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P05503

- COX1_RAT

UniProt

P05503 - COX1_RAT

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Protein
Cytochrome c oxidase subunit 1
Gene
Mtco1, Coi, mt-Co1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Iron (heme A axial ligand) Inferred
Metal bindingi240 – 2401Copper B Inferred
Metal bindingi244 – 2441Copper B Inferred
Metal bindingi290 – 2901Copper B Inferred
Metal bindingi291 – 2911Copper B Inferred
Metal bindingi376 – 3761Iron (heme A3 axial ligand) Inferred
Metal bindingi378 – 3781Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. aging Source: RGD
  3. cerebellum development Source: RGD
  4. hydrogen ion transmembrane transport Source: GOC
  5. oxidative phosphorylation Source: UniProtKB-UniPathway
  6. response to copper ion Source: RGD
  7. response to electrical stimulus Source: RGD
  8. response to oxidative stress Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:Mtco1
Synonyms:Coi, mt-Co1
Encoded oniMitochondrion
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi621871. mt-Co1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei17 – 3721Helical; Reviewed prediction
Add
BLAST
Transmembranei56 – 7621Helical; Reviewed prediction
Add
BLAST
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Transmembranei145 – 16521Helical; Reviewed prediction
Add
BLAST
Transmembranei183 – 20321Helical; Reviewed prediction
Add
BLAST
Transmembranei234 – 25421Helical; Reviewed prediction
Add
BLAST
Transmembranei268 – 28821Helical; Reviewed prediction
Add
BLAST
Transmembranei310 – 33021Helical; Reviewed prediction
Add
BLAST
Transmembranei338 – 35821Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei414 – 43421Helical; Reviewed prediction
Add
BLAST
Transmembranei456 – 47621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: RGD
  4. respiratory chain complex IV Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1
PRO_0000183406Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki240 ↔ 2441'-histidyl-3'-tyrosine (His-Tyr) By similarity

Proteomic databases

PaxDbiP05503.
PRIDEiP05503.

Expressioni

Gene expression databases

GenevestigatoriP05503.

Structurei

3D structure databases

ProteinModelPortaliP05503.
SMRiP05503. Positions 1-514.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
HOGENOMiHOG000085274.
HOVERGENiHBG003841.
InParanoidiP05503.
PhylomeDBiP05503.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05503-1 [UniParc]FASTAAdd to Basket

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MFVNRWLFST NHKDIGTLYL LFGAWAGMVG TALSILIRAE LGQPGALLGD    50
DQIYNVIVTA HAFVMIFFMV MPMMIGGFGN WLVPLMIGAP DMAFPRMNNM 100
SFWLLPPSFL LLLASSMVEA GAGTGWTVYP PLAGNLAHAG VSVDLTIFSL 150
HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP 200
VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG 250
FGIISHVVTY YSGKKEPFGY MGMVWTMMSI GFLGFIVWAH HMFTVGLDVD 300
TRAYFTSATM IIAIPTGVKV FSWLATLHGG NIKWSPAMLW ALGFIFLFTV 350
GGLTGIVLSN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM AGFVHWFPLF 400
SGYTLNDTWA KAHFAIMFVG VNMTFFPQHF LGLAGMPRRY SDYPDAYTTW 450
NTVSSMGSFI SLTAVLVMIF MIWEAFASKR EVLSISYSST NLEWLHGCPP 500
PYHTFEEPSY VKVK 514
Length:514
Mass (Da):56,937
Last modified:October 1, 1989 - v2
Checksum:i20BCE1C7857ED6FD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → G in AAD15016. 1 Publication
Sequence conflicti12 – 121H → P in AAD15016. 1 Publication
Sequence conflicti44 – 441P → L in AAD15016. 1 Publication
Sequence conflicti57 – 571I → L in AAD15016. 1 Publication
Sequence conflicti216 – 2183NTT → EFP in AAB21298. 1 Publication
Sequence conflicti227 – 2271D → G in AAD15016. 1 Publication
Sequence conflicti249 – 2491P → L in AAD15016. 1 Publication
Sequence conflicti252 – 2521G → E in AAD15016. 1 Publication
Sequence conflicti276 – 2761T → A in AAB21298. 1 Publication
Sequence conflicti392 – 3921G → C in AAD15016. 1 Publication
Sequence conflicti392 – 3921G → C in AAB21298. 1 Publication
Sequence conflicti413 – 4131H → L in AAD15016. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14848 Genomic DNA. Translation: CAA32956.1.
J01435 Genomic DNA. Translation: AAD15016.1.
V00676 Genomic DNA. Translation: CAA24046.1.
V00678 Genomic DNA. Translation: CAA24050.1.
S79304 mRNA. Translation: AAB21298.2.
PIRiS04749.
RefSeqiAP_004894.1. AC_000022.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14848 Genomic DNA. Translation: CAA32956.1 .
J01435 Genomic DNA. Translation: AAD15016.1 .
V00676 Genomic DNA. Translation: CAA24046.1 .
V00678 Genomic DNA. Translation: CAA24050.1 .
S79304 mRNA. Translation: AAB21298.2 .
PIRi S04749.
RefSeqi AP_004894.1. AC_000022.2.

3D structure databases

ProteinModelPortali P05503.
SMRi P05503. Positions 1-514.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi P05503.
PRIDEi P05503.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 621871. mt-Co1.

Phylogenomic databases

eggNOGi COG0843.
HOGENOMi HOG000085274.
HOVERGENi HBG003841.
InParanoidi P05503.
PhylomeDBi P05503.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Miscellaneous databases

NextBioi 35584672.
PROi P05503.

Gene expression databases

Genevestigatori P05503.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates."
    Gadaleta G., Pepe G., de Candia G., Quagliariello C., Sbisa E., Saccone C.
    J. Mol. Evol. 28:497-516(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Wistar.
  2. "Analysis of a DNA segment from rat liver mitochondria containing the genes for the cytochrome oxidase subunits I, II, II, ATPase subunit 6, and several tRNA genes."
    Grosskopf R., Feldmann H.
    Curr. Genet. 4:151-158(1981)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  3. "Tumor-associated mutations of rat mitochondrial transfer RNA genes."
    Taira M., Yoshida E., Kobayashi M., Yaginuma K., Koike K.
    Nucleic Acids Res. 11:1635-1643(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7.
  4. "Hormonal regulation of cytochrome oxidase subunit messenger RNAs in rat Sertoli cells."
    Ku C.Y., Lu Q., Ussuf K.K., Weinstock G.M., Sanborn B.M.
    Mol. Endocrinol. 5:1669-1676(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 216-514.
    Tissue: Sertoli cell.

Entry informationi

Entry nameiCOX1_RAT
AccessioniPrimary (citable) accession number: P05503
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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