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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Mitochondrion

Organism-specific databases

RGDi620494. mt-Nd4l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898NADH-ubiquinone oxidoreductase chain 4LPRO_0000118483Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP05507.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260597.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
PhylomeDBiP05507.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN
60 70 80 90
SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC
Length:98
Mass (Da):10,633
Last modified:October 1, 1989 - v2
Checksum:iA22AA1102433CA7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → V in AAD15022. 1 PublicationCurated
Sequence conflicti85 – 851H → Y in CAA32962. (PubMed:2504926)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32962.1.
J01435 Genomic DNA. Translation: AAD15022.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

Genome annotation databases

GeneIDi26200.
KEGGirno:26200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32962.1.
J01435 Genomic DNA. Translation: AAD15022.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi26200.
KEGGirno:26200.

Organism-specific databases

CTDi4539.
RGDi620494. mt-Nd4l.

Phylogenomic databases

eggNOGiNOG260597.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
PhylomeDBiP05507.

Miscellaneous databases

NextBioi607989.
PROiP05507.

Gene expression databases

GenevestigatoriP05507.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
    Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
    J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  2. "Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes."
    Grosskopf R., Feldmann H.
    Curr. Genet. 4:151-158(1981)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiNU4LM_RAT
AccessioniPrimary (citable) accession number: P05507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1989
Last modified: January 7, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.