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P05408

- 7B2_HUMAN

UniProt

P05408 - 7B2_HUMAN

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Protein

Neuroendocrine protein 7B2

Gene
SCG5, SGNE1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.1 Publication

GO - Molecular functioni

  1. enzyme inhibitor activity Source: UniProtKB
  2. GTP binding Source: ProtInc
  3. protein binding Source: UniProtKB
  4. unfolded protein binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
  2. neuropeptide signaling pathway Source: UniProtKB-KW
  3. peptide hormone processing Source: UniProtKB
  4. regulation of hormone secretion Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Neuropeptide

Keywords - Biological processi

Transport

Protein family/group databases

MEROPSiI21.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuroendocrine protein 7B2
Alternative name(s):
Pituitary polypeptide
Secretogranin V
Secretogranin-5
Secretory granule endocrine protein I
Cleaved into the following 2 chains:
Gene namesi
Name:SCG5
Synonyms:SGNE1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:10816. SCG5.

Subcellular locationi

Secreted
Note: Neuroendocrine and endocrine secretory granules.

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. secretory granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26261 PublicationAdd
BLAST
Chaini27 – 212186Neuroendocrine protein 7B2PRO_0000000041Add
BLAST
Chaini27 – 176150N-terminal peptide By similarityPRO_0000000042Add
BLAST
Peptidei200 – 21213C-terminal peptide By similarityPRO_0000000043Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi120 ↔ 130 By similarity

Post-translational modificationi

Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides By similarity.
Sulfated on tyrosine residues By similarity.

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Sulfation

Proteomic databases

PaxDbiP05408.
PRIDEiP05408.

PTM databases

PhosphoSiteiP05408.

Expressioni

Gene expression databases

ArrayExpressiP05408.
BgeeiP05408.
CleanExiHS_SCG5.
GenevestigatoriP05408.

Organism-specific databases

HPAiHPA013136.

Interactioni

Subunit structurei

Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.1 Publication

Protein-protein interaction databases

BioGridi112345. 3 interactions.
IntActiP05408. 2 interactions.
MINTiMINT-1402757.
STRINGi9606.ENSP00000300175.

Structurei

3D structure databases

ProteinModelPortaliP05408.

Family & Domainsi

Sequence similaritiesi

Belongs to the 7B2 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG271457.
HOGENOMiHOG000259690.
HOVERGENiHBG000031.
InParanoidiP05408.
OMAiNNGISIS.
OrthoDBiEOG7KSX9R.
PhylomeDBiP05408.
TreeFamiTF314328.

Family and domain databases

InterProiIPR007945. Secretogranin_V.
[Graphical view]
PANTHERiPTHR12738. PTHR12738. 1 hit.
PfamiPF05281. Secretogranin_V. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P05408-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVSRMVSTML SGLLFWLASG WTPAFAYSPR TPDRVSEADI QRLLHGVMEQ    50
LGIARPRVEY PAHQAMNLVG PQSIEGGAHE GLQHLGPFGN IPNIVAELTG 100
DNIPKDFSED QGYPDPPNPC PVGKTADDGC LENTPDTAEF SREFQLHQHL 150
FDPEHDYPGL GKWNKKLLYE KMKGGERRKR RSVNPYLQGQ RLDNVVAKKS 200
VPHFSDEDKD PE 212
Length:212
Mass (Da):23,730
Last modified:October 10, 2002 - v2
Checksum:iA459702055C0FE84
GO
Isoform 2 (identifier: P05408-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     126-126: Missing.

Show »
Length:211
Mass (Da):23,659
Checksum:i649AA3FF2EC2A0A6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei126 – 1261Missing in isoform 2. VSP_011754

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1511F → S in AAH05349. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00757 mRNA. Translation: CAA68726.1.
AJ290438
, AJ290439, AJ290440, AJ290441, AJ290442 Genomic DNA. Translation: CAB90397.1.
CR541824 mRNA. Translation: CAG46623.1.
CH471125 Genomic DNA. Translation: EAW92262.1.
BC005349 mRNA. Translation: AAH05349.1.
BC093053 mRNA. Translation: AAH93053.1.
CCDSiCCDS45207.1. [P05408-1]
CCDS45208.1. [P05408-2]
PIRiS01008. PUHU.
RefSeqiNP_001138229.1. NM_001144757.1. [P05408-1]
NP_003011.1. NM_003020.3. [P05408-2]
UniGeneiHs.156540.

