P05386 (RLA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60S acidic ribosomal protein P1

Gene names

Name:	RPLP1
Synonyms:	RRP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	114 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the elongation step of protein synthesis. HAMAP-Rule MF_01478
Subunit structure	P1 and P2 exist as dimers at the large ribosomal subunit.
Sequence similarities	Belongs to the ribosomal protein L12P family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	SRP-dependent cotranslational protein targeting to membrane Traceable author statement. Source: Reactome nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Traceable author statement. Source: Reactome translational elongation Traceable author statement. Source: Reactome translational initiation Traceable author statement. Source: Reactome translational termination Traceable author statement. Source: Reactome viral transcription Traceable author statement. Source: Reactome
Cellular_component	cytosolic large ribosomal subunit Inferred from direct assay PubMed 12962325. Source: UniProtKB
Molecular_function	RNA binding Traceable author statement Ref.1. Source: ProtInc structural constituent of ribosome Non-traceable author statement PubMed 12962325. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P05386-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P05386-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-49: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 114

114

60S acidic ribosomal protein P1 HAMAP-Rule MF_01478

PRO_0000157686

Amino acid modifications

Modified residue

101

1

Phosphoserine Ref.6 Ref.7

Modified residue

104

1

Phosphoserine By similarity

Natural variations

Alternative sequence

25 – 49

25

Missing in isoform 2.

VSP_045244

Secondary structure

1

.

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.

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.

.

.

.

.

114

Helix Strand Turn

Details...

Helix

4 – 19

16

Helix

25 – 35

11

Helix

42 – 50

9

Turn

51 – 53

3

Helix

56 – 60

5

Turn

61 – 64

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 4C282AB8DCA079C8	FASTA	114	11,514
	10 20 30 40 50 60 MASVSELACI YSALILHDDE VTVTEDKINA LIKAAGVNVE PFWPGLFAKA LANVNIGSLI 70 80 90 100 110 CNVGAGGPAP AAGAAPAGGP APSTAAAPAE EKKVEAKKEE SEESDDDMGF GLFD
	Isoform 2 [UniParc]. Checksum: B84B9045B930348B	FASTA	89	8,804
	10 20 30 40 50 60 MASVSELACI YSALILHDDE VTVTALANVN IGSLICNVGA GGPAPAAGAA PAGGPAPSTA 70 80 AAPAEEKKVE AKKEESEESD DDMGFGLFD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly." Rich B.E., Steitz J.A. Mol. Cell. Biol. 7:4065-4074(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye, Placenta and Trophoblast.
[6]	"Identification and characterization of phosphorylated proteins in the human pituitary." Giorgianni F., Beranova-Giorgianni S., Desiderio D.M. Proteomics 4:587-598(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-101. Tissue: Pituitary.
[7]	"Phosphoproteomic analysis of the human pituitary." Beranova-Giorgianni S., Zhao Y., Desiderio D.M., Giorgianni F. Pituitary 9:109-120(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, MASS SPECTROMETRY. Tissue: Pituitary.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

M17886 mRNA. Translation: AAA36471.1.
AB061836 Genomic DNA. Translation: BAB79474.1.
AC027237 Genomic DNA. No translation available.
CH471082 Genomic DNA. Translation: EAW77845.1.
BC003369 mRNA. Translation: AAH03369.1.
BC007590 mRNA. Translation: AAH07590.1.
CD388103 mRNA. No translation available.

IPI

IPI00008527.
IPI00412779.

PIR

R6HUP1. B27125.

RefSeq

NP_000994.1. NM_001003.2.
NP_998890.1. NM_213725.1.

UniGene

Hs.356502.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LBF	NMR	-	A	1-69	[»]

ProteinModelPortal

P05386.

ModBase

Search...

Protein-protein interaction databases

IntAct

P05386. 37 interactions.

MINT

MINT-193188.

STRING

9606.ENSP00000346037.

PTM databases

PhosphoSite

P05386.

Polymorphism databases

DMDM

133051.

Proteomic databases

PaxDb

P05386.

PRIDE

P05386.

Protocols and materials databases

DNASU

6176.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000260379; ENSP00000346037; ENSG00000137818.
ENST00000357790; ENSP00000350437; ENSG00000137818.

GeneID

6176.

KEGG

hsa:6176.

UCSC

uc002asd.1. human.
uc002ase.1. human.

Organism-specific databases

CTD

6176.

GeneCards

GC15P069745.

HGNC

HGNC:10372. RPLP1.

HPA

HPA003368.

MIM

180520. gene.

neXtProt

NX_P05386.

PharmGKB

PA34775.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG2058.

HOGENOM

HOG000229898.

HOVERGEN

HBG002291.

InParanoid

P05386.

KO

K02942.

OMA

DVEPYWP.

OrthoDB

EOG44J2KS.

PhylomeDB

P05386.

Enzyme and pathway databases

Reactome

REACT_116125. Disease.
REACT_17015. Metabolism of proteins.
REACT_1762. 3' -UTR-mediated translational regulation.
REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

P05386.

Bgee

P05386.

CleanEx

HS_RPLP1.
HS_RRP1.

Genevestigator

P05386.

GermOnline

ENSG00000137818. Homo sapiens.

Family and domain databases

HAMAP

MF_01478. Ribosomal_L12_arch.

InterPro

IPR001813. Ribosomal_L10/L12.
IPR027534. Ribosomal_L12.
[Graphical view]

Pfam

PF00428. Ribosomal_60s. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

RpLP1. human.

GenomeRNAi

6176.

NextBio

23995.

SOURCE

Search...

Entry information

Entry name

RLA1_HUMAN

Accession

Primary (citable) accession number: P05386
Secondary accession number(s): A6NIB2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	May 29, 2013
This is version 139 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.