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Protein

Neuroendocrine protein 7B2

Gene

SCG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.1 Publication

GO - Molecular functioni

  • enzyme inhibitor activity Source: UniProtKB
  • GTP binding Source: ProtInc
  • unfolded protein binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Neuropeptide

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166922-MONOMER.

Protein family/group databases

MEROPSiI21.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroendocrine protein 7B2
Alternative name(s):
Pituitary polypeptide
Secretogranin V
Secretogranin-5
Secretory granule endocrine protein I
Cleaved into the following 2 chains:
Gene namesi
Name:SCG5
Synonyms:SGNE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:10816. SCG5.

Subcellular locationi

  • Secreted

  • Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6447.
MalaCardsiSCG5.
OpenTargetsiENSG00000166922.
ENSG00000277614.
ENSG00000281931.
PharmGKBiPA35724.

Polymorphism and mutation databases

BioMutaiSCG5.
DMDMi23830842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000004127 – 212Neuroendocrine protein 7B2Add BLAST186
ChainiPRO_000000004227 – 176N-terminal peptideBy similarityAdd BLAST150
PeptideiPRO_0000000043200 – 212C-terminal peptideBy similarityAdd BLAST13

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 130By similarity
Modified residuei141PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.By similarity
Sulfated on tyrosine residues.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein, Sulfation

Proteomic databases

PaxDbiP05408.
PeptideAtlasiP05408.
PRIDEiP05408.

PTM databases

iPTMnetiP05408.
PhosphoSitePlusiP05408.

Expressioni

Gene expression databases

BgeeiENSG00000166922.
CleanExiHS_SCG5.
ExpressionAtlasiP05408. baseline and differential.
GenevisibleiP05408. HS.

Organism-specific databases

HPAiHPA013136.

Interactioni

Subunit structurei

Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
UBQLN1Q9UMX03EBI-722635,EBI-741480
UBQLN1Q9UMX0-23EBI-722635,EBI-10173939

GO - Molecular functioni

  • unfolded protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112345. 5 interactors.
IntActiP05408. 5 interactors.
MINTiMINT-1402757.
STRINGi9606.ENSP00000300175.

Structurei

3D structure databases

ProteinModelPortaliP05408.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 7B2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4187. Eukaryota.
ENOG410ZRXV. LUCA.
GeneTreeiENSGT00390000009816.
HOGENOMiHOG000259690.
HOVERGENiHBG000031.
InParanoidiP05408.
OMAiQATNIVG.
OrthoDBiEOG091G0LE0.
PhylomeDBiP05408.
TreeFamiTF314328.

Family and domain databases

InterProiIPR007945. Secretogranin_V.
[Graphical view]
PANTHERiPTHR12738. PTHR12738. 1 hit.
PfamiPF05281. Secretogranin_V. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P05408-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ
60 70 80 90 100
LGIARPRVEY PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG
110 120 130 140 150
DNIPKDFSED QGYPDPPNPC PVGKTADDGC LENTPDTAEF SREFQLHQHL
160 170 180 190 200
FDPEHDYPGL GKWNKKLLYE KMKGGERRKR RSVNPYLQGQ RLDNVVAKKS
210
VPHFSDEDKD PE
Length:212
Mass (Da):23,730
Last modified:October 10, 2002 - v2
Checksum:iA459702055C0FE84
GO
Isoform 2 (identifier: P05408-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: Missing.

Show »
Length:211
Mass (Da):23,659
Checksum:i649AA3FF2EC2A0A6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti151F → S in AAH05349 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011754126Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00757 mRNA. Translation: CAA68726.1.
AJ290438
, AJ290439, AJ290440, AJ290441, AJ290442 Genomic DNA. Translation: CAB90397.1.
CR541824 mRNA. Translation: CAG46623.1.
CH471125 Genomic DNA. Translation: EAW92262.1.
BC005349 mRNA. Translation: AAH05349.1.
BC093053 mRNA. Translation: AAH93053.1.
CCDSiCCDS45207.1. [P05408-1]
CCDS45208.1. [P05408-2]
PIRiS01008. PUHU.
RefSeqiNP_001138229.1. NM_001144757.2. [P05408-1]
NP_003011.1. NM_003020.4. [P05408-2]
UniGeneiHs.156540.

