Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lymphocyte antigen 6A-2/6E-1

Gene

Ly6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

T-cell activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphocyte antigen 6A-2/6E-1
Short name:
Ly-6A.2/Ly-6E.1
Alternative name(s):
Stem cell antigen 1
Short name:
SCA-1
T-cell-activating protein
Short name:
TAP
Gene namesi
Name:Ly6a
Synonyms:Ly6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107527. Ly6a.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • external side of plasma membrane Source: MGI
  • intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 11286Lymphocyte antigen 6A-2/6E-1PRO_0000036130Add
BLAST
Propeptidei113 – 13422Removed in mature formSequence analysisPRO_0000036131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi29 ↔ 53By similarity
Disulfide bondi32 ↔ 41By similarity
Disulfide bondi46 ↔ 74By similarity
Disulfide bondi78 ↔ 98By similarity
Disulfide bondi99 ↔ 104By similarity
Lipidationi112 – 1121GPI-anchor amidated glycineSequence analysis

Post-translational modificationi

O-glycosylated. Not N-glycosylated.1 Publication
Not phosphorylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP05533.
MaxQBiP05533.
PaxDbiP05533.
PeptideAtlasiP05533.
PRIDEiP05533.

Expressioni

Tissue specificityi

Widely expressed.2 Publications

Gene expression databases

BgeeiENSMUSG00000075602.
CleanExiMM_LY6A.
ExpressionAtlasiP05533. baseline and differential.
GenevisibleiP05533. MM.

Interactioni

Protein-protein interaction databases

DIPiDIP-59628N.
IntActiP05533. 1 interaction.
STRINGi10090.ENSMUSP00000023248.

Structurei

3D structure databases

ProteinModelPortaliP05533.
SMRiP05533. Positions 42-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 11993UPAR/Ly6Add
BLAST

Sequence similaritiesi

Contains 1 UPAR/Ly6 domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JI0Q. Eukaryota.
ENOG41117PH. LUCA.
GeneTreeiENSGT00730000111651.
HOGENOMiHOG000035114.
HOVERGENiHBG001716.
InParanoidiP05533.
KOiK06846.
OMAiNIESMEI.
OrthoDBiEOG091G12TM.
PhylomeDBiP05533.
TreeFamiTF337757.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05533-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSHTTKSC LLILLVALLC AERAQGLECY QCYGVPFETS CPSITCPYPD
60 70 80 90 100
GVCVTQEAAV IVDSQTRKVK NNLCLPICPP NIESMEILGT KVNVKTSCCQ
110 120 130
EDLCNVAVPN GGSTWTMAGV LLFSLSSVLL QTLL
Length:134
Mass (Da):14,377
Last modified:November 1, 1988 - v1
Checksum:i883C771EB3430315
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321C → S in BAC36250 (PubMed:16141072).Curated
Sequence conflicti56 – 561Q → H in BAC36250 (PubMed:16141072).Curated
Sequence conflicti59 – 591A → T in BAC36250 (PubMed:16141072).Curated
Sequence conflicti101 – 1011E → Q in BAC36250 (PubMed:16141072).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631D → G in Ly-6E.1.
Natural varianti106 – 1061V → A in Ly-6E.1.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18184 mRNA. Translation: AAA39463.1.
J03636 mRNA. Translation: AAA40163.1.
X04653 mRNA. Translation: CAA28351.1.
M37707 Genomic DNA. Translation: AAA39467.1.
M74013 Genomic DNA. Translation: AAA39464.1.
M73552 Genomic DNA. Translation: AAA39465.1.
M59713 Genomic DNA. Translation: AAA40164.1.
AK076200 mRNA. Translation: BAC36250.1.
BC002070 mRNA. Translation: AAH02070.1.
CCDSiCCDS27540.1.
PIRiA25708.
A35921. A32506.
RefSeqiNP_001258345.1. NM_001271416.1.
NP_001258346.1. NM_001271417.1.
NP_001258347.1. NM_001271418.1.
NP_001258348.1. NM_001271419.1.
NP_001258375.1. NM_001271446.1.
NP_034868.1. NM_010738.3.
UniGeneiMm.425949.

