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Protein

Transcription factor Adf-1

Gene

Adf1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play an important role not only in the regulation of Adh expression but also in the transcription of other genes.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi24 – 104MADFPROSITE-ProRule annotationAdd BLAST81

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SignaLinkiP05552

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Adf-1
Alternative name(s):
ADH distal factor 1
Gene namesi
Name:Adf1
ORF Names:CG15845
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0284249 Adf1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000644521 – 262Transcription factor Adf-1Add BLAST262

Post-translational modificationi

O-glycosylated; contains N-acetylglucosamine side chains.

Proteomic databases

PaxDbiP05552
PRIDEiP05552

Expressioni

Developmental stagei

Expressed during later stages of embryogenesis.1 Publication

Gene expression databases

BgeeiFBgn0000054
ExpressionAtlasiP05552 differential
GenevisibleiP05552 DM

Interactioni

Protein-protein interaction databases

BioGridi70573, 16 interactors
DIPiDIP-21836N
IntActiP05552, 11 interactors
STRINGi7227.FBpp0303284

Structurei

3D structure databases

ProteinModelPortaliP05552
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini217 – 256BESSPROSITE-ProRule annotationAdd BLAST40

Phylogenomic databases

eggNOGiENOG410J7ID Eukaryota
ENOG410Y6DQ LUCA
GeneTreeiENSGT00530000065360
InParanoidiP05552
KOiK09427
OrthoDBiEOG091G0I9A
PhylomeDBiP05552

Family and domain databases

InterProiView protein in InterPro
IPR004210 BESS_motif
IPR006578 MADF-dom
PfamiView protein in Pfam
PF10545 MADF_DNA_bdg, 1 hit
SMARTiView protein in SMART
SM00595 MADF, 1 hit
PROSITEiView protein in PROSITE
PS51031 BESS, 1 hit
PS51029 MADF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: P05552-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHTLTAAIEM DKLDANLEQQ FDLNLIEAVK LNPVIYDRSH YNYKHFVRKA
60 70 80 90 100
QTWKQIAETL GVPEQKCTKR WKSLRDKFAR EMKLCQESRW RYFKQMQFLV
110 120 130 140 150
DSIRQYRESL LGKCANGSQS ANQVADPSQQ QQAQQQTVVD IFAQPFNGSA
160 170 180 190 200
TTSAQALTHP HEITVTSDAQ LATAVGKDQK PYFYEPPLKR ERSEEEHSDN
210 220 230 240 250
MLNTIKIFQN NVSQAVSAED QSFGMVVTDM LNTLGVRQKA EAKVHIIKYL
260
TDMQLLAQHN KY
Note: No experimental confirmation available.
Length:262
Mass (Da):30,188
Last modified:November 14, 2006 - v2
Checksum:i0941D5692E7213F8
GO
Isoform A (identifier: P05552-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:253
Mass (Da):29,220
Checksum:i852B288E39B92DF9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0215681 – 9Missing in isoform A. 2 Publications9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M37787 mRNA Translation: AAA28325.1
AE013599 Genomic DNA Translation: AAF57369.1
AE013599 Genomic DNA Translation: AAS64778.1
AY069387 mRNA Translation: AAL39532.1
PIRiA38201
RefSeqiNP_724481.1, NM_165479.2 [P05552-2]
NP_724482.1, NM_165480.2 [P05552-2]
NP_995750.1, NM_206028.2 [P05552-1]
UniGeneiDm.7167

Genome annotation databases

EnsemblMetazoaiFBtr0086111; FBpp0085446; FBgn0284249 [P05552-2]
FBtr0086112; FBpp0085447; FBgn0284249 [P05552-2]
FBtr0086113; FBpp0089262; FBgn0284249 [P05552-1]
GeneIDi47082
KEGGidme:Dmel_CG15845

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiADF1_DROME
AccessioniPrimary (citable) accession number: P05552
Secondary accession number(s): Q0E9N5, Q9V9C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1991
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health