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P05490 (COX2_OENBE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COII, COXII
Encoded onMitochondrion
OrganismOenothera berteroana (Bertero's evening primrose)
Taxonomic identifier3950 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOenothera

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Cytochrome c oxidase subunit 2
PRO_0000183642

Regions

Topological domain1 – 4141Mitochondrial intermembrane Potential
Transmembrane42 – 5817Helical; Potential
Topological domain59 – 8224Mitochondrial matrix Potential
Transmembrane83 – 10422Helical; Potential
Topological domain105 – 258154Mitochondrial intermembrane Potential

Sites

Metal binding1871Copper A Probable
Metal binding2221Copper A Probable
Metal binding2261Copper A Probable
Metal binding2301Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P05490 [UniParc].

Last modified October 1, 1996. Version 3.
Checksum: E9FC86733F527CB2

FASTA25829,457
        10         20         30         40         50         60 
MIVNECLFFT IALCDAAEPW QLGFQDAATP MMQGIIDLHH DILFFLILIL VFVLWILVRA 

        70         80         90        100        110        120 
LWHFYYKKNP IPQRIVHGTT IEILWTIFPS IILMFIAIPS FALLYSMDEV VVDPAMTLKA 

       130        140        150        160        170        180 
IGHQWYWTYE YSDYNSSDEQ SLTFDSYMIP EDDLELGQLR LLEVDNRVVV PVKTNLRLIV 

       190        200        210        220        230        240 
TSADVLHSWA VPSLGVKCDA VPGRLNQISM LVQREGVYYG QCSEICGTNH AFMPIVIEAV 

       250 
SATDYTNWVS NLFIPPTS 

« Hide

References

[1]"Cytochrome oxidase subunit II gene in mitochondria of Oenothera has no intron."
Hiesel R., Brennicke A.
EMBO J. 2:2173-2178(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cv. Munzia.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X00212 Genomic DNA. Translation: CAA25038.1.

3D structure databases

ProteinModelPortalP05490.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR014222. Cyt_c_oxidase_su2.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
TIGRFAMsTIGR02866. CoxB. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_OENBE
AccessionPrimary (citable) accession number: P05490
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families