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Protein

Serum amyloid A-2 protein

Gene

Saa2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Major acute phase reactant. Apolipoprotein of the HDL complex.

GO - Molecular functioni

GO - Biological processi

  • acute-phase response Source: UniProtKB-KW
  • cell chemotaxis Source: GO_Central
  • response to stilbenoid Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Acute phase

Names & Taxonomyi

Protein namesi
Recommended name:
Serum amyloid A-2 protein
Cleaved into the following chain:
Alternative name(s):
Amyloid fibril protein AA
Gene namesi
Name:Saa2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:98222. Saa2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 122103Serum amyloid A-2 proteinPRO_0000031589Add
BLAST
Chaini20 – 9273Amyloid protein APRO_0000031590Add
BLAST

Post-translational modificationi

This protein is the precursor of amyloid protein A, which is formed by the removal of residues from the C-terminal end.

Proteomic databases

MaxQBiP05367.
PaxDbiP05367.
PeptideAtlasiP05367.
PRIDEiP05367.

PTM databases

PhosphoSiteiP05367.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Inductioni

Upon cytokine stimulation.

Gene expression databases

BgeeiENSMUSG00000057465.
CleanExiMM_SAA2.
GenevisibleiP05367. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203062. 1 interaction.
STRINGi10090.ENSMUSP00000075365.

Structurei

3D structure databases

ProteinModelPortaliP05367.
SMRiP05367. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05367.
KOiK17310.
OMAiLANEWGR.
OrthoDBiEOG091G17YH.
PhylomeDBiP05367.
TreeFamiTF332544.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P05367-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTSLVFC SLLLGVCHGG FFSFIGEAFQ GAGDMWRAYT DMKEAGWKDG
60 70 80 90 100
DKYFHARGNY DAAQRGPGGV WAAEKISDAR ESFQEFFGRG HEDTMADQEA
110 120
NRHGRSGKDP NYYRPPGLPA KY
Length:122
Mass (Da):13,622
Last modified:November 1, 1988 - v1
Checksum:i99E79D6FF97E96E0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti120 – 1201A → D in strain: SJL/J.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13522 Genomic DNA. Translation: AAA40086.1.
M11130 mRNA. Translation: AAA40085.1.
M17791 Genomic DNA. Translation: AAA40087.1.
CCDSiCCDS21285.1.
PIRiB23843.
RefSeqiNP_035444.1. NM_011314.2.
XP_006540790.1. XM_006540727.1.
UniGeneiMm.200941.

Genome annotation databases

EnsembliENSMUST00000075982; ENSMUSP00000075365; ENSMUSG00000057465.
GeneIDi20209.
KEGGimmu:20209.
UCSCiuc009gzb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13522 Genomic DNA. Translation: AAA40086.1.
M11130 mRNA. Translation: AAA40085.1.
M17791 Genomic DNA. Translation: AAA40087.1.
CCDSiCCDS21285.1.
PIRiB23843.
RefSeqiNP_035444.1. NM_011314.2.
XP_006540790.1. XM_006540727.1.
UniGeneiMm.200941.

3D structure databases

ProteinModelPortaliP05367.
SMRiP05367. Positions 21-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203062. 1 interaction.
STRINGi10090.ENSMUSP00000075365.

PTM databases

PhosphoSiteiP05367.

Proteomic databases

MaxQBiP05367.
PaxDbiP05367.
PeptideAtlasiP05367.
PRIDEiP05367.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075982; ENSMUSP00000075365; ENSMUSG00000057465.
GeneIDi20209.
KEGGimmu:20209.
UCSCiuc009gzb.2. mouse.

Organism-specific databases

CTDi6289.
MGIiMGI:98222. Saa2.

Phylogenomic databases

eggNOGiENOG410IXU4. Eukaryota.
ENOG410YSBK. LUCA.
GeneTreeiENSGT00390000004737.
HOGENOMiHOG000126881.
HOVERGENiHBG016327.
InParanoidiP05367.
KOiK17310.
OMAiLANEWGR.
OrthoDBiEOG091G17YH.
PhylomeDBiP05367.
TreeFamiTF332544.

Miscellaneous databases

PROiP05367.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000057465.
CleanExiMM_SAA2.
GenevisibleiP05367. MM.

Family and domain databases

InterProiIPR000096. Serum_amyloid_A.
[Graphical view]
PfamiPF00277. SAA. 1 hit.
[Graphical view]
PIRSFiPIRSF002472. Serum_amyloid_A. 1 hit.
PRINTSiPR00306. SERUMAMYLOID.
SMARTiSM00197. SAA. 1 hit.
[Graphical view]
PROSITEiPS00992. SAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAA2_MOUSE
AccessioniPrimary (citable) accession number: P05367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: September 7, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

SAA2 is the preferred amyloid-forming precursor.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.