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Protein

T-cell surface glycoprotein CD8 beta chain

Gene

Cd8b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD8 beta chain
Alternative name(s):
CD8 antigen 37 kDa chain
OX-8 membrane antigen
CD_antigen: CD8b
Gene namesi
Name:Cd8b
Synonyms:Cd8b1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2317. Cd8b.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 168ExtracellularSequence analysisAdd BLAST147
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 208CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001464622 – 208T-cell surface glycoprotein CD8 beta chainAdd BLAST187

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP05541.

Interactioni

Subunit structurei

In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009392.

Structurei

3D structure databases

ProteinModelPortaliP05541.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 131Ig-like V-typeAdd BLAST110

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY5X. Eukaryota.
ENOG410ZF37. LUCA.
HOGENOMiHOG000008681.
HOVERGENiHBG105700.
InParanoidiP05541.
KOiK06459.
PhylomeDBiP05541.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05541-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPWLWLVFS VKLSALWGSS ALLQTPSSLL VQTNQTAKMS CEAKTFPKGT
60 70 80 90 100
TIYWLRELQD SNKNKHFEFL ASRTSTKGIK YGERVKKNMT LSFNSTLPFL
110 120 130 140 150
KIMDVKPEDS GFYFCAMVGS PMVVFGTGTK LTVVDVLPTT APTKKTTLKK
160 170 180 190 200
KQCPTPHPKT QKGLTCGLIT LSLLVACILV LLVSLSVAIH FHCMRRRARI

HFMKQFHK
Length:208
Mass (Da):23,400
Last modified:November 1, 1988 - v1
Checksum:i1A2DA164DFA1B1F2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti201H → R.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04310 mRNA. Translation: CAA27850.1.
PIRiA24184.
RefSeqiNP_113727.1. NM_031539.1.
UniGeneiRn.10330.

Genome annotation databases

GeneIDi24931.
KEGGirno:24931.
UCSCiRGD:2317. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04310 mRNA. Translation: CAA27850.1.
PIRiA24184.
RefSeqiNP_113727.1. NM_031539.1.
UniGeneiRn.10330.

3D structure databases

ProteinModelPortaliP05541.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009392.

Proteomic databases

PaxDbiP05541.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24931.
KEGGirno:24931.
UCSCiRGD:2317. rat.

Organism-specific databases

CTDi926.
RGDi2317. Cd8b.

Phylogenomic databases

eggNOGiENOG410IY5X. Eukaryota.
ENOG410ZF37. LUCA.
HOGENOMiHOG000008681.
HOVERGENiHBG105700.
InParanoidiP05541.
KOiK06459.
PhylomeDBiP05541.

Miscellaneous databases

PROiP05541.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD8B_RAT
AccessioniPrimary (citable) accession number: P05541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 5, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.