M34189 mRNA. Translation: AAA59182.1. M84237 mRNA. Translation: AAA74402.1. M84237 mRNA. Translation: AAA74403.1. U28252 mRNA. Translation: AAA81366.1. |
| CCDSi | CCDS7174.1. [P05556-1] |
| PIRi | B27079. |
| RefSeqi | NP_002202.2. NM_002211.3. [P05556-1] NP_391988.1. NM_033668.2. [P05556-5] NP_596867.1. NM_133376.2. [P05556-1] |
| UniGenei | Hs.643813. |
Genome annotation databases
| Ensembli | ENST00000302278; ENSP00000303351; ENSG00000150093. [P05556-1] ENST00000396033; ENSP00000379350; ENSG00000150093. [P05556-1] ENST00000423113; ENSP00000388694; ENSG00000150093. [P05556-5] |
| GeneIDi | 3688. |
| KEGGi | hsa:3688. |
| UCSCi | uc001iwr.5. human. [P05556-1] |
Keywords - Coding sequence diversityi
Alternative splicingCross-referencesi
Web resourcesi
| Wikipedia CD29 entry |
Sequence databases
|
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X07979 mRNA. Translation: CAA30790.1. AK291697 mRNA. Translation: BAF84386.1. BX537407 mRNA. Translation: CAD97649.1. Different initiation. AL365203 Genomic DNA. Translation: CAI14426.1. CH471072 Genomic DNA. Translation: EAW85948.1. CH471072 Genomic DNA. Translation: EAW85949.1. CH471072 Genomic DNA. Translation: EAW85950.1. CH471072 Genomic DNA. Translation: EAW85951.1. CH471072 Genomic DNA. Translation: EAW85952.1. CH471072 Genomic DNA. Translation: EAW85953.1. CH471072 Genomic DNA. Translation: EAW85954.1. CH471072 Genomic DNA. Translation: EAW85955.1. CH471072 Genomic DNA. Translation: EAW85957.1. CH471072 Genomic DNA. Translation: EAW85958.1. CH471072 Genomic DNA. Translation: EAW85959.1. BC020057 mRNA. Translation: AAH20057.1. BC113901 mRNA. Translation: AAI13902.1. U33879 Genomic DNA. Translation: AAA79832.1. U33880, U33879 Genomic DNA. Translation: AAA79833.1. U33882, U33879, U33881 Genomic DNA. Translation: AAA79834.1. U33882, U33879 Genomic DNA. Translation: AAA79835.1. M34189 mRNA. Translation: AAA59182.1. M84237 mRNA. Translation: AAA74402.1. M84237 mRNA. Translation: AAA74403.1. U28252 mRNA. Translation: AAA81366.1. |
| CCDSi | CCDS7174.1. [P05556-1] |
| PIRi | B27079. |
| RefSeqi | NP_002202.2. NM_002211.3. [P05556-1] NP_391988.1. NM_033668.2. [P05556-5] NP_596867.1. NM_133376.2. [P05556-1] |
| UniGenei | Hs.643813. |
3D structure databases
|
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ProteinModelPortali | P05556. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMRi | P05556. Positions 24-787. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ModBasei | Search... | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MobiDBi | Search... |
Protein-protein interaction databases
| BioGridi | 109894. 87 interactions. |
| DIPi | DIP-312N. |
| IntActi | P05556. 58 interactions. |
| MINTi | MINT-140089. |
| STRINGi | 9606.ENSP00000303351. |
Chemistry
| BindingDBi | P05556. |
| ChEMBLi | CHEMBL3137268. |
| DrugBanki | DB00098. Anti-thymocyte Globulin (Rabbit). |
Protein family/group databases
| TCDBi | 9.B.87.1.8. the selenoprotein p receptor (selp-receptor) family. |
PTM databases
| iPTMneti | P05556. |
| PhosphoSitei | P05556. |
| SwissPalmi | P05556. |
| UniCarbKBi | P05556. |
Polymorphism and mutation databases
| BioMutai | ITGB1. |
| DMDMi | 218563324. |
Proteomic databases
| EPDi | P05556. |
| MaxQBi | P05556. |
| PaxDbi | P05556. |
| PeptideAtlasi | P05556. |
| PRIDEi | P05556. |
Protocols and materials databases
| DNASUi | 3688. |
| Structural Biology Knowledgebase | Search... |
Genome annotation databases
| Ensembli | ENST00000302278; ENSP00000303351; ENSG00000150093. [P05556-1] ENST00000396033; ENSP00000379350; ENSG00000150093. [P05556-1] ENST00000423113; ENSP00000388694; ENSG00000150093. [P05556-5] |
| GeneIDi | 3688. |
| KEGGi | hsa:3688. |
