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Protein

Lupus La protein

Gene

SSB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).3 Publications

Miscellaneous

Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular La protein as if this antigen was foreign.

GO - Molecular functioni

  • mRNA binding Source: ProtInc
  • poly(U) RNA binding Source: CAFA
  • RNA binding Source: UniProtKB
  • sequence-specific mRNA binding Source: CAFA
  • tRNA binding Source: CAFA

GO - Biological processi

  • histone mRNA metabolic process Source: ProtInc
  • IRES-dependent viral translational initiation Source: UniProtKB
  • nuclear histone mRNA catabolic process Source: CAFA
  • protein localization to cytoplasmic stress granule Source: AgBase
  • tRNA 3'-end processing Source: CAFA
  • tRNA 5'-leader removal Source: CAFA
  • tRNA export from nucleus Source: CAFA
  • tRNA modification Source: ProtInc
  • tRNA processing Source: CAFA

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SIGNORiP05455.

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein
Alternative name(s):
La autoantigen
La ribonucleoprotein
Sjoegren syndrome type B antigen
Short name:
SS-B
Gene namesi
Name:SSB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:11316. SSB.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: CAFA
  • intracellular ribonucleoprotein complex Source: ProtInc
  • nuclear chromosome, telomeric region Source: BHF-UCL
  • nucleus Source: CAFA

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Systemic lupus erythematosus

Organism-specific databases

DisGeNETi6741.
OpenTargetsiENSG00000138385.
PharmGKBiPA36140.

Chemistry databases

ChEMBLiCHEMBL2040701.

Polymorphism and mutation databases

BioMutaiSSB.
DMDMi125985.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002075991 – 408Lupus La proteinAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineCombined sources1
Modified residuei94PhosphoserineCombined sources1
Modified residuei116N6-acetyllysineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Modified residuei128N6-acetyllysineCombined sources1
Modified residuei225PhosphoserineCombined sources1
Modified residuei328N6-acetyllysineCombined sources1
Modified residuei341N6-acetyllysineBy similarity1
Modified residuei360N6-acetyllysineCombined sources1
Modified residuei362PhosphothreonineCombined sources1
Modified residuei366Phosphoserine; by CK2Combined sources1 Publication1

Post-translational modificationi

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05455.
MaxQBiP05455.
PaxDbiP05455.
PeptideAtlasiP05455.
PRIDEiP05455.

PTM databases

iPTMnetiP05455.
PhosphoSitePlusiP05455.
SwissPalmiP05455.

Miscellaneous databases

PMAP-CutDBiP05455.

Expressioni

Gene expression databases

BgeeiENSG00000138385.
CleanExiHS_SSB.
ExpressionAtlasiP05455. baseline and differential.
GenevisibleiP05455. HS.

Organism-specific databases

HPAiCAB004643.
HPA017287.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB82EBI-358037,EBI-6858501From Hepatitis C virus genotype 2a (isolate JFH-1).

Protein-protein interaction databases

BioGridi112619. 101 interactors.
DIPiDIP-29750N.
IntActiP05455. 37 interactors.
MINTiMINT-5002383.
STRINGi9606.ENSP00000260956.

Structurei

Secondary structure

1408
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 24Combined sources14
Turni27 – 29Combined sources3
Helixi30 – 32Combined sources3
Helixi34 – 42Combined sources9
Turni43 – 45Combined sources3
Beta strandi46 – 48Combined sources3
Helixi49 – 52Combined sources4
Helixi56 – 61Combined sources6
Helixi65 – 73Combined sources9
Beta strandi80 – 82Combined sources3
Beta strandi86 – 91Combined sources6
Helixi102 – 110Combined sources9
Beta strandi112 – 116Combined sources5
Helixi124 – 131Combined sources8
Helixi132 – 134Combined sources3
Beta strandi137 – 144Combined sources8
Beta strandi146 – 148Combined sources3
Beta strandi150 – 160Combined sources11
Helixi161 – 169Combined sources9
Beta strandi174 – 177Combined sources4
Beta strandi181 – 184Combined sources4
Turni185 – 187Combined sources3
Beta strandi233 – 239Combined sources7
Helixi246 – 252Combined sources7
Beta strandi259 – 263Combined sources5
Beta strandi269 – 277Combined sources9
Helixi279 – 288Combined sources10
Turni289 – 291Combined sources3
Beta strandi298 – 304Combined sources7
Helixi308 – 326Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OWXNMR-A225-334[»]
1S79NMR-A105-202[»]
1S7ANMR-A1-103[»]
1YTYX-ray2.29A/B1-194[»]
1ZH5X-ray1.85A/B1-194[»]
2VODX-ray2.10A/B4-194[»]
2VONX-ray2.10A/B4-194[»]
2VOOX-ray1.80A/B4-194[»]
2VOPX-ray2.80A4-194[»]
DisProtiDP00229.
ProteinModelPortaliP05455.
SMRiP05455.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05455.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 99HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini111 – 187RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00830000128380.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP05455.
KOiK11090.
OMAiPEHNEER.
OrthoDBiEOG091G0K95.
PhylomeDBiP05455.
TreeFamiTF314476.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR006630. La_HTH.
IPR014886. La_RRM.
IPR002344. Lupus_La.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
PRINTSiPR00302. LUPUSLA.
SMARTiView protein in SMART
SM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.

Sequencei

Sequence statusi: Complete.

