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P05538

- DQB2_HUMAN

UniProt

P05538 - DQB2_HUMAN

Protein

HLA class II histocompatibility antigen, DQ beta 2 chain

Gene

HLA-DQB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (01 Feb 1991)
      Previous versions | rss
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    Functioni

    Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.1 Publication

    GO - Molecular functioni

    1. MHC class II receptor activity Source: UniProtKB

    GO - Biological processi

    1. antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
    2. cytokine-mediated signaling pathway Source: Reactome
    3. immune response Source: UniProtKB
    4. interferon-gamma-mediated signaling pathway Source: Reactome
    5. T cell costimulation Source: Reactome
    6. T cell receptor signaling pathway Source: Reactome

    Keywords - Biological processi

    Immunity

    Enzyme and pathway databases

    ReactomeiREACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HLA class II histocompatibility antigen, DQ beta 2 chain
    Alternative name(s):
    HLA class II histocompatibility antigen, DX beta chain
    MHC class II antigen DQB2
    Gene namesi
    Name:HLA-DQB2
    Synonyms:HLA-DXB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4945. HLA-DQB2.

    Subcellular locationi

    Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Endosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication. Lysosome membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.

    GO - Cellular componenti

    1. clathrin-coated endocytic vesicle membrane Source: Reactome
    2. endocytic vesicle membrane Source: Reactome
    3. endosome membrane Source: UniProtKB-SubCell
    4. ER to Golgi transport vesicle membrane Source: Reactome
    5. Golgi membrane Source: Reactome
    6. integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
    7. lysosomal membrane Source: Reactome
    8. MHC class II protein complex Source: UniProtKB
    9. plasma membrane Source: Reactome
    10. trans-Golgi network membrane Source: Reactome
    11. transport vesicle membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Add
    BLAST
    Chaini33 – 268236HLA class II histocompatibility antigen, DQ beta 2 chainPRO_0000018992Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 110PROSITE-ProRule annotation
    Glycosylationi51 – 511N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi148 ↔ 204PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP05538.
    PRIDEiP05538.

    Expressioni

    Tissue specificityi

    Restricted to skin Langerhans cells (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiP05538.
    GenevestigatoriP05538.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. Dimer formation with HLA-DQA2, but not with HLA-DQA1, is required for efficient exit from the endoplasmic reticulum (ER). In the ER, forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides. Association with HLA-DMA also occurs in skin Langerhans cells, in post-Golgi compartments.1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000409159.

    Structurei

    3D structure databases

    ProteinModelPortaliP05538.
    SMRiP05538. Positions 36-223.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini33 – 229197ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini251 – 26818CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei230 – 25021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini128 – 21689Ig-like C1-typeAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 12694Beta-1Add
    BLAST
    Regioni127 – 229103Beta-2Add
    BLAST

    Sequence similaritiesi

    Belongs to the MHC class II family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68200.
    PhylomeDBiP05538.
    TreeFamiTF336626.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P05538-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSWKMALQIP GGFWAAAVTV MLVMLSTPVA EARDFPKDFL VQFKGMCYFT    50
    NGTERVRGVA RYIYNREEYG RFDSDVGEFQ AVTELGRSIE DWNNYKDFLE 100
    QERAAVDKVC RHNYEAELRT TLQRQVEPTV TISPSRTEAL NHHNLLVCSV 150
    TDFYPAQIKV RWFRNDQEET AGVVSTSLIR NGDWTFQILV MLEITPQRGD 200
    IYTCQVEHPS LQSPITVEWR AQSESAQSKM LSGIGGFVLG LIFLGLGLII 250
    RHRGQKGPRG PPPAGLLH 268
    Length:268
    Mass (Da):30,387
    Last modified:February 1, 1991 - v2
    Checksum:i2746ED6CC5D44AF2
    GO
    Isoform 2 (identifier: P05538-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: Missing.
         221-257: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:227
    Mass (Da):26,031
    Checksum:iB03817F038B6371F
    GO

