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UniProtKB - P05534 (1A24_HUMAN)

UniProt

P05534 - 1A24_HUMAN

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Protein

HLA class I histocompatibility antigen, A-24 alpha chain

Gene

HLA-A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the presentation of foreign antigens to the immune system.

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • peptide antigen binding Source: UniProtKB
  • TAP binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Names & Taxonomyi

Protein namesi
Recommended name:
HLA class I histocompatibility antigen, A-24 alpha chain
Alternative name(s):
Aw-24
HLA class I histocompatibility antigen, A-9 alpha chain
MHC class I antigen A*24
Gene namesi
Name:HLA-A
Synonyms:HLAA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4931. HLA-A.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 308284ExtracellularSequence analysisAdd
BLAST
Transmembranei309 – 33224HelicalSequence analysisAdd
BLAST
Topological domaini333 – 36533CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

Pathology & Biotechi

Organism-specific databases

MalaCardsiHLA-A.

Polymorphism and mutation databases

DMDMi32363482.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Add
BLAST
Chaini25 – 365341HLA class I histocompatibility antigen, A-24 alpha chainPRO_0000018818Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101N-linked (GlcNAc...)1 Publication
Disulfide bondi125 ↔ 188PROSITE-ProRule annotation1 Publication
Disulfide bondi227 ↔ 283PROSITE-ProRule annotation1 Publication
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei344 – 3441PhosphotyrosineBy similarity
Modified residuei345 – 3451PhosphoserineBy similarity
Modified residuei349 – 3491PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineCombined sources
Modified residuei352 – 3521PhosphoserineCombined sources
Modified residuei356 – 3561PhosphoserineCombined sources
Modified residuei359 – 3591PhosphoserineCombined sources

Post-translational modificationi

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP05534.
MaxQBiP05534.
PeptideAtlasiP05534.
PRIDEiP05534.

PTM databases

iPTMnetiP05534.
SwissPalmiP05534.

Expressioni

Gene expression databases

BgeeiENSG00000224320.
CleanExiHS_HLA-A.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity

GO - Molecular functioni

  • beta-2-microglobulin binding Source: UniProtKB
  • TAP binding Source: UniProtKB

Structurei

Secondary structure

1
365
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi27 – 3610Combined sources
Beta strandi41 – 433Combined sources
Beta strandi45 – 528Combined sources
Beta strandi55 – 617Combined sources
Beta strandi64 – 663Combined sources
Beta strandi70 – 734Combined sources
Helixi74 – 763Combined sources
Helixi81 – 10929Combined sources
Beta strandi113 – 1153Combined sources
Beta strandi118 – 12710Combined sources
Beta strandi133 – 14210Combined sources
Beta strandi145 – 1506Combined sources
Beta strandi157 – 1593Combined sources
Helixi162 – 17312Combined sources
Helixi176 – 18510Combined sources
Helixi187 – 19812Combined sources
Helixi200 – 2034Combined sources
Beta strandi210 – 23526Combined sources
Beta strandi238 – 2436Combined sources
Beta strandi246 – 2483Combined sources
Helixi249 – 2513Combined sources
Beta strandi252 – 2543Combined sources
Beta strandi261 – 2633Combined sources
Beta strandi265 – 27410Combined sources
Helixi278 – 2803Combined sources
Beta strandi281 – 2866Combined sources
Beta strandi290 – 2923Combined sources
Beta strandi294 – 2974Combined sources
Beta strandi298 – 3003Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BCKX-ray2.80A/D25-300[»]
3I6LX-ray2.40D25-298[»]
3NFNX-ray2.39A25-298[»]
3QZWX-ray2.80A/D25-298[»]
3VXMX-ray2.50A25-298[»]
3VXNX-ray1.95A25-298[»]
3VXOX-ray2.61A/D25-298[»]
3VXPX-ray2.50A/D25-298[»]
3VXRX-ray2.40A25-298[»]
3VXSX-ray1.80A25-298[»]
3VXUX-ray2.70A/F25-298[»]
3W0WX-ray2.60A25-298[»]
3WL9X-ray1.66A25-298[»]
3WLBX-ray2.00A25-298[»]
4F7MX-ray2.40A/D25-298[»]
4F7PX-ray1.90A25-298[»]
4F7TX-ray1.70A/D25-298[»]
4WU5X-ray2.40A/D25-298[»]
4WU7X-ray2.30A/D25-298[»]
5HGAX-ray2.20A/D25-298[»]
5HGBX-ray2.40A/D/G/J25-298[»]
5HGDX-ray2.07A/D25-298[»]
5HGHX-ray2.39A25-298[»]
ProteinModelPortaliP05534.
SMRiP05534. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05534.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 29587Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 11490Alpha-1Add
BLAST
Regioni115 – 20692Alpha-2Add
BLAST
Regioni207 – 29892Alpha-3Add
BLAST
Regioni299 – 30810Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.Curated
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG016709.
PhylomeDBiP05534.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05534-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG 
        60         70         80         90        100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE 
       110        120        130        140        150
NLRIALRYYN QSEAGSHTLQ MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL 
       160        170        180        190        200
KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ RAYLEGTCVD GLRRYLENGK 
       210        220        230        240        250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 
       260        270        280        290        300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 
       310        320        330        340        350
SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS 
       360 
DSAQGSDVSL TACKV
Length:365
Mass (Da):40,689
Last modified:June 27, 2003 - v2
Checksum:iD33684D126F98EC3
GO

