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Protein

Fatty acid-binding protein, heart

Gene

FABP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271Fatty acid
Binding sitei129 – 1291Fatty acid

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB
  • icosatetraenoic acid binding Source: Ensembl
  • long-chain fatty acid binding Source: BHF-UCL
  • long-chain fatty acid transporter activity Source: Ensembl
  • oleic acid binding Source: BHF-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Chemistry

SwissLipidsiSLP:000001521.

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, heart
Alternative name(s):
Fatty acid-binding protein 3
Heart-type fatty acid-binding protein
Short name:
H-FABP
Mammary-derived growth inhibitor
Short name:
MDGI
Muscle fatty acid-binding protein
Short name:
M-FABP
Gene namesi
Name:FABP3
Synonyms:FABP11, MDGI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3557. FABP3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • sarcoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27958.

Chemistry

ChEMBLiCHEMBL3344.
DrugBankiDB04224. Oleic Acid.
GuidetoPHARMACOLOGYi2533.

Polymorphism and mutation databases

BioMutaiFABP3.
DMDMi119802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources2 Publications
Chaini2 – 133132Fatty acid-binding protein, heartPRO_0000067321Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylvalineCombined sources
Modified residuei8 – 81PhosphothreonineBy similarity
Modified residuei20 – 201Phosphotyrosine; by Tyr-kinasesBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei30 – 301PhosphothreonineBy similarity
Modified residuei83 – 831PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP05413.
MaxQBiP05413.
PaxDbiP05413.
PeptideAtlasiP05413.
PRIDEiP05413.

2D gel databases

REPRODUCTION-2DPAGEIPI00219684.
UCD-2DPAGEP05413.

PTM databases

iPTMnetiP05413.
PhosphoSiteiP05413.
SwissPalmiP05413.

Expressioni

Gene expression databases

BgeeiENSG00000121769.
CleanExiHS_FABP3.
ExpressionAtlasiP05413. baseline and differential.
GenevisibleiP05413. HS.

Organism-specific databases

HPAiCAB017830.
HPA055754.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB1P055562EBI-704216,EBI-703066
NUP62P371984EBI-704216,EBI-347978
SHTN1A0MZ663EBI-704216,EBI-308778

GO - Molecular functioni

  • cytoskeletal protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi108468. 11 interactions.
IntActiP05413. 12 interactions.
MINTiMINT-1432076.
STRINGi9606.ENSP00000362817.

Chemistry

BindingDBiP05413.

Structurei

Secondary structure

1
133
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi7 – 1610Combined sources
Helixi17 – 237Combined sources
Helixi28 – 347Combined sources
Beta strandi40 – 467Combined sources
Beta strandi49 – 557Combined sources
Beta strandi61 – 666Combined sources
Beta strandi71 – 744Combined sources
Beta strandi80 – 889Combined sources
Beta strandi91 – 988Combined sources
Beta strandi101 – 11010Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi123 – 1319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G5WNMR-A2-133[»]
1HMRX-ray1.40A2-133[»]
1HMSX-ray1.40A2-133[»]
1HMTX-ray1.40A2-133[»]
2HMBX-ray2.10A2-133[»]
3RSWX-ray2.60A/B1-133[»]
3WBGX-ray2.15A/B/C/D1-133[»]
3WVMX-ray0.88A1-133[»]
3WXQX-ray1.60A1-133[»]
4TJZX-ray0.87A1-133[»]
4TKBX-ray0.86A1-133[»]
4TKHX-ray0.93A1-133[»]
4TKJX-ray0.87A1-133[»]
4WBKX-ray1.37A1-133[»]
5CE4Other0.98A1-132[»]
ProteinModelPortaliP05413.
SMRiP05413. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05413.

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP05413.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP05413.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05413-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFLGTWK LVDSKNFDDY MKSLGVGFAT RQVASMTKPT TIIEKNGDIL
60 70 80 90 100
TLKTHSTFKN TEISFKLGVE FDETTADDRK VKSIVTLDGG KLVHLQKWDG
110 120 130
QETTLVRELI DGKLILTLTH GTAVCTRTYE KEA
Length:133
Mass (Da):14,858
Last modified:January 23, 2007 - v4
Checksum:i5FD396B1BE538A3C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21V → A in CAA71305 (Ref. 2) Curated
Sequence conflicti105 – 1051L → K AA sequence (PubMed:3421901).Curated
Sequence conflicti125 – 1251C → S AA sequence (PubMed:3421901).Curated
Sequence conflicti130 – 1301E → Q AA sequence (PubMed:2266954).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531K → R.
Corresponds to variant rs2228194 [ dbSNP | Ensembl ].
VAR_061165

