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Protein

ATP synthase subunit a

Gene

Mt-atp6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • ATP synthesis coupled proton transport Source: InterPro
  • response to hyperoxia Source: RGD
Complete GO annotation...

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase subunit a
Alternative name(s):
F-ATPase protein 6
Gene namesi
Name:Mt-atp6
Synonyms:Atp6, Atpase6, Mtatp6
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Mitochondrion

Organism-specific databases

RGDi621239. Mt-atp6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei97 – 117HelicalSequence analysisAdd BLAST21
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Transmembranei164 – 184HelicalSequence analysisAdd BLAST21
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000821631 – 226ATP synthase subunit aAdd BLAST226

Proteomic databases

PaxDbiP05504.
PRIDEiP05504.

Expressioni

Gene expression databases

ExpressionAtlasiP05504. differential.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049769.

Chemistry databases

BindingDBiP05504.

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 36Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55C/F29-41[»]
ProteinModelPortaliP05504.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05504.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase A chain family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4665. Eukaryota.
COG0356. LUCA.
GeneTreeiENSGT00390000005568.
HOGENOMiHOG000034185.
HOVERGENiHBG016693.
InParanoidiP05504.
KOiK02126.
OMAiMFIGSTN.
OrthoDBiEOG091G12DP.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
InterProiIPR000568. ATP_synth_F0_asu.
IPR023011. ATP_synth_F0_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENLFASFI TPTMMGLPIV VTIIMFPSIL FPSSERLISN RLHSFQHWLI
60 70 80 90 100
KLIIKQMMLI HTPKGRTWAL MIVSLIMFIG STNLLGLLPH TFTPTTQLSM
110 120 130 140 150
NLSMAIPLWA GAVILGFRHK LKNSLAHFLP QGTPISLIPM LIIIETISLF
160 170 180 190 200
IQPMALAVRL TANITAGHLL MHLIGGATLV LMDISPPTAT ITFIILLLLT
210 220
VLEFAVALIQ AYVFTLLVSL YLHDNT
Length:226
Mass (Da):25,076
Last modified:April 1, 2015 - v3
Checksum:iA3674941F4143BCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7A → P in AAD15019 (PubMed:24185961).Curated1
Sequence conflicti101N → D in CAA32959 (PubMed:2504926).Curated1
Sequence conflicti129L → S in CAA32959 (PubMed:2504926).Curated1
Sequence conflicti129L → S in AAD22965 (PubMed:8529844).Curated1
Sequence conflicti205A → V in AAD15019 (PubMed:24185961).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15019.1.
X14848 Genomic DNA. Translation: CAA32959.1.
AF115770 Genomic DNA. Translation: AAD22965.1.
AY172581 Genomic DNA. Translation: AAN77599.1.
PIRiS04752.
RefSeqiAP_004897.1. AC_000022.2.
YP_665634.1. NC_001665.2.

Genome annotation databases

EnsembliENSRNOT00000046108; ENSRNOP00000049769; ENSRNOG00000031979.
GeneIDi26197.
KEGGirno:26197.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01435 Genomic DNA. Translation: AAD15019.1.
X14848 Genomic DNA. Translation: CAA32959.1.
AF115770 Genomic DNA. Translation: AAD22965.1.
AY172581 Genomic DNA. Translation: AAN77599.1.
PIRiS04752.
RefSeqiAP_004897.1. AC_000022.2.
YP_665634.1. NC_001665.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ED3X-ray2.55C/F29-41[»]
ProteinModelPortaliP05504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049769.

Chemistry databases

BindingDBiP05504.

Proteomic databases

PaxDbiP05504.
PRIDEiP05504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000046108; ENSRNOP00000049769; ENSRNOG00000031979.
GeneIDi26197.
KEGGirno:26197.

Organism-specific databases

CTDi4508.
RGDi621239. Mt-atp6.

Phylogenomic databases

eggNOGiKOG4665. Eukaryota.
COG0356. LUCA.
GeneTreeiENSGT00390000005568.
HOGENOMiHOG000034185.
HOVERGENiHBG016693.
InParanoidiP05504.
KOiK02126.
OMAiMFIGSTN.
OrthoDBiEOG091G12DP.

Enzyme and pathway databases

ReactomeiR-RNO-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

EvolutionaryTraceiP05504.
PROiP05504.

Gene expression databases

ExpressionAtlasiP05504. differential.

Family and domain databases

Gene3Di1.20.120.220. 1 hit.
InterProiIPR000568. ATP_synth_F0_asu.
IPR023011. ATP_synth_F0_asu_AS.
[Graphical view]
PANTHERiPTHR11410. PTHR11410. 1 hit.
PfamiPF00119. ATP-synt_A. 1 hit.
[Graphical view]
PRINTSiPR00123. ATPASEA.
SUPFAMiSSF81336. SSF81336. 1 hit.
TIGRFAMsiTIGR01131. ATP_synt_6_or_A. 1 hit.
PROSITEiPS00449. ATPASE_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATP6_RAT
AccessioniPrimary (citable) accession number: P05504
Secondary accession number(s): Q9T2E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 2015
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.