P05541 (CD8B_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
T-cell surface glycoprotein CD8 beta chain

Alternative name(s):
CD8 antigen 37 kDa chain
OX-8 membrane antigen
CD_antigen=CD8b

Gene names

Name:	Cd8b
Synonyms:	Cd8b1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	208 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.
Subunit structure	In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Biological process	Adaptive immunity Immunity
Cellular component	Membrane
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21
	Chain	22 – 208	187	T-cell surface glycoprotein CD8 beta chain		PRO_0000014646
Regions
	Topological domain	22 – 168	147	Extracellular Potential
	Transmembrane	169 – 189	21	Helical; Potential
	Topological domain	190 – 208	19	Cytoplasmic Potential
	Domain	22 – 131	110	Ig-like V-type
Amino acid modifications
	Modified residue	129	1	Phosphothreonine By similarity
	Glycosylation	34	1	N-linked (GlcNAc...) Potential
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
	Disulfide bond	41 ↔ 115		Potential
Natural variations
	Natural variant	201	1	H → R.

Sequences

	Sequence		Length	Mass (Da)
	P05541 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 1A2DA164DFA1B1F2	FASTA	208	23,400
	10 20 30 40 50 60 MQPWLWLVFS VKLSALWGSS ALLQTPSSLL VQTNQTAKMS CEAKTFPKGT TIYWLRELQD 70 80 90 100 110 120 SNKNKHFEFL ASRTSTKGIK YGERVKKNMT LSFNSTLPFL KIMDVKPEDS GFYFCAMVGS 130 140 150 160 170 180 PMVVFGTGTK LTVVDVLPTT APTKKTTLKK KQCPTPHPKT QKGLTCGLIT LSLLVACILV 190 200 LLVSLSVAIH FHCMRRRARI HFMKQFHK

References

[1]	"Striking similarities between antigen receptor J pieces and sequence in the second chain of the murine CD8 antigen." Johnson P., Williams A.F. Nature 323:74-76(1986) [PubMed: 3092111] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Thymocyte.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X04310 mRNA. Translation: CAA27850.1.
IPI	IPI00200585.
PIR	A24184.
RefSeq	NP_113727.1. NM_031539.1.
UniGene	Rn.10330.
3D structure databases
ProteinModelPortal	P05541.
SMR	P05541. Positions 22-134.
ModBase	Search...
Protein-protein interaction databases
STRING	P05541.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	24931.
KEGG	rno:24931.
UCSC	NM_031539. rat.
Organism-specific databases
CTD	926.
RGD	2317. Cd8b.
Phylogenomic databases
eggNOG	roNOG17531.
HOVERGEN	HBG105700.
InParanoid	P05541.
OrthoDB	EOG4GMTZF.
Gene expression databases
Genevestigator	P05541.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013106. Ig_V-set. IPR003596. Ig_V-set_subgr. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
KO	K06459.
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00406. IGv. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	604899.

Entry information

Entry name

CD8B_RAT

Accession

Primary (citable) accession number: P05541

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	November 16, 2011
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program