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56549 mRNA. Translation: CAA39889.1.
Y10255 mRNA. Translation: CAA71305.1.
U57623 Genomic DNA. Translation: AAB02555.1.
AK314122 mRNA. Translation: BAG36813.1.
U17081 Genomic DNA. Translation: AAC99800.1.
S67314 mRNA. Translation: AAB29294.1.
BT006727 mRNA. Translation: AAP35373.1.
AL451070 Genomic DNA. Translation: CAH71850.1.
CH471059 Genomic DNA. Translation: EAX07619.1.
BC007021 mRNA. Translation: AAH07021.1.
CCDSiCCDS342.1.
PIRiS15432. FZHUC.
RefSeqiNP_004093.1. NM_004102.4.
UniGeneiHs.576372.
Hs.657242.

Genome annotation databases

EnsembliENST00000373713; ENSP00000362817; ENSG00000121769.
GeneIDi2170.
KEGGihsa:2170.
UCSCiuc001bss.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56549 mRNA. Translation: CAA39889.1.
Y10255 mRNA. Translation: CAA71305.1.
U57623 Genomic DNA. Translation: AAB02555.1.
AK314122 mRNA. Translation: BAG36813.1.
U17081 Genomic DNA. Translation: AAC99800.1.
S67314 mRNA. Translation: AAB29294.1.
BT006727 mRNA. Translation: AAP35373.1.
AL451070 Genomic DNA. Translation: CAH71850.1.
CH471059 Genomic DNA. Translation: EAX07619.1.
BC007021 mRNA. Translation: AAH07021.1.
CCDSiCCDS342.1.
PIRiS15432. FZHUC.
RefSeqiNP_004093.1. NM_004102.4.
UniGeneiHs.576372.
Hs.657242.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1G5WNMR-A2-133[»]
1HMRX-ray1.40A2-133[»]
1HMSX-ray1.40A2-133[»]
1HMTX-ray1.40A2-133[»]
2HMBX-ray2.10A2-133[»]
3RSWX-ray2.60A/B1-133[»]
3WBGX-ray2.15A/B/C/D1-133[»]
3WVMX-ray0.88A1-133[»]
3WXQX-ray1.60A1-133[»]
4TJZX-ray0.87A1-133[»]
4TKBX-ray0.86A1-133[»]
4TKHX-ray0.93A1-133[»]
4TKJX-ray0.87A1-133[»]
4WBKX-ray1.37A1-133[»]
5CE4Other0.98A1-132[»]
ProteinModelPortaliP05413.
SMRiP05413. Positions 1-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108468. 11 interactions.
IntActiP05413. 12 interactions.
MINTiMINT-1432076.
STRINGi9606.ENSP00000362817.

Chemistry

BindingDBiP05413.
ChEMBLiCHEMBL3344.
DrugBankiDB04224. Oleic Acid.
GuidetoPHARMACOLOGYi2533.
SwissLipidsiSLP:000001521.

PTM databases

iPTMnetiP05413.
PhosphoSiteiP05413.
SwissPalmiP05413.

Polymorphism and mutation databases

BioMutaiFABP3.
DMDMi119802.

2D gel databases

REPRODUCTION-2DPAGEIPI00219684.
UCD-2DPAGEP05413.

Proteomic databases

EPDiP05413.
MaxQBiP05413.
PaxDbiP05413.
PeptideAtlasiP05413.
PRIDEiP05413.

Protocols and materials databases

DNASUi2170.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373713; ENSP00000362817; ENSG00000121769.
GeneIDi2170.
KEGGihsa:2170.
UCSCiuc001bss.2. human.

Organism-specific databases

CTDi2170.
GeneCardsiFABP3.
HGNCiHGNC:3557. FABP3.
HPAiCAB017830.
HPA055754.
MIMi134651. gene.
neXtProtiNX_P05413.
PharmGKBiPA27958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP05413.
KOiK08752.
OMAiTWNLKES.
OrthoDBiEOG091G0QSV.
PhylomeDBiP05413.
TreeFamiTF316894.

Enzyme and pathway databases

ReactomeiR-HSA-163560. Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis.

Miscellaneous databases

ChiTaRSiFABP3. human.
EvolutionaryTraceiP05413.
GeneWikiiHeart-type_fatty_acid_binding_protein.
GenomeRNAii2170.
PROiP05413.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000121769.
CleanExiHS_FABP3.
ExpressionAtlasiP05413. baseline and differential.
GenevisibleiP05413. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFABPH_HUMAN
AccessioniPrimary (citable) accession number: P05413
Secondary accession number(s): B2RAB6, Q5VV93, Q99957
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 170 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.