UniProtKB - P05534 (1A24_HUMAN)
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Protein
HLA class I histocompatibility antigen, A-24 alpha chain
Gene
HLA-A
Organism
Homo sapiens (Human)
Status
Functioni
Involved in the presentation of foreign antigens to the immune system.
GO - Molecular functioni
- beta-2-microglobulin binding Source: UniProtKB
- peptide antigen binding Source: UniProtKB
- TAP binding Source: UniProtKB
GO - Biological processi
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent Source: Reactome
- antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
- interferon-gamma-mediated signaling pathway Source: Reactome
- protection from natural killer cell mediated cytotoxicity Source: UniProtKB
- regulation of immune response Source: Reactome
- type I interferon signaling pathway Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Immunity |
Enzyme and pathway databases
Reactomei | R-HSA-1236974. ER-Phagosome pathway. R-HSA-1236977. Endosomal/Vacuolar pathway. R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. R-HSA-877300. Interferon gamma signaling. R-HSA-909733. Interferon alpha/beta signaling. R-HSA-983170. Antigen Presentation: Folding, assembly and peptide loading of class I MHC. |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class I histocompatibility antigen, A-24 alpha chainAlternative name(s): Aw-24 HLA class I histocompatibility antigen, A-9 alpha chain MHC class I antigen A*24 |
Gene namesi | Name:HLA-A Synonyms:HLAA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4931. HLA-A. |
MIMi | 142800. gene. |
neXtProti | NX_P05534. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 308 | ExtracellularSequence analysisAdd BLAST | 284 | |
Transmembranei | 309 – 332 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 333 – 365 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
Membrane, MHC IPathology & Biotechi
Organism-specific databases
DisGeNETi | 3105. |
MalaCardsi | HLA-A. |
Polymorphism and mutation databases
DMDMi | 32363482. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000018818 | 25 – 365 | HLA class I histocompatibility antigen, A-24 alpha chainAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 125 ↔ 188 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 227 ↔ 283 | PROSITE-ProRule annotation1 Publication | ||
Modified residuei | 343 | PhosphoserineBy similarity | 1 | |
Modified residuei | 344 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 345 | PhosphoserineBy similarity | 1 | |
Modified residuei | 349 | PhosphoserineBy similarity | 1 | |
Modified residuei | 350 | PhosphoserineCombined sources | 1 | |
Modified residuei | 352 | PhosphoserineCombined sources | 1 | |
Modified residuei | 356 | PhosphoserineCombined sources | 1 | |
Modified residuei | 359 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity).By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P05534. |
MaxQBi | P05534. |
PeptideAtlasi | P05534. |
PRIDEi | P05534. |
PTM databases
iPTMneti | P05534. |
SwissPalmi | P05534. |
Interactioni
Subunit structurei
Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity).By similarity
GO - Molecular functioni
- beta-2-microglobulin binding Source: UniProtKB
- TAP binding Source: UniProtKB
Protein-protein interaction databases
IntActi | P05534. 5 interactors. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Beta strandi | 27 – 36 | Combined sources | 10 | |
