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Protein

Neuroendocrine protein 7B2

Gene

SCG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.1 Publication

GO - Molecular functioni

  • enzyme inhibitor activity Source: UniProtKB
  • GTP binding Source: ProtInc
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone, Neuropeptide
Biological processTransport

Protein family/group databases

MEROPSiI21.001

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroendocrine protein 7B2
Alternative name(s):
Pituitary polypeptide
Secretogranin V
Secretogranin-5
Secretory granule endocrine protein I
Cleaved into the following 2 chains:
Gene namesi
Name:SCG5
Synonyms:SGNE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000166922.8
HGNCiHGNC:10816 SCG5
MIMi173120 gene
neXtProtiNX_P05408

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6447
MalaCardsiSCG5
OpenTargetsiENSG00000166922
PharmGKBiPA35724

Polymorphism and mutation databases

BioMutaiSCG5
DMDMi23830842

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000004127 – 212Neuroendocrine protein 7B2Add BLAST186
ChainiPRO_000000004227 – 176N-terminal peptideBy similarityAdd BLAST150
PeptideiPRO_0000000043200 – 212C-terminal peptideBy similarityAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 130By similarity
Modified residuei141PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.By similarity
Sulfated on tyrosine residues.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP05408
PeptideAtlasiP05408
PRIDEiP05408

PTM databases

iPTMnetiP05408
PhosphoSitePlusiP05408

Expressioni

Gene expression databases

BgeeiENSG00000166922
CleanExiHS_SCG5
ExpressionAtlasiP05408 baseline and differential
GenevisibleiP05408 HS

Organism-specific databases

HPAiHPA013136

Interactioni

Subunit structurei

Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112345, 5 interactors
IntActiP05408, 5 interactors
STRINGi9606.ENSP00000300175

Structurei

3D structure databases

ProteinModelPortaliP05408
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 7B2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4187 Eukaryota
ENOG410ZRXV LUCA
GeneTreeiENSGT00390000009816
HOGENOMiHOG000259690
HOVERGENiHBG000031
InParanoidiP05408
OMAiVGPQSIQ
OrthoDBiEOG091G0LE0
PhylomeDBiP05408
TreeFamiTF314328

Family and domain databases

InterProiView protein in InterPro
IPR007945 Secretogranin_V
PANTHERiPTHR12738 PTHR12738, 1 hit
PfamiView protein in Pfam
PF05281 Secretogranin_V, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ
60 70 80 90 100
LGIARPRVEY PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG
110 120 130 140 150
DNIPKDFSED QGYPDPPNPC PVGKTADDGC LENTPDTAEF SREFQLHQHL
160 170 180 190 200
FDPEHDYPGL GKWNKKLLYE KMKGGERRKR RSVNPYLQGQ RLDNVVAKKS
210
VPHFSDEDKD PE
Length:212
Mass (Da):23,730
Last modified:October 10, 2002 - v2
Checksum:iA459702055C0FE84
GO
Isoform 2 (identifier: P05408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: Missing.

Show »
Length:211
Mass (Da):23,659
Checksum:i649AA3FF2EC2A0A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151F → S in AAH05349 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011754126Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00757 mRNA Translation: CAA68726.1
AJ290438
, AJ290439, AJ290440, AJ290441, AJ290442 Genomic DNA Translation: CAB90397.1
CR541824 mRNA Translation: CAG46623.1
CH471125 Genomic DNA Translation: EAW92262.1
BC005349 mRNA Translation: AAH05349.1
BC093053 mRNA Translation: AAH93053.1
CCDSiCCDS45207.1 [P05408-1]
CCDS45208.1 [P05408-2]
PIRiS01008 PUHU
RefSeqiNP_001138229.1, NM_001144757.2 [P05408-1]
NP_003011.1, NM_003020.4 [P05408-2]
UniGeneiHs.156540

Genome annotation databases

EnsembliENST00000300175; ENSP00000300175; ENSG00000166922 [P05408-1]
ENST00000413748; ENSP00000388560; ENSG00000166922 [P05408-2]
ENST00000614359; ENSP00000482615; ENSG00000277614 [P05408-1]
ENST00000632219; ENSP00000488109; ENSG00000281931 [P05408-1]
ENST00000632674; ENSP00000488509; ENSG00000281931 [P05408-2]
GeneIDi6447
KEGGihsa:6447
UCSCiuc001zgz.3 human [P05408-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry namei7B2_HUMAN
AccessioniPrimary (citable) accession number: P05408
Secondary accession number(s): P01164, Q6FHD0, Q9BS38
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 10, 2002
Last modified: May 23, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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