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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Oenothera berteroana (Bertero's evening primrose)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi187Copper ACurated1
Metal bindingi222Copper ACurated1
Metal bindingi226Copper ACurated1
Metal bindingi230Copper ACurated1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COX2
Synonyms:COII, COXII
Encoded oniMitochondrion
OrganismiOenothera berteroana (Bertero's evening primrose)
Taxonomic identifieri3950 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOnagroideaeOnagreaeOenothera

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41Mitochondrial intermembraneSequence analysisAdd BLAST41
Transmembranei42 – 58HelicalSequence analysisAdd BLAST17
Topological domaini59 – 82Mitochondrial matrixSequence analysisAdd BLAST24
Transmembranei83 – 104HelicalSequence analysisAdd BLAST22
Topological domaini105 – 258Mitochondrial intermembraneSequence analysisAdd BLAST154

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001836421 – 258Cytochrome c oxidase subunit 2Add BLAST258

Structurei

3D structure databases

ProteinModelPortaliP05490.
SMRiP05490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

CDDicd13912. CcO_II_C. 1 hit.
Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProiView protein in InterPro
IPR002429. CcO_II-like_C.
IPR034210. CcO_II_C.
IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
IPR036257. Cyt_c_oxidase_su2_TM_sf.
PfamiView protein in Pfam
PF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
SUPFAMiSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsiTIGR02866. CoxB. 1 hit.
PROSITEiView protein in PROSITE
PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.

Sequencei

Sequence statusi: Complete.

P05490-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVNECLFFT IALCDAAEPW QLGFQDAATP MMQGIIDLHH DILFFLILIL
60 70 80 90 100
VFVLWILVRA LWHFYYKKNP IPQRIVHGTT IEILWTIFPS IILMFIAIPS
110 120 130 140 150
FALLYSMDEV VVDPAMTLKA IGHQWYWTYE YSDYNSSDEQ SLTFDSYMIP
160 170 180 190 200
EDDLELGQLR LLEVDNRVVV PVKTNLRLIV TSADVLHSWA VPSLGVKCDA
210 220 230 240 250
VPGRLNQISM LVQREGVYYG QCSEICGTNH AFMPIVIEAV SATDYTNWVS

NLFIPPTS
Length:258
Mass (Da):29,457
Last modified:October 1, 1996 - v3
Checksum:iE9FC86733F527CB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00212 Genomic DNA. Translation: CAA25038.1.

Similar proteinsi

Entry informationi

Entry nameiCOX2_OENBE
AccessioniPrimary (citable) accession number: P05490
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program