ID   SAA1_MOUSE              Reviewed;         122 AA.
AC   P05366;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 2.
DT   24-JAN-2024, entry version 155.
DE   RecName: Full=Serum amyloid A-1 protein;
DE   Flags: Precursor;
GN   Name=Saa1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3013853; DOI=10.1016/s0021-9258(19)83932-7;
RA   Lowell C.A., Potter D.A., Stearman R.S., Morrow J.F.;
RT   "Structure of the murine serum amyloid A gene family. Gene conversion.";
RL   J. Biol. Chem. 261:8442-8452(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE OF 9-122, TISSUE SPECIFICITY, AND INDUCTION BY
RP   LIPOPOLYSACCHARIDE.
RX   PubMed=3857624; DOI=10.1073/pnas.82.9.2915;
RA   Yamamoto K., Migita S.;
RT   "Complete primary structures of two major murine serum amyloid A proteins
RT   deduced from cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 82:2915-2919(1985).
RN   [3]
RP   PROTEIN SEQUENCE OF 20-39, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   FUNCTION.
RX   PubMed=9518179; DOI=10.1016/s0378-4347(97)00462-3;
RA   Kaplan B., Yakar S., Balta Y., Pras M., Martin B.;
RT   "Isolation and purification of two major serum amyloid A isotypes SAA1 and
RT   SAA2 from the acute phase plasma of mice.";
RL   J. Chromatogr. B 704:69-76(1997).
CC   -!- FUNCTION: Major acute phase protein. {ECO:0000269|PubMed:9518179}.
CC   -!- SUBUNIT: Homohexamer; dimer of trimers. Can form amyloid fibrils after
CC       partial proteolysis; the native, undenatured protein does not form
CC       amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to
CC       heparin (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9518179}.
CC   -!- TISSUE SPECIFICITY: Detected in blood plasma (at protein level).
CC       Detected in liver. {ECO:0000269|PubMed:3857624,
CC       ECO:0000269|PubMed:9518179}.
CC   -!- INDUCTION: By bacterial lipopolysaccharide.
CC       {ECO:0000269|PubMed:3857624}.
CC   -!- SIMILARITY: Belongs to the SAA family. {ECO:0000305}.
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DR   EMBL; M13521; AAA40084.1; -; Genomic_DNA.
DR   EMBL; M11131; AAA40083.1; -; Genomic_RNA.
DR   CCDS; CCDS21284.1; -.
DR   PIR; A23843; A23843.
DR   RefSeq; NP_033143.1; NM_009117.3.
DR   RefSeq; XP_006540789.1; XM_006540726.3.
DR   AlphaFoldDB; P05366; -.
DR   SMR; P05366; -.
DR   STRING; 10090.ENSMUSP00000119150; -.
DR   iPTMnet; P05366; -.
DR   PhosphoSitePlus; P05366; -.
DR   CPTAC; non-CPTAC-3437; -.
DR   PaxDb; 10090-ENSMUSP00000119150; -.
DR   PeptideAtlas; P05366; -.
DR   ProteomicsDB; 260809; -.
DR   DNASU; 20208; -.
DR   Ensembl; ENSMUST00000128088.4; ENSMUSP00000119150.2; ENSMUSG00000074115.6.
DR   GeneID; 20208; -.
DR   KEGG; mmu:20208; -.
DR   UCSC; uc009gyz.1; mouse.
DR   AGR; MGI:98221; -.
DR   CTD; 6288; -.
DR   MGI; MGI:98221; Saa1.
DR   VEuPathDB; HostDB:ENSMUSG00000074115; -.
DR   eggNOG; ENOG502S4PB; Eukaryota.
DR   GeneTree; ENSGT00390000004737; -.
DR   HOGENOM; CLU_129936_0_0_1; -.
DR   InParanoid; P05366; -.
DR   OMA; HEDTIAD; -.
DR   OrthoDB; 2958429at2759; -.
DR   PhylomeDB; P05366; -.
DR   TreeFam; TF332544; -.
DR   BioGRID-ORCS; 20208; 1 hit in 58 CRISPR screens.
DR   ChiTaRS; Saa1; mouse.
DR   PRO; PR:P05366; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; P05366; Protein.
DR   Bgee; ENSMUSG00000074115; Expressed in left colon and 54 other cell types or tissues.
DR   ExpressionAtlas; P05366; baseline and differential.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISO:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:MGI.
DR   GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   GO; GO:0008203; P:cholesterol metabolic process; IDA:MGI.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   Gene3D; 1.10.132.110; Serum amyloid A protein; 1.
DR   InterPro; IPR000096; Serum_amyloid_A.
DR   Pfam; PF00277; SAA; 1.
DR   PIRSF; PIRSF002472; Serum_amyloid_A; 1.
DR   PRINTS; PR00306; SERUMAMYLOID.
DR   SMART; SM00197; SAA; 1.
DR   PROSITE; PS00992; SAA; 1.
DR   Genevisible; P05366; MM.
PE   1: Evidence at protein level;
KW   Acute phase; Direct protein sequencing; HDL; Heparin-binding;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:9518179"
FT   CHAIN           20..122
FT                   /note="Serum amyloid A-1 protein"
FT                   /id="PRO_0000031588"
FT   REGION          20..45
FT                   /note="Important for amyloid formation"
FT                   /evidence="ECO:0000250"
FT   REGION          91..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   122 AA;  13770 MW;  0AEF6D5F208EA4D0 CRC64;
     MKLLTSLVFC SLLLGVCHGG FFSFVHEAFQ GAGDMWRAYT DMKEANWKNS DKYFHARGNY
     DAAQRGPGGV WAAEKISDGR EAFQEFFGRG HEDTIADQEA NRHGRSGKDP NYYRPPGLPD
     KY
//