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P05490

- COX2_OENBE

UniProt

P05490 - COX2_OENBE

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Protein
Cytochrome c oxidase subunit 2
Gene
COX2, COII, COXII
Organism
Oenothera berteroana (Bertero's evening primrose)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi187 – 1871Copper A Inferred
Metal bindingi222 – 2221Copper A Inferred
Metal bindingi226 – 2261Copper A Inferred
Metal bindingi230 – 2301Copper A Inferred

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII, COXII
Encoded oniMitochondrion
OrganismiOenothera berteroana (Bertero's evening primrose)
Taxonomic identifieri3950 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOenothera

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4141Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei42 – 5817Helical; Reviewed prediction
Add
BLAST
Topological domaini59 – 8224Mitochondrial matrix Reviewed prediction
Add
BLAST
Transmembranei83 – 10422Helical; Reviewed prediction
Add
BLAST
Topological domaini105 – 258154Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Cytochrome c oxidase subunit 2
PRO_0000183642Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP05490.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05490-1 [UniParc]FASTAAdd to Basket

« Hide

MIVNECLFFT IALCDAAEPW QLGFQDAATP MMQGIIDLHH DILFFLILIL    50
VFVLWILVRA LWHFYYKKNP IPQRIVHGTT IEILWTIFPS IILMFIAIPS 100
FALLYSMDEV VVDPAMTLKA IGHQWYWTYE YSDYNSSDEQ SLTFDSYMIP 150
EDDLELGQLR LLEVDNRVVV PVKTNLRLIV TSADVLHSWA VPSLGVKCDA 200
VPGRLNQISM LVQREGVYYG QCSEICGTNH AFMPIVIEAV SATDYTNWVS 250
NLFIPPTS 258
Length:258
Mass (Da):29,457
Last modified:October 1, 1996 - v3
Checksum:iE9FC86733F527CB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00212 Genomic DNA. Translation: CAA25038.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00212 Genomic DNA. Translation: CAA25038.1 .

3D structure databases

ProteinModelPortali P05490.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsi TIGR02866. CoxB. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cytochrome oxidase subunit II gene in mitochondria of Oenothera has no intron."
    Hiesel R., Brennicke A.
    EMBO J. 2:2173-2178(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Munzia.

Entry informationi

Entry nameiCOX2_OENBE
AccessioniPrimary (citable) accession number: P05490
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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