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Protein

Cytochrome c oxidase subunit 3

Gene

Mtco3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunits I, II and III form the functional core of the enzyme complex.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 3
Alternative name(s):
Cytochrome c oxidase polypeptide III
Gene namesi
Name:Mtco3
Synonyms:Coiii, mt-Co3
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi621873. mt-Co3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521HelicalSequence analysisAdd
BLAST
Transmembranei38 – 5821HelicalSequence analysisAdd
BLAST
Transmembranei81 – 10121HelicalSequence analysisAdd
BLAST
Transmembranei127 – 14721HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei197 – 21721HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 261260Cytochrome c oxidase subunit 3PRO_0000183844Add
BLAST

Proteomic databases

PaxDbiP05505.
PRIDEiP05505.

PTM databases

iPTMnetiP05505.
PhosphoSiteiP05505.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030700.
ExpressionAtlasiP05505. baseline.
GenevisibleiP05505. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051326.

Structurei

3D structure databases

ProteinModelPortaliP05505.
SMRiP05505. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP05505.
KOiK02262.
OMAiPWPLTGA.
OrthoDBiEOG091G0GH8.
PhylomeDBiP05505.
TreeFamiTF343435.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05505-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHQTHAYHM VNPSPWPLTG ALSALLLTSG LVMWFHYNST ILLSLGLLTN
60 70 80 90 100
ILTMYQWWRD IIREGTYQGH HTPIVQKGLR YGMILFIVSE VFFFAGFFWA
110 120 130 140 150
FYHSSLVPTH DLGGCWPPTG ITPLNPLEVP LLNTSVLLAS GVSITWAHHS
160 170 180 190 200
LMEGNRNHMN QALLITILLG LYFTILQASE YFETSFSISD GIYGSTFFMA
210 220 230 240 250
TGFHGLHVII GSTFLIVCLL RQLKFHFTSK HHFGFEAAAW YWHFVDVVWL
260
FLYVSIYWWG S
Length:261
Mass (Da):29,871
Last modified:January 23, 2007 - v5
Checksum:i8B5CF8B2AF36F3D3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21T → S AA sequence (PubMed:7601105).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15020.1.
M27315 Genomic DNA. Translation: AAB00994.1.
X14848 Genomic DNA. Translation: CAA32960.1.
AY172581 Genomic DNA. Translation: AAN77600.1.
PIRiS04753.
RefSeqiAP_004898.1. AC_000022.2.
YP_665635.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000049683; ENSRNOP00000051326; ENSRNOG00000030700.
GeneIDi26204.
KEGGirno:26204.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15020.1.
M27315 Genomic DNA. Translation: AAB00994.1.
X14848 Genomic DNA. Translation: CAA32960.1.
AY172581 Genomic DNA. Translation: AAN77600.1.
PIRiS04753.
RefSeqiAP_004898.1. AC_000022.2.
YP_665635.1. NC_001665.2.

3D structure databases

ProteinModelPortaliP05505.
SMRiP05505. Positions 1-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051326.

PTM databases

iPTMnetiP05505.
PhosphoSiteiP05505.

Proteomic databases

PaxDbiP05505.
PRIDEiP05505.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049683; ENSRNOP00000051326; ENSRNOG00000030700.
GeneIDi26204.
KEGGirno:26204.

Organism-specific databases

CTDi4514.
RGDi621873. mt-Co3.

Phylogenomic databases

eggNOGiKOG4664. Eukaryota.
COG1845. LUCA.
HOGENOMiHOG000264954.
HOVERGENiHBG016686.
InParanoidiP05505.
KOiK02262.
OMAiPWPLTGA.
OrthoDBiEOG091G0GH8.
PhylomeDBiP05505.
TreeFamiTF343435.

Miscellaneous databases

PROiP05505.

Gene expression databases

BgeeiENSRNOG00000030700.
ExpressionAtlasiP05505. baseline.
GenevisibleiP05505. RN.

Family and domain databases

Gene3Di1.20.120.80. 1 hit.
InterProiIPR013833. Cyt_c_oxidase_su3_a-hlx.
IPR000298. Cyt_c_oxidase_su3_dom.
[Graphical view]
PfamiPF00510. COX3. 1 hit.
[Graphical view]
SUPFAMiSSF81452. SSF81452. 1 hit.
PROSITEiPS50253. COX3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOX3_RAT
AccessioniPrimary (citable) accession number: P05505
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 127 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.