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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi620494. mt-Nd4l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence analysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence analysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898NADH-ubiquinone oxidoreductase chain 4LPRO_0000118483Add
BLAST

Proteomic databases

PaxDbiP05507.

Expressioni

Gene expression databases

ExpressionAtlasiP05507. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042064.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669. Eukaryota.
COG0713. LUCA.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
OMAiMMLSLFI.
OrthoDBiEOG091G0ZRL.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN
60 70 80 90
SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,659
Last modified:April 1, 2015 - v3
Checksum:iA22AA1102426DF7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → V in AAD15022 (PubMed:24185961).Curated
Sequence conflicti85 – 851Y → H in AAD15022 (PubMed:24185961).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15022.1.
X14848 Genomic DNA. Translation: CAA32962.1.
AY172581 Genomic DNA. Translation: AAN77602.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000044582; ENSRNOP00000042064; ENSRNOG00000031053.
GeneIDi26200.
KEGGirno:26200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15022.1.
X14848 Genomic DNA. Translation: CAA32962.1.
AY172581 Genomic DNA. Translation: AAN77602.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042064.

Proteomic databases

PaxDbiP05507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044582; ENSRNOP00000042064; ENSRNOG00000031053.
GeneIDi26200.
KEGGirno:26200.

Organism-specific databases

CTDi4539.
RGDi620494. mt-Nd4l.

Phylogenomic databases

eggNOGiKOG4669. Eukaryota.
COG0713. LUCA.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
OMAiMMLSLFI.
OrthoDBiEOG091G0ZRL.

Miscellaneous databases

PROiP05507.

Gene expression databases

ExpressionAtlasiP05507. baseline.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNU4LM_RAT
AccessioniPrimary (citable) accession number: P05507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 2015
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.