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Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Paramecium tetraurelia
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54Iron (heme A axial ligand)Curated1
Metal bindingi343Copper BCurated1
Metal bindingi347Copper BCurated1
Metal bindingi392Copper BCurated1
Metal bindingi393Copper BCurated1
Metal bindingi478Iron (heme A3 axial ligand)Curated1
Metal bindingi480Iron (heme A axial ligand)Curated1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 28HelicalSequence analysisAdd BLAST21
Transmembranei56 – 76HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei475 – 495HelicalSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Transmembranei555 – 575HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001833831 – 645Cytochrome c oxidase subunit 1Add BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki343 ↔ 3471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Proteomic databases

PRIDEiP05489

Structurei

3D structure databases

ProteinModelPortaliP05489
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10, 2 hits
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
PfamiView protein in Pfam
PF00115 COX1, 2 hits
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 2 hits
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

P05489-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHKRIALNY FYFSMWTGLS GAALATMIRL EMAYPGSPFF KGDSIKYLQV
60 70 80 90 100
ATAHGLIMVF FVVVPIFFGG FANFLIPYHV GSKDVAFPRL NSIGFWIQPL
110 120 130 140 150
GFLLVAKIAF LRTTSWKYYD KTSFFLQPYN KSLYRDFFNF LTGELSFNPF
160 170 180 190 200
KKSLDESLFL FLWKPRKKIT NTEYTSFFFN PLNLSFLDSF FYYSDNLWSL
210 220 230 240 250
ANKVVSSRRK KIYVTKCSNR AAVTAGWTFI TPFSSNMKYS GFGAQDVLSV
260 270 280 290 300
AVVLAGISTT ISLLTLITRR TLVAPGLRNR RVLIPFITIS LLLTLRLLAI
310 320 330 340 350
VTPILGAAVL MSLMDRHWQT SFFDFAYGGD PILFQHLFWF FGHPEVYILI
360 370 380 390 400
IPSFGVANIV LPFYTMRRMS SKHHMIWAVY VMAYMGFVVW GHHMYLVGLD
410 420 430 440 450
HRSRNIYSTI TIMICLPATI KLVNWTLTLA NAAIHVDLVF LFFCSYVFFF
460 470 480 490 500
LTGGFTGMWL SHVGLNISVH DTFYVVAHFH LMLAGAAMMG AFTGLYYYYN
510 520 530 540 550
TFFDVQYSKI FGFLHLVYYS AGIWTTFFPM FFLGFSGLPR RIHDFPAFFL
560 570 580 590 600
GWHGLASCGH FLTLAGVCFF FFGIFDSTSE NKSSILANFG IPKIAKRAHL
610 620 630 640
YFFKISYNNY TNEIASELPK VEVRKFIIEN TFGEYECVKL VPVTK
Length:645
Mass (Da):74,037
Last modified:November 1, 1988 - v1
Checksum:iEF034E5B0D927502
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15917 Genomic DNA Translation: CAA34030.1
M15281 Genomic DNA Translation: AAA79251.1
PIRiA24988 ODPP1
S07751

Entry informationi

Entry nameiCOX1_PARTE
AccessioniPrimary (citable) accession number: P05489
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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