| UCSCi | uc001iwr.5. human. [P05556-1] |
Organism-specific databases
| CTDi | 3688. |
| GeneCardsi | ITGB1. |
| HGNCi | HGNC:6153. ITGB1. |
| HPAi | CAB003434. |
| MIMi | 135630. gene. |
| neXtProti | NX_P05556. |
| PharmGKBi | PA29953. |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | KOG1226. Eukaryota. ENOG410XP60. LUCA. |
| GeneTreei | ENSGT00760000119064. |
| HOVERGENi | HBG006190. |
| InParanoidi | P05556. |
| KOi | K05719. |
| OMAi | SSVCCVF. |
| OrthoDBi | EOG091G029W. |
| PhylomeDBi | P05556. |
| TreeFami | TF105392. |
Enzyme and pathway databases
| Reactomei | R-HSA-1566948. Elastic fibre formation. R-HSA-1566977. Fibronectin matrix formation. R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. R-HSA-202733. Cell surface interactions at the vascular wall. R-HSA-210991. Basigin interactions. R-HSA-2129379. Molecules associated with elastic fibres. R-HSA-216083. Integrin cell surface interactions. R-HSA-3000157. Laminin interactions. R-HSA-3000170. Syndecan interactions. R-HSA-3000178. ECM proteoglycans. R-HSA-416700. Other semaphorin interactions. R-HSA-445144. Signal transduction by L1. R-HSA-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions. R-HSA-447041. CHL1 interactions. R-HSA-5663220. RHO GTPases Activate Formins. R-HSA-75892. Platelet Adhesion to exposed collagen. |
| SABIO-RK | P05556. |
| SignaLinki | P05556. |
| SIGNORi | P05556. |
Miscellaneous databases
| ChiTaRSi | ITGB1. human. |
| EvolutionaryTracei | P05556. |
| GeneWikii | CD29. |
| GenomeRNAii | 3688. |
| PMAP-CutDB | Q8WUM6. |
| PROi | P05556. |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000150093. |
| ExpressionAtlasi | P05556. baseline and differential. |
| Genevisiblei | P05556. HS. |
Family and domain databases
| Gene3Di | 1.20.5.630. 1 hit. 3.40.50.410. 1 hit. |
| InterProi | IPR013111. EGF_extracell. IPR027071. Integrin_beta-1. IPR015812. Integrin_bsu. IPR014836. Integrin_bsu_cyt_dom. IPR002369. Integrin_bsu_N. IPR012896. Integrin_bsu_tail. IPR032695. Integrin_dom. IPR016201. Plexin-like_fold. IPR002035. VWF_A. [Graphical view] |
| PANTHERi | PTHR10082. PTHR10082. 1 hit. PTHR10082:SF28. PTHR10082:SF28. 1 hit. |
| Pfami | PF07974. EGF_2. 1 hit. PF08725. Integrin_b_cyt. 1 hit. PF07965. Integrin_B_tail. 1 hit. PF00362. Integrin_beta. 1 hit. [Graphical view] |
| PIRSFi | PIRSF002512. Integrin_B. 1 hit. |
| PRINTSi | PR01186. INTEGRINB. |
| SMARTi | SM00187. INB. 1 hit. SM01241. Integrin_b_cyt. 1 hit. SM01242. Integrin_B_tail. 1 hit. SM00423. PSI. 1 hit. [Graphical view] |
| SUPFAMi | SSF103575. SSF103575. 1 hit. SSF53300. SSF53300. 1 hit. SSF69179. SSF69179. 1 hit. SSF69687. SSF69687. 1 hit. |
| PROSITEi | PS00022. EGF_1. 2 hits. PS00243. INTEGRIN_BETA. 3 hits. [Graphical view] |
| ProtoNeti | Search... |
Entry informationi
| Entry namei | ITB1_HUMAN | ||||||||
| Accessioni | P05556Primary (citable) accession number: P05556 Secondary accession number(s): A8K6N2 Q8WUM6 | ||||||||
| Entry historyi |
| ||||||||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation moleculesCD nomenclature of surface proteins of human leucocytes and list of entries
- Human chromosome 10Human chromosome 10: entries, gene names and cross-references to MIM
- MIM cross-referencesOnline Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
- PDB cross-referencesIndex of Protein Data Bank (PDB) cross-references
- SIMILARITY commentsIndex of protein domains and families
Similar proteinsi
Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:| 100% | UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry. |
| 90% | UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence). |
| 50% | UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster. |