Beta strandi | 41 – 43 | Combined sources | 3 | |
Beta strandi | 45 – 52 | Combined sources | 8 | |
Beta strandi | 55 – 61 | Combined sources | 7 | |
Beta strandi | 64 – 66 | Combined sources | 3 | |
Beta strandi | 70 – 73 | Combined sources | 4 | |
Helixi | 74 – 76 | Combined sources | 3 | |
Helixi | 81 – 109 | Combined sources | 29 | |
Beta strandi | 113 – 115 | Combined sources | 3 | |
Beta strandi | 118 – 127 | Combined sources | 10 | |
Beta strandi | 133 – 142 | Combined sources | 10 | |
Beta strandi | 145 – 150 | Combined sources | 6 | |
Beta strandi | 157 – 159 | Combined sources | 3 | |
Helixi | 162 – 173 | Combined sources | 12 | |
Helixi | 176 – 185 | Combined sources | 10 | |
Helixi | 187 – 198 | Combined sources | 12 | |
Helixi | 200 – 203 | Combined sources | 4 | |
Beta strandi | 210 – 235 | Combined sources | 26 | |
Beta strandi | 238 – 243 | Combined sources | 6 | |
Beta strandi | 246 – 248 | Combined sources | 3 | |
Helixi | 249 – 251 | Combined sources | 3 | |
Beta strandi | 252 – 254 | Combined sources | 3 | |
Beta strandi | 261 – 263 | Combined sources | 3 | |
Beta strandi | 265 – 274 | Combined sources | 10 | |
Helixi | 278 – 280 | Combined sources | 3 | |
Beta strandi | 281 – 286 | Combined sources | 6 | |
Beta strandi | 290 – 292 | Combined sources | 3 | |
Beta strandi | 294 – 297 | Combined sources | 4 | |
Beta strandi | 298 – 300 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BCK | X-ray | 2.80 | A/D | 25-300 | [»] | |
3I6L | X-ray | 2.40 | D | 25-298 | [»] | |
3NFN | X-ray | 2.39 | A | 25-298 | [»] | |
3QZW | X-ray | 2.80 | A/D | 25-298 | [»] | |
3VXM | X-ray | 2.50 | A | 25-298 | [»] | |
3VXN | X-ray | 1.95 | A | 25-298 | [»] | |
3VXO | X-ray | 2.61 | A/D | 25-298 | [»] | |
3VXP | X-ray | 2.50 | A/D | 25-298 | [»] | |
3VXR | X-ray | 2.40 | A | 25-298 | [»] | |
3VXS | X-ray | 1.80 | A | 25-298 | [»] | |
3VXU | X-ray | 2.70 | A/F | 25-298 | [»] | |
3W0W | X-ray | 2.60 | A | 25-298 | [»] | |
3WL9 | X-ray | 1.66 | A | 25-298 | [»] | |
3WLB | X-ray | 2.00 | A | 25-298 | [»] | |
4F7M | X-ray | 2.40 | A/D | 25-298 | [»] | |
4F7P | X-ray | 1.90 | A | 25-298 | [»] | |
4F7T | X-ray | 1.70 | A/D | 25-298 | [»] | |
4WU5 | X-ray | 2.40 | A/D | 25-298 | [»] | |
4WU7 | X-ray | 2.30 | A/D | 25-298 | [»] | |
5HGA | X-ray | 2.20 | A/D | 25-298 | [»] | |
5HGB | X-ray | 2.40 | A/D/G/J | 25-298 | [»] | |
5HGD | X-ray | 2.07 | A/D | 25-298 | [»] | |
5HGH | X-ray | 2.39 | A | 25-298 | [»] | |
5WWI | X-ray | 3.19 | A | 25-298 | [»] | |
5WWJ | X-ray | 2.29 | A/C | 25-298 | [»] | |
5WWU | X-ray | 2.79 | A | 25-298 | [»] | |
5WXC | X-ray | 2.29 | A/C | 25-298 | [»] | |
5WXD | X-ray | 3.29 | A | 25-298 | [»] | |
5XOV | X-ray | 2.68 | A/D | 25-298 | [»] | |
ProteinModelPortali | P05534. | |||||
SMRi | P05534. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P05534. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 295 | Ig-like C1-typeAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 114 | Alpha-1Add BLAST | 90 | |
Regioni | 115 – 206 | Alpha-2Add BLAST | 92 | |
Regioni | 207 – 298 | Alpha-3Add BLAST | 92 | |
Regioni | 299 – 308 | Connecting peptide | 10 |
Sequence similaritiesi
Belongs to the MHC class I family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
HOVERGENi | HBG016709. |
PhylomeDBi | P05534. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. 3.30.500.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR037055. MHC_I-like_Ag-recog_sf. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. |