Genome annotation databases

EnsembliENSMUST00000023248; ENSMUSP00000023248; ENSMUSG00000075602.
ENSMUST00000186526; ENSMUSP00000140998; ENSMUSG00000075602.
ENSMUST00000187171; ENSMUSP00000140099; ENSMUSG00000075602.
ENSMUST00000187994; ENSMUSP00000140287; ENSMUSG00000075602.
ENSMUST00000189068; ENSMUSP00000140638; ENSMUSG00000075602.
GeneIDi110454.
KEGGimmu:110454.
UCSCiuc007wgk.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18184 mRNA. Translation: AAA39463.1.
J03636 mRNA. Translation: AAA40163.1.
X04653 mRNA. Translation: CAA28351.1.
M37707 Genomic DNA. Translation: AAA39467.1.
M74013 Genomic DNA. Translation: AAA39464.1.
M73552 Genomic DNA. Translation: AAA39465.1.
M59713 Genomic DNA. Translation: AAA40164.1.
AK076200 mRNA. Translation: BAC36250.1.
BC002070 mRNA. Translation: AAH02070.1.
CCDSiCCDS27540.1.
PIRiA25708.
A35921. A32506.
RefSeqiNP_001258345.1. NM_001271416.1.
NP_001258346.1. NM_001271417.1.
NP_001258347.1. NM_001271418.1.
NP_001258348.1. NM_001271419.1.
NP_001258375.1. NM_001271446.1.
NP_034868.1. NM_010738.3.
UniGeneiMm.425949.

3D structure databases

ProteinModelPortaliP05533.
SMRiP05533. Positions 42-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59628N.
IntActiP05533. 1 interaction.
STRINGi10090.ENSMUSP00000023248.

Proteomic databases

EPDiP05533.
MaxQBiP05533.
PaxDbiP05533.
PeptideAtlasiP05533.
PRIDEiP05533.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023248; ENSMUSP00000023248; ENSMUSG00000075602.
ENSMUST00000186526; ENSMUSP00000140998; ENSMUSG00000075602.
ENSMUST00000187171; ENSMUSP00000140099; ENSMUSG00000075602.
ENSMUST00000187994; ENSMUSP00000140287; ENSMUSG00000075602.
ENSMUST00000189068; ENSMUSP00000140638; ENSMUSG00000075602.
GeneIDi110454.
KEGGimmu:110454.
UCSCiuc007wgk.2. mouse.

Organism-specific databases

CTDi110454.
MGIiMGI:107527. Ly6a.

Phylogenomic databases

eggNOGiENOG410JI0Q. Eukaryota.
ENOG41117PH. LUCA.
GeneTreeiENSGT00730000111651.
HOGENOMiHOG000035114.
HOVERGENiHBG001716.
InParanoidiP05533.
KOiK06846.
OMAiNIESMEI.
OrthoDBiEOG091G12TM.
PhylomeDBiP05533.
TreeFamiTF337757.

Miscellaneous databases

PROiP05533.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000075602.
CleanExiMM_LY6A.
ExpressionAtlasiP05533. baseline and differential.
GenevisibleiP05533. MM.

Family and domain databases

InterProiIPR018363. CD59_antigen_CS.
IPR016054. LY6_UPA_recep-like.
[Graphical view]
PfamiPF00021. UPAR_LY6. 1 hit.
[Graphical view]
SMARTiSM00134. LU. 1 hit.
[Graphical view]
PROSITEiPS00983. LY6_UPAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLY6A_MOUSE
AccessioniPrimary (citable) accession number: P05533
Secondary accession number(s): Q8BPD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 7, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.