Genome annotation databases

EnsembliENST00000300175; ENSP00000300175; ENSG00000166922. [P05408-1]
ENST00000413748; ENSP00000388560; ENSG00000166922. [P05408-2]
ENST00000614359; ENSP00000482615; ENSG00000277614. [P05408-1]
ENST00000632219; ENSP00000488109; ENSG00000281931. [P05408-1]
ENST00000632674; ENSP00000488509; ENSG00000281931. [P05408-2]
GeneIDi6447.
KEGGihsa:6447.
UCSCiuc001zgz.3. human. [P05408-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00757 mRNA. Translation: CAA68726.1.
AJ290438
, AJ290439, AJ290440, AJ290441, AJ290442 Genomic DNA. Translation: CAB90397.1.
CR541824 mRNA. Translation: CAG46623.1.
CH471125 Genomic DNA. Translation: EAW92262.1.
BC005349 mRNA. Translation: AAH05349.1.
BC093053 mRNA. Translation: AAH93053.1.
CCDSiCCDS45207.1. [P05408-1]
CCDS45208.1. [P05408-2]
PIRiS01008. PUHU.
RefSeqiNP_001138229.1. NM_001144757.2. [P05408-1]
NP_003011.1. NM_003020.4. [P05408-2]
UniGeneiHs.156540.

3D structure databases

ProteinModelPortaliP05408.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112345. 5 interactors.
IntActiP05408. 5 interactors.
MINTiMINT-1402757.
STRINGi9606.ENSP00000300175.

Protein family/group databases

MEROPSiI21.001.

PTM databases

iPTMnetiP05408.
PhosphoSitePlusiP05408.

Polymorphism and mutation databases

BioMutaiSCG5.
DMDMi23830842.

Proteomic databases

PaxDbiP05408.
PeptideAtlasiP05408.
PRIDEiP05408.

Protocols and materials databases

DNASUi6447.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300175; ENSP00000300175; ENSG00000166922. [P05408-1]
ENST00000413748; ENSP00000388560; ENSG00000166922. [P05408-2]
ENST00000614359; ENSP00000482615; ENSG00000277614. [P05408-1]
ENST00000632219; ENSP00000488109; ENSG00000281931. [P05408-1]
ENST00000632674; ENSP00000488509; ENSG00000281931. [P05408-2]
GeneIDi6447.
KEGGihsa:6447.
UCSCiuc001zgz.3. human. [P05408-1]

Organism-specific databases

CTDi6447.
DisGeNETi6447.
GeneCardsiSCG5.
HGNCiHGNC:10816. SCG5.
HPAiHPA013136.
MalaCardsiSCG5.
MIMi173120. gene.
neXtProtiNX_P05408.
OpenTargetsiENSG00000166922.
ENSG00000277614.
ENSG00000281931.
PharmGKBiPA35724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4187. Eukaryota.
ENOG410ZRXV. LUCA.
GeneTreeiENSGT00390000009816.
HOGENOMiHOG000259690.
HOVERGENiHBG000031.
InParanoidiP05408.
OMAiQATNIVG.
OrthoDBiEOG091G0LE0.
PhylomeDBiP05408.
TreeFamiTF314328.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000166922-MONOMER.

Miscellaneous databases

ChiTaRSiSCG5. human.
GeneWikiiSCG5.
GenomeRNAii6447.
PROiP05408.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166922.
CleanExiHS_SCG5.
ExpressionAtlasiP05408. baseline and differential.
GenevisibleiP05408. HS.

Family and domain databases

InterProiIPR007945. Secretogranin_V.
[Graphical view]
PANTHERiPTHR12738. PTHR12738. 1 hit.
PfamiPF05281. Secretogranin_V. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei7B2_HUMAN
AccessioniPrimary (citable) accession number: P05408
Secondary accession number(s): P01164, Q6FHD0, Q9BS38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 10, 2002
Last modified: November 30, 2016
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.