##gff-version 3 P05532 UniProtKB Signal peptide 1 24 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Chain 25 979 . . . ID=PRO_0000016755;Note=Mast/stem cell growth factor receptor Kit P05532 UniProtKB Topological domain 25 527 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Transmembrane 528 548 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Topological domain 549 979 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Domain 31 117 . . . Note=Ig-like C2-type 1 P05532 UniProtKB Domain 126 210 . . . Note=Ig-like C2-type 2 P05532 UniProtKB Domain 217 315 . . . Note=Ig-like C2-type 3 P05532 UniProtKB Domain 324 417 . . . Note=Ig-like C2-type 4 P05532 UniProtKB Domain 420 514 . . . Note=Ig-like C2-type 5 P05532 UniProtKB Domain 592 939 . . . Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P05532 UniProtKB Region 571 573 . . . Note=Important for interaction with phosphotyrosine-binding proteins;Ontology_term=ECO:0000250;evidence=ECO:0000250 P05532 UniProtKB Active site 794 794 . . . Note=Proton acceptor;Ontology_term=ECO:0000255,ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159,ECO:0000255|PROSITE-ProRule:PRU10028 P05532 UniProtKB Binding site 571 571 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P05532 UniProtKB Binding site 599 606 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P05532 UniProtKB Binding site 626 626 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P05532 UniProtKB Binding site 674 680 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P05532 UniProtKB Binding site 798 798 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159 P05532 UniProtKB Binding site 799 799 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P05532 UniProtKB Binding site 812 812 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P05532 UniProtKB Site 938 938 . . . Note=Important for interaction with phosphotyrosine-binding proteins;Ontology_term=ECO:0000250;evidence=ECO:0000250 P05532 UniProtKB Modified residue 550 550 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 556 556 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 571 571 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P05532 UniProtKB Modified residue 573 573 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P05532 UniProtKB Modified residue 706 706 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P05532 UniProtKB Modified residue 720 720 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P05532 UniProtKB Modified residue 723 723 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 732 732 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 743 743 . . . Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 748 748 . . . Note=Phosphoserine%3B by PKC/PRKCA;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 823 823 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 825 825 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7527401;Dbxref=PMID:7527401 P05532 UniProtKB Modified residue 893 893 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 902 902 . . . Note=Phosphotyrosine%3B by autocatalysis;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Modified residue 938 938 . . . Note=Phosphotyrosine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:17947660;Dbxref=PMID:17947660 P05532 UniProtKB Modified residue 962 962 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P10721 P05532 UniProtKB Glycosylation 146 146 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Glycosylation 296 296 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Glycosylation 303 303 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Glycosylation 323 323 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Glycosylation 355 355 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Glycosylation 370 370 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Glycosylation 466 466 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Glycosylation 489 489 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P05532 UniProtKB Disulfide bond 58 98 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Disulfide bond 137 187 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Disulfide bond 152 184 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Disulfide bond 234 293 . . . Ontology_term=ECO:0000255,ECO:0000269;evidence=ECO:0000255|PROSITE-ProRule:PRU00114,ECO:0000269|PubMed:17255936;Dbxref=PMID:17255936 P05532 UniProtKB Disulfide bond 431 494 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00114 P05532 UniProtKB Alternative sequence 1 12 . . . ID=VSP_041868;Note=In isoform 3. MRGARGAWDLLC->MAVAVFPFLPQQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1378413;Dbxref=PMID:1378413 P05532 UniProtKB Alternative sequence 13 789 . . . ID=VSP_041869;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:1378413;Dbxref=PMID:1378413 P05532 UniProtKB Alternative sequence 512 515 . . . ID=VSP_041870;Note=In isoform 2. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:15731517,ECO:0000303|PubMed:2456920;Dbxref=PMID:15489334,PMID:15731517,PMID:2456920 P05532 UniProtKB Natural variant 207 207 . . . Note=Loss-of-function mutation abolishing ligand binding. A->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:2456920,ECO:0000269|Ref.22;Dbxref=PMID:2456920 P05532 UniProtKB Natural variant 586 586 . . . Note=In W37%3B impaired protein stability and loss of kinase activity. E->K;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1693331,ECO:0000269|PubMed:1714377;Dbxref=PMID:1693331,PMID:1714377 P05532 UniProtKB Natural variant 664 664 . . . Note=In Wv. T->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:1693331;Dbxref=PMID:1693331 P05532 UniProtKB Natural variant 794 794 . . . Note=In W42%3B loss of kinase activity and impaired internalization after exposure to KITLG/SCF. D->N;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1688471,ECO:0000269|PubMed:7527401;Dbxref=PMID:1688471,PMID:7527401 P05532 UniProtKB Natural variant 835 835 . . . Note=In W41%3B decreased kinase activity. V->M;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:1693331,ECO:0000269|PubMed:1714377;Dbxref=PMID:1693331,PMID:1714377 P05532 UniProtKB Mutagenesis 571 571 . . . Note=Abolishes interaction with PTPN11/SHP-2. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9528781;Dbxref=PMID:9528781 P05532 UniProtKB Mutagenesis 573 573 . . . Note=Abolishes interaction with PTPN6/SHP-1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9528781;Dbxref=PMID:9528781 P05532 UniProtKB Mutagenesis 573 573 . . . Note=Abolishes interaction with PTPN6/SHP-1. Missing;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9528781;Dbxref=PMID:9528781 P05532 UniProtKB Mutagenesis 723 723 . . . Note=Abolishes interaction with PIK3R1. Y->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:7527401;Dbxref=PMID:7527401 P05532 UniProtKB Mutagenesis 860 860 . . . Note=Mice display white fur%2C hearing loss%2C anemia and mast cell deficiency%2C plus sterility in both males and females. F->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15731517;Dbxref=PMID:15731517 P05532 UniProtKB Sequence conflict 551 551 . . . Note=L->F;Ontology_term=ECO:0000305;evidence=ECO:0000305 P05532 UniProtKB Sequence conflict 781 781 . . . Note=G->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 P05532 UniProtKB Sequence conflict 860 860 . . . Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P05532 UniProtKB Beta strand 38 41 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 43 49 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 54 59 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 63 69 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 71 73 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 75 78 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 80 85 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Helix 90 92 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 94 103 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 105 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 125 128 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 133 135 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 145 151 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 162 166 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Turn 167 169 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 170 175 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Helix 178 180 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 184 191 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 194 197 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 201 206 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 214 216 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 230 240 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 244 256 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 264 268 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 271 282 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 285 287 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 289 296 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26 P05532 UniProtKB Beta strand 301 308 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2O26