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Protein

Viral jun-transforming protein

Gene

JUN

Organism
Avian sarcoma virus (strain 17)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This oncogene is the viral derivative of the AP-1 transcription factor.

Miscellaneous

This protein is synthesized as a Gag-vJun chimeric protein. The sequence shown here corresponds to the Jun homolog fragment of the chimera.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Viral jun-transforming protein
Short name:
v-Jun
Gene namesi
Name:JUN
OrganismiAvian sarcoma virus (strain 17)
Taxonomic identifieri11877 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeAlpharetrovirusunclassified Alpharetrovirus
Virus hostiGalliformes [TaxID: 8976]

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host nucleus

Pathology & Biotechi

Keywords - Diseasei

Oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000764361 – 287Viral jun-transforming proteinAdd BLAST287

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi211 – 264Combined sources54

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7HX-ray2.30A/B210-271[»]
ProteinModelPortaliP05411.
SMRiP05411.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP05411.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini208 – 271bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni208 – 235Basic motifPROSITE-ProRule annotationAdd BLAST28
Regioni236 – 264Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. Jun subfamily.Curated

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR015558. C_Jun/v-Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
PANTHERiPTHR11462:SF43. PTHR11462:SF43. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.

Sequencei

Sequence statusi: Complete.

P05411-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKMEPTFY EDALNASFAP PESGGYGYNN ADILTSPDVG LLKLASPELE
60 70 80 90 100
RLIIQSSNGL ITTTPTPTQF LCPKNVTDEQ EGFAEGFVRA LAELHNQNTL
110 120 130 140 150
PSVTSAAQPV SGGMAPVSSM AGGGSFNTSL HSEPPVYANL SNFNPNALNS
160 170 180 190 200
APNYNANRMG YAPQHHINPQ MPVQHPRLQA LKEEPQTVPE MPGETPPLFP
210 220 230 240 250
IDMESQERIK AERKRMRNRI AASKSRKRKL ERIARLEEKV KTLKAQNSEL
260 270 280
ASTANMLREQ VAQLKQKVMN HVNSGCQLML TQQLQTF
Length:287
Mass (Da):31,554
Last modified:November 22, 2005 - v2
Checksum:iB24E12AF208BD6A3
GO

Sequence cautioni

The sequence AAA42416 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16266 Genomic RNA. Translation: AAA42416.1. Different initiation.
PIRiA29870. TVFVJN.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16266 Genomic RNA. Translation: AAA42416.1. Different initiation.
PIRiA29870. TVFVJN.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2H7HX-ray2.30A/B210-271[»]
ProteinModelPortaliP05411.
SMRiP05411.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP05411.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiView protein in InterPro
IPR004827. bZIP.
IPR015558. C_Jun/v-Jun.
IPR005643. JNK.
IPR002112. Leuzip_Jun.
IPR008917. TF_DNA-bd.
PANTHERiPTHR11462:SF43. PTHR11462:SF43. 1 hit.
PfamiView protein in Pfam
PF00170. bZIP_1. 1 hit.
PF03957. Jun. 1 hit.
PRINTSiPR00043. LEUZIPPRJUN.
SMARTiView protein in SMART
SM00338. BRLZ. 1 hit.
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiView protein in PROSITE
PS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiJUN_AVIS1
AccessioniPrimary (citable) accession number: P05411
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 22, 2005
Last modified: February 15, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.