Polymorphismi

The following alleles of A-24 are known: A*24:01, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is found in individuals of South American descent. The sequence shown is that of A*24:02.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51A → G in allele A*24:01. 1 Publication
VAR_004354
Natural varianti27 – 271H → Q in allele A*24:08. 1 Publication
Corresponds to variant rs41541319 [ dbSNP | Ensembl ].		VAR_004355
Natural varianti86 – 861E → G in allele A*24:08. 1 Publication
VAR_004356
Natural varianti89 – 891G → R in allele A*24:08 and allele A*24:29. 2 Publications
VAR_004357
Natural varianti119 – 1191L → V in allele A*24:14. 1 Publication
VAR_015765
Natural varianti121 – 1211M → R in allele A*24:14. 1 Publication
VAR_015766
Natural varianti123 – 1231F → Y in allele A*24:14. 1 Publication
VAR_015767
Natural varianti131 – 1311G → W in allele A*24:14. 1 Publication
VAR_015768
Natural varianti180 – 1801Q → L in allele A*24:13. 1 Publication
VAR_015769
Natural varianti180 – 1801Q → W in allele A*24:06; requires 2 nucleotide substitutions. Combined sources1 Publication
VAR_004358
Natural varianti187 – 1871T → R in allele A*24:10. 1 Publication
VAR_015770
Natural varianti190 – 1912DG → EW in allele A*24:03 and allele A*24:10. 2 Publications
VAR_004359
Natural varianti205 – 2051R → H.
Corresponds to variant rs17185861 [ dbSNP | Ensembl ].		VAR_056263
Natural varianti206 – 2061T → A in allele A*24:01. 1 Publication
VAR_004360

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15497 Genomic DNA. Translation: AAA59611.1.
M64740 mRNA. Translation: AAA59600.1.
M64741 Genomic DNA. Translation: AAA59601.1.
Z72422 Genomic DNA. Translation: CAA96532.1.
D83516 mRNA. Translation: BAA11936.1.
U37111, U37110 Genomic DNA. Translation: AAA83264.1.
U37113, U37112 Genomic DNA. Translation: AAA83265.1.
AH004915 Genomic DNA. Translation: AAB40048.1.
AH005378 Genomic DNA. Translation: AAB60651.1.
PIRiI54416.
UniGeneiHs.181244.
Hs.713441.

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215.
ENST00000443552; ENSP00000404678; ENSG00000224320.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15497 Genomic DNA. Translation: AAA59611.1.
M64740 mRNA. Translation: AAA59600.1.
M64741 Genomic DNA. Translation: AAA59601.1.
Z72422 Genomic DNA. Translation: CAA96532.1.
D83516 mRNA. Translation: BAA11936.1.
U37111, U37110 Genomic DNA. Translation: AAA83264.1.
U37113, U37112 Genomic DNA. Translation: AAA83265.1.
AH004915 Genomic DNA. Translation: AAB40048.1.
AH005378 Genomic DNA. Translation: AAB60651.1.
PIRiI54416.
UniGeneiHs.181244.
Hs.713441.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BCKX-ray2.80A/D25-300[»]
3I6LX-ray2.40D25-298[»]
3NFNX-ray2.39A25-298[»]
3QZWX-ray2.80A/D25-298[»]
3VXMX-ray2.50A25-298[»]
3VXNX-ray1.95A25-298[»]
3VXOX-ray2.61A/D25-298[»]
3VXPX-ray2.50A/D25-298[»]
3VXRX-ray2.40A25-298[»]
3VXSX-ray1.80A25-298[»]
3VXUX-ray2.70A/F25-298[»]
3W0WX-ray2.60A25-298[»]
3WL9X-ray1.66A25-298[»]
3WLBX-ray2.00A25-298[»]
4F7MX-ray2.40A/D25-298[»]
4F7PX-ray1.90A25-298[»]
4F7TX-ray1.70A/D25-298[»]
4WU5X-ray2.40A/D25-298[»]
4WU7X-ray2.30A/D25-298[»]
5HGAX-ray2.20A/D25-298[»]
5HGBX-ray2.40A/D/G/J25-298[»]
5HGDX-ray2.07A/D25-298[»]
5HGHX-ray2.39A25-298[»]
ProteinModelPortaliP05534.
SMRiP05534. Positions 25-298.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP05534.
SwissPalmiP05534.

Polymorphism and mutation databases

DMDMi32363482.

Proteomic databases

EPDiP05534.
MaxQBiP05534.
PeptideAtlasiP05534.
PRIDEiP05534.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000431930; ENSP00000406366; ENSG00000229215.
ENST00000443552; ENSP00000404678; ENSG00000224320.

Organism-specific databases

GeneCardsiHLA-A.
H-InvDBHIX0165910.
HIX0165954.
HIX0166079.
HIX0166152.
HIX0166432.
HIX0166685.
HIX0166954.
HGNCiHGNC:4931. HLA-A.
MalaCardsiHLA-A.
MIMi142800. gene.
neXtProtiNX_P05534.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016709.
PhylomeDBiP05534.

Enzyme and pathway databases

ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1236977. Endosomal/Vacuolar pathway.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-877300. Interferon gamma signaling.
R-HSA-909733. Interferon alpha/beta signaling.
R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC.

Miscellaneous databases

ChiTaRSiHLA-A. human.
EvolutionaryTraceiP05534.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000224320.
CleanExiHS_HLA-A.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei1A24_HUMAN
AccessioniPrimary (citable) accession number: P05534
Secondary accession number(s): P30448
, P30449, Q29908, Q29909, Q29910, Q95355
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 27, 2003
Last modified: September 7, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.