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P05534 (1A24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 147. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
HLA class I histocompatibility antigen, A-24 alpha chain
Alternative name(s):
Aw-24
HLA class I histocompatibility antigen, A-9 alpha chain
MHC class I antigen A*24
Gene names
Name:HLA-A
Synonyms:HLAA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system.

Subunit structure

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Post-translational modification

Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system By similarity.

Polymorphism

The following alleles of A-24 are known: A*2401, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is found in individuals of South American descent. The sequence shown is that of A*24:02.

Sequence similarities

Belongs to the MHC class I family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Biological processHost-virus interaction
Immunity
   Cellular componentMembrane
MHC I
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
Ubl conjugation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent

Traceable author statement. Source: Reactome

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent

Traceable author statement. Source: Reactome

antigen processing and presentation of peptide antigen via MHC class I

Traceable author statement. Source: Reactome

cytokine-mediated signaling pathway

Traceable author statement. Source: Reactome

interferon-gamma-mediated signaling pathway

Traceable author statement. Source: Reactome

positive regulation of T cell mediated cytotoxicity

Inferred from electronic annotation. Source: InterPro

regulation of immune response

Traceable author statement. Source: Reactome

type I interferon signaling pathway

Traceable author statement. Source: Reactome

viral process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentER to Golgi transport vesicle membrane

Traceable author statement. Source: Reactome

Golgi apparatus

Inferred from sequence or structural similarity. Source: UniProt

Golgi membrane

Traceable author statement. Source: Reactome

MHC class I protein complex

Inferred from sequence or structural similarity. Source: UniProt

cell surface

Inferred from sequence or structural similarity. Source: UniProt

early endosome membrane

Traceable author statement. Source: Reactome

endoplasmic reticulum

Inferred from sequence or structural similarity. Source: UniProt

extracellular vesicular exosome

Inferred from direct assay PubMed 11487543. Source: UniProt

integral component of lumenal side of endoplasmic reticulum membrane

Traceable author statement. Source: Reactome

phagocytic vesicle membrane

Traceable author statement. Source: Reactome

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionTAP binding

Inferred from direct assay PubMed 8617941. Source: UniProt

beta-2-microglobulin binding

Inferred from sequence or structural similarity. Source: UniProt

peptide antigen binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424
Chain25 – 365341HLA class I histocompatibility antigen, A-24 alpha chain
PRO_0000018818

Regions

Topological domain25 – 308284Extracellular Potential
Transmembrane309 – 33224Helical; Potential
Topological domain333 – 36533Cytoplasmic Potential
Domain209 – 29587Ig-like C1-type
Region25 – 11490Alpha-1
Region115 – 20692Alpha-2
Region207 – 29892Alpha-3
Region299 – 30810Connecting peptide

Amino acid modifications

Modified residue3561Phosphoserine Ref.10
Glycosylation1101N-linked (GlcNAc...) Ref.12
Disulfide bond125 ↔ 188 Ref.13
Disulfide bond227 ↔ 283 Ref.13

Natural variations

Natural variant51A → G in allele A*2401.
VAR_004354
Natural variant271H → Q in allele A*24:08.
Corresponds to variant rs41541319 [ dbSNP | Ensembl ].
VAR_004355
Natural variant861E → G in allele A*24:08.
VAR_004356
Natural variant891G → R in allele A*24:08 and allele A*24:29.
VAR_004357
Natural variant1191L → V in allele A*24:14.
VAR_015765
Natural variant1211M → R in allele A*24:14.
VAR_015766
Natural variant1231F → Y in allele A*24:14.
VAR_015767
Natural variant1311G → W in allele A*24:14.
VAR_015768
Natural variant1801Q → L in allele A*24:13.
VAR_015769
Natural variant1801Q → W in allele A*24:06; requires 2 nucleotide substitutions. Ref.14
VAR_004358
Natural variant1871T → R in allele A*24:10.
VAR_015770
Natural variant190 – 1912DG → EW in allele A*24:03 and allele A*24:10.
VAR_004359
Natural variant2051R → H.
Corresponds to variant rs17185861 [ dbSNP | Ensembl ].
VAR_056263
Natural variant2061T → A in allele A*2401.
VAR_004360

Secondary structure

....................................................... 365
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P05534 [UniParc].

