Reviewed,
UniProtKB/Swiss-Prot P05417 (UCRI_PARDE)
Last modified
June 16, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquinol-cytochrome c reductase iron-sulfur subunit EC=1.10.2.2 Alternative name(s): Rieske iron-sulfur protein Short name=RISP | ||
| Gene names |
| ||
| Organism | Paracoccus denitrificans | ||
| Taxonomic identifier | 266 [NCBI] | ||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodobacterales › Rhodobacteraceae › Paracoccus |
Protein attributes
| Sequence length | 190 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. |
| Catalytic activity | QH2 + 2 ferricytochrome c = Q + 2 ferrocytochrome c + 2 H+. |
| Cofactor | Binds 1 2Fe-2S cluster per subunit By similarity. |
| Subunit structure | The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein. |
| Subcellular location | |
| Miscellaneous | The Rieske protein is a high potential 2Fe-2S protein. |
| Sequence similarities | Contains 1 Rieske domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Electron transport Transport |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Ligand | 2Fe-2S Iron Iron-sulfur Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Disulfide bond |
| Technical term | Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transportInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | 2 iron, 2 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activityInferred from electronic annotation. Source: InterPro iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW ubiquinol-cytochrome-c reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 190 | 190 | Ubiquinol-cytochrome c reductase iron-sulfur subunit | PRO_0000127761 | |||||||
Regions | |||||||||||
| Transmembrane | 18 – 39 | 22 | Potential | ||||||||
| Domain | 95 – 188 | 94 | Rieske | ||||||||
Sites | |||||||||||
| Metal binding | 132 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 134 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
| Metal binding | 152 | 1 | Iron-sulfur (2Fe-2S) By similarity | ||||||||
| Metal binding | 155 | 1 | Iron-sulfur (2Fe-2S); via pros nitrogen By similarity | ||||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 137 ↔ 154 | By similarity | |||||||||
Sequences
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References
| [1] | "The genes of the Paracoccus denitrificans bc1 complex. Nucleotide sequence and homologies between bacterial and mitochondrial subunits." Kurowski B., Ludwig B. J. Biol. Chem. 262:13805-13811(1987) [PubMed: 2820981] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "Immunoelectron microscopy and epitope mapping with monoclonal antibodies suggest the existence of an additional N-terminal transmembrane helix in the cytochrome b subunit of bacterial ubiquinol:cytochrome-c oxidoreductases." Kleymann G., Iwata S., Wiesmueller K.-H., Ludwig B., Haase W., Michel H. Eur. J. Biochem. 230:359-363(1995) [PubMed: 7601123] [Abstract] Cited for: PROTEIN SEQUENCE OF 17-23 AND 37-60. |
Cross-references
Sequence databases | |
|---|---|
| M17522 Genomic DNA. Translation: AAA25571.1. X05799 Genomic DNA. Translation: CAA29243.1. | |
| PIR | A29413. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1RIE based on UniProtKB P13272. |
| SMR | P05417. Positions 13-190. |
| ModBase | Search... |
Protein family/group databases | |
| TCDB | 3.D.3.1.1. proton-translocating quinol:cytochrome c reductase (QCR) superfamily. |
Enzyme and pathway databases | |
| BRENDA | 1.10.2.2. 59. |
Family and domain databases | |
| InterPro | IPR017941. Rieske_2Fe-2S. IPR014349. Rieske_Fe-S_prot. IPR006311. Tat. IPR017909. Twin_arg_translocation_Tat. IPR019470. Ubiq_cytC_Rdtase_Fe-S_su_TAT. IPR006317. Ubiquinol_cyt_c_Rdtase_Fe-S-su. [Graphical view] |
| Gene3D | G3DSA:2.102.10.10. Rieske_reg. 1 hit. |
| PANTHER | PTHR10134. Rieske. 1 hit. |
| Pfam | PF00355. Rieske. 1 hit. PF10399. UCR_Fe-S_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01416. Rieske_proteo. 1 hit. TIGR01409. TAT_signal_seq. 1 hit. |
| PROSITE | PS51296. RIESKE. 1 hit. PS51318. TAT. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UCRI_PARDE | ||||||||
| Accession | Primary (citable) accession number: P05417 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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