Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P05489

- COX1_PARTE

UniProt

P05489 - COX1_PARTE

Protein

Cytochrome c oxidase subunit 1

Gene

COI

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi54 – 541Iron (heme A axial ligand)Curated
    Metal bindingi343 – 3431Copper BCurated
    Metal bindingi347 – 3471Copper BCurated
    Metal bindingi392 – 3921Copper BCurated
    Metal bindingi393 – 3931Copper BCurated
    Metal bindingi478 – 4781Iron (heme A3 axial ligand)Curated
    Metal bindingi480 – 4801Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COI
    Encoded oniMitochondrion
    OrganismiParamecium tetraurelia
    Taxonomic identifieri5888 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 645645Cytochrome c oxidase subunit 1PRO_0000183383Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki343 ↔ 3471'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP05489.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei282 – 30221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei438 – 45821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei475 – 49521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei513 – 53321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.210.10. 2 hits.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 2 hits.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 2 hits.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P05489-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNHKRIALNY FYFSMWTGLS GAALATMIRL EMAYPGSPFF KGDSIKYLQV    50
    ATAHGLIMVF FVVVPIFFGG FANFLIPYHV GSKDVAFPRL NSIGFWIQPL 100
    GFLLVAKIAF LRTTSWKYYD KTSFFLQPYN KSLYRDFFNF LTGELSFNPF 150
    KKSLDESLFL FLWKPRKKIT NTEYTSFFFN PLNLSFLDSF FYYSDNLWSL 200
    ANKVVSSRRK KIYVTKCSNR AAVTAGWTFI TPFSSNMKYS GFGAQDVLSV 250
    AVVLAGISTT ISLLTLITRR TLVAPGLRNR RVLIPFITIS LLLTLRLLAI 300
    VTPILGAAVL MSLMDRHWQT SFFDFAYGGD PILFQHLFWF FGHPEVYILI 350
    IPSFGVANIV LPFYTMRRMS SKHHMIWAVY VMAYMGFVVW GHHMYLVGLD 400
    HRSRNIYSTI TIMICLPATI KLVNWTLTLA NAAIHVDLVF LFFCSYVFFF 450
    LTGGFTGMWL SHVGLNISVH DTFYVVAHFH LMLAGAAMMG AFTGLYYYYN 500
    TFFDVQYSKI FGFLHLVYYS AGIWTTFFPM FFLGFSGLPR RIHDFPAFFL 550
    GWHGLASCGH FLTLAGVCFF FFGIFDSTSE NKSSILANFG IPKIAKRAHL 600
    YFFKISYNNY TNEIASELPK VEVRKFIIEN TFGEYECVKL VPVTK 645
    Length:645
    Mass (Da):74,037
    Last modified:November 1, 1988 - v1
    Checksum:iEF034E5B0D927502
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15917 Genomic DNA. Translation: CAA34030.1.
    M15281 Genomic DNA. Translation: AAA79251.1.
    PIRiA24988. ODPP1.
    S07751.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X15917 Genomic DNA. Translation: CAA34030.1 .
    M15281 Genomic DNA. Translation: AAA79251.1 .
    PIRi A24988. ODPP1.
    S07751.

    3D structure databases

    ProteinModelPortali P05489.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 2 hits.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 2 hits.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 2 hits.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Stock 51.
    2. "Paramecium mitochondrial DNA sequences and RNA transcripts for cytochrome oxidase subunit I, URF1, and three ORFs adjacent to the replication origin."
      Pritchard A.E., Seilhamer J.J., Cummings D.J.
      Gene 44:243-253(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCOX1_PARTE
    AccessioniPrimary (citable) accession number: P05489
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3