P05452 (TETN_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tetranectin
Short name=TN

Alternative name(s):
C-type lectin domain family 3 member B
Plasminogen kringle 4-binding protein

Gene names

Name:	CLEC3B
Synonyms:	TNA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	202 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis.
Subunit structure	Homotrimer.
Subcellular location	Secreted.
Tissue specificity	Found in plasma.
Sequence similarities	Contains 1 C-type lectin domain.
Mass spectrometry	Molecular mass is 20535.8±2.4 Da from positions 22 - 202. Determined by ESI. Ref.8

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Lectin
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological process	skeletal system development Traceable author statement. Source: ProtInc
Cellular component	extracellular space Inferred from direct assay. Source: BHF-UCL
Molecular function	sugar binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

21

Ref.7

Chain

22 – 202

181

Tetranectin Ref.1

PRO_0000017471

Regions

Domain

77 – 198

122

C-type lectin

Amino acid modifications

Glycosylation

25

1

O-linked (GalNAc...)

Disulfide bond

71 ↔ 81

Ref.7

Disulfide bond

98 ↔ 197

Ref.7

Disulfide bond

173 ↔ 189

Ref.7

Natural variations

Natural variant

55

1

A → S. Ref.7

VAR_004189

Natural variant

58

1

V → M. Ref.7

VAR_004190

Natural variant

106

1

G → S. Ref.1 Ref.2 Ref.3 Ref.5 Ref.7
Corresponds to variant rs13963 [ dbSNP | Ensembl ].

VAR_012318

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

202

Helix Strand Turn

Details...

Beta strand

69 – 73

5

Beta strand

75 – 89

15

Helix

91 – 100

10

Helix

111 – 124

14

Beta strand

130 – 140

11

Beta strand

143 – 146

4

Turn

160 – 162

3

Helix

168 – 170

3

Beta strand

173 – 177

5

Turn

178 – 182

5

Beta strand

183 – 187

5

Beta strand

193 – 200

8

Sequences

	Sequence		Length	Mass (Da)
	P05452 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 370C174033F21B78	FASTA	202	22,537
	10 20 30 40 50 60 MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR LDTLAQEVAL 70 80 90 100 110 120 LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS RGGTLGTPQT GSENDALYEY 130 140 150 160 170 180 LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE ITAQPDGGKT ENCAVLSGAA 190 200 NGKWFDKRCR DQLPYICQFG IV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer." Wewer U.M., Albrechtsen R. Lab. Invest. 67:253-262(1992) [PubMed: 1354271] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-106. Tissue: Placenta.
[2]	"The gene structure of tetranectin, a plasminogen binding protein." Berglund L., Petersen T.E. FEBS Lett. 309:15-19(1992) [PubMed: 1511740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT SER-106.
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106.
[4]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed: 16641997] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-106. Tissue: Lung.
[6]	"Cloning and mapping of the murine tetranectin gene." Sorensen C.B., Berglund L., Petersen T.E. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-36. Tissue: Placenta.
[7]	"Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein." Fuhlendorff J., Clemmensen I., Magnusson S. Biochemistry 26:6757-6764(1987) [PubMed: 3427041] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-202, VARIANTS SER-55; MET-58 AND SER-106.
[8]	"Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin." Jaquinod M., Holtet T.L., Etzerodt M., Clemmensen I., Thoegersen H.C., Roepstorff P. Biol. Chem. 380:1307-1314(1999) [PubMed: 10614823] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, MASS SPECTROMETRY. Tissue: Plasma.
[9]	"Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil." Nielsen B.B., Kastrup J.S., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K. FEBS Lett. 412:388-396(1997) [PubMed: 9256258] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
[10]	"Structure of the C-type lectin carbohydrate recognition domain of human tetranectin." Kastrup J.S., Nielsen B.B., Rasmussen H., Holtet T.L., Graversen J.H., Etzerodt M., Thoegersen H.C., Larsen I.K. Acta Crystallogr. D 54:757-766(1998) [PubMed: 9757090] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 66-202.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Tetranectin

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X64559 mRNA. Translation: CAA45860.1.
X70910, X70911, X70912 Genomic DNA. Translation: CAA50265.1.
CR541981 mRNA. Translation: CAG46778.1.
CR542009 mRNA. Translation: CAG46806.1.
AC104165 Genomic DNA. No translation available.
BC011024 mRNA. Translation: AAH11024.1.
X98121 Genomic DNA. Translation: CAA66803.1.

IPI

IPI00009028.

PIR

TTHUN. S24126.

RefSeq

NP_003269.2. NM_003278.2.

UniGene

Hs.476092.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HTN	X-ray	2.80	A	22-202	[»]
1RJH	NMR	-	A	85-202	[»]
1TN3	X-ray	2.00	A	66-202	[»]

ProteinModelPortal

P05452.

SMR

P05452. Positions 66-202.

ModBase

Search...

Protein-protein interaction databases

STRING

P05452.

Polymorphism databases

DMDM

267108.

2D gel databases

Cornea-2DPAGE

P05452.

Proteomic databases

PeptideAtlas

P05452.

PRIDE

P05452.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000296130; ENSP00000296130; ENSG00000163815.

GeneID

7123.

KEGG

hsa:7123.

Organism-specific databases

CTD

7123.

GeneCards

GC03P045043.

H-InvDB

HIX0003237.

HGNC

HGNC:11891. CLEC3B.

HPA

CAB002582.

MIM

187520. gene.

neXtProt

NX_P05452.

PharmGKB

PA36590.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19148.

HOGENOM

HBG714884.

HOVERGEN

HBG108270.

InParanoid

P05452.

OMA

MELWGAY.

OrthoDB

EOG4M91SQ.

PhylomeDB

P05452.

Gene expression databases

ArrayExpress

P05452.

CleanEx

HS_CLEC3B.

Genevestigator

P05452.

GermOnline

ENSG00000163815. Homo sapiens.

Family and domain databases

InterPro

IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR003990. Pancreatis_ac.
[Graphical view]

Gene3D

G3DSA:3.10.100.10. C-type_lectin-like. 1 hit.

Pfam

PF00059. Lectin_C. 1 hit.
[Graphical view]

PRINTS

PR01504. PNCREATITSAP.

SMART

SM00034. CLECT. 1 hit.
[Graphical view]

SUPFAM

SSF56436. C-type_lectin_fold. 1 hit.

PROSITE

PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00009. Alteplase.
DB00029. Anistreplase.
DB00015. Reteplase.
DB00031. Tenecteplase.

NextBio

27875.

SOURCE

Search...

Entry information

Entry name

TETN_HUMAN

Accession

Primary (citable) accession number: P05452
Secondary accession number(s): Q6FGX6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 11, 2011
Last modified:	December 14, 2011
This is version 123 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.