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Protein

NADH-ubiquinone oxidoreductase chain 4L

Gene

Mtnd4l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

Catalytic activityi

NADH + ubiquinone + 5 H+(In) = NAD+ + ubiquinol + 4 H+(Out).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandNAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-ubiquinone oxidoreductase chain 4L (EC:1.6.5.3)
Alternative name(s):
NADH dehydrogenase subunit 4L
Gene namesi
Name:Mtnd4l
Synonyms:mt-Nd4l, Nd4l
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi620494. mt-Nd4l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Transmembranei59 – 79HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001184831 – 98NADH-ubiquinone oxidoreductase chain 4LAdd BLAST98

Proteomic databases

PaxDbiP05507.

Expressioni

Gene expression databases

ExpressionAtlasiP05507. baseline.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042064.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4669. Eukaryota.
COG0713. LUCA.
GeneTreeiENSGT00390000004755.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
OMAiMMLSLFI.
OrthoDBiEOG09040N96.

Family and domain databases

InterProiView protein in InterPro
IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
PANTHERiPTHR11434. PTHR11434. 1 hit.

Sequencei

Sequence statusi: Complete.

P05507-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN
60 70 80 90
SNSMISMTIP ITILVFAACE AAVGLALLVK ISNTYGTDYV QNLNLLQC
Length:98
Mass (Da):10,659
Last modified:April 1, 2015 - v3
Checksum:iA22AA1102426DF7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71A → V in AAD15022 (PubMed:24185961).Curated1
Sequence conflicti85Y → H in AAD15022 (PubMed:24185961).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15022.1.
X14848 Genomic DNA. Translation: CAA32962.1.
AY172581 Genomic DNA. Translation: AAN77602.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000044582; ENSRNOP00000042064; ENSRNOG00000031053.
GeneIDi26200.
KEGGirno:26200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15022.1.
X14848 Genomic DNA. Translation: CAA32962.1.
AY172581 Genomic DNA. Translation: AAN77602.1.
PIRiS04755.
RefSeqiAP_004900.1. AC_000022.2.
YP_665637.1. NC_001665.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000042064.

Proteomic databases

PaxDbiP05507.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044582; ENSRNOP00000042064; ENSRNOG00000031053.
GeneIDi26200.
KEGGirno:26200.

Organism-specific databases

CTDi4539.
RGDi620494. mt-Nd4l.

Phylogenomic databases

eggNOGiKOG4669. Eukaryota.
COG0713. LUCA.
GeneTreeiENSGT00390000004755.
HOGENOMiHOG000113880.
HOVERGENiHBG071122.
InParanoidiP05507.
KOiK03882.
OMAiMMLSLFI.
OrthoDBiEOG09040N96.

Miscellaneous databases

PROiP05507.

Gene expression databases

ExpressionAtlasiP05507. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
PANTHERiPTHR11434. PTHR11434. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNU4LM_RAT
AccessioniPrimary (citable) accession number: P05507
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 2015
Last modified: February 15, 2017
This is version 114 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.