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Protein

Lupus La protein

Gene

SSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).3 Publications

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • tRNA binding Source: ProtInc

GO - Biological processi

  • histone mRNA metabolic process Source: ProtInc
  • IRES-dependent viral translational initiation Source: UniProtKB
  • protein localization to cytoplasmic stress granule Source: AgBase
  • tRNA modification Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SIGNORiP05455.

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein
Alternative name(s):
La autoantigen
La ribonucleoprotein
Sjoegren syndrome type B antigen
Short name:
SS-B
Gene namesi
Name:SSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11316. SSB.

Subcellular locationi

GO - Cellular componenti

  • intracellular ribonucleoprotein complex Source: ProtInc
  • nuclear chromosome, telomeric region Source: BHF-UCL
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

PharmGKBiPA36140.

Chemistry

ChEMBLiCHEMBL2040701.

Polymorphism and mutation databases

BioMutaiSSB.
DMDMi125985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Lupus La proteinPRO_0000207599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921PhosphoserineCombined sources
Modified residuei94 – 941PhosphoserineCombined sources
Modified residuei116 – 1161N6-acetyllysineCombined sources
Modified residuei120 – 1201PhosphothreonineCombined sources
Modified residuei128 – 1281N6-acetyllysineCombined sources
Modified residuei225 – 2251PhosphoserineCombined sources
Modified residuei328 – 3281N6-acetyllysineCombined sources
Modified residuei341 – 3411N6-acetyllysineBy similarity
Modified residuei360 – 3601N6-acetyllysineCombined sources
Modified residuei362 – 3621PhosphothreonineCombined sources
Modified residuei366 – 3661Phosphoserine; by CK2Combined sources1 Publication

Post-translational modificationi

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05455.
MaxQBiP05455.
PaxDbiP05455.
PeptideAtlasiP05455.
PRIDEiP05455.

PTM databases

iPTMnetiP05455.
PhosphoSiteiP05455.
SwissPalmiP05455.

Miscellaneous databases

PMAP-CutDBP05455.

Expressioni

Gene expression databases

BgeeiENSG00000138385.
CleanExiHS_SSB.
ExpressionAtlasiP05455. baseline and differential.
GenevisibleiP05455. HS.

Organism-specific databases

HPAiCAB004643.
HPA012385.
HPA017287.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB82EBI-358037,EBI-6927928From a different organism.

Protein-protein interaction databases

BioGridi112619. 100 interactions.
DIPiDIP-29750N.
IntActiP05455. 36 interactions.
MINTiMINT-5002383.
STRINGi9606.ENSP00000260956.

Structurei

Secondary structure

1
408
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi11 – 2414Combined sources
Turni27 – 293Combined sources
Helixi30 – 323Combined sources
Helixi34 – 429Combined sources
Turni43 – 453Combined sources
Beta strandi46 – 483Combined sources
Helixi49 – 524Combined sources
Helixi56 – 616Combined sources
Helixi65 – 739Combined sources
Beta strandi80 – 823Combined sources
Beta strandi86 – 916Combined sources
Helixi102 – 1109Combined sources
Beta strandi112 – 1165Combined sources
Helixi124 – 1318Combined sources
Helixi132 – 1343Combined sources
Beta strandi137 – 1448Combined sources
Beta strandi146 – 1483Combined sources
Beta strandi150 – 16011Combined sources
Helixi161 – 1699Combined sources
Beta strandi174 – 1774Combined sources
Beta strandi181 – 1844Combined sources
Turni185 – 1873Combined sources
Beta strandi233 – 2397Combined sources
Helixi246 – 2527Combined sources
Beta strandi259 – 2635Combined sources
Beta strandi269 – 2779Combined sources
Helixi279 – 28810Combined sources
Turni289 – 2913Combined sources
Beta strandi298 – 3047Combined sources
Helixi308 – 32619Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OWXNMR-A225-334[»]
1S79NMR-A105-202[»]
1S7ANMR-A1-103[»]
1YTYX-ray2.29A/B1-194[»]
1ZH5X-ray1.85A/B1-194[»]
2VODX-ray2.10A/B4-194[»]
2VONX-ray2.10A/B4-194[»]
2VOOX-ray1.80A/B4-194[»]
2VOPX-ray2.80A4-194[»]
DisProtiDP00229.
ProteinModelPortaliP05455.
SMRiP05455. Positions 10-188, 225-334.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18777RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00830000128380.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP05455.
KOiK11090.
OMAiTPDQKYK.
OrthoDBiEOG091G0K95.
PhylomeDBiP05455.
TreeFamiTF314476.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P05455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF
160 170 180 190 200
KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK
210 220 230 240 250
VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH
260 270 280 290 300
ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE
310 320 330 340 350
VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS
360 370 380 390 400
GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK

