P05452 (TETN_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 123.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Tetranectin Short name=TN Alternative name(s): C-type lectin domain family 3 member B Plasminogen kringle 4-binding protein | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 202 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. |
| Subunit structure | Homotrimer. |
| Subcellular location | |
| Tissue specificity | Found in plasma. |
| Sequence similarities | Contains 1 C-type lectin domain. |
| Mass spectrometry | Molecular mass is 20535.8±2.4 Da from positions 22 - 202. Determined by ESI. Ref.8 |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Coding sequence diversity | Polymorphism |
| Domain | Signal |
| Ligand | Lectin |
| PTM | Disulfide bond Glycoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | skeletal system development Traceable author statement. Source: ProtInc |
| Cellular component | extracellular space Inferred from direct assay. Source: BHF-UCL |
| Molecular function | sugar binding Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Ref.7 | ||||||||||||||||||||||||||||
| Chain | 22 – 202 | 181 | Tetranectin Ref.1 | PRO_0000017471 | |||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||
| Domain | 77 – 198 | 122 | C-type lectin | ||||||||||||||||||||||||||||
Amino acid modifications | |||||||||||||||||||||||||||||||
| Glycosylation | 25 | 1 | O-linked (GalNAc...) | ||||||||||||||||||||||||||||
| Disulfide bond | 71 ↔ 81 | Ref.7 | |||||||||||||||||||||||||||||
| Disulfide bond | 98 ↔ 197 | Ref.7 | |||||||||||||||||||||||||||||
| Disulfide bond | 173 ↔ 189 | Ref.7 | |||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||
| Natural variant | 55 | 1 | A → S. Ref.7 | VAR_004189 | |||||||||||||||||||||||||||
| Natural variant | 58 | 1 | V → M. Ref.7 | VAR_004190 | |||||||||||||||||||||||||||
| Natural variant | 106 | 1 | G → S. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7 Corresponds to variant rs13963 [ dbSNP | Ensembl ]. | VAR_012318 | |||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||
| Beta strand | 69 – 73 | 5 | |||||||||||||||||||||||||||||
| Beta strand | 75 – 89 | 15 | |||||||||||||||||||||||||||||
| Helix | 91 – 100 | 10 | |||||||||||||||||||||||||||||
| Helix | 111 – 124 | 14 | |||||||||||||||||||||||||||||
| Beta strand | 130 – 140 | 11 | |||||||||||||||||||||||||||||
| Beta strand | 143 – 146 | 4 | |||||||||||||||||||||||||||||
| Turn | 160 – 162 | 3 | |||||||||||||||||||||||||||||
| Helix | 168 – 170 | 3 | |||||||||||||||||||||||||||||
| Beta strand | 173 – 177 | 5 | |||||||||||||||||||||||||||||
| Turn | 178 – 182 | 5 | |||||||||||||||||||||||||||||
| Beta strand | 183 – 187 | 5 | |||||||||||||||||||||||||||||
| Beta strand | 193 – 200 | 8 | |||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer." Wewer U.M., Albrechtsen R. Lab. Invest. 67:253-262(1992) [PubMed: 1354271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-106. Tissue: Placenta. |
| [2] | "The gene structure of tetranectin, a plasminogen binding protein." Berglund L., Petersen T.E. FEBS Lett. 309:15-19(1992) [PubMed: 1511740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-106. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106. |
| [4] | "The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. Gibbs R.A.Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106. Tissue: Lung. |
| [6] | "Cloning and mapping of the murine tetranectin gene." Sorensen C.B., Berglund L., Petersen T.E. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36. Tissue: Placenta. |
| [7] | "Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein." Fuhlendorff J., Clemmensen I., Magnusson S. Biochemistry 26:6757-6764(1987) [PubMed: 3427041] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-202, VARIANTS SER-55; MET-58 AND SER-106. |
| [8] | "Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin." Jaquinod M., Holtet T.L., Etzerodt M., Clemmensen I., Thoegersen H.C., Roepstorff P. Biol. Chem. 380:1307-1314(1999) [PubMed: 10614823] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Plasma. |