Last modified June 27, 2003. Version 2.
Checksum: D33684D126F98EC3

FASTA36540,689
        10         20         30         40         50         60 
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE NLRIALRYYN QSEAGSHTLQ 

       130        140        150        160        170        180 
MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ 

       190        200        210        220        230        240 
RAYLEGTCVD GLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP 

       310        320        330        340        350        360 
SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS DSAQGSDVSL 


TACKV 

« Hide

References

« Hide 'large scale' references
[1]"The HLA-AW24 gene: sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes."
N'Guyen C., Sodoyer R., Trucy J., Strachan T., Jordan B.R.
Immunogenetics 21:479-489(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*2401).
[2]Jordan B.R.
Submitted (JUL-1988) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Molecular definition of an elusive third HLA-A9 molecule: HLA-A9.3."
Little A.-M., Madrigal J.A., Parham P.
Immunogenetics 35:41-45(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ALLELES A*24:02 AND A*24:03).
[4]"Unusual HLA-B alleles in two tribes of Brazilian Indians."
Belich M.P., Madrigal J.A., Hildebrand W.H., Zemmour J., Williams R.C., Luz R., Petzl-Erler M.L., Parham P.
Nature 357:326-329(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*24:02).
[5]"An intronic mutation responsible for a low level of expression of an HLA-A*24 allele."
Laforet M., Froelich N., Parissiadis A., Bausinger H., Pfeiffer B., Tongio M.M.
Tissue Antigens 50:340-346(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE A*24:02).
[6]"Sequence analysis of a serological subtype, HLA-A9HH, observed in Japanese and the confirmatory sequence of A*2408."
Kashiwase K., Tokunaga K., Ishikawa Y., Qiu L., Furuya M., Sawanaka K., Akaza T., Tadokoro K., Juji T.
MHC 3:9-14(1996)
Cited for: NUCLEOTIDE SEQUENCE (ALLELE A*24:08).
Tissue: Blood.
[7]"Confirmation of the sequence of HLA-A*2429 allele found in a potential bone marrow donor."
Dunn P.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-337 (ALLELE A*24:29).
[8]"A novel HLA-A*24 (A*2410) identified in a Javanese population."
Gao X., Matheson B.
Tissue Antigens 48:711-713(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELE A*24:10).
Tissue: Blood.
[9]"Three newly identified A*24 alleles: A*2406, A*2413 and A*2414."
Gao X., Lester S., Matheson B., Boettcher B., McCluskey J.
Tissue Antigens 50:192-196(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-206 (ALLELES A*24:06; A*24:13 AND A*24:14).
Tissue: Blood.
[10]"Phosphoproteome of resting human platelets."
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A.
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Platelet.
[11]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-110.
Tissue: Liver.
[13]"Plasticity of human CD8alphaalpha binding to peptide-HLA-A*2402."
Shi Y., Qi J., Iwamoto A., Gao G.F.
Mol. Immunol. 48:2198-2202(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.39 ANGSTROMS) OF 25-298 (ALLELE A*24:02) IN COMPLEX WITH B2M AND CD8, DISULFIDE BONDS.
[14]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15497 Genomic DNA. Translation: AAA59611.1.
M64740 mRNA. Translation: AAA59600.1.
M64741 Genomic DNA. Translation: AAA59601.1.
Z72422 Genomic DNA. Translation: CAA96532.1.
D83516 mRNA. Translation: BAA11936.1.
U37111, U37110 Genomic DNA. Translation: AAA83264.1.
U37113, U37112 Genomic DNA. Translation: AAA83265.1.
AH004915 Genomic DNA. Translation: AAB40048.1.
AH005378 Genomic DNA. Translation: AAB60651.1.
PIRI54416.
UniGeneHs.181244.
Hs.713441.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BCKX-ray2.80A/D25-300[»]
3I6LX-ray2.40D25-298[»]
3NFNX-ray2.39A25-298[»]
3QZWX-ray2.80A/D25-298[»]
3VXMX-ray2.50A25-298[»]
3VXNX-ray1.95A25-298[»]
3VXOX-ray2.61A/D25-298[»]
3VXPX-ray2.50A/D25-298[»]
3VXRX-ray2.40A25-298[»]
3VXSX-ray1.80A25-298[»]
3VXUX-ray2.70A/F25-298[»]
3W0WX-ray2.60A25-298[»]
4F7MX-ray2.40A/D25-298[»]
4F7PX-ray1.90A25-298[»]
4F7TX-ray1.70A/D25-298[»]
ProteinModelPortalP05534.
SMRP05534. Positions 25-298.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM32363482.

Proteomic databases

MaxQBP05534.
PaxDbP05534.
PRIDEP05534.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000431930; ENSP00000406366; ENSG00000229215.
ENST00000443552; ENSP00000404678; ENSG00000224320.

Organism-specific databases

GeneCardsGC06P029949.
GC06Pi29846.
GC06Pj29898.
H-InvDBHIX0165910.
HIX0165954.
HIX0166079.
HIX0166152.
HIX0166432.
HIX0166685.
HIX0166954.
HGNCHGNC:4931. HLA-A.
MIM142800. gene.
neXtProtNX_P05534.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42056.
HOVERGENHBG016709.
PhylomeDBP05534.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_HLA-A.
GenevestigatorP05534.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-A. human.
EvolutionaryTraceP05534.
PROP05534.
SOURCESearch...

Entry information

Entry name1A24_HUMAN
AccessionPrimary (citable) accession number: P05534
Secondary accession number(s): P30448 expand/collapse secondary AC list , P30449, Q29908, Q29909, Q29910, Q95355
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: June 27, 2003
Last modified: July 9, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM