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Protein

ATP synthase F(0) complex subunit C1, mitochondrial

Gene

ATP5G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Miscellaneous

There are three genes which encode the mitochondrial ATP synthase proteolipid and they specify precursors with different import sequences but identical mature proteins. Is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei119Reversibly protonated during proton transportBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-163210. Formation of ATP by chemiosmotic coupling.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP synthase F(0) complex subunit C1, mitochondrial
Alternative name(s):
ATP synthase lipid-binding protein
ATP synthase proteolipid P1
ATP synthase proton-transporting mitochondrial F(0) complex subunit C1
ATPase protein 9
ATPase subunit c
Gene namesi
Name:ATP5G1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:841. ATP5G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

CF(0), Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi516.
OpenTargetsiENSG00000159199.
PharmGKBiPA25131.

Polymorphism and mutation databases

BioMutaiATP5G1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 61MitochondrionAdd BLAST61
ChainiPRO_000000255762 – 136ATP synthase F(0) complex subunit C1, mitochondrialAdd BLAST75

Proteomic databases

PaxDbiP05496.
PeptideAtlasiP05496.
PRIDEiP05496.
TopDownProteomicsiP05496.

PTM databases

iPTMnetiP05496.
PhosphoSitePlusiP05496.

Expressioni

Gene expression databases

BgeeiENSG00000159199.
CleanExiHS_ATP5G1.
ExpressionAtlasiP05496. baseline and differential.
GenevisibleiP05496. HS.

Interactioni

Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c. Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi107001. 8 interactors.
IntActiP05496. 2 interactors.
STRINGi9606.ENSP00000348205.

Structurei

3D structure databases

ProteinModelPortaliP05496.
SMRiP05496.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase C chain family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiP05496.
KOiK02128.
OMAiPPALIRC.
OrthoDBiEOG091G13J1.
PhylomeDBiP05496.
TreeFamiTF300140.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05496-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA
60 70 80 90 100
RREFQTSVVS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN
110 120 130
PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM
Length:136
Mass (Da):14,277
Last modified:February 1, 1994 - v2
Checksum:i1AFF1F16BB532647
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53E → G in AAA51806 (PubMed:2883974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69907 Genomic DNA. Translation: CAA49532.1.
D13118 mRNA. Translation: BAA02420.1.
AL080089 mRNA. Translation: CAB45704.1.
BT007230 mRNA. Translation: AAP35894.1.
BC004963 mRNA. Translation: AAH04963.1.
M16453 mRNA. Translation: AAA51806.1.
CCDSiCCDS11539.1.
PIRiS34066.
RefSeqiNP_001002027.1. NM_001002027.1.
NP_005166.1. NM_005175.2.
UniGeneiHs.80986.

Genome annotation databases

EnsembliENST00000355938; ENSP00000348205; ENSG00000159199.
ENST00000393366; ENSP00000377033; ENSG00000159199.
GeneIDi516.
KEGGihsa:516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X69907 Genomic DNA. Translation: CAA49532.1.
D13118 mRNA. Translation: BAA02420.1.
AL080089 mRNA. Translation: CAB45704.1.
BT007230 mRNA. Translation: AAP35894.1.
BC004963 mRNA. Translation: AAH04963.1.
M16453 mRNA. Translation: AAA51806.1.
CCDSiCCDS11539.1.
PIRiS34066.
RefSeqiNP_001002027.1. NM_001002027.1.
NP_005166.1. NM_005175.2.
UniGeneiHs.80986.

3D structure databases

ProteinModelPortaliP05496.
SMRiP05496.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107001. 8 interactors.
IntActiP05496. 2 interactors.
STRINGi9606.ENSP00000348205.

PTM databases

iPTMnetiP05496.
PhosphoSitePlusiP05496.

Polymorphism and mutation databases

BioMutaiATP5G1.

Proteomic databases

PaxDbiP05496.
PeptideAtlasiP05496.
PRIDEiP05496.
TopDownProteomicsiP05496.

Protocols and materials databases

DNASUi516.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355938; ENSP00000348205; ENSG00000159199.
ENST00000393366; ENSP00000377033; ENSG00000159199.
GeneIDi516.
KEGGihsa:516.

Organism-specific databases

CTDi516.
DisGeNETi516.
GeneCardsiATP5G1.
HGNCiHGNC:841. ATP5G1.
MIMi603192. gene.
neXtProtiNX_P05496.
OpenTargetsiENSG00000159199.
PharmGKBiPA25131.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3025. Eukaryota.
COG0636. LUCA.
GeneTreeiENSGT00390000006210.
HOGENOMiHOG000235246.
HOVERGENiHBG050605.
InParanoidiP05496.
KOiK02128.
OMAiPPALIRC.
OrthoDBiEOG091G13J1.
PhylomeDBiP05496.
TreeFamiTF300140.

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-163210. Formation of ATP by chemiosmotic coupling.

Miscellaneous databases

GeneWikiiATP5G1.
GenomeRNAii516.
PROiPR:P05496.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159199.
CleanExiHS_ATP5G1.
ExpressionAtlasiP05496. baseline and differential.
GenevisibleiP05496. HS.

Family and domain databases

Gene3Di1.20.20.10. 1 hit.
HAMAPiMF_01396. ATP_synth_c_bact. 1 hit.
InterProiView protein in InterPro
IPR000454. ATP_synth_F0_csu.
IPR020537. ATP_synth_F0_csu_DDCD_BS.
IPR002379. ATPase_proteolipid_c-like_dom.
PANTHERiPTHR10031. PTHR10031. 1 hit.
PfamiView protein in Pfam
PF00137. ATP-synt_C. 1 hit.
PRINTSiPR00124. ATPASEC.
SUPFAMiSSF81333. SSF81333. 1 hit.
PROSITEiView protein in PROSITE
PS00605. ATPASE_C. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAT5G1_HUMAN
AccessioniPrimary (citable) accession number: P05496
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 1994
Last modified: March 15, 2017
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.