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P05491

- COX2_SOYBN

UniProt

P05491 - COX2_SOYBN

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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Glycine max (Soybean) (Glycine hispida)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi186 – 1861Copper ACurated
Metal bindingi221 – 2211Copper ACurated
Metal bindingi225 – 2251Copper ACurated
Metal bindingi229 – 2291Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII, COXII
ORF Names:GlmaxMp76
Encoded oniMitochondrion
OrganismiGlycine max (Soybean) (Glycine hispida)
Taxonomic identifieri3847 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaePhaseoleaeGlycineSoja
ProteomesiUP000008827: Mitochondrion

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Cytochrome c oxidase subunit 2PRO_0000183693Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriP05491.

Structurei

3D structure databases

ProteinModelPortaliP05491.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Topological domaini62 – 7615Mitochondrial matrixSequence AnalysisAdd
BLAST
Topological domaini105 – 260156Mitochondrial intermembraneSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6122HelicalSequence AnalysisAdd
BLAST
Transmembranei77 – 10428HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02261.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05491-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFEWLFLTI APCDAAEPWQ LGFQDAATPM MQGIIDLHHD IFFFLILILV
60 70 80 90 100
FVSRILVRAL WHFHYKKNPI PQRIVHGTTI EILRTIFPSI IPMFIAIPSF
110 120 130 140 150
ALLYSMDEVV VDPAITIKAI GHQWYRTYEY SDYNSSDEQS LTFDSYTIPE
160 170 180 190 200
DDLELGQSRL LEVDNRVVVP AKTHLRIIVT PADVPHSWAV PSLGVKCDAV
210 220 230 240 250
PGRLNQISIS VQREGVYYGQ CSEICGTNHA FTPIVVEAVP SKDYGSRVFN
260
QLIPQTTGEA
Length:260
Mass (Da):29,437
Last modified:November 1, 1995 - v2
Checksum:i400FCAE14AD98000
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04825 Genomic DNA. Translation: CAA28508.1.
JX463295 Genomic DNA. Translation: AFR34332.1.
PIRiS07169.
RefSeqiYP_007516925.1. NC_020455.1.

Genome annotation databases

GeneIDi15308623.
KEGGigmx:15308623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X04825 Genomic DNA. Translation: CAA28508.1 .
JX463295 Genomic DNA. Translation: AFR34332.1 .
PIRi S07169.
RefSeqi YP_007516925.1. NC_020455.1.

3D structure databases

ProteinModelPortali P05491.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15308623.
KEGGi gmx:15308623.

Phylogenomic databases

KOi K02261.

Gene expression databases

Genevestigatori P05491.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cytochrome oxidase subunit II gene is adjacent to an initiator methionine tRNA gene in soybean mitochondrial DNA."
    Grabau E.A.
    Curr. Genet. 11:287-293(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The mitochondrial genome of soybean reveals complex genome structures and gene evolution at intercellular and phylogenetic levels."
    Chang S., Wang Y., Lu J., Gai J., Li J., Chu P., Guan R., Zhao T.
    PLoS ONE 8:E56502-E56502(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Aiganhuang.
    Tissue: Etiolated seedling.

Entry informationi

Entry nameiCOX2_SOYBN
AccessioniPrimary (citable) accession number: P05491
Secondary accession number(s): M1FPH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The gene coding for this protein is probably silent. Soybean nuclear genome encode an active cox2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3