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P05507

- NU4LM_RAT

UniProt

P05507 - NU4LM_RAT

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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620494. mt-Nd4l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST
Transmembranei26 – 4621HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrion Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9898NADH-ubiquinone oxidoreductase chain 4LPRO_0000118483Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP05507.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG260597.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
PhylomeDBiP05507.

Family and domain databases

InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05507-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN
60 70 80 90
SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC
Length:98
Mass (Da):10,633
Last modified:October 1, 1989 - v2
Checksum:iA22AA1102433CA7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti71 – 711A → V in AAD15022. 1 PublicationCurated
Sequence conflicti85 – 851H → Y in CAA32962. (PubMed:2504926)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32962.1.
J01435 Genomic DNA. Translation: AAD15022.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

Genome annotation databases

GeneIDi26200.
KEGGirno:26200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14848 Genomic DNA. Translation: CAA32962.1 .
J01435 Genomic DNA. Translation: AAD15022.1 .
PIRi S04755.
RefSeqi AP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 26200.
KEGGi rno:26200.

Organism-specific databases

CTDi 4539.
RGDi 620494. mt-Nd4l.

Phylogenomic databases

eggNOGi NOG260597.
HOGENOMi HOG000113880.
HOVERGENi HBG071122.
InParanoidi P05507.
KOi K03882.
PhylomeDBi P05507.

Miscellaneous databases

NextBioi 607989.
PROi P05507.

Gene expression databases

Genevestigatori P05507.

Family and domain databases

InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view ]
PANTHERi PTHR11434. PTHR11434. 1 hit.
Pfami PF00420. Oxidored_q2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
    Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
    J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  2. "Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes."
    Grosskopf R., Feldmann H.
    Curr. Genet. 4:151-158(1981)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiNU4LM_RAT
AccessioniPrimary (citable) accession number: P05507
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1989
Last modified: October 29, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3