| [9] | "Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil." Nielsen B.B., Kastrup J.S., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K. FEBS Lett. 412:388-396(1997) [PubMed: 9256258] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS). |
| [10] | "Structure of the C-type lectin carbohydrate recognition domain of human tetranectin." Kastrup J.S., Nielsen B.B., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K. Acta Crystallogr. D 54:757-766(1998) [PubMed: 9757090] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 66-202. |
| + | Additional computationally mapped references. |
Web resources
| Functional Glycomics Gateway - Glycan Binding Tetranectin |
Cross-references
Sequence databases | |||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | X64559 mRNA. Translation: CAA45860.1. X70910, X70911, X70912 Genomic DNA. Translation: CAA50265.1. CR541981 mRNA. Translation: CAG46778.1. CR542009 mRNA. Translation: CAG46806.1. AC104165 Genomic DNA. No translation available. BC011024 mRNA. Translation: AAH11024.1. X98121 Genomic DNA. Translation: CAA66803.1. | ||||||||||||||||||||||||
| IPI | IPI00009028. | ||||||||||||||||||||||||
| PIR | TTHUN. S24126. | ||||||||||||||||||||||||
| RefSeq | NP_003269.2. NM_003278.2. | ||||||||||||||||||||||||
| UniGene | Hs.476092. | ||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | P05452. | ||||||||||||||||||||||||
| SMR | P05452. Positions 66-202. | ||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||
| STRING | P05452. | ||||||||||||||||||||||||
Polymorphism databases | |||||||||||||||||||||||||
| DMDM | 267108. | ||||||||||||||||||||||||
2D gel databases | |||||||||||||||||||||||||
| Cornea-2DPAGE | P05452. | ||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||
| PeptideAtlas | P05452. | ||||||||||||||||||||||||
| PRIDE | P05452. | ||||||||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||
| Ensembl | ENST00000296130; ENSP00000296130; ENSG00000163815. | ||||||||||||||||||||||||
| GeneID | 7123. | ||||||||||||||||||||||||
| KEGG | hsa:7123. | ||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||
| CTD | 7123. | ||||||||||||||||||||||||
| GeneCards | GC03P045043. | ||||||||||||||||||||||||
| H-InvDB | HIX0003237. | ||||||||||||||||||||||||
| HGNC | HGNC:11891. CLEC3B. | ||||||||||||||||||||||||
| HPA | CAB002582. | ||||||||||||||||||||||||
| MIM | 187520. gene. | ||||||||||||||||||||||||
| neXtProt | NX_P05452. | ||||||||||||||||||||||||
| PharmGKB | PA36590. | ||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||
| eggNOG | prNOG19148. | ||||||||||||||||||||||||
| HOGENOM | HBG714884. | ||||||||||||||||||||||||
| HOVERGEN | HBG108270. | ||||||||||||||||||||||||
| InParanoid | P05452. | ||||||||||||||||||||||||
| OMA | MELWGAY. | ||||||||||||||||||||||||
| OrthoDB | EOG4M91SQ. | ||||||||||||||||||||||||
| PhylomeDB | P05452. | ||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||
| ArrayExpress | P05452. | ||||||||||||||||||||||||
| CleanEx | HS_CLEC3B. | ||||||||||||||||||||||||
| Genevestigator | P05452. | ||||||||||||||||||||||||
| GermOnline | ENSG00000163815. Homo sapiens. | ||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||
| InterPro | IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. IPR003990. Pancreatis_ac. [Graphical view] | ||||||||||||||||||||||||
| Gene3D | G3DSA:3.10.100.10. C-type_lectin-like. 1 hit. | ||||||||||||||||||||||||
| Pfam | PF00059. Lectin_C. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| PRINTS | PR01504. PNCREATITSAP. | ||||||||||||||||||||||||
| SMART | SM00034. CLECT. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| SUPFAM | SSF56436. C-type_lectin_fold. 1 hit. | ||||||||||||||||||||||||
| PROSITE | PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view] | ||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||
Other | |||||||||||||||||||||||||
| DrugBank | DB00009. Alteplase. DB00029. Anistreplase. DB00015. Reteplase. DB00031. Tenecteplase. | ||||||||||||||||||||||||
| NextBio | 27875. | ||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||
Entry information
| Entry name | TETN_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P05452 Secondary accession number(s): Q6FGX6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

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