Viral jun-transforming protein - Avian sarcoma virus (strain 17)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Viral jun-transforming protein
Short name=v-Jun

Gene names

Name:

JUN

Organism

Avian sarcoma virus (strain 17)

Taxonomic identifier

11877 [NCBI]

Taxonomic lineage

Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Alpharetrovirus › unclassified Alpharetrovirus ›

Virus host

Galliformes [TaxID: 8976]

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	This oncogene is the viral derivative of the AP-1 transcription factor.
Subcellular location	Host nucleus Potential.
Miscellaneous	This protein is synthesized as a Gag-vJun chimeric protein. The sequence shown here corresponds to the Jun homolog fragment of the chimera.
Sequence similarities	Belongs to the bZIP family. Jun subfamily. Contains 1 bZIP (basic-leucine zipper) domain.
Sequence caution	The sequence AAA42416.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Host nucleus
Disease	Oncogene
Ligand	DNA-binding
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	host cell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 287

287

Viral jun-transforming protein

PRO_0000076436

Regions

Domain

208 – 271

64

bZIP

Region

208 – 235

28

Basic motif By similarity

Region

236 – 264

29

Leucine-zipper By similarity

Secondary structure

1

.

287

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P05411 [UniParc].

Last modified November 22, 2005. Version 2.
Checksum: B24E12AF208BD6A3
Show »

FASTA

287

31,554

        10         20         30         40         50         60 
MSAKMEPTFY EDALNASFAP PESGGYGYNN ADILTSPDVG LLKLASPELE RLIIQSSNGL 

        70         80         90        100        110        120 
ITTTPTPTQF LCPKNVTDEQ EGFAEGFVRA LAELHNQNTL PSVTSAAQPV SGGMAPVSSM 

       130        140        150        160        170        180 
AGGGSFNTSL HSEPPVYANL SNFNPNALNS APNYNANRMG YAPQHHINPQ MPVQHPRLQA 

       190        200        210        220        230        240 
LKEEPQTVPE MPGETPPLFP IDMESQERIK AERKRMRNRI AASKSRKRKL ERIARLEEKV 

       250        260        270        280 
KTLKAQNSEL ASTANMLREQ VAQLKQKVMN HVNSGCQLML TQQLQTF

« Hide

References

[1]	"Avian sarcoma virus 17 carries the jun oncogene." Maki Y., Bos T.J., Davis C., Starbuck M., Vogt P.K. Proc. Natl. Acad. Sci. U.S.A. 84:2848-2852(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M16266 Genomic RNA. Translation: AAA42416.1. Different initiation.

PIR

TVFVJN. A29870.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2H7H	X-ray	2.30	A/B	210-271	[»]

ProteinModelPortal

P05411.

SMR

P05411. Positions 212-269.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.880.10. 1 hit.

InterPro

IPR004827. bZIP.
IPR015558. C_Jun.
IPR008917. Euk_TF_DNA-bd.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
[Graphical view]

PANTHER

PTHR11462:SF8. PTHR11462:SF8. 1 hit.

Pfam

PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
[Graphical view]

PRINTS

PR00043. LEUZIPPRJUN.

SMART

SM00338. BRLZ. 1 hit.
[Graphical view]

SUPFAM

SSF47454. Euk_transcr_DNA. 1 hit.

PROSITE

PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P05411.

Entry information

Entry name

JUN_AVIS1

Accession

Primary (citable) accession number: P05411

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 22, 2005
Last modified:	April 3, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families