Pfami | View protein in Pfam PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. |
PRINTSi | PR01638. MHCCLASSI. |
SMARTi | View protein in SMART SM00407. IGc1. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P05534-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDEETGK VKAHSQTDRE
110 120 130 140 150
NLRIALRYYN QSEAGSHTLQ MMFGCDVGSD GRFLRGYHQY AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQITKRK WEAAHVAEQQ RAYLEGTCVD GLRRYLENGK
210 220 230 240 250
ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTVPIVG IIAGLVLLGA VITGAVVAAV MWRRNSSDRK GGSYSQAASS
360
DSAQGSDVSL TACKV
Polymorphismi
The following alleles of A-24 are known: A*24:01, A*24:02, A*24:03, A*24:06, A*24:08 (A9HH), A*24:10 (A*24JV), A*24:13 (A*24YM), A*24:14 (A*24SA) and A*24:29. Allele A*24:02 is represented in all major racial groups. Allele A*24:06 and allele A*24:13 are found in the Australian Aboriginal population. Allele A*24:14 is found in individuals of South American descent. The sequence shown is that of A*24:02.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_004354 | 5 | A → G in allele A*24:01. 1 Publication | 1 | |
Natural variantiVAR_004355 | 27 | H → Q in allele A*24:08. 1 PublicationCorresponds to variant dbSNP:rs41541319Ensembl. | 1 | |
Natural variantiVAR_004356 | 86 | E → G in allele A*24:08. 1 Publication | 1 | |
Natural variantiVAR_004357 | 89 | G → R in allele A*24:08 and allele A*24:29. 2 Publications | 1 | |
Natural variantiVAR_015765 | 119 | L → V in allele A*24:14. 1 Publication | 1 | |
Natural variantiVAR_015766 | 121 | M → R in allele A*24:14. 1 Publication | 1 | |
Natural variantiVAR_015767 | 123 | F → Y in allele A*24:14. 1 Publication | 1 | |
Natural variantiVAR_015768 | 131 | G → W in allele A*24:14. 1 Publication | 1 | |
Natural variantiVAR_015769 | 180 | Q → L in allele A*24:13. 1 Publication | 1 | |
Natural variantiVAR_004358 | 180 | Q → W in allele A*24:06; requires 2 nucleotide substitutions. Combined sources1 Publication | 1 | |
Natural variantiVAR_015770 | 187 | T → R in allele A*24:10. 1 Publication | 1 | |
Natural variantiVAR_004359 | 190 – 191 | DG → EW in allele A*24:03 and allele A*24:10. 2 Publications | 2 | |
Natural variantiVAR_056263 | 205 | R → H. Corresponds to variant dbSNP:rs17185861Ensembl. | 1 | |
Natural variantiVAR_004360 | 206 | T → A in allele A*24:01. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15497 Genomic DNA. Translation: AAA59611.1. M64740 mRNA. Translation: AAA59600.1. M64741 Genomic DNA. Translation: AAA59601.1. Z72422 Genomic DNA. Translation: CAA96532.1. D83516 mRNA. Translation: BAA11936.1. U37111, U37110 Genomic DNA. Translation: AAA83264.1. U37113, U37112 Genomic DNA. Translation: AAA83265.1. AH004915 Genomic DNA. Translation: AAB40048.1. AH005378 Genomic DNA. Translation: AAB60651.1. |
PIRi | I54416. |
UniGenei | Hs.181244. Hs.713441. |
Genome annotation databases
Ensembli | ENST00000431930; ENSP00000406366; ENSG00000229215. ENST00000443552; ENSP00000404678; ENSG00000224320. |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Entry informationi
Entry namei | 1A24_HUMAN | |
Accessioni | P05534Primary (citable) accession number: P05534 Secondary accession number(s): P30448 Q95355 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1988 |
Last sequence update: | June 27, 2003 | |
Last modified: | March 28, 2018 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |