P05378 (TRPE_THET8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	TTHA1844

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Taxonomic identifier

300852 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus

Protein attributes

Sequence length	462 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 462	462	Anthranilate synthase component 1		PRO_0000154117

Sequences

	Sequence		Length	Mass (Da)
	P05378 [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 62C9AF94B65D010C	FASTA	462	51,635
	10 20 30 40 50 60 MERIRPYRKT FLADLETPVT AYLKLAEKAP VSFLLESVER GRQSRFSIVG VGARRTFRLK 70 80 90 100 110 120 DGVFTVNGER VETRDPLRAL YERVYAPLER HPDLPPFFGG VVGYAAYDLV RYYERLPSLK 130 140 150 160 170 180 PDDLGLPDLL FVEPEVVAVF DHLKNLLHLV APGRDPEEAE ARLFWAERRL KGPLPGVPGE 190 200 210 220 230 240 RAGGRARFQA DFSREAYLEA VRRALDYIRA GDIFQVVLSL RLSSPLTVHP FALYRALRSV 250 260 270 280 290 300 NPSPYMGYLD LGEVVLVSAS PESLLRSDGR RVVTRPIAGT RPRGKDEEED KRLAEELLRD 310 320 330 340 350 360 EKEVAEHVML LDLSRNDIGR VAAFGTVRVL EPLHVEHYSH VMHLVSTVEG ILAEGKTPLD 370 380 390 400 410 420 ALASVLPMGT VSGAPKIRAM EIIEELEPHR RGPYGGSFGY LAYDGAMDMA LTLRTFVVAK 430 440 450 460 GWMHVQAGAG IVADSVPERE YEECWNKARA LLKAVEMAEA GL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and nucleotide sequence of Thermus thermophilus HB8 trpE and trpG." Sato S., Nakada Y., Kanaya S., Tanaka T. Biochim. Biophys. Acta 950:303-312(1988) [PubMed: 2844259] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Thermus thermophilus HB8." Masui R., Kurokawa K., Nakagawa N., Tokunaga F., Koyama Y., Shibata T., Oshima T., Yokoyama S., Yasunaga T., Kuramitsu S. Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HB8 / ATCC 27634 / DSM 579.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07744 Genomic DNA. Translation: CAA30566.1. AP008226 Genomic DNA. Translation: BAD71667.1.
RefSeq	YP_145110.1. NC_006461.1.
3D structure databases
ProteinModelPortal	P05378.
ModBase	Search...
Protein-protein interaction databases
STRING	P05378.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3168049.
GenomeReviews	Gene locus TTHA1844 in contig AP008226_GR.
KEGG	ttj:TTHA1844.
PATRIC	23958657. VBITheThe93045_1815.
Phylogenomic databases
eggNOG	COG0147.
HOGENOM	HBG507440.
OMA	RTIYGRA.
PhylomeDB	P05378.
ProtClustDB	CLSK445246.
Enzyme and pathway databases
BioCyc	TTHE300852:TTHA1844-MONOMER.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
KO	K01657.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_THET8

Accession

Primary (citable) accession number: P05378
Secondary accession number(s): Q5SH86

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	January 25, 2012
This is version 84 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program