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P05489

- COX1_PARTE

UniProt

P05489 - COX1_PARTE

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Protein

Cytochrome c oxidase subunit 1

Gene
COI
Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Iron (heme A axial ligand) Inferred
Metal bindingi343 – 3431Copper B Inferred
Metal bindingi347 – 3471Copper B Inferred
Metal bindingi392 – 3921Copper B Inferred
Metal bindingi393 – 3931Copper B Inferred
Metal bindingi478 – 4781Iron (heme A3 axial ligand) Inferred
Metal bindingi480 – 4801Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COI
Encoded oniMitochondrion
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Reviewed predictionAdd
BLAST
Transmembranei56 – 7621Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei247 – 26721Helical; Reviewed predictionAdd
BLAST
Transmembranei282 – 30221Helical; Reviewed predictionAdd
BLAST
Transmembranei337 – 35721Helical; Reviewed predictionAdd
BLAST
Transmembranei376 – 39621Helical; Reviewed predictionAdd
BLAST
Transmembranei410 – 43021Helical; Reviewed predictionAdd
BLAST
Transmembranei438 – 45821Helical; Reviewed predictionAdd
BLAST
Transmembranei475 – 49521Helical; Reviewed predictionAdd
BLAST
Transmembranei513 – 53321Helical; Reviewed predictionAdd
BLAST
Transmembranei555 – 57521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 645645Cytochrome c oxidase subunit 1PRO_0000183383Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki343 ↔ 3471'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP05489.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 2 hits.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 2 hits.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 2 hits.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05489-1 [UniParc]FASTAAdd to Basket

« Hide

MNHKRIALNY FYFSMWTGLS GAALATMIRL EMAYPGSPFF KGDSIKYLQV    50
ATAHGLIMVF FVVVPIFFGG FANFLIPYHV GSKDVAFPRL NSIGFWIQPL 100
GFLLVAKIAF LRTTSWKYYD KTSFFLQPYN KSLYRDFFNF LTGELSFNPF 150
KKSLDESLFL FLWKPRKKIT NTEYTSFFFN PLNLSFLDSF FYYSDNLWSL 200
ANKVVSSRRK KIYVTKCSNR AAVTAGWTFI TPFSSNMKYS GFGAQDVLSV 250
AVVLAGISTT ISLLTLITRR TLVAPGLRNR RVLIPFITIS LLLTLRLLAI 300
VTPILGAAVL MSLMDRHWQT SFFDFAYGGD PILFQHLFWF FGHPEVYILI 350
IPSFGVANIV LPFYTMRRMS SKHHMIWAVY VMAYMGFVVW GHHMYLVGLD 400
HRSRNIYSTI TIMICLPATI KLVNWTLTLA NAAIHVDLVF LFFCSYVFFF 450
LTGGFTGMWL SHVGLNISVH DTFYVVAHFH LMLAGAAMMG AFTGLYYYYN 500
TFFDVQYSKI FGFLHLVYYS AGIWTTFFPM FFLGFSGLPR RIHDFPAFFL 550
GWHGLASCGH FLTLAGVCFF FFGIFDSTSE NKSSILANFG IPKIAKRAHL 600
YFFKISYNNY TNEIASELPK VEVRKFIIEN TFGEYECVKL VPVTK 645
Length:645
Mass (Da):74,037
Last modified:November 1, 1988 - v1
Checksum:iEF034E5B0D927502
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15917 Genomic DNA. Translation: CAA34030.1.
M15281 Genomic DNA. Translation: AAA79251.1.
PIRiA24988. ODPP1.
S07751.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X15917 Genomic DNA. Translation: CAA34030.1 .
M15281 Genomic DNA. Translation: AAA79251.1 .
PIRi A24988. ODPP1.
S07751.

3D structure databases

ProteinModelPortali P05489.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 2 hits.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 2 hits.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 2 hits.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock 51.
  2. "Paramecium mitochondrial DNA sequences and RNA transcripts for cytochrome oxidase subunit I, URF1, and three ORFs adjacent to the replication origin."
    Pritchard A.E., Seilhamer J.J., Cummings D.J.
    Gene 44:243-253(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX1_PARTE
AccessioniPrimary (citable) accession number: P05489
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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