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Protein

Cytochrome c oxidase subunit 3

Gene

Mtco3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:Mtco3
Synonyms:Coiii, mt-Co3
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi621873. mt-Co3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001838442 – 261Cytochrome c oxidase subunit 3Add BLAST260

Proteomic databases

PaxDbiP05505.
PRIDEiP05505.

PTM databases

iPTMnetiP05505.
PhosphoSitePlusiP05505.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030700.
ExpressionAtlasiP05505. baseline.
GenevisibleiP05505. RN.

Interactioni

Protein-protein interaction databases

CORUMiP05505.
STRINGi10116.ENSRNOP00000051326.

Structurei

3D structure databases

ProteinModelPortaliP05505.
SMRiP05505.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
GeneTreeiENSGT00390000013064.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP05505.
KOiK02262.
OMAiPWPLTGA.
OrthoDBiEOG091G0GH8.
PhylomeDBiP05505.
TreeFamiTF343435.

Family and domain databases

CDDicd01665. Cyt_c_Oxidase_III. 1 hit.
Gene3Di1.20.120.80. 1 hit.
InterProiView protein in InterPro
IPR024791. Cyt_c/ubiquinol_Oxase_su3.
IPR033945. Cyt_c_oxase_su3_dom.
IPR000298. Cyt_c_oxidase-like_su3.
IPR035973. Cyt_c_oxidase_su3-like_sf.
IPR013833. Cyt_c_oxidase_su3_a-hlx.
PANTHERiPTHR11403. PTHR11403. 1 hit.
PfamiView protein in Pfam
PF00510. COX3. 1 hit.
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiView protein in PROSITE
PS50253. COX3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG ALSALLLTSG LVMWFHYNST ILLSLGLLTN
60 70 80 90 100
ILTMYQWWRD IIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGNRNHMN QALLITILLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,871
Last modified:January 23, 2007 - v5
Checksum:i8B5CF8B2AF36F3D3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → S AA sequence (PubMed:7601105).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15020.1.
M27315 Genomic DNA. Translation: AAB00994.1.
X14848 Genomic DNA. Translation: CAA32960.1.
AY172581 Genomic DNA. Translation: AAN77600.1.
PIRiS04753.
RefSeqiAP_004898.1. AC_000022.2.
YP_665635.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000049683; ENSRNOP00000051326; ENSRNOG00000030700.
GeneIDi26204.
KEGGirno:26204.

Similar proteinsi

Entry informationi

Entry nameiCOX3_RAT
AccessioniPrimary (citable) accession number: P05505
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 137 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families