Genome annotation databases

EnsembliENST00000300175; ENSP00000300175; ENSG00000166922. [P05408-1]
ENST00000413748; ENSP00000388560; ENSG00000166922. [P05408-2]
GeneIDi6447.
KEGGihsa:6447.
UCSCiuc001zgz.2. human.
uc001zha.2. human. [P05408-1]

Polymorphism databases

DMDMi23830842.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y00757 mRNA. Translation: CAA68726.1 .
AJ290438
, AJ290439 , AJ290440 , AJ290441 , AJ290442 Genomic DNA. Translation: CAB90397.1 .
CR541824 mRNA. Translation: CAG46623.1 .
CH471125 Genomic DNA. Translation: EAW92262.1 .
BC005349 mRNA. Translation: AAH05349.1 .
BC093053 mRNA. Translation: AAH93053.1 .
CCDSi CCDS45207.1. [P05408-1 ]
CCDS45208.1. [P05408-2 ]
PIRi S01008. PUHU.
RefSeqi NP_001138229.1. NM_001144757.1. [P05408-1 ]
NP_003011.1. NM_003020.3. [P05408-2 ]
UniGenei Hs.156540.

3D structure databases

ProteinModelPortali P05408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112345. 3 interactions.
IntActi P05408. 2 interactions.
MINTi MINT-1402757.
STRINGi 9606.ENSP00000300175.

Protein family/group databases

MEROPSi I21.001.

PTM databases

PhosphoSitei P05408.

Polymorphism databases

DMDMi 23830842.

Proteomic databases

PaxDbi P05408.
PRIDEi P05408.

Protocols and materials databases

DNASUi 6447.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000300175 ; ENSP00000300175 ; ENSG00000166922 . [P05408-1 ]
ENST00000413748 ; ENSP00000388560 ; ENSG00000166922 . [P05408-2 ]
GeneIDi 6447.
KEGGi hsa:6447.
UCSCi uc001zgz.2. human.
uc001zha.2. human. [P05408-1 ]

Organism-specific databases

CTDi 6447.
GeneCardsi GC15P032933.
HGNCi HGNC:10816. SCG5.
HPAi HPA013136.
MIMi 173120. gene.
neXtProti NX_P05408.
PharmGKBi PA35724.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271457.
HOGENOMi HOG000259690.
HOVERGENi HBG000031.
InParanoidi P05408.
OMAi NNGISIS.
OrthoDBi EOG7KSX9R.
PhylomeDBi P05408.
TreeFami TF314328.

Miscellaneous databases

GeneWikii SCG5.
GenomeRNAii 6447.
NextBioi 25057.
PROi P05408.
SOURCEi Search...

Gene expression databases

ArrayExpressi P05408.
Bgeei P05408.
CleanExi HS_SCG5.
Genevestigatori P05408.

Family and domain databases

InterProi IPR007945. Secretogranin_V.
[Graphical view ]
PANTHERi PTHR12738. PTHR12738. 1 hit.
Pfami PF05281. Secretogranin_V. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2."
    Martens G.J.M.
    FEBS Lett. 234:160-164(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Pituitary.
  2. "The production by alternate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man."
    Paquet L., Lazure C., Seidah N.G., Chretien M., Mbikay M.
    Biochem. Biophys. Res. Commun. 174:156-162(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 125-140 (ISOFORM 1), PROTEIN SEQUENCE OF 126-132 (ISOFORM 2).
    Tissue: Pituitary.
  3. "Human neuroendocrine protein 7B2 genomic organization."
    Jackson R.S.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  7. "Structural organization of the gene encoding the neuroendocrine chaperone 7B2."
    Braks J.A., Broers C.A., Danger J.M., Martens G.J.M.
    Eur. J. Biochem. 236:60-67(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-92.
  8. "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus."
    Seidah N.G., Hsi K.L., de Serres G., Rochemont J., Hamelin J., Antakly T., Cantin M., Chretien M.
    Arch. Biochem. Biophys. 225:525-534(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-103.
  9. "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway."
    Braks J.A., Martens G.J.M.
    Cell 78:263-273(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PCSK2.
  10. "Neuroendocrine secretory protein 7B2: structure, expression and functions."
    Mbikay M., Seidah N.G., Chretien M.
    Biochem. J. 357:329-342(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry namei7B2_HUMAN
AccessioniPrimary (citable) accession number: P05408
Secondary accession number(s): P01164, Q6FHD0, Q9BS38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 10, 2002
Last modified: July 9, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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