TENGAGDQ
Length:408
Mass (Da):46,837
Last modified:July 1, 1989 - v2
Checksum:iEC153C15F9187FC4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541K → E in AAA36577 (PubMed:2452201).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481P → S.
Corresponds to variant rs17160793 [ dbSNP | Ensembl ].
VAR_034066

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA. Translation: CAA31985.1.
J04205 mRNA. Translation: AAA51885.1.
BT009862 mRNA. Translation: AAP88864.1.
AB451228 mRNA. Translation: BAG70042.1.
AC009967 Genomic DNA. Translation: AAY14868.1.
CH471058 Genomic DNA. Translation: EAX11258.1.
CH471058 Genomic DNA. Translation: EAX11259.1.
BC001289 mRNA. Translation: AAH01289.1.
BC020818 mRNA. Translation: AAH20818.1.
M20328 mRNA. Translation: AAA36577.1.
CCDSiCCDS2237.1.
PIRiA31888.
RefSeqiNP_001281074.1. NM_001294145.1.
NP_003133.1. NM_003142.4.
UniGeneiHs.632535.

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385.
ENST00000409333; ENSP00000386636; ENSG00000138385.
GeneIDi6741.
KEGGihsa:6741.
UCSCiuc002ufk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA. Translation: CAA31985.1.
J04205 mRNA. Translation: AAA51885.1.
BT009862 mRNA. Translation: AAP88864.1.
AB451228 mRNA. Translation: BAG70042.1.
AC009967 Genomic DNA. Translation: AAY14868.1.
CH471058 Genomic DNA. Translation: EAX11258.1.
CH471058 Genomic DNA. Translation: EAX11259.1.
BC001289 mRNA. Translation: AAH01289.1.
BC020818 mRNA. Translation: AAH20818.1.
M20328 mRNA. Translation: AAA36577.1.
CCDSiCCDS2237.1.
PIRiA31888.
RefSeqiNP_001281074.1. NM_001294145.1.
NP_003133.1. NM_003142.4.
UniGeneiHs.632535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OWXNMR-A225-334[»]
1S79NMR-A105-202[»]
1S7ANMR-A1-103[»]
1YTYX-ray2.29A/B1-194[»]
1ZH5X-ray1.85A/B1-194[»]
2VODX-ray2.10A/B4-194[»]
2VONX-ray2.10A/B4-194[»]
2VOOX-ray1.80A/B4-194[»]
2VOPX-ray2.80A4-194[»]
DisProtiDP00229.
ProteinModelPortaliP05455.
SMRiP05455. Positions 10-188, 225-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112619. 100 interactions.
DIPiDIP-29750N.
IntActiP05455. 36 interactions.
MINTiMINT-5002383.
STRINGi9606.ENSP00000260956.

Chemistry

ChEMBLiCHEMBL2040701.

PTM databases

iPTMnetiP05455.
PhosphoSiteiP05455.
SwissPalmiP05455.

Polymorphism and mutation databases

BioMutaiSSB.
DMDMi125985.

Proteomic databases

EPDiP05455.
MaxQBiP05455.
PaxDbiP05455.
PeptideAtlasiP05455.
PRIDEiP05455.

Protocols and materials databases

DNASUi6741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385.
ENST00000409333; ENSP00000386636; ENSG00000138385.
GeneIDi6741.
KEGGihsa:6741.
UCSCiuc002ufk.4. human.

Organism-specific databases

CTDi6741.
GeneCardsiSSB.
HGNCiHGNC:11316. SSB.
HPAiCAB004643.
HPA012385.
HPA017287.
MIMi109090. gene.
neXtProtiNX_P05455.
PharmGKBiPA36140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00830000128380.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP05455.
KOiK11090.
OMAiTPDQKYK.
OrthoDBiEOG091G0K95.
PhylomeDBiP05455.
TreeFamiTF314476.

Enzyme and pathway databases

ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SIGNORiP05455.

Miscellaneous databases

ChiTaRSiSSB. human.
EvolutionaryTraceiP05455.
GeneWikiiSjogren_syndrome_antigen_B.
GenomeRNAii6741.
PMAP-CutDBP05455.
PROiP05455.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138385.
CleanExiHS_SSB.
ExpressionAtlasiP05455. baseline and differential.
GenevisibleiP05455. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLA_HUMAN
AccessioniPrimary (citable) accession number: P05455
Secondary accession number(s): Q15367, Q53XJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 197 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.