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P05507

- NU4LM_RAT

UniProt

P05507 - NU4LM_RAT

Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.By similarity

    Catalytic activityi

    NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
    Alternative name(s):
    NADH dehydrogenase subunit 4L
    Gene namesi
    Name:Mtnd4l
    Synonyms:mt-Nd4l, Nd4l
    Encoded oniMitochondrion
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi620494. mt-Nd4l.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9898NADH-ubiquinone oxidoreductase chain 4LPRO_0000118483Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriP05507.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei2 – 2221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei26 – 4621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4L family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG260597.
    HOGENOMiHOG000113880.
    HOVERGENiHBG071122.
    InParanoidiP05507.
    KOiK03882.
    PhylomeDBiP05507.

    Family and domain databases

    InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view]
    PANTHERiPTHR11434. PTHR11434. 1 hit.
    PfamiPF00420. Oxidored_q2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05507-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN   50
    SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC 98
    Length:98
    Mass (Da):10,633
    Last modified:October 1, 1989 - v2
    Checksum:iA22AA1102433CA7E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti71 – 711A → V in AAD15022. 1 PublicationCurated
    Sequence conflicti85 – 851H → Y in CAA32962. (PubMed:2504926)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14848 Genomic DNA. Translation: CAA32962.1.
    J01435 Genomic DNA. Translation: AAD15022.1.
    PIRiS04755.
    RefSeqiAP_004900.1. AC_000022.2.
    YP_665637.1. NC_001665.2.

    Genome annotation databases

    GeneIDi26200.
    KEGGirno:26200.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14848 Genomic DNA. Translation: CAA32962.1 .
    J01435 Genomic DNA. Translation: AAD15022.1 .
    PIRi S04755.
    RefSeqi AP_004900.1. AC_000022.2.
    YP_665637.1. NC_001665.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 26200.
    KEGGi rno:26200.

    Organism-specific databases

    CTDi 4539.
    RGDi 620494. mt-Nd4l.

    Phylogenomic databases

    eggNOGi NOG260597.
    HOGENOMi HOG000113880.
    HOVERGENi HBG071122.
    InParanoidi P05507.
    KOi K03882.
    PhylomeDBi P05507.

    Miscellaneous databases

    NextBioi 607989.
    PROi P05507.

    Gene expression databases

    Genevestigatori P05507.

    Family and domain databases

    InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view ]
    PANTHERi PTHR11434. PTHR11434. 1 hit.
    Pfami PF00420. Oxidored_q2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
      Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
      J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Wistar.
    2. "Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes."
      Grosskopf R., Feldmann H.
      Curr. Genet. 4:151-158(1981)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiNU4LM_RAT
    AccessioniPrimary (citable) accession number: P05507
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: October 1, 1989
    Last modified: October 1, 2014
    This is version 95 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3