Lymphocyte antigen 6A-2/6E-1 precursor

Contribute

Send feedback

Read comments (?) or add your own

P05533 (LY6A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Lymphocyte antigen 6A-2/6E-1
Short name=Ly-6A.2/Ly-6E.1

Alternative name(s):
Stem cell antigen 1
Short name=SCA-1
T-cell-activating protein
Short name=TAP

Gene names

Name:	Ly6a
Synonyms:	Ly6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	T-cell activation.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor.
Tissue specificity	Widely expressed. Ref.10 Ref.11
Post-translational modification	O-glycosylated. Not N-glycosylated. Ref.9 Not phosphorylated.
Sequence similarities	Contains 1 UPAR/Ly6 domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Signal
PTM	Disulfide bond GPI-anchor Glycoprotein Lipoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW external side of plasma membrane Inferred from direct assay PubMed 12714519 PubMed 12935903 PubMed 16455951 PubMed 18971422 PubMed 20103531 PubMed 20660734 PubMed 21508411 PubMed 21708977. Source: MGI intracellular Inferred from direct assay PubMed 11146504. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

Ref.9

Chain

27 – 112

Lymphocyte antigen 6A-2/6E-1

PRO_0000036130

Propeptide

113 – 134

Removed in mature form Potential

PRO_0000036131

Regions

Domain

27 – 119

UPAR/Ly6

Amino acid modifications

Lipidation

112

GPI-anchor amidated glycine Potential

Disulfide bond

29 ↔ 53

By similarity

Disulfide bond

32 ↔ 41

By similarity

Disulfide bond

46 ↔ 74

By similarity

Disulfide bond

78 ↔ 98

By similarity

Disulfide bond

99 ↔ 104

By similarity

Natural variations

Natural variant

D → G in Ly-6E.1.

Natural variant

106

V → A in Ly-6E.1.

Experimental info

Sequence conflict

C → S in BAC36250. Ref.7

Sequence conflict

Q → H in BAC36250. Ref.7

Sequence conflict

A → T in BAC36250. Ref.7

Sequence conflict

101

E → Q in BAC36250. Ref.7

Sequences

Sequence

Length

Mass (Da)

Tools

P05533 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: 883C771EB3430315
Show »

FASTA

134

14,377

        10         20         30         40         50         60 
MDTSHTTKSC LLILLVALLC AERAQGLECY QCYGVPFETS CPSITCPYPD GVCVTQEAAV 

        70         80         90        100        110        120 
IVDSQTRKVK NNLCLPICPP NIESMEILGT KVNVKTSCCQ EDLCNVAVPN GGSTWTMAGV 

       130 
LLFSLSSVLL QTLL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA characterization of an Ly-6.2 gene expressed in BW5147 tumor cells." Palfree R.G.E., Leclair K.P., Bothwell A.L.M., Haemmerling U. Immunogenetics 26:389-391(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and expression of a cDNA for the T-cell-activating protein TAP." Reiser H., Coligan J., Benacerraf B., Rock K.L. Proc. Natl. Acad. Sci. U.S.A. 85:2255-2259(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Isolation of a murine Ly-6 cDNA reveals a new multigene family." Leclair K.P., Palfree R.G.E., Flood P.M., Hammerling U., Bothwell A.L.M. EMBO J. 5:3227-3234(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (LY-6E.1).
[4]	"Characterization of promoter elements of an interferon-inducible Ly-6E/A differentiation antigen, which is expressed on activated T cells and hematopoietic stem cells." Khan K., Dad Lindwall G., Maher S.E., Bothwell A.L.M. Mol. Cell. Biol. 10:5150-5159(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BALB/c.
[5]	"The isolation and sequence of the chromosomal gene and regulatory regions of Ly-6A.2." Stanford W.L., Bruyns E., Snodgrass H.R. Immunogenetics 35:408-411(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Isolation, expression, and sequence of the TAP/Ly-6A.2 chromosomal gene." McGrew J.T., Rock K.L. J. Immunol. 146:3633-3638(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Extraembryonic tissue and Placenta.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Mammary gland.
[9]	"Biosynthesis, glycosylation, and partial N-terminal amino acid sequence of the T-cell-activating protein TAP." Reiser H., Coligan J., Benacerraf B., Rock K.L. Proc. Natl. Acad. Sci. U.S.A. 84:3370-3374(1987) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 27-49, GLYCOSYLATION.
[10]	"Mouse hematopoietic stem-cell antigen Sca-1 is a member of the Ly-6 antigen family." van de Rijn M., Heimfeld S., Spangrude G.J., Weissman I.L. Proc. Natl. Acad. Sci. U.S.A. 86:4634-4638(1989) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[11]	"LY6A/E (SCA-1) expression in the mouse testis." van Bragt M.P., Ciliberti N., Stanford W.L., de Rooij D.G., van Pelt A.M. Biol. Reprod. 73:634-638(2005) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M18184 mRNA. Translation: AAA39463.1. J03636 mRNA. Translation: AAA40163.1. X04653 mRNA. Translation: CAA28351.1. M37707 Genomic DNA. Translation: AAA39467.1. M74013 Genomic DNA. Translation: AAA39464.1. M73552 Genomic DNA. Translation: AAA39465.1. M59713 Genomic DNA. Translation: AAA40164.1. AK076200 mRNA. Translation: BAC36250.1. BC002070 mRNA. Translation: AAH02070.1.
IPI	IPI00120592.
PIR	A25708. A32506. A35921.
RefSeq	NP_001258345.1. NM_001271416.1. NP_001258346.1. NM_001271417.1. NP_001258347.1. NM_001271418.1. NP_001258348.1. NM_001271419.1. NP_001258375.1. NM_001271446.1. NP_034868.1. NM_010738.3.
UniGene	Mm.425949.
3D structure databases
ProteinModelPortal	P05533.
SMR	P05533. Positions 27-106.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-59628N.
STRING	10090.ENSMUSP00000023248.
Proteomic databases
PaxDb	P05533.
PRIDE	P05533.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023248; ENSMUSP00000023248; ENSMUSG00000075602.
GeneID	110454.
KEGG	mmu:110454.
UCSC	uc007wgk.1. mouse.
Organism-specific databases
CTD	110454.
MGI	MGI:107527. Ly6a.
Phylogenomic databases
eggNOG	NOG125401.
GeneTree	ENSGT00610000086181.
HOGENOM	HOG000035114.
HOVERGEN	HBG001716.
InParanoid	P05533.
KO	K06846.
OMA	DLCNVAV.
Gene expression databases
Bgee	P05533.
CleanEx	MM_LY6A.
Genevestigator	P05533.
GermOnline	ENSMUSG00000075602. Mus musculus.
Family and domain databases
InterPro	IPR018363. CD59_antigen_CS. IPR016054. LY6_UPA_recep-like. IPR001526. LY6_UPAR. [Graphical view]
Pfam	PF00021. UPAR_LY6. 1 hit. [Graphical view]
SMART	SM00134. LU. 1 hit. [Graphical view]
PROSITE	PS00983. LY6_UPAR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Ly6a. mouse.
NextBio	364009.
SOURCE	Search...

Entry information

Entry name

LY6A_MOUSE

Accession

Primary (citable) accession number: P05533
Secondary accession number(s): Q8BPD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	April 3, 2013
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents