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Protein

DNA-binding protein HU

Gene

hup

Organism
Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. It is essential for heterocyst differentiation.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein HU
Gene namesi
Name:hup
Synonyms:hanA
Ordered Locus Names:asr3935
OrganismiNostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576)
Taxonomic identifieri103690 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc
Proteomesi
  • UP000002483 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001049061 – 94DNA-binding protein HUAdd BLAST94

Expressioni

Keywords - Developmental stagei

Heterocyst

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi103690.asr3935.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 14Combined sources12
Helixi18 – 37Combined sources20
Beta strandi42 – 44Combined sources3
Turni45 – 47Combined sources3
Beta strandi48 – 55Combined sources8
Beta strandi58 – 61Combined sources4
Turni63 – 65Combined sources3
Beta strandi68 – 71Combined sources4
Beta strandi74 – 81Combined sources8
Helixi83 – 89Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P51X-ray2.50A/B/C/D1-94[»]
1P71X-ray1.90A/B1-94[»]
1P78X-ray2.25A/B1-94[»]
ProteinModelPortaliP05514.
SMRiP05514.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05514.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043828.
KOiK03530.
OMAiKMDIPAT.
OrthoDBiPOG091H01KX.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05514-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKGELVDAV AEKASVTKKQ ADAVLTAALE TIIEAVSSGD KVTLVGFGSF
60 70 80 90
ESRERKAREG RNPKTNEKME IPATRVPAFS AGKLFREKVA PPKA
Length:94
Mass (Da):10,073
Last modified:November 1, 1997 - v2
Checksum:i045BD1FAE4F85DDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38S → R AA sequence (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46038 Genomic DNA. Translation: AAB06445.1.
S78244 Genomic DNA. Translation: AAB34352.1.
BA000019 Genomic DNA. Translation: BAB75634.1.
PIRiAH2297.
RefSeqiWP_010998076.1. NC_003272.1.

Genome annotation databases

EnsemblBacteriaiBAB75634; BAB75634; BAB75634.
KEGGiana:asr3935.
PATRICi22778374. VBINosSp37423_4641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46038 Genomic DNA. Translation: AAB06445.1.
S78244 Genomic DNA. Translation: AAB34352.1.
BA000019 Genomic DNA. Translation: BAB75634.1.
PIRiAH2297.
RefSeqiWP_010998076.1. NC_003272.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1P51X-ray2.50A/B/C/D1-94[»]
1P71X-ray1.90A/B1-94[»]
1P78X-ray2.25A/B1-94[»]
ProteinModelPortaliP05514.
SMRiP05514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi103690.asr3935.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB75634; BAB75634; BAB75634.
KEGGiana:asr3935.
PATRICi22778374. VBINosSp37423_4641.

Phylogenomic databases

eggNOGiENOG4105K70. Bacteria.
COG0776. LUCA.
HOGENOMiHOG000043828.
KOiK03530.
OMAiKMDIPAT.
OrthoDBiPOG091H01KX.

Miscellaneous databases

EvolutionaryTraceiP05514.

Family and domain databases

Gene3Di4.10.520.10. 1 hit.
InterProiIPR000119. Hist_DNA-bd.
IPR020816. Histone-like_DNA-bd_CS.
IPR010992. IHF-like_DNA-bd_dom.
[Graphical view]
PfamiPF00216. Bac_DNA_binding. 1 hit.
[Graphical view]
PRINTSiPR01727. DNABINDINGHU.
SMARTiSM00411. BHL. 1 hit.
[Graphical view]
SUPFAMiSSF47729. SSF47729. 1 hit.
PROSITEiPS00045. HISTONE_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDBH_NOSS1
AccessioniPrimary (citable) accession number: P05514
Secondary accession number(s): Q57356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.