    Sequence cautioni

    The sequence CAA60790.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061V → L in AAA52667. (PubMed:2564844)Curated
    Sequence conflicti106 – 1061V → L in AAA52668. (PubMed:2564844)Curated
    Sequence conflicti106 – 1061V → L in AAA52669. (PubMed:2564844)Curated
    Sequence conflicti106 – 1061V → L in AAA52670. (PubMed:2564844)Curated
    Sequence conflicti266 – 2683LLH → HLL in CAA60790. (PubMed:8568858)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti161 – 1611R → Q.2 Publications
    Corresponds to variant rs1049110 [ dbSNP | Ensembl ].
    VAR_069445
    Natural varianti232 – 2321S → G.1 Publication
    VAR_069446
    Natural varianti234 – 2341I → V.1 Publication
    VAR_069447

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44Missing in isoform 2. 1 PublicationVSP_045914
    Alternative sequencei221 – 25737Missing in isoform 2. 1 PublicationVSP_045915Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29614 Genomic DNA. No translation available.
    M29615 Genomic DNA. No translation available.
    X87344 Genomic DNA. Translation: CAA60790.1. Different initiation.
    AL671681 Genomic DNA. No translation available.
    AL672104 Genomic DNA. No translation available.
    AL713890 Genomic DNA. No translation available.
    BX296564 Genomic DNA. Translation: CAM26036.1.
    CR936921 Genomic DNA. Translation: CAQ07315.1.
    BC031995 mRNA. No translation available.
    M11136 Genomic DNA. No translation available.
    M24920 Genomic DNA. Translation: AAA52667.1.
    M24921 Genomic DNA. Translation: AAA52668.1.
    M24922 Genomic DNA. Translation: AAA52669.1.
    M24923 Genomic DNA. Translation: AAA52670.1.
    CCDSiCCDS56419.1. [P05538-2]
    PIRiD29312.
    G35058.
    RefSeqiNP_001185787.1. NM_001198858.1. [P05538-2]
    UniGeneiHs.731563.

    Genome annotation databases

    EnsembliENST00000399661; ENSP00000382569; ENSG00000196610.
    ENST00000411527; ENSP00000390431; ENSG00000232629. [P05538-2]
    ENST00000426733; ENSP00000393969; ENSG00000226165. [P05538-2]
    ENST00000430849; ENSP00000389067; ENSG00000228813.
    ENST00000432486; ENSP00000410132; ENSG00000228254.
    ENST00000438757; ENSP00000408884; ENSG00000224305. [P05538-2]
    ENST00000456529; ENSP00000399594; ENSG00000230675. [P05538-2]
    ENST00000457432; ENSP00000396502; ENSG00000229493.
    GeneIDi3120.
    KEGGihsa:3120.
    UCSCiuc003oby.4. human.

    Polymorphism databases

    DMDMi122271.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M29614 Genomic DNA. No translation available.
    M29615 Genomic DNA. No translation available.
    X87344 Genomic DNA. Translation: CAA60790.1 . Different initiation.
    AL671681 Genomic DNA. No translation available.
    AL672104 Genomic DNA. No translation available.
    AL713890 Genomic DNA. No translation available.
    BX296564 Genomic DNA. Translation: CAM26036.1 .
    CR936921 Genomic DNA. Translation: CAQ07315.1 .
    BC031995 mRNA. No translation available.
    M11136 Genomic DNA. No translation available.
    M24920 Genomic DNA. Translation: AAA52667.1 .
    M24921 Genomic DNA. Translation: AAA52668.1 .
    M24922 Genomic DNA. Translation: AAA52669.1 .
    M24923 Genomic DNA. Translation: AAA52670.1 .
    CCDSi CCDS56419.1. [P05538-2 ]
    PIRi D29312.
    G35058.
    RefSeqi NP_001185787.1. NM_001198858.1. [P05538-2 ]
    UniGenei Hs.731563.

    3D structure databases

    ProteinModelPortali P05538.
    SMRi P05538. Positions 36-223.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000409159.

    Polymorphism databases

    DMDMi 122271.

    Proteomic databases

    PaxDbi P05538.
    PRIDEi P05538.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000399661 ; ENSP00000382569 ; ENSG00000196610 .
    ENST00000411527 ; ENSP00000390431 ; ENSG00000232629 . [P05538-2 ]
    ENST00000426733 ; ENSP00000393969 ; ENSG00000226165 . [P05538-2 ]
    ENST00000430849 ; ENSP00000389067 ; ENSG00000228813 .
    ENST00000432486 ; ENSP00000410132 ; ENSG00000228254 .
    ENST00000438757 ; ENSP00000408884 ; ENSG00000224305 . [P05538-2 ]
    ENST00000456529 ; ENSP00000399594 ; ENSG00000230675 . [P05538-2 ]
    ENST00000457432 ; ENSP00000396502 ; ENSG00000229493 .
    GeneIDi 3120.
    KEGGi hsa:3120.
    UCSCi uc003oby.4. human.

