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P05452 (TETN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 147. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tetranectin

Short name=TN
Alternative name(s):
C-type lectin domain family 3 member B
Plasminogen kringle 4-binding protein
Gene names
Name:CLEC3B
Synonyms:TNA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length202 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.

Subunit structure

Homotrimer.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Sequence similarities

Contains 1 C-type lectin domain.

Mass spectrometry

Molecular mass is 20535.8±2.4 Da from positions 22 - 202. Determined by ESI. Ref.8

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainSignal
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processbone mineralization

Inferred from direct assay PubMed 7798325. Source: UniProtKB

cellular response to organic substance

Inferred from expression pattern PubMed 7589422. Source: UniProtKB

cellular response to transforming growth factor beta stimulus

Inferred from expression pattern PubMed 7589422. Source: UniProtKB

ossification

Inferred from expression pattern PubMed 7798325. Source: UniProtKB

positive regulation of plasminogen activation

Inferred from sequence or structural similarity. Source: UniProtKB

skeletal system development

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15848710PubMed 15901484PubMed 7798325. Source: UniProtKB

extracellular region

Non-traceable author statement PubMed 14718574. Source: UniProtKB

extracellular space

Inferred from direct assay PubMed 15901484PubMed 7798325. Source: UniProtKB

granular component

Inferred from direct assay PubMed 15848710. Source: UniProtKB

   Molecular_functioncalcium ion binding

Inferred from direct assay PubMed 9786936. Source: UniProtKB

carbohydrate binding

Inferred from electronic annotation. Source: InterPro

heparin binding

Inferred from direct assay PubMed 10727405. Source: UniProtKB

kringle domain binding

Inferred from physical interaction PubMed 9786936. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.7
Chain22 – 202181Tetranectin Ref.1
PRO_0000017471

Regions

Domain77 – 198122C-type lectin

Amino acid modifications

Glycosylation251O-linked (GalNAc...)
Disulfide bond71 ↔ 81 Ref.7
Disulfide bond98 ↔ 197 Ref.7
Disulfide bond173 ↔ 189 Ref.7

Natural variations

Natural variant551A → S. Ref.7
VAR_004189
Natural variant581V → M. Ref.7
VAR_004190
Natural variant1061G → S. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7
Corresponds to variant rs13963 [ dbSNP | Ensembl ].
VAR_012318

Secondary structure

............................. 202
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P05452 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 370C174033F21B78

FASTA20222,537
        10         20         30         40         50         60 
MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR LDTLAQEVAL 

        70         80         90        100        110        120 
LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS RGGTLGTPQT GSENDALYEY 

       130        140        150        160        170        180 
LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE ITAQPDGGKT ENCAVLSGAA 

       190        200 
NGKWFDKRCR DQLPYICQFG IV 

« Hide

References

« Hide 'large scale' references
[1]"Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer."
Wewer U.M., Albrechtsen R.
Lab. Invest. 67:253-262(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-106.
Tissue: Placenta.
[2]"The gene structure of tetranectin, a plasminogen binding protein."
Berglund L., Petersen T.E.
FEBS Lett. 309:15-19(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-106.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106.
[4]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106.
Tissue: Lung.
[6]"Cloning and mapping of the murine tetranectin gene."
Sorensen C.B., Berglund L., Petersen T.E.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36.
Tissue: Placenta.
[7]"Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein."
Fuhlendorff J., Clemmensen I., Magnusson S.
Biochemistry 26:6757-6764(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 22-202, VARIANTS SER-55; MET-58 AND SER-106.
[8]"Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin."
Jaquinod M., Holtet T.L., Etzerodt M., Clemmensen I., Thoegersen H.C., Roepstorff P.
Biol. Chem. 380:1307-1314(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY.
Tissue: Plasma.
[9]"Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil."
Nielsen B.B., Kastrup J.S., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K.
FEBS Lett. 412:388-396(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[10]"Structure of the C-type lectin carbohydrate recognition domain of human tetranectin."
Kastrup J.S., Nielsen B.B., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K.
Acta Crystallogr. D 54:757-766(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 66-202.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X64559 mRNA. Translation: CAA45860.1.
X70910, X70911, X70912 Genomic DNA. Translation: CAA50265.1.
CR541981 mRNA. Translation: CAG46778.1.
CR542009 mRNA. Translation: CAG46806.1.
AC104165 Genomic DNA. No translation available.
BC011024 mRNA. Translation: AAH11024.1.
X98121 Genomic DNA. Translation: CAA66803.1.
CCDSCCDS2726.1.
PIRTTHUN. S24126.
RefSeqNP_003269.2. NM_003278.2.
UniGeneHs.476092.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1HTNX-ray2.80A22-202[»]
1RJHNMR-A85-202[»]
1TN3X-ray2.00A66-202[»]
3L9JX-ray2.10C67-201[»]
ProteinModelPortalP05452.
SMRP05452. Positions 66-202.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112978. 15 interactions.
IntActP05452. 8 interactions.
MINTMINT-8247353.
STRING9606.ENSP00000296130.

Chemistry

DrugBankDB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.

Polymorphism databases

DMDM317373499.

Proteomic databases

MaxQBP05452.
PaxDbP05452.
PeptideAtlasP05452.
PRIDEP05452.

Protocols and materials databases

DNASU7123.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000296130; ENSP00000296130; ENSG00000163815.
GeneID7123.
KEGGhsa:7123.
UCSCuc003cok.4. human.

Organism-specific databases

CTD7123.
GeneCardsGC03P045043.
H-InvDBHIX0163464.
HGNCHGNC:11891. CLEC3B.
HPACAB002582.
MIM187520. gene.
neXtProtNX_P05452.
PharmGKBPA36590.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG252273.
HOGENOMHOG000060248.
HOVERGENHBG108270.
InParanoidP05452.
KOK17520.
OMAICQFAIV.
OrthoDBEOG754HQT.
PhylomeDBP05452.
TreeFamTF330481.

Gene expression databases

BgeeP05452.
CleanExHS_CLEC3B.
GenevestigatorP05452.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLEC3B. human.
EvolutionaryTraceP05452.
GeneWikiCLEC3B.
GenomeRNAi7123.
NextBio27875.
PROP05452.
SOURCESearch...

Entry information

Entry nameTETN_HUMAN
AccessionPrimary (citable) accession number: P05452
Secondary accession number(s): Q6FGX6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM