ID   GLGA_SALTY              Reviewed;         477 AA.
AC   P05416;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   19-DEC-2001, sequence version 2.
DT   27-MAR-2024, entry version 128.
DE   RecName: Full=Glycogen synthase;
DE            EC=2.4.1.21;
DE   AltName: Full=Starch [bacterial glycogen] synthase;
GN   Name=glgA; OrderedLocusNames=STM3535;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-29.
RX   PubMed=3040691; DOI=10.1128/jb.169.9.4355-4360.1987;
RA   Leung P.S.C., Preiss J.;
RT   "Biosynthesis of bacterial glycogen: primary structure of Salmonella
RT   typhimurium ADPglucose synthetase as deduced from the nucleotide sequence
RT   of the glgC gene.";
RL   J. Bacteriol. 169:4355-4360(1987).
CC   -!- FUNCTION: Synthesizes alpha-1,4-glucan chains using ADP-glucose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-
CC         alpha-D-glucosyl](n+1) + ADP + H(+); Xref=Rhea:RHEA:18189, Rhea:RHEA-
CC         COMP:9584, Rhea:RHEA-COMP:9587, ChEBI:CHEBI:15378, ChEBI:CHEBI:15444,
CC         ChEBI:CHEBI:57498, ChEBI:CHEBI:456216; EC=2.4.1.21;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 1 family.
CC       Bacterial/plant glycogen synthase subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE006468; AAL22395.1; -; Genomic_DNA.
DR   EMBL; M17363; AAA27133.1; -; Genomic_DNA.
DR   RefSeq; NP_462436.1; NC_003197.2.
DR   RefSeq; WP_001197669.1; NC_003197.2.
DR   AlphaFoldDB; P05416; -.
DR   SMR; P05416; -.
DR   STRING; 99287.STM3535; -.
DR   CAZy; GT5; Glycosyltransferase Family 5.
DR   PaxDb; 99287-STM3535; -.
DR   GeneID; 1255058; -.
DR   KEGG; stm:STM3535; -.
DR   PATRIC; fig|99287.12.peg.3737; -.
DR   HOGENOM; CLU_009583_18_4_6; -.
DR   OMA; TWCPWYM; -.
DR   PhylomeDB; P05416; -.
DR   BioCyc; SENT99287:STM3535-MONOMER; -.
DR   UniPathway; UPA00164; -.
DR   PHI-base; PHI:10051; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0033201; F:alpha-1,4-glucan synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004373; F:glycogen (starch) synthase activity; IEA:InterPro.
DR   GO; GO:0009011; F:starch synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IBA:GO_Central.
DR   CDD; cd03791; GT5_Glycogen_synthase_DULL1-like; 1.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR   HAMAP; MF_00484; Glycogen_synth; 1.
DR   InterPro; IPR001296; Glyco_trans_1.
DR   InterPro; IPR011835; GS/SS.
DR   InterPro; IPR013534; Starch_synth_cat_dom.
DR   NCBIfam; TIGR02095; glgA; 1.
DR   PANTHER; PTHR45825; GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC; 1.
DR   PANTHER; PTHR45825:SF11; STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC; 1.
DR   Pfam; PF08323; Glyco_transf_5; 1.
DR   Pfam; PF00534; Glycos_transf_1; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   3: Inferred from homology;
KW   Glycogen biosynthesis; Glycosyltransferase; Reference proteome;
KW   Transferase.
FT   CHAIN           1..477
FT                   /note="Glycogen synthase"
FT                   /id="PRO_0000188644"
FT   BINDING         15
FT                   /ligand="ADP-alpha-D-glucose"
FT                   /ligand_id="ChEBI:CHEBI:57498"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        29
FT                   /note="A -> R (in Ref. 2; AAA27133)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   477 AA;  52946 MW;  004D2E49B6AA380D CRC64;
     MQVLHVCSEM FPLLKTGGLA DVIGALPAAQ IADGVDVRVL LPGFPDIRRG IPDAHVVSRR
     DTFAGKISLL FGHYNGVGIY LIDAPHLYER PGSPYHDTNL YAYTDNVLRF ALLGWVGCEM
     ACGLDPFWRP DVVHAHDWHA GLAPAYLAAR GRPAKSVFTV HNLAYQGMFY AKHMDDIELP
     WSFFNMHGLE FNGQLSFLKA GLYYADHITA VSPTYAREIT EPQFAYGMEG LLRQRHLEGR
     LSGILNGVDE KIWNPESDLL LASRYTRDTL EEKAENKRQL QIAMGLKVND KVPLFAVVSR
     LTNQKGLDLV LEALPGLLEQ GGQLALLGAG DPVLQEGFLA AAAEHPGQVG VQIGYHEAFS
     HRIMGGADVI LVPSRFEPCG LTQLYGLKYG TLPLVRRTGG LADTVSDSSL ENLADGIASG
     FVFEDSNAWS LLRAIRRAFV LWSRPSLWRF VQRQAMAMDF SWQVAAKSYR ELYYRLK
//