    Organism-specific databases

    CTDi 3120.
    GeneCardsi GC06M032728.
    GC06Mi32708.
    GC06Mj32647.
    GC06Mk32703.
    GC06Ml32877.
    GC06Mm32757.
    GC06Mn32652.
    GC06Mo32814.
    H-InvDB HIX0165918.
    HIX0166089.
    HIX0166694.
    HIX0167203.
    HGNCi HGNC:4945. HLA-DQB2.
    MIMi 615161. gene.
    neXtProti NX_P05538.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68200.
    PhylomeDBi P05538.
    TreeFami TF336626.

    Enzyme and pathway databases

    Reactomei REACT_121399. MHC class II antigen presentation.
    REACT_12555. Downstream TCR signaling.
    REACT_12582. Phosphorylation of CD3 and TCR zeta chains.
    REACT_12596. Translocation of ZAP-70 to Immunological synapse.
    REACT_12623. Generation of second messenger molecules.
    REACT_19324. PD-1 signaling.
    REACT_25078. Interferon gamma signaling.

    Miscellaneous databases

    GeneWikii HLA-DQB2.
    GenomeRNAii 3120.
    NextBioi 12384.
    PROi P05538.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P05538.
    Genevestigatori P05538.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes."
      Jonsson A.-K., Hyldig-Nielsen J.-J., Servenius B., Larhammar D., Andersson G., Joergensen F., Peterson P.A., Rask L.
      J. Biol. Chem. 262:8767-8777(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
      Beck S., Abdulla S., Alderton R.P., Glynne R.J., Gut I.G., Hosking L.K., Jackson A., Kelly A., Newell W.R., Sanseau P., Radley E., Thorpe K.L., Trowsdale J.
      J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLN-161.
      Tissue: Squamous cell carcinoma.
    5. "Gene organization of DC and DX subregions of the human major histocompatibility complex."
      Okada K., Boss J.M., Prentice H., Spies T., Mengler R., Auffray C., Lillie J.W., Grossberger D., Strominger J.L.
      Proc. Natl. Acad. Sci. U.S.A. 82:3410-3414(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-125.
    6. "Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC."
      Berdoz J., Tiercy J.-M., Rollini P., Mach B., Gorski J.
      Immunogenetics 29:241-248(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 38-125.
    7. "The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells."
      Rudy G.B., Lew A.M.
      J. Immunol. 158:2116-2125(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF EXPRESSION.
    8. "Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions."
      Indovina P., Megiorni F., Fontemaggi G., Coni P., Mora B., Mazzilli M.C.
      Hum. Immunol. 62:504-508(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF EXPRESSION.
    9. "Invariant chain structure and MHC class II function."
      Cresswell P.
      Cell 84:505-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    10. "Presentation of antigens by MHC class II molecules: getting the most out of them."
      Villadangos J.A.
      Mol. Immunol. 38:329-346(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    11. "MHC class II molecules on the move for successful antigen presentation."
      Rocha N., Neefjes J.
      EMBO J. 27:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    12. "Autophagy in MHC class II presentation: sampling from within."
      Menendez-Benito V., Neefjes J.
      Immunity 26:1-3(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    13. "MHC class II transport at a glance."
      Berger A.C., Roche P.A.
      J. Cell Sci. 122:1-4(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract."
      Beswick E.J., Reyes V.E.
      World J. Gastroenterol. 15:2855-2861(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. "HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule."
      Lenormand C., Bausinger H., Gross F., Signorino-Gelo F., Koch S., Peressin M., Fricker D., Cazenave J.P., Bieber T., Hanau D., de la Salle H., Tourne S.
      J. Immunol. 188:3903-3911(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CD74; HLA-DMA; HLA-DQA1 AND HLA-DQA2, VARIANTS GLN-161; GLY-232 AND VAL-234, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDQB2_HUMAN
    AccessioniPrimary (citable) accession number: P05538
    Secondary accession number(s): A6NIA5
    , Q29826, Q29870, Q29871, Q29872, Q29873, Q5SR06
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: February 1, 1991
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3