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Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acid1
Binding sitei129Fatty acid1

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB
  • icosatetraenoic acid binding Source: Ensembl
  • long-chain fatty acid binding Source: BHF-UCL
  • long-chain fatty acid transporter activity Source: Ensembl
  • oleic acid binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560. Triglyceride catabolism.

Chemistry databases

SwissLipidsiSLP:000001521.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Muscle fatty acid-binding protein
Short name:
M-FABP
Gene namesi
Name:FABP3
Synonyms:FABP11, MDGI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3557. FABP3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • sarcoplasm Source: Ensembl

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2170.
OpenTargetsiENSG00000121769.
PharmGKBiPA27958.

Chemistry databases

ChEMBLiCHEMBL3344.
DrugBankiDB04224. Oleic Acid.
DB03796. Palmitic Acid.
DB03193. Stearic acid.
GuidetoPHARMACOLOGYi2533.

Polymorphism and mutation databases

BioMutaiFABP3.
DMDMi119802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00000673212 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineCombined sources1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05413.
MaxQBiP05413.
PaxDbiP05413.
PeptideAtlasiP05413.
PRIDEiP05413.

2D gel databases

REPRODUCTION-2DPAGEiIPI00219684.
UCD-2DPAGEiP05413.

PTM databases

iPTMnetiP05413.
PhosphoSitePlusiP05413.
SwissPalmiP05413.

Expressioni

Gene expression databases

BgeeiENSG00000121769.
CleanExiHS_FABP3.
ExpressionAtlasiP05413. baseline and differential.
GenevisibleiP05413. HS.

Organism-specific databases

HPAiCAB017830.
HPA055754.

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108468. 11 interactors.
IntActiP05413. 12 interactors.
MINTiMINT-1432076.
STRINGi9606.ENSP00000362817.

Chemistry databases

BindingDBiP05413.

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi7 – 16Combined sources10
Helixi17 – 23Combined sources7
Helixi28 – 34Combined sources7
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi61 – 66Combined sources6
Beta strandi71 – 74Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi91 – 98Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5WNMR-A2-133[»]
1HMRX-ray1.40A2-133[»]
1HMSX-ray1.40A2-133[»]
1HMTX-ray1.40A2-133[»]
2HMBX-ray2.10A2-133[»]
3RSWX-ray2.60A/B1-133[»]
3WBGX-ray2.15A/B/C/D1-133[»]
3WVMX-ray0.88A1-133[»]
3WXQX-ray1.60A1-133[»]
4TJZX-ray0.87A1-133[»]
4TKBX-ray0.86A1-133[»]
4TKHX-ray0.93A1-133[»]
4TKJX-ray0.87A1-133[»]
4WBKX-ray1.37A1-133[»]
5B27X-ray1.02A1-133[»]
5B28X-ray0.90A1-133[»]
5B29X-ray1.28A2-133[»]
5CE4Other0.98A1-132[»]
5HZ9X-ray2.30A/B/C/D/E/F/G/H1-133[»]
ProteinModelPortaliP05413.
SMRiP05413.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05413.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP05413.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP05413.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiView protein in InterPro
IPR012674. Calycin.
IPR000463. Fatty_acid-bd.
IPR031259. ILBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiView protein in Pfam
PF00061. Lipocalin. 1 hit.
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiView protein in PROSITE
PS00214. FABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL
60 70 80 90 100
TLKTHSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG
110 120 130
QETTLVRELI DGKLILTLTH GTAVCTRTYE KEA
Length:133
Mass (Da):14,858
Last modified:January 23, 2007 - v4
Checksum:i5FD396B1BE538A3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → A in CAA71305 (Ref. 2) Curated1
Sequence conflicti105L → K AA sequence (PubMed:3421901).Curated1
Sequence conflicti125C → S AA sequence (PubMed:3421901).Curated1
Sequence conflicti130E → Q AA sequence (PubMed:2266954).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06116553K → R. Corresponds to variant dbSNP:rs2228194Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56549 mRNA. Translation: CAA39889.1.
Y10255 mRNA. Translation: CAA71305.1.
U57623 Genomic DNA. Translation: AAB02555.1.
AK314122 mRNA. Translation: BAG36813.1.
U17081 Genomic DNA. Translation: AAC99800.1.
S67314 mRNA. Translation: AAB29294.1.
BT006727 mRNA. Translation: AAP35373.1.
AL451070 Genomic DNA. No translation available.
CH471059 Genomic DNA. Translation: EAX07619.1.
BC007021 mRNA. Translation: AAH07021.1.
CCDSiCCDS342.1.
PIRiS15432. FZHUC.
RefSeqiNP_004093.1. NM_004102.4.
UniGeneiHs.576372.
Hs.657242.

Genome annotation databases

EnsembliENST00000373713; ENSP00000362817; ENSG00000121769.
GeneIDi2170.
KEGGihsa:2170.
UCSCiuc001bss.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFABPH_HUMAN
AccessioniPrimary (citable) accession number: P05413
Secondary accession number(s): B2RAB6, Q5VV93, Q99957
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 178 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families