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Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Fatty acid1
Binding sitei129Fatty acid1

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB
  • icosatetraenoic acid binding Source: Ensembl
  • long-chain fatty acid binding Source: BHF-UCL
  • long-chain fatty acid transporter activity Source: Ensembl
  • oleic acid binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560 Triglyceride catabolism

Chemistry databases

SwissLipidsiSLP:000001521

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Muscle fatty acid-binding protein
Short name:
M-FABP
Gene namesi
Name:FABP3
Synonyms:FABP11, MDGI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121769.7
HGNCiHGNC:3557 FABP3
MIMi134651 gene
neXtProtiNX_P05413

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2170
OpenTargetsiENSG00000121769
PharmGKBiPA27958

Chemistry databases

ChEMBLiCHEMBL3344
DrugBankiDB04224 Oleic Acid
DB03796 Palmitic Acid
DB03193 Stearic acid
GuidetoPHARMACOLOGYi2533

Polymorphism and mutation databases

BioMutaiFABP3
DMDMi119802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources2 Publications
ChainiPRO_00000673212 – 133Fatty acid-binding protein, heartAdd BLAST132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineCombined sources1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei20Phosphotyrosine; by Tyr-kinasesBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei30PhosphothreonineBy similarity1
Modified residuei83PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05413
MaxQBiP05413
PaxDbiP05413
PeptideAtlasiP05413
PRIDEiP05413

2D gel databases

REPRODUCTION-2DPAGEiIPI00219684
UCD-2DPAGEiP05413

PTM databases

CarbonylDBiP05413
iPTMnetiP05413
PhosphoSitePlusiP05413
SwissPalmiP05413

Expressioni

Gene expression databases

BgeeiENSG00000121769
CleanExiHS_FABP3
ExpressionAtlasiP05413 baseline and differential
GenevisibleiP05413 HS

Organism-specific databases

HPAiCAB017830
HPA055754

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108468, 11 interactors
IntActiP05413, 13 interactors
MINTiP05413
STRINGi9606.ENSP00000362817

Chemistry databases

BindingDBiP05413

Structurei

Secondary structure

1133
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi7 – 16Combined sources10
Helixi17 – 23Combined sources7
Helixi28 – 34Combined sources7
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi61 – 66Combined sources6
Beta strandi71 – 74Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi91 – 98Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G5WNMR-A2-133[»]
1HMRX-ray1.40A2-133[»]
1HMSX-ray1.40A2-133[»]
1HMTX-ray1.40A2-133[»]
2HMBX-ray2.10A2-133[»]
3RSWX-ray2.60A/B1-133[»]
3WBGX-ray2.15A/B/C/D1-133[»]
3WVMX-ray0.88A1-133[»]
3WXQX-ray1.60A1-133[»]
4TJZX-ray0.87A1-133[»]
4TKBX-ray0.86A1-133[»]
4TKHX-ray0.93A1-133[»]
4TKJX-ray0.87A1-133[»]
4WBKX-ray1.37A1-133[»]
5B27X-ray1.02A1-133[»]
5B28X-ray0.90A1-133[»]
5B29X-ray1.28A2-133[»]
5CE4Other0.98A1-132[»]
5HZ9X-ray2.30A/B/C/D/E/F/G/H1-133[»]
ProteinModelPortaliP05413
SMRiP05413
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05413

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004829
HOVERGENiHBG005633
InParanoidiP05413
KOiK08752
OMAiTWNLKES
OrthoDBiEOG091G0QSV
PhylomeDBiP05413
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL
60 70 80 90 100
TLKTHSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG
110 120 130
QETTLVRELI DGKLILTLTH GTAVCTRTYE KEA
Length:133
Mass (Da):14,858
Last modified:January 23, 2007 - v4
Checksum:i5FD396B1BE538A3C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2V → A in CAA71305 (Ref. 2) Curated1
Sequence conflicti105L → K AA sequence (PubMed:3421901).Curated1
Sequence conflicti125C → S AA sequence (PubMed:3421901).Curated1
Sequence conflicti130E → Q AA sequence (PubMed:2266954).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06116553K → R. Corresponds to variant dbSNP:rs2228194Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56549 mRNA Translation: CAA39889.1
Y10255 mRNA Translation: CAA71305.1
U57623 Genomic DNA Translation: AAB02555.1
AK314122 mRNA Translation: BAG36813.1
U17081 Genomic DNA Translation: AAC99800.1
S67314 mRNA Translation: AAB29294.1
BT006727 mRNA Translation: AAP35373.1
AL451070 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07619.1
BC007021 mRNA Translation: AAH07021.1
CCDSiCCDS342.1
PIRiS15432 FZHUC
RefSeqiNP_004093.1, NM_004102.4
UniGeneiHs.576372
Hs.657242

Genome annotation databases

EnsembliENST00000373713; ENSP00000362817; ENSG00000121769
GeneIDi2170
KEGGihsa:2170
UCSCiuc001bss.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFABPH_HUMAN
AccessioniPrimary (citable) accession number: P05413
Secondary accession number(s): B2RAB6, Q5VV93, Q99957
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: February 28, 2018
This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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