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Protein

Transcription factor Adf-1

Gene

Adf1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play an important role not only in the regulation of Adh expression but also in the transcription of other genes.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 104MADFPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiP05552.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Adf-1
Alternative name(s):
ADH distal factor 1
Gene namesi
Name:Adf1
ORF Names:CG15845
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000054. Adf1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644521 – 262Transcription factor Adf-1Add BLAST262

Post-translational modificationi

O-glycosylated; contains N-acetylglucosamine side chains.

Proteomic databases

PaxDbiP05552.
PRIDEiP05552.

Expressioni

Developmental stagei

Expressed during later stages of embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0000054.
ExpressionAtlasiP05552. baseline.
GenevisibleiP05552. DM.

Interactioni

Protein-protein interaction databases

BioGridi70573. 10 interactors.
DIPiDIP-21836N.
IntActiP05552. 5 interactors.
MINTiMINT-278578.
STRINGi7227.FBpp0303284.

Structurei

3D structure databases

ProteinModelPortaliP05552.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 256BESSPROSITE-ProRule annotationAdd BLAST40

Sequence similaritiesi

Contains 1 BESS domain.PROSITE-ProRule annotation
Contains 1 MADF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410J7ID. Eukaryota.
ENOG410Y6DQ. LUCA.
GeneTreeiENSGT00530000065360.
InParanoidiP05552.
KOiK09427.
OrthoDBiEOG091G0I9A.
PhylomeDBiP05552.

Family and domain databases

InterProiIPR004210. BESS_motif.
IPR006578. MADF-dom.
[Graphical view]
PfamiPF10545. MADF_DNA_bdg. 1 hit.
[Graphical view]
SMARTiSM00595. MADF. 1 hit.
[Graphical view]
PROSITEiPS51031. BESS. 1 hit.
PS51029. MADF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: P05552-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTLTAAIEM DKLDANLEQQ FDLNLIEAVK LNPVIYDRSH YNYKHFVRKA
60 70 80 90 100
QTWKQIAETL GVPEQKCTKR WKSLRDKFAR EMKLCQESRW RYFKQMQFLV
110 120 130 140 150
DSIRQYRESL LGKCANGSQS ANQVADPSQQ QQAQQQTVVD IFAQPFNGSA
160 170 180 190 200
TTSAQALTHP HEITVTSDAQ LATAVGKDQK PYFYEPPLKR ERSEEEHSDN
210 220 230 240 250
MLNTIKIFQN NVSQAVSAED QSFGMVVTDM LNTLGVRQKA EAKVHIIKYL
260
TDMQLLAQHN KY
Note: No experimental confirmation available.
Length:262
Mass (Da):30,188
Last modified:November 14, 2006 - v2
Checksum:i0941D5692E7213F8
GO
Isoform A (identifier: P05552-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:253
Mass (Da):29,220
Checksum:i852B288E39B92DF9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0215681 – 9Missing in isoform A. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37787 mRNA. Translation: AAA28325.1.
AE013599 Genomic DNA. Translation: AAF57369.1.
AE013599 Genomic DNA. Translation: AAS64778.1.
AY069387 mRNA. Translation: AAL39532.1.
PIRiA38201.
RefSeqiNP_724481.1. NM_165479.2. [P05552-2]
NP_724482.1. NM_165480.2. [P05552-2]
NP_995750.1. NM_206028.2. [P05552-1]
UniGeneiDm.7167.

Genome annotation databases

EnsemblMetazoaiFBtr0086113; FBpp0089262; FBgn0000054. [P05552-1]
GeneIDi47082.
KEGGidme:Dmel_CG15845.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37787 mRNA. Translation: AAA28325.1.
AE013599 Genomic DNA. Translation: AAF57369.1.
AE013599 Genomic DNA. Translation: AAS64778.1.
AY069387 mRNA. Translation: AAL39532.1.
PIRiA38201.
RefSeqiNP_724481.1. NM_165479.2. [P05552-2]
NP_724482.1. NM_165480.2. [P05552-2]
NP_995750.1. NM_206028.2. [P05552-1]
UniGeneiDm.7167.

3D structure databases

ProteinModelPortaliP05552.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi70573. 10 interactors.
DIPiDIP-21836N.
IntActiP05552. 5 interactors.
MINTiMINT-278578.
STRINGi7227.FBpp0303284.

Proteomic databases

PaxDbiP05552.
PRIDEiP05552.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0086113; FBpp0089262; FBgn0000054. [P05552-1]
GeneIDi47082.
KEGGidme:Dmel_CG15845.

Organism-specific databases

CTDi47082.
FlyBaseiFBgn0000054. Adf1.

Phylogenomic databases

eggNOGiENOG410J7ID. Eukaryota.
ENOG410Y6DQ. LUCA.
GeneTreeiENSGT00530000065360.
InParanoidiP05552.
KOiK09427.
OrthoDBiEOG091G0I9A.
PhylomeDBiP05552.

Enzyme and pathway databases

SignaLinkiP05552.

Miscellaneous databases

ChiTaRSiAdf1. fly.
GenomeRNAii47082.
PROiP05552.

Gene expression databases

BgeeiFBgn0000054.
ExpressionAtlasiP05552. baseline.
GenevisibleiP05552. DM.

Family and domain databases

InterProiIPR004210. BESS_motif.
IPR006578. MADF-dom.
[Graphical view]
PfamiPF10545. MADF_DNA_bdg. 1 hit.
[Graphical view]
SMARTiSM00595. MADF. 1 hit.
[Graphical view]
PROSITEiPS51031. BESS. 1 hit.
PS51029. MADF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADF1_DROME
AccessioniPrimary (citable) accession number: P05552
Secondary accession number(s): Q0E9N5, Q9V9C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 14, 2006
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.