P05455-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM AALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
IMIKFNRLNR LTTDFNVIVE ALSKSKAELM EISEDKTKIR RSPSKPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LEDKGQVLNI QMRRTLHKAF
160 170 180 190 200
KGSIFVVFDS IESAKKFVET PGQKYKETDL LILFKDDYFA KKNEERKQNK
210 220 230 240 250
VEAKLRAKQE QEAKQKLEED AEMKSLEEKI GCLLKFSGDL DDQTCREDLH
260 270 280 290 300
ILFSNHGEIK WIDFVRGAKE GIILFKEKAK EALGKAKDAN NGNLQLRNKE
310 320 330 340 350
VTWEVLEGEV EKEALKKIIE DQQESLNKWK SKGRRFKGKG KGNKAAQPGS
360 370 380 390 400
GKGKVQFQGK KTKFASDDEH DEHDENGATG PVKRAREETD KEEPASKQQK

TENGAGDQ
Length:408
Mass (Da):46,837
Last modified:July 1, 1989 - v2
Checksum:iEC153C15F9187FC4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54K → E in AAA36577 (PubMed:2452201).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03406648P → S. Corresponds to variant dbSNP:rs17160793Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA. Translation: CAA31985.1.
J04205 mRNA. Translation: AAA51885.1.
BT009862 mRNA. Translation: AAP88864.1.
AB451228 mRNA. Translation: BAG70042.1.
AC009967 Genomic DNA. Translation: AAY14868.1.
CH471058 Genomic DNA. Translation: EAX11258.1.
CH471058 Genomic DNA. Translation: EAX11259.1.
BC001289 mRNA. Translation: AAH01289.1.
BC020818 mRNA. Translation: AAH20818.1.
M20328 mRNA. Translation: AAA36577.1.
CCDSiCCDS2237.1.
PIRiA31888.
RefSeqiNP_001281074.1. NM_001294145.1.
NP_003133.1. NM_003142.4.
UniGeneiHs.632535.

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385.
ENST00000409333; ENSP00000386636; ENSG00000138385.
GeneIDi6741.
KEGGihsa:6741.
UCSCiuc002ufk.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13697 mRNA. Translation: CAA31985.1.
J04205 mRNA. Translation: AAA51885.1.
BT009862 mRNA. Translation: AAP88864.1.
AB451228 mRNA. Translation: BAG70042.1.
AC009967 Genomic DNA. Translation: AAY14868.1.
CH471058 Genomic DNA. Translation: EAX11258.1.
CH471058 Genomic DNA. Translation: EAX11259.1.
BC001289 mRNA. Translation: AAH01289.1.
BC020818 mRNA. Translation: AAH20818.1.
M20328 mRNA. Translation: AAA36577.1.
CCDSiCCDS2237.1.
PIRiA31888.
RefSeqiNP_001281074.1. NM_001294145.1.
NP_003133.1. NM_003142.4.
UniGeneiHs.632535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OWXNMR-A225-334[»]
1S79NMR-A105-202[»]
1S7ANMR-A1-103[»]
1YTYX-ray2.29A/B1-194[»]
1ZH5X-ray1.85A/B1-194[»]
2VODX-ray2.10A/B4-194[»]
2VONX-ray2.10A/B4-194[»]
2VOOX-ray1.80A/B4-194[»]
2VOPX-ray2.80A4-194[»]
DisProtiDP00229.
ProteinModelPortaliP05455.
SMRiP05455.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112619. 101 interactors.
DIPiDIP-29750N.
IntActiP05455. 37 interactors.
MINTiMINT-5002383.
STRINGi9606.ENSP00000260956.

Chemistry databases

ChEMBLiCHEMBL2040701.

PTM databases

iPTMnetiP05455.
PhosphoSitePlusiP05455.
SwissPalmiP05455.

Polymorphism and mutation databases

BioMutaiSSB.
DMDMi125985.

Proteomic databases

EPDiP05455.
MaxQBiP05455.
PaxDbiP05455.
PeptideAtlasiP05455.
PRIDEiP05455.

Protocols and materials databases

DNASUi6741.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260956; ENSP00000260956; ENSG00000138385.
ENST00000409333; ENSP00000386636; ENSG00000138385.
GeneIDi6741.
KEGGihsa:6741.
UCSCiuc002ufk.4. human.

Organism-specific databases

CTDi6741.
DisGeNETi6741.
GeneCardsiSSB.
HGNCiHGNC:11316. SSB.
HPAiCAB004643.
HPA017287.
MIMi109090. gene.
neXtProtiNX_P05455.
OpenTargetsiENSG00000138385.
PharmGKBiPA36140.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
GeneTreeiENSGT00830000128380.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP05455.
KOiK11090.
OMAiPEHNEER.
OrthoDBiEOG091G0K95.
PhylomeDBiP05455.
TreeFamiTF314476.

Enzyme and pathway databases

ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SIGNORiP05455.

Miscellaneous databases

ChiTaRSiSSB. human.
EvolutionaryTraceiP05455.
GeneWikiiSjogren_syndrome_antigen_B.
GenomeRNAii6741.
PMAP-CutDBiP05455.
PROiPR:P05455.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138385.
CleanExiHS_SSB.
ExpressionAtlasiP05455. baseline and differential.
GenevisibleiP05455. HS.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiView protein in InterPro
IPR006630. La_HTH.
IPR014886. La_RRM.
IPR002344. Lupus_La.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
PRINTSiPR00302. LUPUSLA.
SMARTiView protein in SMART
SM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiView protein in PROSITE
PS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLA_HUMAN
AccessioniPrimary (citable) accession number: P05455
Secondary accession number(s): Q15367, Q53XJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: July 1, 1989
Last modified: June 7, 2017
This is version 204 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.