P05507 (NU4LM_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH-ubiquinone oxidoreductase chain 4L
EC=1.6.5.3

Alternative name(s):
NADH dehydrogenase subunit 4L

Gene names

Name:	Mtnd4l
Synonyms:	mt-Nd4l, Nd4l

Encoded on

Mitochondrion

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	98 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone By similarity.
Catalytic activity	NADH + ubiquinone = NAD+ + ubiquinol.
Subcellular location	Mitochondrion membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the complex I subunit 4L family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion
Domain	Transmembrane Transmembrane helix
Ligand	NAD Ubiquinone
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP synthesis coupled electron transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 98	98	NADH-ubiquinone oxidoreductase chain 4L		PRO_0000118483
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	26 – 46	21	Helical; Potential
	Transmembrane	59 – 79	21	Helical; Potential
Experimental info
	Sequence conflict	71	1	A → V in AAD15022. Ref.2
	Sequence conflict	85	1	H → Y in CAA32962. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P05507 [UniParc]. Last modified October 1, 1989. Version 2. Checksum: A22AA1102433CA7E	FASTA	98	10,633
	10 20 30 40 50 60 MTSAFLNLTM AFTLSLLGTF MFRSHLMSTL LCLEGMMLSL FVMTSTSTLN SNSMISMTIP 70 80 90 ITILVFAACE AAVGLALLVK ISNTHGTDYV QNLNLLQC

References

[1]	"The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates." Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C. J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Wistar.
[2]	"Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes." Grosskopf R., Feldmann H. Curr. Genet. 4:151-158(1981) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14848 Genomic DNA. Translation: CAA32962.1. J01435 Genomic DNA. Translation: AAD15022.1.
IPI	IPI00200484.
PIR	S04755.
RefSeq	AP_004900.1. AC_000022.2. YP_665637.1. NC_001665.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	26200.
KEGG	rno:26200.
Organism-specific databases
CTD	4539.
RGD	620494. mt-Nd4l.
Phylogenomic databases
eggNOG	NOG260597.
HOGENOM	HOG000113880.
HOVERGEN	HBG071122.
InParanoid	P05507.
KO	K03882.
OrthoDB	EOG4DZ1WV.
ProtClustDB	MTH00107.
Gene expression databases
ArrayExpress	P05507.
Genevestigator	P05507.
Family and domain databases
InterPro	IPR001133. NADH_UbQ_OxRdtase_chain4L/K. [Graphical view]
PANTHER	PTHR11434. PTHR11434. 1 hit.
Pfam	PF00420. Oxidored_q2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	607989.

Entry information

Entry name

NU4LM_RAT

Accession

Primary (citable) accession number: P05507

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	October 1, 1989
Last modified:	April 3, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program