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P05507 (NU4LM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADH-ubiquinone oxidoreductase chain 4L

EC=1.6.5.3
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene names
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded onMitochondrion
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.

Catalytic activity

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

Subcellular location

Mitochondrion membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the complex I subunit 4L family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9898NADH-ubiquinone oxidoreductase chain 4L
PRO_0000118483

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane26 – 4621Helical; Potential
Transmembrane59 – 7921Helical; Potential

Experimental info

Sequence conflict711A → V in AAD15022. Ref.2
Sequence conflict851H → Y in CAA32962. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P05507 [UniParc].

Last modified October 1, 1989. Version 2.
Checksum: A22AA1102433CA7E

FASTA9810,633
        10         20         30         40         50         60 
MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN SNSMISMTIP 

        70         80         90 
ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC 

« Hide

References

[1]"The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Wistar.
[2]"Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes."
Grosskopf R., Feldmann H.
Curr. Genet. 4:151-158(1981)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14848 Genomic DNA. Translation: CAA32962.1.
J01435 Genomic DNA. Translation: AAD15022.1.
PIRS04755.
RefSeqAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID26200.
KEGGrno:26200.

Organism-specific databases

CTD4539.
RGD620494. mt-Nd4l.

Phylogenomic databases

eggNOGNOG260597.
HOGENOMHOG000113880.
HOVERGENHBG071122.
InParanoidP05507.
KOK03882.
PhylomeDBP05507.

Gene expression databases

GenevestigatorP05507.

Family and domain databases

InterProIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERPTHR11434. PTHR11434. 1 hit.
PfamPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio607989.
PROP05507.

Entry information

Entry nameNU4LM_RAT
AccessionPrimary (citable) accession number: P05507
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1989
Last modified: May 14, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families