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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Miscellaneous

The gene coding for this protein is probably silent. Soybean nuclear genome encode an active cox2.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi186Copper ACurated1
Metal bindingi221Copper ACurated1
Metal bindingi225Copper ACurated1
Metal bindingi229Copper ACurated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII, COXII
ORF Names:GlmaxMp76
Encoded oniMitochondrion
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
Proteomesi
  • UP000008827 Componenti: Mitochondrion

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39Mitochondrial intermembraneSequence analysisAdd BLAST39
Transmembranei40 – 61HelicalSequence analysisAdd BLAST22
Topological domaini62 – 76Mitochondrial matrixSequence analysisAdd BLAST15
Transmembranei77 – 104HelicalSequence analysisAdd BLAST28
Topological domaini105 – 260Mitochondrial intermembraneSequence analysisAdd BLAST156

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836931 – 260Cytochrome c oxidase subunit 2Add BLAST260

Structurei

3D structure databases

ProteinModelPortaliP05491
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02261

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

Sequencei

Sequence statusi: Complete.

P05491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFEWLFLTI APCDAAEPWQ LGFQDAATPM MQGIIDLHHD IFFFLILILV
60 70 80 90 100
FVSRILVRAL WHFHYKKNPI PQRIVHGTTI EILRTIFPSI IPMFIAIPSF
110 120 130 140 150
ALLYSMDEVV VDPAITIKAI GHQWYRTYEY SDYNSSDEQS LTFDSYTIPE
160 170 180 190 200
DDLELGQSRL LEVDNRVVVP AKTHLRIIVT PADVPHSWAV PSLGVKCDAV
210 220 230 240 250
PGRLNQISIS VQREGVYYGQ CSEICGTNHA FTPIVVEAVP SKDYGSRVFN
260
QLIPQTTGEA
Length:260
Mass (Da):29,437
Last modified:November 1, 1995 - v2
Checksum:i400FCAE14AD98000
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04825 Genomic DNA Translation: CAA28508.1
JX463295 Genomic DNA Translation: AFR34332.1
PIRiS07169
RefSeqiYP_007516925.1, NC_020455.1

Genome annotation databases

GeneIDi15308623
KEGGigmx:15308623

Similar proteinsi

Entry informationi

Entry nameiCOX2_SOYBN
AccessioniPrimary (citable) accession number: P05491
Secondary accession number(s): M1FPH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health